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Downregulation of Serum PTEN Expression in Mercury-Exposed Population and PI3K/AKT Pathway-Induced Inflammation

Biomedical and Environmental Sciences 2024年第4期37卷 354-366页

作者： MEI Peng DING En Min YIN Hao Yang DING Xue Xue WANG Huan WANG Jian Feng HAN Lei zhang heng dong ZHU Bao Li School of Public Health Nanjing Medical UniversityNanjing 210000JiangsuChina Institute of Occupational Disease Prevention Jiangsu Province Center for Disease Prevention and ControlNanjing 21000JiangsuChina Suzhou Center for Disease Prevention and Control Suzhou 215004JiangsuChina Center for Global Health School of Public HealthNanjing Medical UniversityNanjing 210000JiangsuChina

Objective This study investigated the impact of occupational mercury(Hg) exposure on human gene transcription and expression, and its potential biological *** Differentially expressed genes related to Hg exposure were identified and validated using gene expression microarray analysis and extended validation. Hg-exposed cell models and PTEN lowexpression models were established in vitro using 293T cells. PTEN gene expression was assessed using qRT-PCR, and Western blotting was used to measure PTEN, AKT, and PI3K protein levels. IL-6 expression was determined by *** Combined findings from gene expression microarray analysis, bioinformatics, and population expansion validation indicated significant downregulation of the PTEN gene in the high-concentration Hg exposure group. In the Hg-exposed cell model(25 and 10 μmol/L), a significant decrease in PTEN expression was observed, accompanied by a significant increase in PI3K, AKT, and IL-6 ***, a low-expression cell model demonstrated that PTEN gene knockdown led to a significant decrease in PTEN protein expression and a substantial increase in PI3K, AKT, and IL-6 *** This is the first study to report that Hg exposure downregulates the PTEN gene, activates the PI3K/AKT regulatory pathway, and increases the expression of inflammatory factors, ultimately resulting in kidney inflammation.

关键词： PTEN Occupational mercury exposure Occupational health PI3K/AKT pathway 293T cell IL-6

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Synthesis and Characterization of {2-Formyl-6-[1-(2,4,6-trimethylphenyl)]-4- chlorophenoxy}_2Ni and Its Ethylene Oligomerization

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Chinese Journal of Structural Chemistry 2005年第8期24卷 930-934页

作者： zhang dong-heng DU Jian-Long HAN Ling-Qin SUN Wen-Hua Key Laboratory of Engineering Plastics Institute of Chemistry The Chinese Academy of Sciences Beijing 100080 State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of Matter The Chinese Academy of Sciences Fuzhou 350002 China College of Chemistry & Environmental Science Hebei UniversityChina Baoding 071002

The title nickel complex （C34H3oCl2N2NiO4, Mr = 660.21） has been synthesized and its crystal structure was determined by single-crystal X-ray structure analysis. It crystallizes in the monoclinic system, space group P21/n with a = 11.026（8）, b = 11.491（8）, c = 12.119（9） A°, β=91.328（13）°, Z= 2, V= 1535.0（19） ,A°^3, Dc = 1.428 g/cm^3, F（000） = 684 andμ（MoKa） = 0.848 mm^-1 The structure was refined to R = 0.0544 for 1813 observed reflections with I 〉 2σ（I） and wR =0.0867 for 3132 unique reflections. The molecule of the complex is high symmetrical. Ni（Ⅱ） atom is located in the symmetric center and coordinated to two phenolic oxygen and two imino nitrogen atoms, forming two six-membered rings. Upon activation with methylaluminoxane （MAO）, it is active for ethylene oligomerization.

关键词： nickel complex salicylaldimine ethylene oligomerization

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Effects of α-adrenoreceptor antagonists on apoptosis and proliferation of pancreatic cancer cells in vitro

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World Journal of Gastroenterology 2008年第15期14卷 2358-2363页

作者： Su-Gang Shen dong zhang heng-Tong Hu Jun-Hui Li Zheng Wang Qing-Yong Ma Department of Hepatobiliary and Pancreas Surgery The First Affiliated Hospital Medical College Xi'an Jiaotong University Xi'an 710061 Shaanxi Province China

AIM: To discuss the expression of α-adrenoreceptors in pancreatic cancer cell lines PC-2 and PC-3 and the effects of α1- and α2-adrenoreceptor antagonists, yohimbine and urapidil hydrochloride, on the cell lines in vitro. METHODS: We cultured the human ductal pancreatic adenocarcinoma cell lines PC-2 and PC-3 and analyzed the mRNA expression of α1- and α2-adrenergic receptors by reverse transcription polymerase chain reaction (RT-PCR). The effects of yohimbine and urapidil hydrochloride on cell proliferation were assessed by 3-(4,5-dimethylthiasol-2-yl)- 2,4,-diphenyltetrazolium bromide (MTT) assay. Apoptosis was detected using the terminal deoxyribonucleotidyl transferase (TdT)-mediated biotin-16-dUTP nick-end labeling (TUNEL) assay and flow cytometry (FCM). RESULTS: PC-2 expressed mRNA in α1- and α2- adrenoreceptors. MTT assays showed that urapidil hydrochloride had no effect on PC-3 cell lines. However, exposure to urapidil hydrochloride increased DNA synthesis in PC-2 cell lines as compared to the control group. PC-2 cell lines were sensitive to both drugs. The proliferation of the 2 cell lines was inhibited by yohimbine. Cell proliferation was inhibited by yohimbine via apoptosis induction. CONCLUSION: The expression of α1- and α2- adrenoreceptors is different in PC-2 and PC-3 cell lines, which might be indicative of their different functions. The α2-adrenoceptor antagonist, yohimbine, can inhibit theproliferation of both cell lines and induce their apoptosis, suggesting that yohimbine can be used as an anticancer drug for apoptosis of PC-2 and PC-3 cells.

关键词： Alpha-adrenoreceptor Pancreatic cancer Yohimbine Urapidil hydrochloride

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Nonlinear Registration of Brain Magnetic Resonance Images with Cross Constraints of Intensity and Structure

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Computers, Materials & Continua 2024年第5期79卷 2295-2313页

作者： Han Zhou HongtaoXu Xinyue Chang Wei zhang heng dong Digital Fujian Research Institute of Big Data forAgriculture and Forestry Fujian Agriculture and Forestry UniversityFuzhou350002China College of Computer and Information Science Fujian Agriculture and Forestry UniversityFuzhou350002China

Many deep learning-based registration methods rely on a single-stream encoder-decoder network for computing deformation fields between 3D ***,these methods often lack constraint information and overlook semantic consistency,limiting their *** address these issues,we present a novel approach for medical image registration called theDual-VoxelMorph,featuring a dual-channel cross-constraint *** innovative network utilizes both intensity and segmentation images,which share identical semantic information and feature *** encoder-decoder structures calculate deformation fields for intensity and segmentation images,as generated by the dual-channel cross-constraint *** design facilitates bidirectional communication between grayscale and segmentation information,enabling the model to better learn the corresponding grayscale and segmentation details of the same anatomical *** ensure semantic and directional consistency,we introduce constraints and apply the cosine similarity function to enhance semantic *** on four public datasets demonstrates superior performance compared to the baselinemethod,achieving Dice scores of 79.9%,64.5%,69.9%,and 63.5%for OASIS-1,OASIS-3,LPBA40,and ADNI,respectively.

关键词： Medical image registration cross constraint semantic consistency directional consistency dual-channel

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Transmissive reconfigurable metasurface enabling independent control of active and passive modules through weak coupling

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Photonics Research 2024年第7期12卷 1449-1456页

作者： KUN XUE heng WEI CILEI zhang YONGHAO zhang HAOLIANG SUN SHAOHUA dong Peng Cheng Laboratory Shenzhen 518055China Department of Electrical and Computer Engineering National University of SingaporeSingapore 117583Singapore State Key Laboratory of Radio Frequency Heterogeneous Integration College of Electronics and Information EngineeringShenzhen UniversityShenzhen 518060China

Metasurfaces have demonstrated rich electromagnetic control capabilities and degrees of freedom in past years. As is well known, for passive metasurfaces, their functionalities cannot be further expanded accordingly once prototypes are established. Therefore, reconfigurable metasurfaces, utilizing active devices to replace geometric changes in passive structures, have received widespread attention, especially with the development of wireless communication recently. In reconfigurable metasurfaces, artificial meta-atoms are composed of active devices and passive structures combined together. However, these two modules are usually utilized as a whole due to the tight coupling of the active devices and the passive structures, which results in passive structures not receiving sufficient attention and being utilized as independent degrees of freedom. In this article, we propose the concept of weakly coupled reconfigurable metasurfaces in transmissive systems, enabling independent control of active and passive modules through weak coupling. As the proof of concept, a simple weakly coupled system is proposed, which can realize the transmission wavefront engineering through the geometric changes of meta-structures in passive mode, while achieving switching between transmission and reflection states in active mode, respectively. Our exploration lies in making use of the physical structure, which is easily neglected in traditional reconfigurable metasurface design, emphasizing the collaborative work of active and passive modules, exploring more available variables within the same aperture, and providing a potential solution for balancing functionality and resource consumption in practical applications.

关键词： modules coupling weakly

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Drinking water quality & health risk assessment of secondary water supply systems in residential neighborhoods

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Frontiers of Environmental Science & Engineering 2024年第2期18卷 47-62页

作者： Yating Wei dong Hu Chengsong Ye heng zhang Haoran Li Xin Yu College of the Environment&Ecology Xiamen UniversityXiamen 361102China School of Public Health Shandong First Medical University&Shandong Academy of Medical SciencesJinan 250117China

Secondary water supply systems(SWSSs)are important components of the water supply infrastructure that ensure residents’drinking water *** are characterized by long detention time,warm temperature,and unreasonable management,which may trigger the deterioration of water quality and increase *** this study,drinking water quality index(DWQI)and health risk assessment(HRA)were selected and modified to quantitatively assess the water quality and health risks of SWSSs in residential *** total,121 seasonal water samples were *** was observed that the water quality was excellent with the DWQI of 0.14±0.04,excluding one sample,which was extremely poor owing to its excessive total bacterial *** HRA results revealed that the health risks were low:negligible non-carcinogenic risk for any population;negligible and acceptable carcinogenic risk for children aged 6–17 and ***,samples revealed higher carcinogenic risk(7.63×10−5±3.29×10−6)for children aged 0–5,and arsenic was the major *** samples had poor water quality and higher health risks,which called for *** further investigate the water quality and health risks of SWSSs,monthly sampling was conducted during *** 24 water samples were qualified in Chinese standard(GB 5749-2022)and characterized as excellent *** HRA results were consistent with the seasonal samples’and the health risks were mainly concentrated in ***,our study provides a suitable framework for water quality security,advice for managers,and references for administrators in other cities.

关键词： Drinking water quality Water quality index Health risk assessment Secondary water supply systems Heavy metals

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Value iteration algorithm for continuous-time linear quadratic stochastic optimal control problems

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Science China(Information Sciences) 2024年第2期67卷 170-180页

作者： Guangchen WANG heng zhang School of Control Science and Engineering Shandong University

In this study, we investigate a continuous-time infinite-horizon linear quadratic stochastic optimal control problem with multiplicative noise in control and state variables. Using the techniques of stochastic stability, exact observability, and stochastic approximation, a value iteration algorithm is developed to solve the corresponding generalized algebraic Riccati equation. Unlike the existing policy iteration algorithm, this algorithm does not rely on an initial stabilizing control. Further, this algorithm can also be used to compute policy evaluation steps that arise in the policy iteration algorithm. Herein, a simulation example is provided to validate the obtained results.

关键词： stochastic systems optimal control linear quadratic stochastic problem generalized algebraic Riccati equation value iteration algorithm

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General radical difluoromethylation using difluoroacetic anhydride via photoredox catalysis

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Science China Chemistry 2024年第8期67卷 2637-2646页

作者： Meng He Yankai Yang heng zhang Zhipeng Guan Zhi-Bing dong Hong Yi Aiwen Lei School of Chemistry and Environmental Engineering Wuhan Institute of TechnologyWuhan 430205China College of Chemistry and Molecular Sciences and Institute for Advanced Studies(IAS) Wuhan UniversityWuhan 430072China

CF_(2)H-containing molecules play pivotal roles in diverse fields from medicinal chemistry to materials science. However, the application of existing CF_(2)H reagents as a source of CF_(2)H radical is limited by their reactivity and preparation. Herein, we develop a simple and general visible-light-catalyzed radical difluoromethylation reaction of alkenes, dienes, and heteroaromatics using commercially available, easy-to-handle, and low-cost difluoroacetic anhydride as the CF_(2)H reagent. This scalable protocol enables the convenient synthesis of a range of CF_(2)H-containing compounds under mild conditions, exhibiting a broad substrate scope and functional group tolerance. Potential applications are further demonstrated by gram-scale synthesis, sunlight experiments, derivatization experiments as well as the synthesis of bioactive molecules.

关键词： radical difluoromethylation alkenes/dienes/heteroaromatics difluoroacetic anhydride photoredox

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An attention graph stacked autoencoder for anomaly detection of electro-mechanical actuator using spatio-temporal multivariate signals

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Chinese Journal of Aeronautics 2024年第9期37卷 506-520页

作者： Jianyu WANG heng zhang Qiang MIAO College of Electrical Engineering Sichuan UniversityChengdu 610065China

Health monitoring of electro-mechanical actuator(EMA)is critical to ensure the security of *** is difficult or even impossible to collect enough labeled failure or degradation data from actual *** autoencoder based on reconstruction loss is a popular model that can carry out anomaly detection with only consideration of normal training data,while it fails to capture spatio-temporal information from multivariate time series signals of multiple monitoring *** mine the spatio-temporal information from multivariate time series signals,this paper proposes an attention graph stacked autoencoder for EMA anomaly ***,attention graph con-volution is introduced into autoencoder to convolve temporal information from neighbor features to current features based on different weight ***,stacked autoencoder is applied to mine spatial information from those new aggregated temporal ***,based on the bench-mark reconstruction loss of normal training data,different health thresholds calculated by several statistic indicators can carry out anomaly detection for new testing *** comparison with tra-ditional stacked autoencoder,the proposed model could obtain higher fault detection rate and lower false alarm rate in EMA anomaly detection experiment.

关键词： Anomaly detection Spatio-temporal informa-tion Multivariate time series signals Attention graph convolution Stacked autoencoder

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铅暴露对人群骨代谢影响的Meta分析

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环境卫生学杂志 2024年第8期14卷 647-653页

作者：韩竣宇黄海茹杨乾磊彭晓琨张恒东安艳苏州大学苏州医学院公共卫生学院江苏省老年病预防与转化医学重点实验室苏州215123 江苏省疾病预防控制中心职业病防治所江苏省预防医学会

目的利用Meta分析的方法,研究铅暴露对人群骨代谢的影响。方法通过对中国期刊全文数据库、万方数据库、维普中文科技期刊数据库、PubMed、Web of science五个数据库,检索建库至2022年3月公开发表的铅暴露对人群骨代谢相关指标影响的文献... 详细信息

目的利用Meta分析的方法,研究铅暴露对人群骨代谢的影响。方法通过对中国期刊全文数据库、万方数据库、维普中文科技期刊数据库、PubMed、Web of science五个数据库,检索建库至2022年3月公开发表的铅暴露对人群骨代谢相关指标影响的文献,对文献进行筛选和资料提取。以AHRQ横断面研究评价标准对纳入文献进行质量评价。维生素D3、骨钙素、骨碱性磷酸酶作为骨代谢指标进行分析。采用Stata16、Review Manager 5.3软件进行森林图绘制、敏感性分析及发表偏倚检验,标准化均数差(SMD)及其95%可信区间(95%CI)作为效应指标。结果共纳入13篇文献(n=2029)。纳入的研究存在中高度异质性(I^(2)>50%),采取随机效应模型。相对于非铅接触人群,铅接触人群的钙磷代谢调节指标维生素D3的SMD为-1.11(95%CI:-2.20~-0.02),骨钙素的SMD为-0.50(95%CI:-0.91~-0.09),骨碱性磷酸酶的SMD为0.80(95%CI:0.42~1.19),差异均具有统计学意义(P<0.01)。结论Meta分析结果表明铅暴露影响人群的骨代谢,其中骨碱性磷酸酶水平升高,维生素D3、骨钙素水平下降。

关键词：铅暴露骨代谢 25-羟基维生素D3 骨钙素骨碱性磷酸酶

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