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Medicinal chemistry strategies towards the development of effective SARS-CoV-2 inhibitors

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Acta Pharmaceutica Sinica B 2022年第2期12卷 581-599页

作者： Shenghua Gao Tianguang Huang Letian Song Shujing Xu Yusen Cheng Srinivasulu Cherukupalli Dongwei Kang Tong Zhao Lin Sun Jian zhang Peng zhan Xinyong Liu Department of Medicinal Chemistry Key Laboratory of Chemical BiologyMinistry of EducationSchool of Pharmaceutical SciencesCheeloo College of MedicineShandong UniversityJi’nan 250012China China-Belgium Collaborative Research Center for Innovative Antiviral Drugs of Shandong Province Ji’nan 250012China

Novel therapies are urgently needed to improve global treatment of SARS-CoV-2 ***,we briefly provide a concise report on the medicinal chemistry strategies towards the development of effective SARS-CoV-2 inhibitors wi... 详细信息

关键词： SARS-CoV-2 COVID-19 Antiviral drugs Drug design Medicinal chemistry strategies

Effects of a Biosurfactant and a Synthetic Surfactant on Phenanthrene Degradation by a Sphingomonas Strain

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Pedosphere 2010年第6期20卷 771-779页

作者： PEI Xiao-Hong zhan Xin-Hua WANG Shi-Mei LIN Yu-Suo ZHOU Li-Xiang College of Resources and Environmental Sciences Nanjing Agricultural University Nanjing 210095 (China) Nanjing Institute of Environmental Sciences Ministry of Environmental Protection of China Nanjing 210042 (China)

A novel phenanthrene (PHE)-degrading strain named as Sphingomonas ***2B was isolated and identified from a farmland *** of a synthetic surfactant (Tween-80) and a rhamnolipid biosurfactant on PHE degradation by Sphin- gomonas ***2B were investigated at different concentrations of the *** results showed that Sphingomonas ***2B was able to mineralize up to 83.6% of PHE within 10 days without addition of *** addition of Tween-80 to the reaction medium inhibited greatly PHE biodegradation,with only 33.5% of PHE ***,the biosurfactant facilitated PHE biodegradation,with up to 99.5% of PHE *** preferential utilization of PHE as a carbon source and the enhanced solubility of PHE by the biosurfactant were likely responsible for the higher biodegra- dation efficiency of PHE in the presence of the ***,it could be concluded that the application of the biosurfactant to PHE-contaminated soils was perhaps a feasible way to facilitate the PHE biodegradation.

关键词： biodegradation contaminated soils rhamnolipid solubility Tween-80

Interconverting Models of Gray Matrix and Geographic Coordinates Based on Space Analytic Geometry

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Applied Mathematics 2013年第1期4卷 46-51页

作者： Ni zhan Liang Lin Ling Lou College of Science Guilin University of Technology Guilin China

With the progress and development of science, the synchronous satellite as the high-tech product is taken something more and more seriously by all countries. Converting gray value matrix into geographic coordinates becomes more and more important. This paper establishes the models for interconverting row and column of gray value matrix which detected by the infrared detectors on synchronous satellites and geographic coordinates based on the related theorems and properties of space analytic geometry. We draw satellite cloud image with the data of gray matrix in MATLAB, convert coastline’s latitude and longitude coordinates into row and column coordinates of a gray matrix according via these models when the sub-satellite point’s row and column coordinates and geographic coordinates are given, then add coast-lines to the original satellite cloud image with the transformation data. We find that coast-lines completely match with the bump characteristics of satellite cloud image, and that verify the correctness of the models.

关键词： Space Analytic Geometry Satellite Cloud Image Geographic Coordinates Gray Value Matrix Coastline

1.7%C超高碳钢高频感应淬火工艺及组织特征

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材料热处理学报 2007年第3期28卷 138-140页

作者：许雁柳永宁朱杰武张占领西北第二民族学院材料科学系宁夏银川750021 西安交通大学金属材料强度国家重点实验室陕西西安710049

研究了含1.7%C超高碳钢高频感应淬火后的组织特征。试验表明,该钢经淬火与高温回火预处理后再进行高频感应淬火后的组织中存在大量的板条马氏体,且板条马氏体数量随感应循环次数的增加而增多,讨论了该钢感应加热淬火后的组织特征。

关键词：超高碳钢高频感应淬火板条马氏体

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浅谈临近既有线施工安全管理工作要点

西部交通科技 2014年第12期 87-89页

作者：卜战杰中交一公局第四工程有限公司广西南宁530031

文章依托兰渝铁路项目背景,从方案编制、方案审核和施工计划编制及实施等方面,对临近既有线施工安全管理工作要点进行了探讨。

关键词：铁路既有线施工安全管理

Short-term effects of air pollution on respiratory diseases among young children in Wuhan city,China

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World Journal of Pediatrics 2022年第5期18卷 333-342页

作者： Zeng-Hui Huang Xing-Yuan Liu Tong Zhao Kui-Zhuang Jiao Xu-Xi Ma zhan Ren Yun-Fei Qiu Jing-Ling Liao Lu Ma School of Public Health Wuhan UniversityNo.115 Donghu RoadWuhan 430071HubeiChina Wuhan Information Center of Health and Family Planning WuhanChina School of Environmental and Municipal Engineering Xi'an University of Architecture and TechnologyXi'anChina Department of Nutrition and Food Hygiene School of Public HealthMedical CollegeWuhan University of Science and TechnologyWuhanChina

Background The high risks for childhood respiratory diseases are associated with exposure to ambient air ***,there are few studies that have explored the association between air pollution exposure and respiratory diseases among young children(particularly aged 0-2 years)based on the entire population in a *** Daily hospital admission records were obtained from 54 municipal hospitals in Wuhan city,*** included all children(aged 0-2 years)hospitalized with respiratory diseases between January 2017 and December *** air pollution exposure assessment was used in Land Use Regression model and inverse distance ***-crossover design and conditional logistic regression models were adopted to estimate the hospitalization risk associated with air *** We identified 62,425 hospitalizations due to respiratory diseases,of which 36,295 were *** matter with an aerodynamic diameter less than 2.5 pm(PM_(2.5))and nitrogen dioxide(NO2)were significantly associated with respiratory diseases and *** of pneumonia were 1.0179(95%CI 1.0097-1.0260)for PM25 and 1.0131(95%CI 1.0042-1.0220)for NO_(2) at lag 0-7 *** analysis suggested that NO2,Ozone(O_(3))and sulfur dioxide(SO_(2))only showed effects on pneumonia hospitalizations on male patients,but PM_(2.5) had effects on patients of both *** O_(3),all pollutants were strongly associated with pneumonia in cold *** addition,children who aged elder months and who were in central urban areas had a higher hospitalization *** Air pollution is associated with higher hospitalization risk for respiratory diseases,especially pneumonia,among young children,and the risk is related to gender,month age,season and residential location.

关键词： Air pollution Children Hospitalization Respiratory disease

Distribution of Rice Grains on Panicle Axis and Its Relationship with Seed-Setting Ability in Liaoning, China

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Agricultural Sciences in China 2006年第3期5卷 202-208页

作者： XU Zheng-jin CHEN Wen-fu SHUN zhan-hui zhanG Shu-lin LIU Li-xia ZHOU Shu-qing Key Laboratory of Crop Physiology Ecology Genetics and Breeding Ministry of Agriculture/Key Laboratory of Northern Japonica Rice Breeding of Liaoning Province/Rice Institute Shenyang Agricultural University Shenyang 110161 P.R.China

Studies were conducted with rice varieties developed in recent years in Liaoning Province of China as test materials. Results showed that the varieties tested could be divided into three types：（1） the high-yielding （HYV）, （2） the mediumyielding （MYV）, and （3） the low-yielding （LYV）. The panicle population was in the order of HYV〈 MYV 〈 LYV, while the grain number per panicle and seed-setting rate were just opposite. There was no significant difference in the 1 000-grain weight. Biomass was higher in HYV than in MYV and LYV, while the harvest index was higher in HYV and MYV than in LYV. Yield was inversely correlated with panicle population, but positively correlated with the grain number per panicle, seed-setting rate, the number of primary and secondary branch grains, seed density and harvest index. Yield was most closely linked with the grain number per panicle which was determined chiefly by the number of secondary branch grains and to a lesser degree by seed density and the number of primary branch grains. The seed-setting rate of the secondary branches was positively correlated with that of the whole panicle and yield. The peak value of primary branches for HYV, MYV and LYV was 12-14, 10-13 and 8-12, respectively. LYV had fewer secondary branch grains, while MYV and HYV had more. Such grains distributed mainly in the middle and lower parts of panicle axis for LYV and in the middle and upper parts for MYV and HYV.

关键词： rice grain distribution primary branch secondary branch seed-setting ability

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中美贸易战前景 ——脱钩或是重新正常化

中美贸易战前景 ——脱钩或是重新正常...

作者： Liu zhan 浙江大学

学位级别：硕士

自由主义观点认为,贸易不是零和博弈,而是正和博弈。那么,中美贸易战对中美贸易关系将会产生怎样的影响呢?本文将探讨中美贸易战的前景,未来中美经贸关系的走向,通过文献分析法、案例分析法、对比分析法等从中美两国的角度深入宽泛的分... 详细信息

自由主义观点认为,贸易不是零和博弈,而是正和博弈。那么,中美贸易战对中美贸易关系将会产生怎样的影响呢?本文将探讨中美贸易战的前景,未来中美经贸关系的走向,通过文献分析法、案例分析法、对比分析法等从中美两国的角度深入宽泛的分析贸易战的原因、影响。贸易逆差、中国科技的快速发展以及对美国霸权的威胁引发的贸易战,源于中美两国都希望保持自己的实力和经济增长,这使得妥协变得困难。如果未来中美经贸关系出现脱钩现象,除了中美两国关系将会进一步恶化外,所带来的负面影响不仅仅是对中美两国产生的,其后果将波及全球经济。因此,中美两国需要通过更多的沟通、协商来解决中美经贸关系上的分歧,避免中美贸易关系脱钩。中国需要深化改革,深化开放,营造国际化营商环境,设立国际化规则标准,重启中美经贸关系正常化。

关键词：中美贸易战中美贸易战前景中美经济关系的脱钩中美经济关系重新正常化

Empirical Study on Credit Risk of Our Listed Company Based on KMV Model

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Applied Mathematics 2014年第13期5卷 2098-2106页

作者： Liang Lin Ting Lou Ni zhan College of Science Guilin University of Technology Guilin China

KMV model is one of the most important credit risk evaluation models in the world. It uses B-S option pricing and Morton formula based on the market value and volatility of the company’s equity, debt maturities, risk-free interest rates and the book value of liabilities to estimate the market value of the company’s assets and the volatility of the asset value. In this paper, based on the theory of KMV model, we can derive the listed company’s default rate, and assess credit risk. And the result is reasonable.

关键词： KMV Model Credit Risk Default Point