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Ameliorative effect of berberine on high-fat diet/streptozotocin-induced early diabetic nephropathy in rats

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中国药理学与毒理学杂志 2016年第10期30卷 1056-1057页

作者： XIE zhan-xiong WU Zhu-feng LIU Jiang-hong WU Qun-hua WANG Xiao-kang Department of Pharmacy Shenzhen Longhua New District Central Hospital Department of Pharmacy The First Affiliated Hospital of Jinan University

OBJECTIVE To investigate possible protective effect of berberine,an isoquinoline alkaloid,is the major active constituent of Rhizoma coptidis and Cortex phellodendri,on high-fat diet/streptozotocin-induced early diabetic nephropathy in rats and various mechanisms underlie this *** The diabetic rat model was generated by a single intraperitoneal injection of streptozotocin(STZ,50 mg·kg-1).Diabetic rats were randomlyassigned into the following five groups:control,DN,losartan(30 mg·kg-1·d-1),berberine(100,200 mg·kg-1·d-1).Berberine and losartan were given intragastricly for nine *** the end of the experiment,urine of each group was collected in a 24 h *** were weighed and then *** and kidneys were *** levels of blood glucose,creatinine(Cr),triglycerides(TG),total cholesterol(TCH)and malondialdehyde(MDA)in serum were determined using commercial kits according to the manufacturer′s *** growth factor(TGF)-β1and intracellular adhesion molecule-1(IAM-1)mR NA levels were evaluated by *** renal histopathology was observed by light *** biochemical analysis of IKKβ1 and p65(nucleus/cytoplasm)was provided using Western blotting *** Our study has demonstrated that berberine has various pharmacological *** DN rats had significantly higher kidney/body weight ratio(17.4±1.4)mg·g-1,and berberine treatment could reduce this ratio change 13.6±0.6 and(11.6±0.8)mg·g-1,respectively;glucose control still remains the only disease-modifying therapy for diabetic complications,FBG was also recorded in the *** findings reveal that the DN group showed a significantly higher glucose level(28.67±2.78)mmol·*** with8 weeks of berberine improved these parameters except blood glucose〔(18.67±2.59)mmol·L-1and 16.45±1.80 vs(28.67±2.78)mmol·L-1:plasma levels of urea nitrogen(15.67±2.48)mmol·L-1and 14.45±2.40 vs(12.26±2.40)mmol·L-1〕;plasma levels of 24 h urine albuminur

关键词： berberine creatinine diabetic nephropathy inflammation

Clinical characteristics and prognosis of community-acquired pneumonia in autoimmune disease-induced

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World Journal of Emergency Medicine 2020年第3期11卷 145-151页

作者： Zhong-shu Kuang Yi-lin Yang Wei Wei Jian-li Wang Xiang-yu Long Ke-yong Li Chao-yang Tong zhan Sun Zhen-ju Song Department of Emergency Medicine Zhongshan HospitalFudan UniversityShanghai 200032China Department of Pharmacology University of Virginia School of Medicine CharlottesvilleVirginiaUSA

BACKGROUND:Community-acquired pneumonia(CAP)in autoimmune diseases(AID)-induced immunocompromised host(ICH)had a high incidence and poor ***,only a few studies had determined the clinical characteristics of these *** study was to explore the characteristics and predictors of mortality in CAP patients accompanied with AID-induced ***:From 2013 to 2018,a total of 94 CAP patients accompanied with AID-induced ICH,admitted to Emergency Department of Zhongshan Hospital,Fudan University,were enrolled in this *** data and the risk regression estimates of repeated predictors were evaluated by generalized estimating equations(GEEs)*** open-cohort approach was used to classify patient's outcomes into the survival or non-survival ***:The hospital mortality of patients with CAP occurring in AID-induced ICH was 60.64%.No significant differences were found with respect to clinical symptoms and lung images between survival and non-survival groups,while renal insufficiency and dysfunction of coagulation had higher proportions in non-survival patients(P<0.05).Both noninvasive ventilation(NIV)and invasive mechanical ventilation(IMV)were performed more frequently in non-survival group(P<0.05).By the multivariate GEEs analysis,the repeated measured longitudinal indices of neutrophilto-lymphocyte ratio(NLR)(odds ratio[OR]=1.055,95%confidence interval[95%CI]1.025–1.086),lactate dehydrogenase(LDH)(OR=1.004,95%CI 1.002–1.006)and serum creatinine(s Cr)(OR=1.018,95%CI 1.008–1.028),were associated with a higher risk of ***:The CAP patients in AID-induced ICH had a high mortality.A significant relationship was demonstrated between the factors of NLR,LDH,s Cr and mortality risk in these patients.

关键词： Community-acquired pneumonia Immunocompromised hosts Autoimmune disease Prognostic marker

基于GPS的目标飞行时间异地高精度测量技术

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光电工程 2010年第8期37卷 1-4,11页

作者：黄战华孟南赵杰蔡怀宇天津大学精密仪器与光电子工程学院光电信息技术科学教育部重点实验室天津300072

针对远程目标异地作用的特性以及异地时间测量对时间统一标准的严格要求,提出了一种基于GPS的高精度异地目标光信号时间测量系统。该系统将GPS授时与本地温补晶振时钟结合起来,利用GPS授时秒脉冲1pps进行时间同步,由本地时钟结合GPS的... 详细信息

针对远程目标异地作用的特性以及异地时间测量对时间统一标准的严格要求,提出了一种基于GPS的高精度异地目标光信号时间测量系统。该系统将GPS授时与本地温补晶振时钟结合起来,利用GPS授时秒脉冲1pps进行时间同步,由本地时钟结合GPS的标准时间测量出飞行目标启动和停止的精确时间及时间间隔;同时设计了高精度的授时方案,对GPS秒脉冲进行监控和补偿,有效提高了系统的可靠性。实验表明,该系统测量在400s内所产生的累积测量误差小于300μs,等效精度达到7.5×10-7。

关键词： GPS授时本地温补晶振时钟时间同步异地目标飞行时间测量

Androgen signaling inhibits de novo lipogenesis to alleviate lipid deposition in zebrafish

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Zoological Research 2024年第2期45卷 355-366页

作者： Jing-Yi Jia Guang-Hui Chen Ting-Ting Shu Qi-Yong Lou Xia Jin Jiang-Yan He Wu-Han Xiao Gang Zhai zhan Yin College of Fisheries Huazhong Agriculture UniversityWuhanHubei 430070China State Key Laboratory of Freshwater Ecology and Biotechnology Institute of HydrobiologyChinese Academy of SciencesWuhanHubei 430072China College of Advanced Agricultural Sciences University of Chinese Academy of SciencesBeijing 100049China Hubei Key Laboratory of Three Gorges Project for Conservation of Fishes Chinese Sturgeon Research InstituteChina Three Gorges CorporationYichangHubei 443100China Hubei Hongshan Laboratory Huazhong Agriculture UniversityWuhanHubei 430070China Innovative Academy of Seed Design Chinese Academy of SciencesBeijing 100049China

Testosterone is closely associated with lipid metabolism and known to affect body fat composition and muscle mass in ***,the mechanisms by which testosterone acts on lipid metabolism are not yet fully understood,especially in *** this study,cyp17a1-/-zebrafish(Danio rerio)exhibited excessive visceral adipose tissue(VAT),lipid content,and up-regulated expression and activity of hepatic de novo lipogenesis(DNL)*** assay for transposase accessible chromatinwithsequencing(ATAC-seq)results demonstrated that chromatin accessibility of DNL genes was increased in cyp17a1-/-fish compared to cyp17a1+/+male fish,including stearoyl-CoA desaturase(scd)and fatty acid synthase(fasn).Androgen response element(ARE)motifs in the androgen signaling pathway were significantly enriched in cyp17a1+/+male fish but not in cyp17a1-/-*** androgen receptor(ar)-/-and wildtype(WT)zebrafish administered with Ar antagonist flutamide displayed excessive visceral adipose tissue,lipid content,and up-regulated expression and activity of hepatic de novo lipogenesis *** Ar agonist BMS-564929 reduced the content of VAT and lipid content,and down-regulated acetyl-CoA carboxylase a(acaca),fasn,and scd ***,the rescue effect of testosterone on cyp17a1-/-fish in terms of phenotypes was abolished when ar was additionally ***,these findings reveal that testosterone inhibits lipid deposition by down-regulating DNL genes via Ar in zebrafish,thus expanding our understanding of the relationship between testosterone and lipid metabolism in teleosts.

关键词： Cyp17a1 Testosterone Androgen receptor De novo lipogenesis Fatty acid synthesis

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基于折叠重排的低功耗BIST技术研究

计算机应用研究 2011年第7期28卷 2583-2585页

作者：谈恩民詹琰刘建军桂林电子科技大学电子工程与自动化学院广西桂林541004 集美大学信息工程学院福建厦门361021

为了降低测试功耗,提出一种新的低功耗测试矢量方案,该方案增设了一个可编程的约翰逊计数器。这种技术首先对确定测试矢量进行编码得到LFSR矢量种子,然后对LFSR种子解码、重排得到新的测试矢量。通过ISCAS85实验结果表明,该技术能够改... 详细信息

为了降低测试功耗,提出一种新的低功耗测试矢量方案,该方案增设了一个可编程的约翰逊计数器。这种技术首先对确定测试矢量进行编码得到LFSR矢量种子,然后对LFSR种子解码、重排得到新的测试矢量。通过ISCAS85实验结果表明,该技术能够改善测试矢量之间的线性相关性,大量减少测试矢量之间的跳变,达到降低功耗的目的。重点介绍了双重编码种子的方法和数据结果分析。

关键词：内建自测试(BIST) 约翰逊折叠计数器线性反馈移位寄存器低功耗

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再生水在不同灌溉方式下对玉米生长的影响

灌溉排水学报 2006年第4期25卷 68-70页

作者：马敏黄占斌苗战霞侯利伟中国矿业大学(北京校区) 北京100083

采用北京市高碑店污水处理厂生产的二级水、三级水,以纯灌、混灌、轮灌等方式灌溉盆栽玉米,设置7种处理研究对玉米生长的影响。结果表明:不同水质的再生水在不同灌溉方式下对玉米生殖生长阶段的株高、叶面积、干重、产量和水分利用效率... 详细信息

采用北京市高碑店污水处理厂生产的二级水、三级水,以纯灌、混灌、轮灌等方式灌溉盆栽玉米,设置7种处理研究对玉米生长的影响。结果表明:不同水质的再生水在不同灌溉方式下对玉米生殖生长阶段的株高、叶面积、干重、产量和水分利用效率影响差异不显著,影响主要体现在营养生长阶段。苗期再生水轮灌比混灌和纯灌较好,二级水相对于清水和三级水对玉米苗期的干重有一定影响。同一水质在纯灌、混灌和轮灌不同方式下对玉米生殖生长和产量影响很小。

关键词：再生水盆栽灌溉玉米

An ultrapotent pan-β-coronavirus lineage B(β-CoV-B)neutralizing antibody locks the receptor-binding domain in closed conformation by targeting its conserved epitope

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Protein & Cell 2022年第9期13卷 655-675页

作者： Zezhong Liu Wei Xu Zhenguo Chen Wangjun Fu Wuqiang zhan Yidan Gao jie Zhou Yunjiao Zhou Jianbo Wu Qian Wang Xiang zhang Aihua Hao Wei Wu Qianqian zhang Yaming Li Kaiyue Fan Ruihong Chen Qiaochu Jiang Christian TMayer Till Schoofs Youhua Xie Shibo Jiang Yumei Wen Zhenghong Yuan Kang Wang Lu Lu Lei Sun Qiao Wang Key Laboratory of Medical Molecular Virology(MOE/NHC/CAMS) School of Basic Medical SciencesShanghai Institute of Infectious Disease and Biosecuritythe Fifth People’s Hospital of ShanghaiShanghai Key Laboratory of Medical EpigeneticsInternational Co-laboratory of Medical Epigenetics and Metabolism(Ministry of Science and Technology)Institutes of Biomedical SciencesBiosafety Level 3 LaboratoryShanghai Medical CollegeFudan UniversityShanghai 200032China CAS Key Laboratory of Infection and Immunity National Laboratory of MacromoleculesInstitute of BiophysicsChinese Academy of SciencesBeijing 100101China Experimental Immunology Branch Center for Cancer ResearchNational Cancer InstituteNational Institutes of HealthBethesdaMD 20892USA GSK Vaccines 1300 WavreBelgium

New threats posed by the emerging circulating variants of SARS-CoV-2 highlight the need to find conserved neutralizing epitopes for therapeutic antibodies and efficient vaccine ***,we identified a receptorbinding domain(RBD)-binding antibody,XG014,which potently neutralizesβ-coronavirus lineage B(β-CoV-B),including SARS-CoV-2,its circulating variants,SARSCoV and bat SARSr-CoV ***,antibody family members competing with XG014 binding show reduced levels of cross-reactivity and induce antibodydependent SARS-CoV-2 spike(S)protein-mediated cellcell fusion,suggesting a unique mode of recognition by *** analyses reveal that XG014 recognizes a conserved epitope outside the ACE2 binding site and completely locks RBD in the non-functional“down”conformation,while its family member XG005 directly competes with ACE2 binding and position the RBD“up”.Single administration of XG014 is effective in protection against and therapy of SARS-CoV-2 infection in *** findings suggest the potential to develop XG014 as pan-β-CoV-B therapeutics and the importance of the XG014 conserved antigenic epitope for designing broadly protective vaccines againstβ-CoV-B and newly emerging SARS-CoV-2 variants of concern.

关键词： SARS-CoV-2 neutralizing antibody receptor-binding domain XG014 antibody-dependent cellcell fusion

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建筑结构振动控制的趋近律滑移模态方法

工程力学 2001年第3期18卷 67-73页

作者：赵斌吕西林吴敏哲梅占馨同济大学土木工程国家重点实验室上海200092 同济大学土木工程国家重点实验室上海200092 西安建筑科技大学建工系西安710055

本文应用变结构滑移模态控制理论中控制律设计的趋近律方法，对地震作用下建筑结构的振动控制问题进行了系统研究，推导了基于指数趋近律和幂次趋近律的变结构控制律表示式，讨论了最大控制力受到限制时控制力的确定方法。算例对比分析... 详细信息

本文应用变结构滑移模态控制理论中控制律设计的趋近律方法，对地震作用下建筑结构的振动控制问题进行了系统研究，推导了基于指数趋近律和幂次趋近律的变结构控制律表示式，讨论了最大控制力受到限制时控制力的确定方法。算例对比分析结果表明，本文控制方法能有效地减小结构的地震响应，具有较好的工程应用前景。

关键词：建筑结构结构控制滑移模态控制趋近律方法地震作用

A nanonewton-scale biomimetic mechanosensor

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Microsystems & Nanoengineering 2023年第4期9卷 45-56页

作者： Chi zhang Mengxi Wu ming Li Lixuan Che Zhiguang Tan Di Guo zhan Kang Shuye Cao Siqi zhang Yu Sui Jining Sun Liding Wang Junshan Liu State Key Laboratory of High-performance Precision Manufacturing Dalian University of Technology116024 DalianLiaoningChina Key Laboratory for Micro/Nano Technology and System of Liaoning Province Dalian University of Technology116024 DalianLiaoningChina State Key Laboratory of Structural Analysis for Industrial Equipment Dalian University of Technology116024 DalianChina

Biomimetic mechanosensors have profound implications for various areas,including health care,prosthetics,human‒machine interfaces,and *** one of the most important parameters,the sensitivity of mechanosensors is intrinsically determined by the detection resolution to mechanical *** this manuscript,we expand the force detection resolution of current biomimetic mechanosensors from the micronewton to nanonewton *** develop a nanocrack-based electronic whisker-type mechanosensor that has a detection resolution of 72.2 *** achieve the perception of subtle mechanical stimuli,such as tiny objects and airflow,and the recognition of surface morphology down to a 30 nm height,which is the finest resolution ever reported in biomimetic *** importantly,we explore the use of this mechanosensor in wearable devices for sensing gravity field orientation with respect to the body,which has not been previously achieved by these types of *** develop a wearable smart system for sensing the body’s posture and movements,which can be used for remote monitoring of falls in elderly *** summary,the proposed device offers great advantages for not only improving sensing ability but also expanding functions and thus can be used in many fields not currently served by mechanosensors.

关键词： mec expanding profound