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Adjuvant chemotherapy for isolated resectable colorectal lung metastasis: A retrospective study using inverse probability treatment weighting propensity analysis

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World Journal of Gastrointestinal Surgery 2024年第10期16卷 3171-3184页

作者： Zhao Gao Shi-Kai Wu Shi-Jie zhang Xin Wang Ying-chao Wu Xuan Jin Department of Medical Oncology Peking University First HospitalBeijing 100034China Department of Thoracic Surgery Peking University First HospitalBeijing 100034China Department of Gastrointestinal Surgery Peking University First HospitalBeijing 100034China

BACKGROUND The benefit of adjuvant chemotherapy(ACT)for patients with no evidence of disease after pulmonary metastasis resection(PM)from colorectal cancer(CRC)remains *** To assess the efficacy of ACT in patients after PM resection for *** This study included 96 patients who underwent pulmonary metastasectomy for CRC at a single institution between April 2008 and July *** primary end-point was overall survival(OS);secondary endpoints included cancer-specific survival(CSS)and disease-free survival(DFS).An inverse probability of treat-ment-weighting(IPTW)analysis was conducted to address indication ***-vival outcomes compared using Kaplan-Meier curves,log-rank test,Cox regre-ssion and confirmed by propensity score-matching(PSM).RESULTS With a median follow-up of 27.5 months(range,18.3-50.4 months),the 5-year OS,CSS and DFS were 72.0%,74.4%and 51.3%,*** had no significant effect on OS after PM resection from CRC[original cohort:P=0.08;IPTW:P=0.15].No differences were observed for CSS(P=0.12)and DFS(P=0.68)between the ACT and non-ACT *** analysis showed no association of ACT with better survival,while sublobar resection(HR=0.45;95%CI:0.20-1.00,P=0.049)and longer disease-free interval(HR=0.45;95%CI:0.20-0.98,P=0.044)were associated with improved *** ACT does not improve survival after PM resection for *** well-designed randomized controlled trials are needed to determine the optimal ACT regimen and duration.

关键词： Colorectal cancer Resection of pulmonary metastasis Adjuvant chemotherapy Inverse probability treatment weighting Prognosis

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Synthesis and biological evaluation of dihydrotriazine derivatives as potential antibacterial agents

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Chinese Chemical Letters 2017年第8期28卷 1737-1742页

作者： Tian-Yi zhang chao Li Yu-Shun Tian Jia-Jun Li Liang-Peng Sun Chang-Ji Zheng Hu-Ri Piao Key Laboratory of Natural Resources of Changbai Mountain&Functional Molecules Ministry of EducationYanbian University College of PharmacyYanji133000China Department of Pharmacy Jilin Medical UniversityJilin 132013China

A series of 1,4-dihydro-1,3,5-triazine derivatives were designed and synthesized and their antibacterial and antifungal activities were evaluated. Most of the synthesized compounds showed potent inhibition of several Gram-positive bacterial strains（including multidrug-resistant clinical isolates） and Gramnegative bacterial strains, with minimum inhibitory concentrations（MICs） in the range of 2.1–181.2 mmol/L. Compounds 7a and 7c presented the most potent inhibitory activities against Grampositive bacteria（e.g., Staphylococcus aureus 4220）, Gram-negative bacteria（e.g., Escherichia coli 1924）,and the fungus Candida albicans 7535, with MICs of 2.1 or 4.1 mmol/L. Especially, compound 7a was the most potent, with an MIC of 2.1 mmol/L against four multidrug-resistant, Gram-positive bacterial *** cytotoxic activity of the compound 7a, 7c and 7f was assessed in HepG2 cells, and the results suggest that 1,4-dihydro-1,3,5-triazine derivatives bearing a 6-benzyloxynaphthalen moiety are interesting scaffolds for the development of novel antibacterial agents.

关键词： Antibacterial activitis Antifungal activities Cytotoxicity Minimal inhibitory concentration 1 4-Dihydro-1 3 5-triazine

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Secondary metabolites from fungus Alternaria sp. CIB 108

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Chinese Chemical Letters 2011年第10期22卷 1226-1228页

作者： Qian Feng Chen Min Zhou Tao Yang Xiao Zhen Chen chun Wang Guo Lin zhang Guo You Li Chengdu Institute of Biology Chinese Academy of Sciences Chengdu 610041 China School of Pharmaceutical Sciences Southwest University Chongqing 400715 China Graduate School of the Chinese Academy of Sciences Beijing 100049 China

A new compound,3-butyryl-6-[rel-（1S,2S）-1,2-dihydroxypropyl]-4-hydroxy-2H-pyran-2-one（1）,was isolated from the solid fermented rice culture of Alternaria *** 108,along with three known ones,deoxyradicinin（2）,3-epiradicinol（3）,and 3- epideoxyradicinol（4）.Their structures were elucidated on the basis of spectroscopic *** single crystal X-ray diffraction was applied to further clarify the structure of ***,compounds 1-4 possessed no cytotoxicity against several cell lines（HeLa, HepG2,and Ros） and showed no antibacterial activity at 40μmol/L.

关键词： Altemaria Fermentation Pyrone

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Interplay of Crosslinking Structures and Segmental Dynamics in Solid-Liquid Elastomers

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Chinese Journal of Polymer Science 2022年第10期40卷 1297-1306,I0012页

作者： Hao Wang Wan-Su Peng Qi Wu Yan Zhao Shi-Tai Wang Yi Yang Jin-Rong Wu Xiao-Liang Wang Rong-chun zhang South China Advanced Institute for Soft Matter Science and Technology(AISMST) School of Emergent Soft MatterSouth China University of TechnologyGuangzhou 510640China Key Laboratory of High-Performance Polymer Materials and Technology of Ministry of Education Department of Polymer Science and EngineeringSchool of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210093China State Key Laboratory of Polymer Materials Engineering College of Polymer Science and EngineeringSichuan UniversityChengdu 610065China Suzhou Niumag Analytical Instrument Corporation Chengdu 610065China Guangdong Provincial Key Laboratory of Functional and Intelligent Hybrid Materials and Devices South China University of TechnologyGuangzhou 510640China

There have been significant interests in recent years for incorporating dynamic bonds into polymer materials for achieving multiple functionalities,such as self-healing,recycling,stimuli-responsiveness,and so ***,the impact of dynamic bonds on the polymer dynamics is actually less *** this study,we investigate a self-healing solid-liquid elastomer(SLE),which is a dual-crosslinked network made by coupling a permanently crosslinked polydimethylsiloxane(PDMS)network with polyborosiloxane(PBS)via abundant dynamic boron/oxygen dative *** double-quantum(DQ)NMR reveals that the crosslinking degree is reduced while the structural heterogeneity of network is enhanced with increasing PBS content,i.e.,increasing the content of dynamic boron/oxygen dative *** experiments clearly reveal two chain relaxation modes in the SLE samples with a characteristic relaxation time of around 2.1 s and 11.8 s,corresponding to the relaxation of coupled PBS and PDMS chains,*** master curves obtained from variable-temperature frequency-dependent rheological experiments also reveal enhanced heterogeneity of chain relaxation with increasing PBS ***,the impact of boron/oxygen dative bonds on the Rouse dynamics is further revealed by fast-field-cycling(FFC)NMR experiments,where the spinlattice relaxation rate(R_(1))of all SLE samples follows the same power law of R_(1)(ω)∝ω^(-0.33).Nevertheless,the incorporation of PBS did slightly increase the energy barrier of Rouse *** study well demonstrates a combined use of rheology and solid-state NMR spectroscopy can provide piercing insights into the interplay of crosslinking structures and dynamics of polymer materials.

关键词： Fast-field-cycling NMR Multiple-quantum NMR Rheology Dynamics Dynamic bonds

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NIR‑II‑Triggered Composite Nanofibers to Simultaneously Achieve Intracranial Hemostasis,Killing Superbug and Residual Cancer Cells in Brain Tumor Resection Surgery

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Advanced Fiber Materials 2023年第1期5卷 209-222页

作者： Jun Yang Lei Xu Yining Ding Chang Liu Bingchang Wang Yanchao Yu chao Hui Seeram Ramakrishna Jun zhang Yunze Long Collaborative Innovation Center for Nanomaterials&Devices College of PhysicsQingdao UniversityQingdao 266071People’s Republic of China Center for Nanofibers&Nanotechnology Department of Mechanical EngineeringNational University of SingaporeSingapore 117574Singapore

Malignant glioblastoma(GBM)is prone to relapse due to the inevitable tumor cells residue by *** the tumor resection surgery in brain,addressing bleeding and superbug infections is also full of ***,no method or material in clinical craniotomy can simultaneously solve these three ***,Chitosan composite nanofibers embed-ded with CuSe nanoparticles were prepared by green electrospinning method,in which the CuSe nanoparticles have strong absorption in the second near-infrared(NIR-II)*** after removing the tumor in craniotomy,nanofibers were electrospun and deposited directly onto the resection site with high precision(>90%)to achieve rapid hemostasis(99%)and effectively induces cell apoptosis of residual tumor thereby to inhibit tumor *** using the same material,a tril-ogy of intracranial hemostasis,killing superbug and residual cancer cells is simultaneously *** short operation time reduces the risk of *** electrospinning strategy could combine with craniotomy and minimally invasive surgery,which may provide novel perspectives in clinical operation besides craniotomy.

关键词： Electrospinning Anti-tumor Anti-microbial Hemostasis

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Stereoselective Synthesis and Anticancer Activities of New Podophyllotoxin Derivatives:4-β-Cyano-4-Deoxy-4'-Demethylepipodophyllotoxin and 4-β-Carboxyl-4-Deoxy-4'-Demethylepipodophyllotoxin

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Chinese Chemical Letters 2000年第6期11卷 505-508页

作者： Zai Xin CHEN Wei Yong MA chun Nian zhang(Department of Medicinal Chemistry Shanghai Institute of Pharmaceutical Industry,Shanghai 200040) Shanghai Inst Pharmaceut Ind Dept Med Chem Shanghai 200040 Peoples R China

4-β-Cyano-4-deoxy-4'-demethylepipodophyllotoxin 4 was synthesized from 4'-de -methylepipodophyllotoxin and Me3SiCN in the presence of BF3· Et2O. 4-β-Carboxyl-4-deoxy-4'-demethylepipodophyllotoxin 5 was obtained by... 详细信息

关键词： Podophyllotoxin derivative anticancer activities

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Omics-based integrated analysis identified ATRX as a biomarker associated with glioma diagnosis and prognosis

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Cancer Biology & Medicine 2019年第4期16卷 784-796页

作者： Yingbin Xie Yanli Tan chao Yang Xuehao zhang Can Xu Xiaoxia Qiao Jianglong Xu Shaohui Tian Chuan Fang chunsheng Kang Department of Neurosurgery Affiliated Hospital of Hebei UniversityBaoding 071000China Department of Neurosurgery Hebei University Medical CollegeBaoding 071000China Department of Pathology Hebei University Medical CollegeBaoding 071000China Department of Pathology Affiliated Hospital of Hebei UniversityBaoding 071000China Lab of Neuro-oncology Tianjin Neurological InstituteKey Laboratory of Post-Neuroinjury Neuro-repair and Regeneration in Central Nervous SystemTianjin Medical University General HospitalTianji n 300052China Department of Oncology Affiliated Cancer Hospital&Institute of Guangzhou Medical UniversityGuangzhou 510095China

Objective:ATRX is a multifunctional protein that is tightly regulated by and implicated in transcriptional regulation and chromatin *** studies have shown that genetic alterations in ATRX play a significant role in *** study aims to further determine the relationship between ATRX and glioma prognosis and identify possible mechanisms for exploring the biological significance of ATRX using large data ***:We used The Cancer Genome Atlas(TCGA)database and 130 immunohistochemical results to confirm the difference in ATRX mutations in high-and low-grade *** online analysis of the TCGA glioma datasets using the cBioPortal platform was performed to study the relationship between ATRX mutations and IDH1,TP53,CDKN2 A and CDKN2 B mutations in the corresponding TCGA glioma *** combination with clinical pathology data,the biological significance of the relationships were *** Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway analyses and annotations of all adjacent genes in the network were performedin the Database for Annotation,Visualization and Integrated Discovery(DAVID)and R language.A protein-protein interaction(PPI)network was constructed,and the interactions of all adjacent nodes were analyzed by the String database and using Cytoscape ***:In the selected TCGA glioma datasets,a total of 2,228 patients were queried,21%of whom had ATRX alterations,which co-occurred frequently with TP53 and IDH1 *** alterations are associated with multiple critical molecular events,which results in a significantly improved overall survival(OS)*** low-grade gliomas,ATRX mutations are significantly associated with multiple important molecular events,such as ZNF274 and FDXR at mRNA and protein levels.A functional cluster analysis revealed that these genes played a role in chromatin binding and P53,and a link was observed between ATRX and IDH1 and TP53 in the interaction *** and TP53

关键词： ATRX mutation copy number variation glioma biomarkers

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Strong metal-support interactions between highly dispersed Cu^(+) species and ceria via mix-MOF pyrolysis toward promoted water-gas shift reaction

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Journal of Energy Chemistry 2024年第4期91卷 475-483页

作者： Xiao-Chen Sun Xing-Chi Li Ze-Wei Xie Chen-Yue Yuan De-Jiu Wang Qian zhang Xiao-Yu Guo Hao Dong Hai-chao Liu Ya-Wen zhang Beijing National Laboratory for Molecular Sciences(BNLMS) State Key Laboratory of Rare Earth Materials Chemistry and ApplicationsPKU-HKU Joint Laboratory in Rare Earth Materials and Bioinorganic ChemistryCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China Beijing National Laboratory for Molecular Sciences(BNLMS) College of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China Beijing National Laboratory for Molecular Sciences(BNLMS) State Key Laboratory for Structural Chemistry of Stable and Unstable SpeciesCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China

The modulation of metal-support interfacial interaction is significant but challenging in the design of high-efficiency and high-stability supported ***,we report a synthetic strategy to upgrade Cu-CeO_(2)interfacial interaction by the pyrolysis of mixed metal-organic framework(MOF)*** obtained highly dispersed Cu/CeO_(2)-MOF catalyst via this strategy was used to catalyze water-gas shift reaction(WGSR),which exhibited high activity of 40.5μmolCOgcat^(-1).s^(-1)at 300℃and high stability of about 120 *** on comprehensive studies of electronic structure,pyrolysis strategy has significant effect on enhancing metal-support interaction and then stabilizing interfacial Cu^(+)species under reaction *** Cu^(+)species and generated oxygen vacancies over Cu/CeO_(2)-MOF catalyst played a key role in CO molecule activation and H2O molecule dissociation,*** collaborated closely and then promoted WGSR catalytic performance in comparison with traditio nal supported *** study shall offer a robust approach to harvest highly dispersed catalysts with finely-tuned metal-support interactions for stabilizing the most interfacial active metal species in diverse heterogeneous catalytic reactions.

关键词： Cu-based catalyst MOF derivative Water-gas shift reaction Metal-support interaction

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Determination of ribose and phosphorus contents in Haemophilus influenzae type b capsular polysaccharide by a quantitative NMR method using a single internal standard

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Chinese Journal of Natural Medicines 2022年第8期20卷 633-640页

作者： QIN chun-Jun HU Jing TONG Wei zhang Teng-Teng TIAN Guang-Zong ZoU Xiao-Peng LIU Jian-Kai YIN Jian Key Laboratory of Carbohydrate Chemistry and Biotechnology Ministry of EducationSchool of BiotechnologyJiangnan UniversityWuxi 214122China National&Local Joint Engineering Laboratory for Novel Vaccine Development Technology Beijing Minhai Biotechnology Co.Ltd.Beijing 102600China Jiangnan University-Beijing Minhai Biotechnology Joint Research Center of Carbohydrate-Based Vaccines Jiangnan UniversityWuxi 214122China

The ribose and phosphorus contents in Haemophilus influenzae type b(Hib)capsular polysaccharide(CPS)are two important chemical indexes for the development and quality control of Hib conjugate vaccine.A quantitative ^(1)H-and ^(31)P-NMR method using a single internal standard was developed for simultaneous determination of ribose and phosphorus contents in Hib ***(HMPA)was successfully utilized as an internal standard in quantitative ^(1)H-NMR method for ribose content *** ribose and phosphorus contents were found to be affected by the concentration of polysaccharide ***,15–20 mg·L^(−1) was the optimal concentration range of Hib CPS in D_(2)O solution for determination of ribose and phosphorus contents by this *** ribose and phosphorus contents obtained by the quantitative NMR were consistent with those obtained by traditional chemical *** conclusion,this quantitative ^(1)H-and ^(31)P-NMR method using a single internal standard shows good specificity,accuracy and precision,providing a valuable approach for the quality control of Hib glycoconjugate vaccines.

关键词： Haemophilus influenzae type b Capsular polysaccharide Quantitative^(1)H-NMR Quantitative^(31)P-NMR Ribose content Phosphorus content

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Isolation and the Full-length Genome Sequencing of Subgroup J Avian Leukosis Virus ZH-08 Isolate Associated with Hemangioma

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畜牧兽医学报 2011年第B12期42卷 51-56页

作者： zhang Xiao-tao SHI Wei-wei LIU Hong-bo zhang He-nan LIAO Ming XIN chao-an CAO Wei-sheng （Key Laboratory of Animal Disease Control and Prevention of the Ministry of Agriculture College of Veterinary Medicine South China Agricultural University Guangzhou 510642 China）

A subgroup J avian leukosis virus (AVL-J), designated as ZH-08, was isolated from a breeder flock in Guangdong province with a novel hemangioma case. The identification results of ELISA test, PCR and immunofluoresecence assay (IFA) specific for ALV-J were all positive. Based on the public full-length proviral genome sequence of ALV-J prototype strain HPRS-103, three pairs of primers were synthesized. The full-length proviral genome sequence of ZH-08 isolate is 7597 bp, which has a little difference with that of published full-length genome sequences, but its organization corresponds with typical retroviral genome structure; and known oncogenes were not included in its genome. According to the gp85 sequence comparison of ZH-08 isolate with those of the other reference strains in China and abroad, the highest similarity (93.7%) was with the YZ9901 isolate. Phylogenetic analysis, based on the gp85 gene, showed that the ZH-08 isolated here had the closest linkage to the SD07LK1 isolate. This study provides the basis for the biological characterization and pathogenesis research of the ZH-08 isolate.

关键词： J亚群禽白血病病毒全基因组测序血管全基因组序列酶联免疫吸附试验 ALV-J 聚合酶链反应 gp85基因

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