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Effect of negative remodeling of the side branch ostium on the efficacy of a two-stent strategy for distal left main bifurcation lesions:an intravascular ultrasound study

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Journal of Geriatric Cardiology 2024年第5期21卷 506-522页

作者： Yi XU Tian XU Jia-Cong NONG Xiao-Han KONG Meng-Yao ZHAO Zhi-Jing GAO Yi-Fei WANG wei YOU Pei-Na MENG Yu-He ZHOU Xiang-Qi WU Zhi-ming WU Mei-En zhan Yan-Qing WANG De-Feng PAN Fei YE Department of Cardiology Nanjing First HospitalNanjing Hospital Affiliated to Nanjing Medical UniversityNanjing Medical UniversityNanjingChina Department of Cardiology Clinical Medicine School of Nanjing UniversityNanjingChina Department of Cardiology Tianchang People’s HospitalTianchangChina Department of Cardiology the Affiliated Hospital of Xuzhou Medical UniversityXuzhouChina

OBJECTIVES To investigate whether negative remodeling(NR) detected by intravascular ultrasound(IVUS) of the side branch ostium(SBO) would affect in-stent neointimal hyperplasia(NIH) at the one-year follow-up and the clinical outcome of target lesion failure(TLF) at the long-term follow-up for patients with left main bifurcation(LMb) lesions treated with a two-stent *** A total of 328 patients with de novo true complex LMb lesions who underwent a 2-stent strategy of percutaneous coronary intervention(PCI) treatment guided by IVUS were enrolled in this study. We divided the study into two phases. Of all the patients, 48 patients who had complete IVUS detection pre-and post-PCI and at the 1-year follow-up were enrolled in phase Ⅰ analysis, which aimed to analyze the correlation between NR and in-stent NIH at SBO at the 1-year follow-up. If the correlation was confirmed, the cutoff value of the remodeling index(RI) for predicting NIH ≥ 50% was analyzed next. The phase Ⅱ analysis focused on the incidence of TLF as the primary endpoint at the 1-to 5-year follow-up for all 328 patients by grouping based on the cutoff value of *** In phase I: according to the results of a binary logistic regression analysis and receiver operating characteristic(ROC) analysis, the RI cutoff value predicting percent NIH ≥ 50% was 0.85 based on the ROC curve analysis, with a sensitivity of 85.7%, a specificity of 88.3%, and an AUC of 0.893(0.778, 1.000), P = 0.002. In phase Ⅱ: the TLR rate(35.8% vs. 5.3%, P < 0.0001)was significantly higher in the several NR(s NR, defined as RI ≤ 0.85) group than in the non-s NR *** The NR of LCx O is associated with more in-stent NIH post-PCI for distal LMb lesions with a 2-stent strategy,and NR with RI ≤ 0.85 is linked to percent NIH area ≥ 50% at the 1-year follow-up and more TLF at the 5-year follow-up.

关键词： lesions remodeling intravascular

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额眶前移手术对额缝早闭患儿额叶容量及社会情绪改善的效果评价

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临床小儿外科杂志 2024年第2期23卷 119-124页

作者：李森詹琪佳肖波蒋文彬魏民陈欣上海市儿童医院上海交通大学医学院附属儿童医院神经外科，上海200062 上海交通大学医学院上海儿童医学中心神经外科，上海200333 上海市儿童医院上海交通大学医学院附属儿童医院6A病区，上海200062

目的探讨额眶前移手术改善额缝早闭患儿额叶容量和社会情绪的效果。方法回顾性分析自2017年1月至2021年10月在上海市儿童医院诊断并接受额眶前移手术治疗的15例额缝早闭患儿临床资料。分别于术前、术后1年及末次随访[术后(52±19)个月]... 详细信息

目的探讨额眶前移手术改善额缝早闭患儿额叶容量和社会情绪的效果。方法回顾性分析自2017年1月至2021年10月在上海市儿童医院诊断并接受额眶前移手术治疗的15例额缝早闭患儿临床资料。分别于术前、术后1年及末次随访[术后(52±19)个月]时,采用头颅MRI检查及Slicer 5.4.0进行前额体积、脑体积和额角的计算,同期采用社会情绪调查量表对患儿社会情绪进行评估。结果15例均行额眶前移手术。术前额叶体积为106.58(103.38,112.35)cm^(3),脑体积为528.65(496.57,563.36)cm^(3),额角为91.3(89.6,93.3)°,额叶/脑比例为20(20,20)%;术后1年额叶体积为149.64(145.64,168.85)cm^(3),脑体积为623.71(587.76,651.87)cm^(3),额角为109.5(106.4,114.6)°,额叶/脑比例为24(20,30)%;末次随访时,额叶体积为217.18(208.44,238.42)cm^(3),脑体积为870.62(786.21,961.88)cm^(3),额角为116.4(113.4,120.7)°,额叶/脑比例25(20,30)%;上述指标于术后1年及末次随访显示均较术前明显改善(P<0.05)。术后1年额叶增长比例32(30,30)%,显著高于脑增长比例15(10,20)%,差异有统计学意义(P<0.05);末次随访时额叶增长比例51(50,50)%,脑增长比例39(30,40)%,差异有统计学意义(P<0.05)。患儿术前社会情绪得分为85(85,95)分,显著高于正常界值(50分);术后1年随访时,社会情绪显著下降至50(50,55)分,基本接近正常界值;末次随访时,社会情绪得分为35(30,40)分,15例患儿均低于界值,达到正常水平,较术前显著改善(P<0.05)。结论额眶前移术可显著增加额缝早闭患儿额叶容量,改善前额畸形,同时有效改善不良社会情绪。

关键词：颅缝早闭额缝早闭外科手术额眶前移治疗结果社会情绪评估儿童

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Oscillations of elastically mounted cylinders in regular waves

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Applied Mathematics and Mechanics(English Edition) 2014年第6期35卷 767-782页

作者：苏炜詹杰民李毓湘 School of Engineering Sun Yat-sen University Department of Civil & Environmental Engineering The Hong Kong Polytechnic University

Under the assumption of potential flow and linear wave theory, a semi-analytic method based on eigenfunciton expansion is proposed to predict the hydrody-namic forces on an array of three bottom-mounted, surface-piercing circular cylinders. The responses of the cylinders induced by wave excitation are determined by the equa-tions of motion coupled with the solutions of the wave radiation and diffraction problems. Experiments for three-cylinder cases are then designed and performed in a wave flume to determine the accuracy of this method for regular waves.

关键词： wave diffraction wave force eigenfunciton method flexible vertical mounted cylinder array

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尖孢镰刀菌亚麻专化型FolGLS2基因功能分析

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中国油料作物学报 2024年第2期46卷 294-302页

作者：高伟娜侯占铭内蒙古师范大学生命科学与技术学院内蒙古自治区高等学校生物多样性保护与可持续利用重点实验室内蒙古呼和浩特010022

亚麻是我国主要的油料作物,且长期受亚麻枯萎病的侵害。β-1,3-葡聚糖合酶的催化亚基FKS/GLS为细胞壁合成所必需,本研究为鉴定尖孢镰刀菌亚麻专化型FolGLS2的功能,进行了FolGLS2基因的克隆、敲除以及敲除突变体表型和致病力的测定等试... 详细信息

亚麻是我国主要的油料作物,且长期受亚麻枯萎病的侵害。β-1,3-葡聚糖合酶的催化亚基FKS/GLS为细胞壁合成所必需,本研究为鉴定尖孢镰刀菌亚麻专化型FolGLS2的功能,进行了FolGLS2基因的克隆、敲除以及敲除突变体表型和致病力的测定等试验。结果显示,FolGLS2基因全长5947 bp,cDNA开放阅读框为5847 bp,编码1948个氨基酸。表型观察发现,敲除突变体菌落小而紧实,生长速率明显降低;菌丝缩短、增粗且无法产生分生孢子;菌丝细胞壁对于常规原生质释放酶液具有抗性,无法释放原生质体;感染试验显示,突变体致病力明显减弱。上述结果表明,FolGLS2基因编码β-1,3-葡聚糖合成酶催化亚基,对菌丝营养生长、菌落形态、分生孢子发生、细胞壁组成及致病性具有调控作用。

关键词：尖孢镰刀菌亚麻专化型 Split-Marker技术 FolGLS2 基因敲除

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High density dislocations enhance creep ageing response and mechanical properties in 2195 alloy sheet

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Journal of Central South University 2024年第7期31卷 2194-2209页

作者： wei Shuo MA Pei-pei CHEN Long-hui YANG Jian-shi zhan Li-hua LIU Chun-hui Light Alloy Research Institute Central South UniversityChangsha 410083China State Key Laboratory of Precision Manufacturing for Extreme Service Performance Central South UniversityChangsha 410083China School of Mechanical and Electrical Engineering Central South UniversityChangsha 410083China Advancd Research Center Central South UniversityChangsha 410083China Light Alloy Research

The creep strain of conventionally treated 2195 alloy is very low,increasing the difficulty of manufacturing Al-Cu-Li alloy sheet parts by creep age ***,finding a solution to improve the creep formability of Al-Cu-Li alloy is vital.A thorough comparison of the effects of cryo-deformation and ambient temperature large pre-deformation(LPD)on the creep ageing response in the 2195 alloy sheet at 160℃with different stresses has been *** evolution of dislocations and precipitates during creep ageing of LPD alloys are revealed by X-ray diffraction and transmission electron ***-quality 2195 alloy sheet largely pre-deformed by 80%without edge-cracking is obtained by cryo-rolling at liquid nitrogen temperature,while severe edge-cracking occurs during room temperature *** creep formability and strength of the 2195 alloy are both enhanced by introducing pre-existing dislocations with a density over 1.4×10^(15)m^(−2).At 160℃and 150 MPa,creep strain and creep-aged strength generally increases by 4−6 times and 30−50 MPa in the LPD sample,respectively,compared to conventional T3 alloy *** elongation of creep-aged LPD sample is low but remains relevant for *** high-density dislocations,though existing in the form of dislocation tangles,promote the formation of refined T1 precipitates with a uniform dispersion.

关键词： creep ageing Al-Cu-Li alloy high dislocation density cryogenic rolling dislocation strengthening

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室温磷光碳点/SiO_(2)复合材料的制备与应用进展

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复合材料学报 2024年第5期41卷 2220-2235页

作者：金鹏王巍孙争光武艺詹园湖北大学材料科学与工程学院功能材料绿色制备与应用教育部重点实验室高分子材料湖北省重点实验室武汉430062 武汉纺织大学纺织纤维及制品教育部重点实验室武汉430200

碳点(Carbon dots,CDs)作为发光材料,在传感、信息安全、生物医学等领域具有重要应用潜力。然而,制备光学性能稳定、寿命长、发光效率高的CDs基室温磷光(RTP)材料仍然是一个巨大的挑战。将CDs固定在SiO_(2)载体上构建CDs/SiO_(2)复合材... 详细信息

碳点(Carbon dots,CDs)作为发光材料,在传感、信息安全、生物医学等领域具有重要应用潜力。然而,制备光学性能稳定、寿命长、发光效率高的CDs基室温磷光(RTP)材料仍然是一个巨大的挑战。将CDs固定在SiO_(2)载体上构建CDs/SiO_(2)复合材料,利用CDs与SiO_(2)之间的协同作用,不仅可以提高CDs的分散性,实现CDs稳定的固态荧光;而且还能诱导三重激发态,产生稳定的三重态激子以实现CDs长寿命发光,这对拓展CDs基复合材料的应用领域具有重要意义。本文综述了近年来RTP CDs/SiO_(2)复合材料的制备方法、性能与应用,总结了其发展中存在的问题,并对RTP CDs/SiO_(2)复合材料的发展方向进行了展望。

关键词：发光材料 CDs/SiO_(2)复合材料室温磷光三重态制备方法传感

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Genotypes and Phenotypes of Uygur Children With Xeroderma Pigmentosum: A Case Study in Xinjiang, China

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International Journal of Dermatology and Venereology 2024年第3期7卷 144-149页

作者： Yun Qiu wei-Jia Wang Jun-Qin Liang Buwajieer Yakeya Peng Wang Jing-zhan zhang Xiao-Jing Kang Department of Dermatology and Venereology People’s Hospital of Xinjiang Uygur Autonomous RegionUrumqiXinjiang Uygur Autonomous Region 830001China Xinjiang Clinical Research Center for Dermatologic Diseases UrumqiXinjiang Uygur Autonomous Region 830001China Xinjiang Key Laboratory of Dermatology Research(XJYS1707) UrumqiXinjiang Uygur Autonomous Region 830001China

Objective:Xeroderma pigmentosum(XP)is a rare autosomal recessive dermatosis caused by genetic defects of DNA *** study was performed to detect and analyze the genes of 2 Uygur patients with XP and their families and assess the patients’phenotypes,which may enrich the understanding of the genetic skin disorder spectrum in Xinjiang ***:We collected the clinical data from 2 patients with XP and peripheral blood samples from the patients and their family *** patients’DNA was sequenced and detected by Sanger sequencing,and gene mutations were ***:The proband in family 1 presented with brown maculae at the exposure site and squamous cell carcinoma secondary to a facial *** proband had a homozygous nucleotide variation of XPC c.2251-2A>G(A change from A to G in the penultimate position of the intron before the 2251 position in the coding region),which was a shear *** this family,both parents were heterozygous,and no similar mutation detected in the *** family 2,the proband had scattered black brown spots and papules on the trunk and *** his younger sister was also a *** proband and his younger sister had homonucleotide variation of XPA c.631C>T,which was nonsense mutation,resulting in the codon for Arg No.211 being changed into termination codon(***211X),thus terminating the peptide chain synthesis *** the normal individuals in the two families were heterozygotes,and homozygous mutations occurred in all the patients,which was consistent with the autosomal recessive ***:XP is rare in Uygur *** study expanded the mutation spectrum of XP and provided a basis for early diagnosis,treatment,prognostic prediction,and prenatal genetic consultation.

关键词： xeroderma pigmentosum gene mutation XPA gene XPC gene

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基于RNA-Seq筛选高粱低氮胁迫相关候选基因

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作物学报 2024年第3期50卷 669-685页

作者：王瑞张福耀詹鹏杰楚建强晋敏姗赵威军程庆军山西农业大学高粱研究所/高粱遗传与种质创新山西省重点实验室山西晋中030600 西北农林科技大学农学院陕西杨凌712100

研究低氮胁迫条件下不同高粱材料间的基因差异表达,为耐低氮型高粱品种选育和耐低氮胁迫的分子机制探究提供参考。选取2个耐低氮型高粱(BSX44和BTx378)为试验材料,设置正常和低氮胁迫2个处理,利用RNA-Seq技术对高粱苗期、抽穗期和开花... 详细信息

研究低氮胁迫条件下不同高粱材料间的基因差异表达,为耐低氮型高粱品种选育和耐低氮胁迫的分子机制探究提供参考。选取2个耐低氮型高粱(BSX44和BTx378)为试验材料,设置正常和低氮胁迫2个处理,利用RNA-Seq技术对高粱苗期、抽穗期和开花期的基因表达进行分析,通过生物信息学对差异基因的生物学功能和代谢途径进行研究,筛选可能参与低氮调控的基因,了解氮高效基因型在氮素吸收利用过程中可能的分子途径。结果表明,在正常和低氮胁迫下,BTx378和BSX44在苗期分别筛选出937个和787个差异表达基因,抽穗期分别筛选出1305个和935个差异表达基因,开花期分别筛选出1402个和963个差异表达基因。对3个时期的差异表达基因进行鉴定,发现在苗期、抽穗期和开花期分别有246、371和306个基因在2个耐低氮高粱品种中共同差异表达,有28个基因在2个耐低氮品种的不同生育时期均差异表达,其中有5个基因上调表达,23个基因下调表达;对共同差异表达基因的KEGG相关代谢通路富集分析,发现主要集中在氮代谢、丙氨酸,天冬氨酸和谷氨酸代谢、甘油磷脂代谢、氨基酸的生物合成等途径,表明耐低氮型高粱可能通过这些途径相关基因的表达影响其对低氮胁迫的耐受性。

关键词：高粱转录组测序低氮胁迫差异表达基因(DEGs)

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馄饨结构的KB@Co-C_(3)N_(4)在中性电解质中作为锌空气电池的高活性和稳定性氧催化剂

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Chinese Journal of Catalysis 2024年第5期60卷 178-189页

作者：吴维凡范晋歌赵振宏潘建敏杨静阎兴斌詹怡中山大学化学工程与技术学院广东珠海519082 中山大学低碳化学与节能工程重点实验室广东广州510275 中山大学材料科学与工程学院光电材料与技术国家重点实验室广东广州510275

金属和氮共掺杂碳(M-N-Cs)由于具有高原子利用率、良好的活性和选择性,因而被认为是具有潜力的氧电催化剂.但其热力学氧化势较低,碳材料在高电位下容易腐蚀.在放电过程中,锌空气电池正极的电位始终比碳氧化的热力学电位高约0.5 V,这导... 详细信息

金属和氮共掺杂碳(M-N-Cs)由于具有高原子利用率、良好的活性和选择性,因而被认为是具有潜力的氧电催化剂.但其热力学氧化势较低,碳材料在高电位下容易腐蚀.在放电过程中,锌空气电池正极的电位始终比碳氧化的热力学电位高约0.5 V,这导致阴极中碳的严重腐蚀.对于M-N-C,腐蚀会破坏金属氮配位(M-Nx)活性位点,导致活性比表面积减少,同时还会改变孔隙形貌和表面特性,进而降低其催化活性.在充电(即氧气析出反应,OER)过程中,这种腐蚀现象会进一步加剧.因此,开发一种既具有高效双功能催化活性,又具有良好抗电化学腐蚀性能的M-N-C催化剂,对于解决上述问题至关重要.本文利用氮化碳(g-C_(3)N_(4))支撑钴氮配位(Co-Nx)活性位点,同时包覆科琴黑(KB)形成馄饨结构,制备了双功能氧催化剂KB@Co-C_(3)N_(4).首先,将剥离的C_(3)N_(4)与KB混合后煅烧,得到C_(3)N_(4)包覆的KB材料(KB@C_(3)N_(4));随后,再次煅烧将Co单原子引入KB@C_(3)N_(4)中,形成具有高活性和高稳定性的KB@Co-C_(3)N_(4)氧催化剂.红外光谱结果证实了,KB@Co-C_(3)N_(4)中存在C_(3)N_(4)成分.透射电镜和元素标记结果表明,C_(3)N_(4)均匀包覆在KB基底上.同步辐射测试确定了Co单原子的配位环境为CoN4结构.在0.5 mol L^(-1) NH_(4)Cl溶液中测试了KB@Co-C_(3)N_(4)氧催化剂ORR/OER的催化活性和稳定性.结果表明,KB@CoC_(3)N_(4)表现出较好的ORR性能,半波电位为0.723 V,显著优于商业铂碳催化剂(0.673 V)和普通Co-N-C催化剂(0.694 V).经过40000圈加速耐久性测试,KB@Co-C_(3)N_(4)仅衰减9 mV,而商业铂碳和Co-N-C在7500圈测试后分别衰减41和44 mV.在OER方面,KB@Co-C_(3)N_(4)在10 mA cm^(-2)时的过电位为550 mV,优于氧化钌的560 mV和Co-N-C的600 mV.经过20000圈测试,KB@Co-C_(3)N_(4)的OER过电位几乎保持不变,而氧化钌和Co-N-C经过4000圈测试后分别增加了37和20 mV.透射电镜观察发现,KB@Co-C_(3)N_(4)在实验前后形貌未发生明显变化,证明了其较好的稳定性.理论计算揭示,C_(3)N_(4)能够优化Co金属活性位点的电子结构,改善Co中心的电荷分布并增强Co-N键强度;同时,C_(3)N_(4)对KB基底的包覆有效避免了KB在高电位下的腐蚀,确保了KB@Co-C_(3)N_(4)的高稳定性和催化活性.将KB@Co-C_(3)N_(4)应用于中性锌空气电池中,该电池展现出1.52 V的开路电压,并在5 mA cm^(-2)的高电流密度下稳定循环运行超过985 h,性能优于大多数报道的采用碳基材料作为阴极催化剂的中性锌空气电池.综上所述,馄饨结构的KB@Co-C_(3)N_(4)具有较好的氧催化活性和稳定性,为设计高稳定性高活性的M-N-C催化剂提供了一定的参考.

关键词：氧电催化单原子催化剂中性电解液抗腐蚀

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Discreet investors exert greater influence on cooperation in the public goods game

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Chinese Physics B 2024年第3期33卷 170-178页

作者：康洪炜金展瑶李明远旺咩孙兴平沈勇陈清毅 School of Software Yunnan UniversityKunming 650000China College of Information Science and Engineering Northeastern UniversityShenyang 110004China

This paper studies the evolutionary process of cooperative behavior in a public goods game model with heterogeneous investment strategies in square *** the proposed model,players are divided into defectors,cooperators and discreet *** these,defectors do not participate in investing,discreet investors make heterogeneous investments based on the investment behavior and cooperation value of their neighbors,and cooperators invest equally in each *** real life,heterogeneous investment is often accompanied by time or economic *** discreet investors in this paper pay a certain price to obtain their neighbors'investment behavior and cooperation value,which quantifies the time and economic costs of the heterogeneous investment *** results of Monte Carlo simulation experiments in this study show that discreet investors can effectively resist the invasion of the defectors,form a stable cooperative group and expand the cooperative advantage in ***,when discreet investors pay too high a price,they lose their strategic *** results in this paper help us understand the role of heterogeneous investment in promoting and maintaining human social cooperation.

关键词： public goods game heterogeneous investment discreet investors cooperation

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