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Direct generation of an ultrafast vortex beam in a CVD-graphene-based passively mode-locked Pr:LiYF4 visible laser

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Photonics Research 2019年第11期7卷 1209-1213页

作者： Nan Li Junjie Huang Bin Xu Yaqi Cai Jie Lu linjie zhan Zhengqian Luo Huiying Xu Zhiping Cai Weiwei Cai Department of Electronic Engineering Xiamen UniversityXiamen 361005China Shenzhen Research Institute of Xiamen University Shenzhen 518057China Department of Physics State Key Laboratory of Physical Chemistry of Solid SurfacesXiamen UniversityXiamen 361005China

We report on the direct generation of passively mode-locked vortex lasers in the visible spectral region, for the first time to the best of our knowledge, using a Pr :Li YF4(Pr:YLF) crystal as the gain medium. A stable mode-locked TEM00 mode has been achieved with a maximum average output power of 75 m W using a graphene saturable absorber mirror. The mode-locked pulse width is measured to be as short as about 73.4 ps at a repetition rate of about 140 MHz, and the laser wavelength is at about 721 nm with spectral width of about 0.5 nm. By slightly misaligning the laser resonator, a first-order Laguerre-Gaussian mode(LG0,1) has also been obtained with output power reduced to about 22 m W. The achieved LG0,1 mode has been verified via a home made improved Fizeau interferometer. This work provides a simple and universal method for direct generation of an ultrafast vortex laser,which can be readily extended to other spectral regions by using different laser gain mediums.

关键词： passive interferometer resonator

大豆浅圆仓中嗜虫书虱种群发生动态及其检测方法研究

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中国粮油学报 2024年第7期39卷 6-11页

作者：吴宗霖叶天伟郭晓勇李林杰张慧民徐展张茹王争艳中央储备粮新郑直属库有限公司新郑451100 河南工业大学粮食和物资储备学院郑州450001

在害虫综合治理中,害虫种群监测可以为害虫防治时机的选择提供依据。本文在大豆浅圆仓内,利用探管诱捕器、圆盘诱捕器、瓦楞纸板诱捕器和取样筛检法检测书虱的发生动态,分析影响害虫发生动态的因素,并比较不同检测方法的检测效果。研究... 详细信息

在害虫综合治理中,害虫种群监测可以为害虫防治时机的选择提供依据。本文在大豆浅圆仓内,利用探管诱捕器、圆盘诱捕器、瓦楞纸板诱捕器和取样筛检法检测书虱的发生动态,分析影响害虫发生动态的因素,并比较不同检测方法的检测效果。研究结果表明,嗜虫书虱主要分布在靠墙的位置,中心部位分布的较少;与温度相比,仓房湿度对嗜虫书虱发生密度的影响更为显著;在3种诱捕器中,探管诱捕器的诱捕效率最高,能较早地检测到低密度的书虱。

关键词：浅圆仓嗜虫书虱取样筛检法诱捕器

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HuR的功能及其对肌肉生长发育的调控作用

畜牧兽医学报 2022年第5期53卷 1345-1353页

作者：孙严金薛亚男仲涛王林杰李利张红平占思远四川农业大学畜禽遗传资源发掘与创新利用四川省重点实验室成都611130

RNA结合蛋白HuR(human antigen R),又被称为类胚胎致死性异常视觉基因1(ELAV like RNA binding protein 1,ELAV1),是一种在机体各组织中广泛表达的重要RNA结合蛋白,其通过调控mRNA前体剪接、多聚腺苷酸化,以及mRNA稳定性与翻译效率等方... 详细信息

RNA结合蛋白HuR(human antigen R),又被称为类胚胎致死性异常视觉基因1(ELAV like RNA binding protein 1,ELAV1),是一种在机体各组织中广泛表达的重要RNA结合蛋白,其通过调控mRNA前体剪接、多聚腺苷酸化,以及mRNA稳定性与翻译效率等方式参与机体各项生命活动。研究表明,RNA结合蛋白参与了肌肉生长发育调控,其中HuR主要通过影响靶mRNAs的稳定性和翻译参与调控肌生成与肌肉疾病的发生。本文结合近年来HuR的相关研究,从HuR的生物学特性、主要功能与作用方式、在肌肉生长发育及肌肉疾病中的调控作用等方面展开综述,以期为进一步研究HuR在肌肉生长发育调控中的作用提供参考。

关键词： HuR 功能肌肉生长发育疾病作用机制

Upregulation of mtSSB by interleukin-6 promotes cell growth through mitochondrial biogenesis-mediated telomere elongation in colorectal cancer

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Upregulation of mtSSB by interleukin-6 promotes cell growth ...

科技社团党建工作模式的创新探索--以中国海洋湖沼学会为例

2018年中国肿瘤标志物学术大会暨第十二届肿瘤标志物青...

作者： Gang Wang Yibing Chen Qian Wang Xiacheng Sun linjie He Lei zhan Xu Guo Qichao Huang Jinliang Xing 第四军医大学唐都医院普通外科

Objective:It is now widely accepted that mitochondrial biogenesis is inhibited in most cancer cells. Interestingly, one of the possible exceptions is colorectal cancer（CRC）, in which the content of mitochondria has been found to be higher than in normal colon mucosa. However, to date,the causes and effects of this phenomenon are still unclear. Methods : In the present study, we systematically investigated the functional role of mitochondrial single-strand DNA binding protein（mtSSB）, a key molecule in the regulation of mitochondrial DNA（mtDNA） replication, in the mitochondrial biogenesis and CRC cell growth. First, we determined the expression of mtSSB in paired CRC tissues and investigated the clinical relevance of mtSSB expression. Then the effect of mtSSB on in vitro and in vivo cell proliferation was assessed. We next investigated the effects of mtSSB on mitochondrial biogenesis and functions in CRC cells. Furthermore,we investigated the effects of mtSSB on telomerase activity and telomere elongation. At last, we investigated the function and mechanism of the regulation of proinflammatory cytokines IL-6 on the expression of mtSSB in ***:Our results demonstrated that mtSSB was frequently upregulated in CRC tissues and found that CRC patients with high mtSSB expression had a significantly poorer overall survival and recurrence-free survival than those with low mtSSB expression（Log rank P = 0.025 and 0.006,respectively）. We also found that forced expression of mtSSB significantly enhanced the proliferation of CRC cells, while knockdown of mtSSB suppressed the proliferation of CRC cell lines. In addition,xenograft nude mice mode showed that CRC cells with stable mtSSB overexpression exhibited a significant increase in tumorigenesis capacity in vivo, whereas CRC cells with stable mtSSB knockdown exhibited decreased tumorigenesis capacity. Mechanistically, the results showed that overexpression of mtSSB in CRC cells resulted in increased mtDNA content, the coun

关键词： mtSSB mitochondrial biogenesis telomere elongation interleukin 6 reactive oxygen species colorectal cancer

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学会 2022年第2期 26-29页

作者：潘文静潘诚展翔天王琳洁中国海洋湖沼学会山东青岛266003 中国科学院海洋研究所山东青岛266071

加强科技社团党建工作是加强党的建设的重要组成部分。根据新形势下科技社团党建与业务工作深度融合的新要求,中国海洋湖沼学会深入推进“党建强会”活动,结合自身实际情况,围绕“以党建促会建,以会建强党建”的工作思路,开展了多种新... 详细信息

加强科技社团党建工作是加强党的建设的重要组成部分。根据新形势下科技社团党建与业务工作深度融合的新要求,中国海洋湖沼学会深入推进“党建强会”活动,结合自身实际情况,围绕“以党建促会建,以会建强党建”的工作思路,开展了多种新形式的党建活动。通过探索实施“互联网+党建”“科普+党建”“学术+党建”等工作模式,探索研究新时期科技社团党建工作的创新思路和方向,通过党建工作促进学会事业的发展,为其他科技社团党建工作提供参考和借鉴。

关键词：科技社团党建工作模式创新

基于全局敏感性分析和PE-HMGE的轴承润滑特性优化

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汽车工程 2018年第12期40卷 1488-1493,1487页

作者：李林洁韦静思何志良陈宇占文锋广州汽车集团有限公司汽车工程研究院广州511434

针对复杂非线性系统多参数优化设计不仅计算工作量大且难以获得理论上最优解的问题,提出将全局敏感性分析和全局多梯度算法(PE-HMGE)相结合的多参数多目标优化策略。通过基于方差的Sobol全局敏感性分析精简系统模型,确定敏感参数,并构... 详细信息

针对复杂非线性系统多参数优化设计不仅计算工作量大且难以获得理论上最优解的问题,提出将全局敏感性分析和全局多梯度算法(PE-HMGE)相结合的多参数多目标优化策略。通过基于方差的Sobol全局敏感性分析精简系统模型,确定敏感参数,并构造基于敏感参数的多目标优化模型,采用PE-HMGE算法得到最优解。将本方法应用于主轴承润滑特性的简化模型优化设计中,对比仿真结果,最小油膜厚度(MOFT)提高了39%;最大峰值粗糙接触压力降低了45%;平均有效摩擦损失降低了19%。测试结果表明轴承的润滑特性得到明显改善,证明了该研究方法的有效性。

关键词：弹性液动轴承全局敏感性分析 PE-HMGE算法多参数优化

Increased mtDNA copy number promotes cancer progression by enhancing mitochondrial oxidative phosphorylation in microsatellite-stable colorectal cancer

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Signal Transduction and Targeted Therapy 2018年第1期3卷 246-254页

作者： Xiacheng Sun Lei zhan Yibing Chen Gang Wang linjie He Qian Wang Feng Zhou Fang Yang Jin Wu Yousheng Wu Jinliang Xing Xianli He Qichao Huang State Key Laboratory of Cancer Biology and Experimental Teaching Center of Basic Medicine Fourth Military Medical University710032 Xi’anChina Department of Gastroenterology Second Affiliated Hospital of Harbin Medical University150086 HarbinChina Center of Genetic&Prenatal Diagnosis First Affiliated HospitalZhengzhou University450052 ZhengzhouChina Department of General Surgery Tangdu HospitalFourth Military Medical University710032 Xi’anChina Department of General Surgery Huaihai HospitalXuzhou Medical UniversityXuzhou 221004China

Colorectal cancer is one of the leading causes of cancer death *** to global genomic status,colorectal cancer can be classified into two main types:microsatellite-stable and microsatellite-instable ***,the two subtypes also exhibit different responses to chemotherapeutic agents through distinctive molecular ***,mitochondrial DNA depletion has been shown to induce apoptotic resistance in microsatellite-instable colorectal ***,the effects of altered mitochondrial DNA copy number on the progression of microsatellite-stable colorectal cancer,which accounts for the majority of colorectal cancer,remain *** this study,we systematically investigated the functional role of altered mitochondrial DNA copy number in the survival and metastasis of microsatellite-stable colorectal cancer ***,the underlying molecular mechanisms were also *** results demonstrated that increased mitochondrial DNA copy number by forced mitochondrial transcription factor A expression significantly facilitated cell proliferation and inhibited apoptosis of microsatellitestable colorectal cancer cells both in vitro and in ***,we demonstrated that increased mitochondrial DNA copy number enhanced the metastasis of microsatellite-stable colorectal cancer ***,the survival advantage conferred by increased mitochondrial DNA copy number was caused in large part by elevated mitochondrial oxidative ***,treatment with oligomycin significantly suppressed the survival and metastasis of microsatellite-stable colorectal cancer cells with increased mitochondrial DNA copy *** study provides evidence supporting a possible tumor-promoting role for mitochondrial DNA and uncovers the underlying mechanism,which suggests a potential novel therapeutic target for microsatellite-stable colorectal cancer.

关键词： colorectal metastasis inhibited

荧光和发光二极管辐射技术调控果蔬采后抗氧化活性及其机制研究进展

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食品科学 2019年第5期40卷 276-281页

作者：马亚丹张翠翠李林杰詹丽娟河南农业大学食品科学技术学院河南郑州450002

如何维持/增加果蔬采后抗氧化活性是当前果蔬采后贮藏保鲜研究的热点问题,光辐射技术作为当前一种新兴的物理保鲜方法,对果蔬采后抗氧化活性具有显著的调控作用。本文首先简要综述光辐射技术主要的光源类型及可能的保鲜机理,重点阐述光... 详细信息

如何维持/增加果蔬采后抗氧化活性是当前果蔬采后贮藏保鲜研究的热点问题,光辐射技术作为当前一种新兴的物理保鲜方法,对果蔬采后抗氧化活性具有显著的调控作用。本文首先简要综述光辐射技术主要的光源类型及可能的保鲜机理,重点阐述光辐射对果蔬采后抗氧化物质(VC、多酚类物质、类胡萝卜素)和抗氧化活性的调控作用,并对其可能的调控机制进行解析;最后就目前光辐射技术在果蔬采后贮藏保鲜研究和应用中存在的问题进行讨论。

关键词：光辐射抗氧化活性保鲜多酚

Increased mtDNA copy number promotes cancer progression by enhancing mitochondrial oxidative phosphorylation in microsatellite stable colorectal cancer

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Increased mtDNA copy number promotes cancer progression by e...