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In-situ TEM study of the effect of hydrogen-helium ratio on defect characteristics in Fe9Cr1.5W0.4Si F/M steel during H_(2)^(+)&He^(+)simultaneous irradiation

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Journal of Materials Science & Technology 2024年第6期173卷 192-201页

作者： Dewang cui Ziqi Cao Kun He Yuanming Li Xi Qiu Guang Ran College of Energy Xiamen UniversityXiamen 361102China Fujian Provincial Nuclear Energy Engineering Technology Research Center Xiamen 361102China Science and Technology on Reactor Fuel and Materials Laboratory Chengdu 610041China Nuclear Power Institute of China Chengdu 610041China Science and Technology on Reactor System Design Technology Laboratory Chengdu 610041China

The effect of hydrogen and helium interaction,especially H-He ratio,on the irradiation behavior of nuclear materials has not yet been ***,this is an important basis for evaluating the irradiation properties of nuclear materials and developing high irradiation resistant ***,30 keV H_(2)^(+)and He^(+)dual beams with four H-He ratios of 0:10,3:10,15:10,and 30:10 were used to irradiate the newly developed Fe9Cr1.5W0.4Si F/M steel in TEM to in-situ study the interaction and ratio effect of hydrogen and *** addition of H atoms significantly promoted the nucleation of dislocation loops and *** the early stage of irradiation,the average size and density of dislocation loops increased with the increase of H-He ***,the larger the H-He ratio,the easier it was to form a complex dislocation ***,the final saturation size of bubbles increased with the increase of H-He *** was first found that the swelling was affected by H concentrations,with high H concentrations slowing down the increase in *** a certain irradiation dose,a specific H-He ratio would lead to a swelling peak of Fe9Cr1.5W0.4Si F/M *** super-sized bubbles at grain boundaries(GBs)were found after H addition,resulting in a bigger swelling of GBs than the *** the swelling of the GBs and the matrix show a dependence on the H-He *** current work is of great significance for understanding the interaction between hydrogen and helium in nuclear materials.

关键词： Dose ratio effect Ferritic-martensitic steel Hydrogen&helium synergetic irradiation In-situ TEM

Impact of H_(2)S on Hg^(0)capture performance over nitrogen-doped carbon microsphere sorbent:experimental and theoretical insights

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Frontiers of Chemical Science and Engineering 2024年第3期18卷 89-100页

作者： Guopei Zhang Xiaoyang Zhang Xiangwen Xing Xiangru Kong Lin cui Dong Yong National Engineering Laboratory for Reducing Emissions from Coal Combustion Shandong UniversityJinan250061China Bingtuan Energy Development Institute Shihezi UniversityShihezi832000China

A nitrogen-doped carbon microsphere sorbent with a hierarchical porous structure was synthesized via aggregation-hydrothermal *** Hg^(0)adsorption performance of the nitrogen-doped carbon microsphere sorbent was tested and compared with that of the coconut shell activated carbon prepared in the *** effect of H_(2)S on Hg^(0)adsorption was also *** nitrogen-doped carbon microsphere sorbent exhibited superior mercury removal performance compared with that of coconut shell activated *** the absence of H_(2)S at a low temperature(≤100℃),the Hg^(0)removal efficiency of the nitrogen-doped carbon microsphere sorbent exceeded 90%.This value is significantly higher than that of coconut shell activated carbon,which is approximately 45%.H_(2)S significantly enhanced the Hg^(0)removal performance of the nitrogen-doped carbon microsphere sorbent at higher temperatures(100–180℃).The hierarchical porous structure facilitated the diffusion and adsorption of H_(2)S and Hg^(0),while the nitrogen-containing active sites significantly improved the adsorption and dissociation capabilities of H_(2)S,contributing to the generation of more active sulfur species on the surface of the nitrogen-doped carbon microsphere *** formation of active sulfur species and HgS on the sorbent surface was further confirmed using X-ray photoelectron spectroscopy and Hg^(0)temperature-programmed desorption *** functional theory was employed to elucidate the adsorption and transformation of Hg^(0)on the sorbent surface.H_(2)S adsorbed and dissociated on the sorbent surface,generating active sulfur species that reacted with gaseous Hg^(0)to form HgS.

关键词： nitrogen-doped carbon microsphere H_(2)S Hg^(0)removal adsorption mechanism

Investigating effect of coke porosity on blast furnace performance based on multi-physical fields

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Journal of Iron and Steel Research International 2024年第2期31卷 357-367页

作者： Ji Chen Zhao Lei Zhe Yao Li Wang Qiang Ling Ping cui Anhui Province Key Laboratory of Coal Clean Conversion and High Valued Utilization School of Chemistry and Chemical EngineeringAnhui University of TechnologyMa’anshan243002AnhuiChina Shanxi Academy of Printing Technology Research Institute Co. Ltd.Xi’an710077ShaanxiChina

Reducing coke use is an effective measure to reduce carbon emission and energy consumption in the blast furnace(BF)***,BF is a high-temperature moving bed reactor,where complex physical transformations coupled with complicated reactions *** makes it challenging to investigate the factors determining BF performance with the conventional method.A multi-physical field coupling mathematical model of BF was thus developed to describe its mass and heat transfer as well as its intrinsic ***,the proposed model was validated with the production *** coupling conditions,influences of dominating reactions on BF performance(temperature distribution,gas distribution,iron formation reaction,and direct reduction degree)were *** results indicated that coke combustion,indirect reduction,and direct reduction of iron ore mainly took place nearby the shaft tuyere,cohesive zone,and dripping zone,***,the rate of coke solution loss reaction was increased with the rising coke porosity in the cohesive *** the effect of coke porosity on the efficiency and stability of BF,the coke porosity of 0.42 was regarded as a reasonable value.

关键词： Blast furnace Mathematical model Multi-physical field Simulation Coke porosity

Research on the Effect of Dance Therapy on Improving Social Communication Ability of Children with Autism

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International Journal of Mental Health Promotion 2024年第5期26卷 407-416页

作者： Xiaorui cui Shan Wang Institute of Education Xinyang UniversityXinyang464000China Hengshui College Conservatory of Music Hengshui053000China

Research motivation:Through the 12 weeks dance therapy intervention for children with autism,the purpose is to explore the intervention model of dance therapy for children with autism and the changes in motor ability,social ability,and communication ability of children with autism after dance therapy *** results of the research are expected to expand the intervention mode of dance therapy in my country and provide practical reference for rehabilitation intervention of children with *** methods:24 autistic boys aged 6 to 12 with mild to moderate symptoms were recruited and screened through the Internet as the subjects of this *** randomly divided them into experimental group(N=12)and control group(N=12).All children with autism have an autism diagnosis certificate issued by Children’s Hospital or a tertiary hospital,excluding other mental diseases(such as epilepsy,major physical disability,mental illness,no history of drugs and other interventions,etc.).We used the paired sample t-test to compare the score difference between the dance treatment group and the control group before and after the two groups,and used the observation method to record the basic communication behavior and the number of active communication behaviors in the experimental group during the intervention *** data analysis is used in SPSS *** results:After 12 weeks of dance therapy intervention,there were statistically significant differences in the gross movement,balance,and coordination abilities of the children in the experimental group compared with those before the intervention(p0.05).After 12 weeks of dance therapy intervention,there were statistically significant differences in the scores of the social response scale for children with autism in the experimental group(p<0.05).There was no significant change in the scores of each item of the SRS scale before an

关键词： Dance therapy movement ability children with autism social interaction communication

NiCoZn/C@melamine sponge-derived carbon composites with highperformance electromagnetic wave absorption

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International Journal of Minerals,Metallurgy and Materials 2024年第10期31卷 2274-2286页

作者： Xiubo Xie Heshan Wang Hideo Kimura cui Ni Wei Du Guanglei Wu School of Environmental and Material Engineering Yantai UniversityYantai 264005China Shandong Key Laboratory of Eco-Environmental Science for the Yellow River Delta Shandong University of AeronauticsBinzhou 256603China Institute of Materials for Energy and Environment State Key Laboratory of Bio-fibers and Eco-textilesCollege of Materials Science and EngineeringQingdao UniversityQingdao 266071China

NiMZn/C@melamine sponge-derived carbon(MSDC)composites(M=Co,Fe,and Mn)were prepared by a vacuum pump-ing solution method followed by carbonization.A large number of carbon nanotubes(CNTs)homogeneously attached to the surfaces of the three-dimensional cross-linked of the sponge-derived carbon in the NiCoZn/C@MSDC composite,and CNTs were detected in the NiFeZn/C@MSDC and NiMnZn/C@MSDC ***_(3)ZnC_(0.7),Ni_(3)Fe,and MnO in-situ formed in the NiFeZn/C@MSDC and NiMnZn/C@MSDC *** CNTs in the NiCoZn/C@MSDC composite efficiently modulated its complex ***,the composite exhibited the best performance among the composites,with the minimum reflection loss(RL_(min))of-33.1 dB at 18 GHz and thickness of 1.4 *** bandwidth for RL of≤-10 dB was up to 5.04 GHz at the thickness of 1.7 mm and loading of 25wt%.The op-timized impedance matching,enhanced interfacial and dipole polarization,remarkable conduction loss,and multiple reflections and scat-tering of the incident microwaves improved the microwave absorption *** effects of Co,Ni,and Fe on the phase and mor-phology provided an alternative way for developing highly efficient and broadband microwave absorbers.

关键词： microwave absorption carbon nanotube element substitution melamine sponge-derived carbon

MnO_(2)-coated nanodiamond-driven photodynamic therapy for enhanced antitumor effect by addressing hypoxia and glutathione depletion

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Particuology 2024年第9期92卷 305-315页

作者： Jicheng cui Dongmei Zhang Hui Qiao Zeyu Yan Wenxia Zhang Yingqi Li Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education Institute of Molecular ScienceShanxi UniversityTaiyuan030006China Taiyuan Central Hospital Taiyuan030009China School of Chemistry and Chemical Engineering Shanxi UniversityTaiyuan030006China

The generation of reactive oxygen species(ROS)at the tumor site to induce destruction is emerging as a novel strategy for cancer treatment,which involves photodynamic therapy(PDT).Nevertheless,tumors typically create a hypoxic environment and are equipped with an endogenous antioxidant defense system that could potentially impede the efficiency of the therapeutic *** overcome these drawbacks,herein,a tumor microenvironment-responsive the ND-PAA-CD-Ce6@MnO_(2)(NPCC@M)delivery system was fabricated by disulfide bond coupling chlorin e6(Ce6)to nanodiamond(ND)and further wrapped by MnO_(2)nanosheets to facilitate *** use of disulfide bond not only stabilizes Ce6 in the blood circulation to prevent premature leakage,but also destroys the antioxidant barrier of overexpressed glutathione(GSH)in tumor ***,the outer MnO_(2)was rapidly degraded by the endogenous hydrogen peroxide(H_(2)O_(2))in the acidic pH and GSH within the tumor cells,which leads to an abundance of O_(2)and while increases the level of 1O_(2)under laser *** results eventually broke the redox homeostasis and attenuate hypoxia,thereby inducing apoptosis and necrosis of tumor *** in vitro and in vivo biological effect has revealed a good biosafety profile and a high tumor suppression *** a novel ND-based system with tumor microenvironment-modulating capability to elevate oxygen content and promote GSH consumption in tumor cells opens new opportunities for enhanced ROS treatment paradigms.

关键词： Nanodiamond Photodynamic Chlorin e6 MnO_(2) Tumor suppression

A review of deep learningg methods for ligand based drug virtual screening

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Fundamental Research 2024年第4期4卷 715-737页

作者： Hongjie Wu Junkai Liu Runhua Zhang Yaoyao Lu Guozeng cui Zhiming cui Yijie Ding School of Electronic and Information Engineering Suzhou University of Science and TechnologySuzhou 215009China Yangtze Delta Region Institute(Quzhou) University of Electronic Science and Technology of ChinaQuzhou 32400China

Drug discovery is costly and time consuming,and modern drug discovery endeavors are progressively reliant on computational methodologies,aiming to mitigate temporal and financial expenditures associated with the *** particular,the time required for vaccine and drug discovery is prolonged during emergency situations such as the coronavirus 2019 ***,the performance of deep learning methods in drug virtual screening has been particularly *** has become a concern for researchers how to summarize the existing deep learning in drug virtual screening,select different models for different drug screening problems,exploit the advantages of deep learning models,and further improve the capability of deep learning in drug virtual *** review first introduces the basic concepts of drug virtual screening,common datasets,and data representation ***,large numbers of common deep learning methods for drug virtual screening are compared and *** addition,a dataset of different sizes is constructed independently to evaluate the performance of each deep learning model for the difficult problem of large-scale ligand virtual ***,the existing challenges and future directions in the field of virtual screening are presented.

关键词： Virtual screening Deeplearning Drug discovery Drug-targetinteraction Drug-target affinity

Numerical investigation of friction-heating-pressurization and its control parameters in the shear band of high-speed landslides

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Journal of Mountain Science 2024年第10期21卷 3380-3395页

作者： ZHAO Nenghao cui Shenghua LU Haijun School of Civil Engineering and Architecture Wuhan Polytechnic UniversityWuhan 430023China State Key Laboratory of Geo-Hazard Prevention and Geo-Environment Protection Chengdu University of TechnologyChengdu 610059China

High-speed sliding often leads to catastrophic landslides,many of which,in the initial sliding phase before disintegration,experience a friction-induced thermal pressurization effect in the bottom shear band,accelerating the movement of the overlying sliding *** quantitatively investigate this complex multiphysical phenomenon,we established a set of equations that describe the variations in temperature and excess pore pressure within the shear band,as well as the conservation of momentum equation for the overlying sliding *** a simplified landslide model,we investigated the variations of temperature and excess pore pressure within the shear band and their impacts on the velocity of the overlying sliding *** this basis,we studied the impact of seven key parameters on the maximum temperature and excess pore pressure in the shear band,as well as the impact on the velocity of the overlying sliding *** simulation results of the standard model show that the temperature and excess pore pressure in the shear band are significantly higher than those in the adjacent areas,and reach the maximum values in the *** a few seconds after the start,the maximum excess pore pressure in the shear zone is close to the initial stress,and the shear strength loss rate exceeds 90%.The thermal pressurization mechanism significantly increases the velocity of the overlying sliding *** results of parameter sensitivity analysis show that the thermal expansion coefficient has the most significant impact on the temperature and excess pore pressure in the shear band,and the sliding surface dip angle has the most significant impact on the velocity of the overlying sliding *** results of this study are of great significance for clarifying the mechanism of thermal pressurization-induced high-speed sliding.

关键词： High-speed landslide Shear band Friction-heating-pressurization Numerical investigation

BTG2 interference ameliorates high glucose-caused oxidative stress, cell apoptosis, and lipid deposition in HK-2 cells

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BIOCELL 2024年第9期48卷 1379-1388页

作者： WENJUAN ZHU ZHENGZHENG JU FAN cui Department of Blood Transfusion The First People’s Hospital of WuhuWuhu241000China Department of Clinical Laboratory The First People’s Hospital of WuhuWuhu241000China

Objective:Diabetic nephropathy(DN)is a deleterious microangiopathy of diabetes,constituting a critical determinant of fatality in diabetic *** work is purposed to disclose the effects and modulatory mechanism of BTG anti-proliferation factor 2(BTG2)during the pathological process of ***:BTG2 expression in kidney tissues of diabetic mice and high glucose(HG)-exposed human proximal tubular cell line HK-2 was assessed with Western blot and *** diabetic mice model was constructed by streptozotocin injection and confirmed by the blood glucose level beyond 16.7 mmol/*** and eosin(H&E)staining and measurement of kidney function hallmarks were conducted to assess kidney *** counting kit(CCK)-8 method and TUNEL assay appraised cell activity and *** red O staining assayed lipid *** commercial kits were used to estimate oxidative stress-related ***-immunoprecipitation(Co-IP)assay testified the binding relationship of BTG2 with protein arginine methyltransferase 1(PRMT1).Results:BTG2 expression was significantly raised in renal tissues of diabetic mice and HK-2 cells exposed to ***2 deficiency improved viability and extenuated the apoptosis,lipid deposition as well as oxidative stress in HK-2 cells following HG *** addition,PRMT1 was also overexpressed in HK-2 cells exposed to ***2 interacted with PRMT1 and positively modulated PRMT1 *** effects of BTG2 interference on viability,apoptosis,lipid deposition,and oxidative stress in HG-challenged HK-2 cells were partially abrogated by PRMT1 ***:Altogether,BTG2 might aggravate HK-2 cell injury in response to HG by binding with PRMT1,providing a novel target for the therapeutic strategy of DN.

关键词： BTG2 Diabetic nephropathy Lipid deposition Oxidative stress PRMT1