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Autophagy-targeting modulation to promote peripheral nerve regeneration

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Neural Regeneration Research 2025年第7期20卷 1864-1882页

作者： Yan Chen Hongxia Deng Nannan zhang Department of Obstetrics and Gynecology West China Second HospitalSichuan UniversityChengduSichuan ProvinceChina Key Laboratory of Birth Defects and Women and Children’s Diseases Ministry of EducationSichuan UniversityChengduSichuan ProvinceChina Laboratory of Reproductive Endocrinology and Reproductive Regulation Sichuan UniversityChengduSichuan ProvinceChina National Center for Birth Defect Monitoring West China Second University HospitalSichuan UniversityChengduSichuan ProvinceChina

Nerve regeneration following traumatic peripheral nerve injuries and neuropathies is a complex process modulated by diverse factors and intricate molecular *** studies have focused on factors that stimulate axonal outgrowth and myelin ***,recent studies have highlighted the pivotal role of autophagy in peripheral nerve regeneration,particularly in the context of traumatic ***,autophagy-targeting modulation has emerged as a promising therapeutic approach to enhancing peripheral nerve *** current understanding suggests that activating autophagy facilitates the rapid clearance of damaged axons and myelin sheaths,thereby enhancing neuronal survival and mitigating injury-induced oxidative stress and *** actions collectively contribute to creating a favorable microenvironment for structural and functional nerve regeneration.A range of autophagyinducing drugs and interventions have demonstrated beneficial effects in alleviating peripheral neuropathy and promoting nerve regeneration in preclinical models of traumatic peripheral nerve *** review delves into the regulation of autophagy in cell types involved in peripheral nerve regeneration,summarizing the potential drugs and interventions that can be harnessed to promote this *** hope that our review will offer novel insights and perspectives on the exploitation of autophagy pathways in the treatment of peripheral nerve injuries and neuropathies.

关键词： autophagy autophagy related genes Charcot–Marie–Tooth diseases diabetic peripheral neuropathy metformin myelination peripheral nerve injury Schwann cells sciatic nerve Wallerian degeneration

The dopaminergic system and Alzheimer's disease

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Neural Regeneration Research 2025年第9期20卷 2495-2512页

作者： Yuhan zhang Yuan Liang Yixue Gu International Medical College Chongqing Medical UniversityChongqingChina College of Pharmacy Chongqing Medical UniversityChongqingChina Department of Neurology The First Affiliated Hospital of Chongqing Medical UniversityChongqing Key Laboratory of NeurologyChongqingChina

Alzheimer's disease is a common neurodegenerative disorder in older *** its prevalence,its pathogenesis remains unclea *** addition to the most widely accepted causes,which in clude excessive amyloid-beta aggregation,tau hyperphosphorylation,and deficiency of the neurotransmitter acetylcholine,numerous studies have shown that the dopaminergic system is also closely associated with the occurrence and development of this *** is a crucial catecholaminergic neurotransmitter in the human ***-associated treatments,such as drugs that target dopamine receptor D and dopamine analogs,can improve cognitive function and alleviate psychiatric symptoms as well as ameliorate other clinical *** r,therapeutics targeting the dopaminergic system are associated with various adverse reactions,such as addiction and exacerbation of cognitive *** review summarizes the role of the dopaminergic system in the pathology of Alzheimer's disease,focusing on currently available dopamine-based therapies for this disorder and the common side effects associated with dopamine-related *** aim of this review is to provide insights into the potential connections between the dopaminergic system and Alzheimer's disease,thus helping to clarify the mechanisms underlying the condition and exploring more effective therapeutic options.

关键词： adverse drug reaction Alzheimer's disease catecholamine dopamine receptor dopamine receptor heterodimers dopaminergic system neurodegenerative disease neurotransmitter signaling pathways traditional Chinese medicine treatment

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新型固体超强酸催化合成羟基乙酸正丁酯

精细与专用化学品 2014年第7期22卷 48-49页

作者：张朝纯李燕王虹陈雨佳张东卫河北诚信有限责任公司河北石家庄051130

以羟基乙酸和正丁醇为原料,用新型固体超强酸SO2-4/ZrO2/La3+为催化剂,合成羟基乙酸正丁酯。其工艺简单,产物转化率高。最佳工艺条件为:n(羟基乙酸)∶n(正丁醇)=1∶3.5,回流反应4h,催化剂用量为醇酸总质量的2.35%,收率83.2%。

关键词：羟基乙酸固体酸羟基乙酸正丁酯催化合成

An Artificial Intelligence‑Assisted Flexible and Wearable Mechanoluminescent Strain Sensor System

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Nano-Micro Letters 2025年第3期17卷 217-231页

作者： Yan Dong Wenzheng An Zihu Wang Dongzhi zhang College of Control Science and Engineering China University of Petroleum(East China)Qingdao 266580People’s Republic of China

The complex wiring,bulky data collection devices,and difficulty in fast and on-site data interpretation significantly limit the practical application of flexible strain sensors as wearable *** tackle these challenges,this work develops an artificial intelligenceassisted,wireless,flexible,and wearable mechanoluminescent strain sensor system(AIFWMLS)by integration of deep learning neural network-based color data processing system(CDPS)with a sandwich-structured flexible mechanoluminescent sensor(SFLC)*** SFLC film shows remarkable and robust mechanoluminescent performance with a simple structure for easy *** CDPS system can rapidly and accurately extract and interpret the color of the SFLC film to strain values with auto-correction of errors caused by the varying color temperature,which significantly improves the accuracy of the predicted strain.A smart glove mechanoluminescent sensor system demonstrates the great potential of the AIFWMLS system in human gesture ***,the versatile SFLC film can also serve as a encryption *** integration of deep learning neural network-based artificial intelligence and SFLC film provides a promising strategy to break the“color to strain value”bottleneck that hinders the practical application of flexible colorimetric strain sensors,which could promote the development of wearable and flexible strain sensors from laboratory research to consumer markets.

关键词： Mechanoluminescent Strain sensor Flexible Deep learning Wireless

Gamma-glutamyl transferase 5 overexpression in cerebrovascular endothelial cells improves brain pathology,cognition,and behavior in APP/PS1 mice

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Neural Regeneration Research 2025年第2期20卷 533-547页

作者： Yanli zhang Tian Li Jie Miao Zhina zhang Mingxuan Yang Zhuoran Wang Bo Yang Jiawei zhang Haiting Li Qiang Su Junhong Guo Department of Neurology First Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Neurology Sixth Hospital of Shanxi Medical University(General Hospital of Tisco)TaiyuanShanxi ProvinceChina Department of Physiology Key Laboratory of Cellular PhysiologyMinistry of EducationShanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Hernia and Abdominal Wall Surgery Shanxi Bethune HospitalShanxi Academy of Medical SciencesTongji Shanxi HospitalThird Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Laboratory Medicine of Fenyang College Shanxi Medical UniversityFenyangShanxi ProvinceChina

In patients with Alzheimer’s disease,gamma-glutamyl transferase 5(GGT5)expression has been observed to be downregulated in cerebrovascular endothelial ***,the functional role of GGT5 in the development of Alzheimer’s disease remains *** study aimed to explore the effect of GGT5 on cognitive function and brain pathology in an APP/PS1 mouse model of Alzheimer’s disease,as well as the underlying *** observed a significant reduction in GGT5 expression in two in vitro models of Alzheimer’s disease(Aβ_(1-42)-treated hCMEC/D3 and bEnd.3 cells),as well as in the APP/PS1 mouse ***,injection of APP/PS1 mice with an adeno-associated virus encoding GGT5 enhanced hippocampal synaptic plasticity and mitigated cognitive ***,increasing GGT5 expression in cerebrovascular endothelial cells reduced levels of both soluble and insoluble amyloid-βin the brains of APP/PS1 *** effect may be attributable to inhibition of the expression ofβ-site APP cleaving enzyme 1,which is mediated by nuclear factor-kappa *** findings demonstrate that GGT5 expression in cerebrovascular endothelial cells is inversely associated with Alzheimer’s disease pathogenesis,and that GGT5 upregulation mitigates cognitive deficits in APP/PS1 *** findings suggest that GGT5 expression in cerebrovascular endothelial cells is a potential therapeutic target and biomarker for Alzheimer’s disease.

关键词： Alzheimer’s disease amyloid-β APP/PS1 mice cerebrovascular endothelial cells cognitive deficits gamma-glutamyl transferase 5 neurovascular unit nuclear factor‐kappa B synaptic plasticity β-site APP cleaving enzyme 1

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氨羧类螯合剂的应用及前景

精细与专用化学品 2014年第9期22卷 26-29页

作者：李燕陈雨佳张朝纯韩永晓河北诚信有限责任公司河北石家庄051130

主要介绍了氨羧类螯合剂在日用洗涤及金属清洗、农田施肥、食品医药、检测分析、油气田管道除垢,鱼虾饵料等方面的应用,并展望了氨羧类螯合剂的未来发展趋势。

关键词：氨羧类螯合剂金属清洗农田施肥

四川几种轮套作体系的产量及小麦玉米磷素利用效率研究

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土壤通报 2014年第5期45卷 1175-1182页

作者：陈远学刘静陈新平陈晓辉张朝春黄蔚徐开未四川农业大学资源环境学院成都611130 长宁县农业局四川宜宾644300 中国农业大学资源与环境学院北京100193

通过2011和2012年2年田间试验研究了"蚕豆-玉米"、"小麦-甘薯"、"小麦-大豆"3种两熟轮作体系和"小麦/玉米/甘薯"、"小麦/玉米/大豆"2种三熟套作体系的产量、小麦玉米磷素积累分配及磷利用效率的变化。结果表明:三熟套作具有明显的产量优... 详细信息

通过2011和2012年2年田间试验研究了"蚕豆-玉米"、"小麦-甘薯"、"小麦-大豆"3种两熟轮作体系和"小麦/玉米/甘薯"、"小麦/玉米/大豆"2种三熟套作体系的产量、小麦玉米磷素积累分配及磷利用效率的变化。结果表明:三熟套作具有明显的产量优势,小麦/玉米、玉米/大豆和玉米/甘薯的土地当量比(LER)分别为1.79、1.51、1.62,小麦/玉米/大豆、小麦/玉米/甘薯周年体系的LER平均分别为2.13、2.32,与同面积单作相比,两体系周年作物产量分别提高了12.5%和31.5%。小麦、玉米产量套作比单作分别高30.3%、12.3%,而大豆和甘薯产量在套作与单作间无显著差异。套作较单作显著提高了小麦和玉米的地上部磷素吸收总量、籽粒磷积累量、磷肥偏生产力,小麦分别提高34.3%、39.3%、29.1%,玉米分别提高11.1%、19.8%、12.4%。玉米磷收获指数套作比轮作平均高7.8%。套作促进了小麦、玉米磷营养从营养器官向籽粒的转运分配。表明三熟套作相对两熟轮作(单作)能显著提高周年产量,促进小麦、玉米对磷素的吸收利用,一定程度提高了磷肥利用效率。

关键词：套作轮作小麦玉米产量磷积累与分配磷素利用效率

Synergistically enhanced ORR and HER performance on Co-N-C coupled in-situ generated PtCo intermetallic

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Journal of Energy Chemistry 2025年第1期100卷 721-729页

作者： Guanyu Luo Min Song Lulu An Xiao Huang Qian zhang Chenhao zhang Tao Shen Shuang Wang Deli Wang Key Laboratory of Material Chemistry for Energy Conversion and Storage (Huazhong University of Science and Technology) Ministry of Education School of Chemistry and Chemical Engineering Huazhong University of Science and Technology

Integrating multi-scale sites in a composite catalyst is vital to realize efficient ***,a synergistic composite catalyst consisting of Co atomic sites and in-situ generated PtCo intermetallic compounds （IMCs）(o-PtCo@CoNC) is proposed through Co pre-anchoring and subsequent impregnation-reduction *** loading of Co atoms provides a chance for in-situ generating PtCo ordered intermetallic *** remaining Co single atoms and PtCo IMCs construct synergistic electrocatalytic *** from the ordered structure,synergistic effect of Pt Co IMCs and Co single atoms,o-PtCo@CoNC exhibits excellent electrocatalytic performance for oxygen reduction reaction （ORR） and hydrogen evolution reaction （HER） with mass activity of 1.21 A mgPt-1（at 0.9 V） and5.70 A mgPt-1（at an overpotential of 100 mV）,***,o-PtCo@CoNC delivers negligible loss of half-wave potential and overpotential during long-term stability test in acid solutions,with 13 mV decay after 50,000 potential cycles for ORR and a 2.7 mV decay after 20,000 potential cycles for *** integration strategy of single-atomic sites coupled IMCs paves the way for enhancing the activity and durability of Pt-based electrocatalysts.

关键词： Synergistic effect Intermetallics Single atomic sites Oxygen reduction reaction Hydrogen evolution reaction

高通量低成本检测牛MSTN基因突变的DAVID技术构建

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农业生物技术学报 2025年第1期33卷 208-219页

作者：裴栋超海超赵春生张立果吴迪王德政张鑫怡杨磊李光鹏内蒙古大学省部共建草原家畜生殖调控与繁育国家重点实验室

肌肉生长抑制素(myostatin, MSTN)是骨骼肌生长发育的负调控因子，MSTN基因突变可促进动物肌肉发育。目前Sanger测序是检测MSTN基因突变的经典方法，但此方法存在检测通量低、可视化程度低和检测费用高等缺点。本研究利用二代测序技术... 详细信息

肌肉生长抑制素(myostatin, MSTN)是骨骼肌生长发育的负调控因子，MSTN基因突变可促进动物肌肉发育。目前Sanger测序是检测MSTN基因突变的经典方法，但此方法存在检测通量低、可视化程度低和检测费用高等缺点。本研究利用二代测序技术，通过设计的特异性Barcode序列，能够一次性检测96头牛(Bos taurus)的MSTN基因突变情况。此外，根据测序Fastq结果文件中的Barcode序列，利用异步线程和并发算法，编写了相关的数据分析DAVID(detect and visualize insertion-deletion)软件。利用DAVID软件将96个混合样本的测序数据逐一拆分，并与扩增子序列(amplicon sequence)比对，最终获得MSTN基因突变的图形和统计信息。利用DAVID技术对96头蒙古牛进行检测，结果发现1头牛的MSTN基因11 bp杂合缺失，剩余95头均为野生型，并且通过Sanger测序对11 bp杂合缺失进行了验证。综上，本研究构建了一个检测牛MSTN基因突变的高通量技术体系，为肉牛遗传改良和育种提供技术支撑。

关键词：肌肉生长抑制素(MSTN) 蒙古牛基因突变基因型检测