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当代教研论丛 2024年第5期10卷 56-58页

作者：张大明兰州市永登县苦水镇沙湾小学甘肃兰州730304

良好的学习习惯是学生获取知识、发展能力和健康成长的基石。文章以数学为例,结合课题研究实践,分别从学生、家庭、教师、学校四个层面,对培养低年级学生良好数学学习习惯的影响因素进行了分析,给出了培养良好数学学习习惯的具体策略。

关键词：低年级数学学习习惯培养

Ion sulphuration-an effective surface engineering technique for reducing friction and wear of rubbing-pairs

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中国有色金属学会会刊：英文版 2004年第Z1期14卷 13-18页

作者： LIU Jia-jun WANG Hai-dou zhang Ning zhang da-ming Department of Mechanical Engineering Tsinghua University Beijing 100084 China National Key Laboratory for Remanufacturing Academy of Armored Force Engineering Beijing 100072 China Chinergy Co. Ltd. Beijing 100084 China Department of Mechanical Engineering Tsinghua University Beijing 100084 China

The low temperature ion sulphuration-an effective surface engineering technique for reducing friction and wear of rubbing-pairs was introduced. It involves the principle of ion sulphuration process, microstructure of FeS film on 1045 steel, tribological properties of FeS film on steels, microstructions and tribological properties of MoS2 and nano-FeS/MoS2 multi-layered films, as well as their applications.

关键词： solid lubrication low temperature ion sulphuration friction and wear surface engineering

Electrochemical sensing of DNA immobilization and hybridization based on carbon nanotubes/nano zinc oxide/chitosan composite film

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Chinese Chemical Letters 2008年第5期19卷 589-591页

作者： Wei zhang Tao Yang da ming Huang Kui Jiao College of Chemistry and Molecular Engineering Qingdao University of Science and Technology Qingdao 266042 China

A novel electrochemical DNA biosensor based on zinc oxide （ZnO） nanoparticles and multi-walled carbon nanotubes （MWNTs） for DNA immobilization and enhanced hybridization detection is presented. The MWNTs/nano ZnO/chitosan composite film modified glassy carbon electrode （MWNTs/ZnO/CHIT/GCE） was fabricated and DNA probes were immobilized on the electrode surface. The hybridization events were monitored by differential pulse voltammetry （DPV） using methylene blue （MB） as an indicator. The sensor can effectively discriminate different DNA sequences related to PAT gene in the transgenic corn, with a detection limit of 2.8× 10^-12 mol/L of target sequence.

关键词： ZnO nanoparticles Multi-walled carbon nanotubes Chitosan DNA sensor PAT gene

Does antecolic reconstruction for duodenojejunostomy improve delayed gastric emptying after pylorus-preserving pancreaticoduodenectomy? A systematic review and meta-analysis

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World Journal of Gastroenterology 2012年第43期18卷 6315-6323页

作者： An-Ping Su Shuang-Shuang Cao Yi zhang Zhao-da zhang Wei-ming Hu Bo-Le Tian Department of Hepatobiliopancreatic Surgery West China Hospital Sichuan University Chengdu 610041 Sichuan Province China

AIM:To evaluate whether antecolic reconstruction for duodenojejunostomy (DJ) can decrease delayed gastric emptying (DGE) rate after pylorus-preserving pancreaticoduodenectomy (PPPD) through literature review and meta-analysis. METHODS:Articles published between January 1991 and April 2012 comparing antecolic and retrocolic reconstruction for DJ after PPPD were retrieved from the databases of MEDLINE (PubMed), EMBASE, OVID and Cochrane Library Central. The primary outcome of interest was DGE. Either fixed effects model or random effects model was used to assess the pooled effect based on the heterogeneity. RESULTS:Five articles were identified for inclusion:two randomized controlled trials and three non-randomized controlled trials. The meta-analysis revealed that antecolic reconstruction for DJ after PPPD was associated with a statistically significant decrease in the incidence of DGE [odds ratio (OR), 0.06; 95% CI, 0.02-0.17; P < 0.00 001] and intra-operative blood loss [mean difference (MD), -317.68; 95% CI, -416.67 to -218.70; P < 0.00 001]. There was no significant difference between the groups of antecolic and retrocolic reconstruction in operative time (MD, 25.23; 95% CI, -14.37 to 64.83; P = 0.21), postoperative mortality, overall morbidity (OR, 0.54; 95% CI, 0.20-1.46; P = 0.22) and length of postoperative hospital stay (MD, -9.08; 95% CI, -21.28 to 3.11; P = 0.14). CONCLUSION:Antecolic reconstruction for DJ can decrease the DGE rate after PPPD.

关键词： Pylorus-preserving pancreaticoduodenectomy Delayed gastric emptying Antecolic reconstruction Retrocolic reconstruction Duodenojejunostomy

External Electro-optic Sampling Utilizing an Asymmetric Fabry-Pérot Film of Poled Electro-optical Polymer

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Chinese Physics Letters 2001年第6期18卷 782-784页

作者： CHEN Kai-Xin YANG Han zhang da-ming zhang Hong-Bo YI Mao-Bin State Key Laboratory on Integrated Optoelectronics Jilin UnversityChangchun 130023

External electro-optic sampling has been first demonstrated using a poled electro-optical polymer asymmetric Fabry-Pérot film,placed freely on the indium-tin oxide coplanar waveguide transmission line and used as electro-optic probe *** one laser beam is required due to the fact that the asymmetric Fabry-Pérot film is utilized to convert the phase modulation to amplitude modulation.A 1.2 GHz microwave signal is sampled,and the voltage sensitivity about 2mV/√Hz is *** results are promising for technical applications in the high-speed electronic devices and monolithic microwave integrated circuits research.

关键词： optical waveguide microwave

Roles of Loss of Chromosome 14q Allele in the Prognosis of Renal Cell Carcinoma with C-reactive Protein Abnormity

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Chinese Medical Journal 2017年第18期130卷 2176-2182页

作者： Gang Wang da-ming zhang Hai-Ying Zhuang Chao Yin Jing Liu Zi-Chun Wang Li-Cheng Cai ming-Hua Ren Wan-Hai Xu Cheng zhang Department of Urology The First Affiliated Hospital of Harbin Medical University Harbin Heilongjiang 150001 China Department of Neurosurgery The First Affiliated Hospital of Harbin Medical University Harbin Heilongjiang 150001 China Department of Pharmacology Harbin Medical University Harbin Heilongjiang 150081 China Department of Pharmacy The First Affiliated Hospital of Harbin Medical University Harbin Heilongjiang 150001 China Department of Urology The Fourth Affiliated Hospital of Harbin Medical University Harbin Heilongjiang 150001 China

Background：Renal cell carcinoma （RCC） is frequently associated with paraneoplastic inflammatory syndrome （PIS）.This study aimed at exploring the connections between the survival rate and specific gene alterations and the potential ***：We retrospectively studied 69 surgical RCC cases from August 2014 to February 2016,including 18 cases of clear cell RCC （ccRCC） demonstrating elevated pretreatment serum C-reactive protein （CRP,Group A）.Twelve of the 18 cases were symptomized with febrile *** also selected 49 cases ofccRCC with normal pretreatment CRP （Group B）.Using 22 microsatellite markers,we compared the incidence of loss of heterozygosity （LOH） between Group A and Group *** statistical tests are ***：The 3p LOH was common in both Group A （89%） and Group B （92%）.The frequency of 14q LOH in Group A （16 of 18） was higher than Group B （4 of 49,χ^2 =40.97 P 〈 0.0001）.The 3p and 14q LOH were the characteristics of ccRCC with elevated acute phase reactants,including PIS,regardless of the presence of *** the contrary,14q LOH was a rare genomic alternation in advanced-staged ccRCC without *** overall survival of patients with elevated CRP （33.3%） was lower than its counterparts （6.1%,hazard ratio=1.852,P 〈 0.0001） in Kaplan-Meier ***：The results imply that the disruption ofa 14q gene（s） might result in not only the inflammatory manifestations in the tumor host but also the poor survival rate as *** isolation of the gene（s） on 14q might be a vital goal in the treatment of PIS-associated RCC.

关键词： C-reactive Protein Gene Alterations Loss of Chromosome Paraneoplastic Inflammatory Syndrome Renal Cell Carcinoma

Properties of DR1/PMMA-co-GMA for High Speed Electro-optical Switch

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Chemical Research in Chinese Universities 2012年第6期28卷 1091-1094页

作者： CAO Zi-jian JIN Lin WANG Xi-bin CUI Zhan-chen zhang da-ming State Key Laboratory on Integrated Optoelectronics College of Electronic Science and Engineering State Key Laboratory of Superamolecular Structure and Materials Jilin University Changchun 130012 P. R. China

A non-linear optical（NLO） material was synthesized by means of a simple *** material can be applied in electro-optical（EO） devices,such as EO switches and *** Disperse Red 1（DR1） was doped in polymethyl-methacrylate-co-glycidyl methacrylate（PMMA-co-GMA） as the NLO active *** synthesis process and material structure were *** thermal properties,surface morphology and optical characteristics of the material were investigated by means of differential scanning calorimetry（DSC）,thermogravimetric analysis（TGA）,atomic force microscopy（AFM）,and m-lines *** the reflection technique,the value of the electro-optical coefficient γ 33 was measured as 11 pm/V at a wavelength of 1310 *** EO switch with nanosecond response based on this material has been fabricated.

关键词： Disperse Red 1/polymethyl-methacrylate-co-glycidyl methacrylate(DR1/PMMA-co-GMA) Electrooptical switch Thermal stability Optical property

Contrast-enhanced Ultrasound in Detecting Endoleaks with Failed Computed Tomography Angiography Diagnosis after Endovascular Abdominal Aortic Aneurysm Repair

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Chinese Medical Journal 2015年第18期128卷 2491-2497页

作者： Xiao Yang Yue-Xin Chen Bo zhang Yu-Xin Jiang Chang-Wei Liu Rui-Na Zhao Qiong Wu da-ming zhang Department of Ultrasound Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100730 China Department of Vascular Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100730 China Department of Radiology Peking Union Medical College Hospital ChineseAcademy of Medical Sciences and Peking Union Medical College Beijing 100730 China

Background： Endovascular aneurysnl repair （EVAR） is one of the first-line therapies of abdominal aortic aneurysms. Postoperative endoleak is the most common complication of EVAR. Computed tomography angiography （CTA）, which is routine for follow-up, has side effects （e.g., radiation） and also has a certain percentage of missed diagnosis. Preliminary studies on contrast-enhanced ultrasound （CEUS） have shown that the sensitivity of CEUS for detecting endoleak is no lower than that of CTA. To investigate the advantages of CEUS, we conducted CEUS examinations of post-EVAR cases in which CTA failed to detect endoleak or could not verify the type of endoleak. Methods： Post-EVAR patients, who were clinically considered to have endoleak and met the inclusion criteria were enrolled between March 2013 and November 2014. All of the patients underwent color Doppler flow imaging （CDFI） and a CEUS examination. Size, location, microbubble dispersion, and hemodynamic characteristics of leaks were recorded. Comparison between the diagnosis of CEUS and CDF1 was conducted using Fisher＇s exact test and clinical outcomes of all patients were followed up. Results： Sixteen patients were enrolled, and 12 （75%） had endoleaks with verified types by CEUS. Among 12 cases of endoleaks were positive by CEUS, 10 were CDFl-positive, and the four CEUS-negative cases were all negative by CDFI. The diagnostic values of CEUS and CDFI were statistically difl＇erent （P = 0,008）. Six patients with high-pressure endoleaks received endovascular re-intervention guided by CEUS results. One patient with type Ⅲ endoleak had open surgery when endovascular repair failed. Conclusions： C EUS is a new, safe, and effective means for detection ofendoleaks post-EVAR. This technique can be used as a supplement for routine CTA follow-up to provide more detailed information on endoleak and its category.

关键词： Abdominal Aortic Aneurysnl: Color Doppler Flow Imaging Contrast-enhanced Ultrasound: Endoleak EndovascularAneurysm Repair

小龙虾prx6基因在对抗金黄色葡萄球菌感染中的分子作用机制研究

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生物技术通报 2024年第7期40卷 314-322页

作者：金博阳秦仕宇张明达李倩倩文静沈秀丽杜志强内蒙古科技大学生命科学与技术学院包头014010 内蒙古科技大学图书馆包头014010

【目的】旨在研究prx 6基因在小龙虾先天免疫中的调控作用机制,探索小龙虾prx 6基因在金黄色葡萄球菌(Staphylococcus aureus)感染后发挥免疫调控作用的可能分子机制。【方法】选取prx 6基因作为研究对象,提取正常小龙虾各组织的总RNA,... 详细信息

【目的】旨在研究prx 6基因在小龙虾先天免疫中的调控作用机制,探索小龙虾prx 6基因在金黄色葡萄球菌(Staphylococcus aureus)感染后发挥免疫调控作用的可能分子机制。【方法】选取prx 6基因作为研究对象,提取正常小龙虾各组织的总RNA,利用RT-qPCR分析目的基因在小龙虾各组织中的分布,并检测***免疫刺激后,prx 6基因在小龙虾相关组织中的表达模式。通过RNA干扰技术(RNAi)敲低prx 6基因表达量,在感染***后,测定小龙虾肝胰腺中Pc-crustin 3、Pc-crustin 4、Pc-ALF 9和Pc-lectin 1免疫效应基因的相对表达量。同时,进一步对小龙虾血淋巴中的细菌载量进行统计分析。【结果】通过对prx 6基因在小龙虾各组织的表达水平分析,观察到该基因在肝胰腺的表达量显著高于其他组织。在***感染后,小龙虾肝胰腺、血细胞和肠组织中prx 6基因的表达量显著上调,在鳃组织仅有早期表达量有所增加。小龙虾存活率的检测结果表明RNAi下调prx 6基因表达量之后,其生存率显著低于dsGFP+***对照组。为了进一步探索死亡率升高的原因,研究了抗菌肽基因在抗细菌防御中的表达水平。RNAi实验结果显示,在prx 6基因表达量降低的情况下,小龙虾肝胰腺Pc-crustin 3、Pc-crustin 4、Pc-ALF 9以及Pc-lectin 1基因表达水平都出现了显著下降。此外,小龙虾血淋巴中的细菌载量检测结果显示,prx 6基因RNAi组的细菌载量显著高于dsGFP+***对照组。【结论】小龙虾prx 6基因通过影响抗菌肽基因的表达,以及血淋巴细菌清除能力来参与抗细菌先天免疫应答。

关键词：先天免疫过氧化物还原酶6 RNA干扰抗菌肽金黄色葡萄球菌

Benefits of Mindfulness Training on the Mental Health of Women During Pregnancy and Early Motherhood:A Randomized Controlled Trial

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Biomedical and Environmental Sciences 2023年第4期36卷 353-366页

作者： WANG Shu Lei SUN Meng Yun HUANG Xing zhang da ming YANG Li XU Tao PAN Xiao Ping ZHENG Rui Min National Center for Women and Children's Health China CDCBeijing 100081China Yantai Center for Disease Control and Prevention Yantai CDCYantai 264003ShandongChina Shanxi Maternal and Child Health Hospital Taiyuan 030001ShanxiChina

Objective This study aimed to evaluate the effects of a mindfulness-based psychosomatic intervention on depression,anxiety,fear of childbirth(FOC),and life satisfaction of pregnant women in *** Women experiencing first-time pregnancy(n=104)were randomly allocated to the intervention group or a parallel active control *** collected data at baseline(T0),postintervention(T1),3 days after delivery(T2),and 42 days after delivery(T3).The participants completed questionnaires for the assessment of the levels of depression,anxiety,FOC,life satisfaction,and *** between the two groups and changes within the same group were analyzed at four time points using repeated-measures analysis of *** Compared with the active control group,the intervention group reported lower depression levels at T2(P=0.038)and T3(P=0.013);reduced anxiety at T1(P=0.001)and T2(P=0.003);reduced FOC at T1(P<0.001)and T2(P=0.04);increased life satisfaction at T1(P<0.001)and T3(P=0.015);and increased mindfulness at T1(P=0.01)and T2(P=0.006).Conclusion The mindfulness-based psychosomatic intervention effectively increased life satisfaction and reduced perinatal depression,anxiety,and FOC.

关键词： Mindfulness Depression Anxiety Fear of childbirth Life satisfaction Randomized controlled trial