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Journal of Integrative Agriculture 2022年第2期21卷 486-495页

作者： zhanG Kai-li PENG Xia zhanG Sai-xian zhan hui-wen LU Jia-hui XIE Sheng-song ZHAO Shu-hong LI Xin-yun MA Yun-long Key Laboratory of Agricultural Animal Genetics Breeding and ReproductionMinistry of Education/Key Laboratory of Swine Genetics and BreedingMinistry of Agriculture and Rural Affairs/College of Animal Science and TechnologyHuazhong Agricultural UniversityWuhan 430070P.R.China

Genotype imputation has become an indispensable part of genomic data analysis. In recent years, imputation based on a multi-breed reference population has received more attention, but the relevant studies are scarce in pigs. In this study, we used the Illumina Porcine SNP50 Bead Chip to investigate the variations of imputation accuracy with various influencing factors and compared the imputation performance of four commonly used imputation software programs. The results indicated that imputation accuracy increased as either the validation population marker density, reference population sample size, or minor allele frequency(MAF) increased. However, the imputation accuracy would have a certain extent of decrease when the pig reference population was a mixed group of multiple breeds or lines. Considering both imputation accuracy and running time, Beagle 4.1 and FImpute are excellent choices among the four software packages tested. This work visually presents the impacts of these influencing factors on imputation and provides a reference for formulating reasonable imputation strategies in actual pig breeding.

关键词： genotype imputation multi-breed reference population imputation accuracy

Huanglian-Renshen-Decoction Maintains Isletβ-Cell Identity in T2DM Mice through Regulating GLP-1 and GLP-1R in Both Islet and Intestine

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Chinese Journal of Integrative Medicine 2025年第1期31卷 39-48页

作者： WU wen-bin GAO Fan TANG Yue-heng WANG Hong-zhan DONG hui LU Fu-er YUAN Fen Institution of Integrated Traditional Chinese and Western Medicine Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Department of Integrated Traditional Chinese and Western Medicine Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China

Objective: To elucidate the effect of Huanglian-Renshen-Decoction(HRD) on ameliorating type 2 diabetes mellitus by maintaining islet β-cell identity through regulating paracrine and endocrine glucagon-like peptide-1(GLP-1)/GLP-1 receptor(GLP-1R) in both islet and intestine. Methods: The db/db mice were divided into the model(distilled water), low-dose HRD(LHRD, 3 g/kg), high-dose HRD(HHRD, 6 g/kg), and liraglutide(400 μg/kg) groups using a random number table, 8 mice in each group. The db/m mice were used as the control group(n=8, distilled water). The entire treatment of mice lasted for 6 weeks. Blood insulin, glucose, and GLP-1levels were quantified using enzyme-linked immunosorbent assay kits. The proliferation and apoptosis factors of islet cells were determined by immunohistochemistry(IHC) and immunofluorescence(IF) staining. Then,GLP-1, GLP-1R, prohormone convertase 1/3(PC1/3), PC2, v-maf musculoaponeurotic fibrosarcoma oncogene homologue A(MafA), and pancreatic and duodenal homeobox 1(PDX1) were detected by Western blot, IHC,IF, and real-time quantitative polymerase chain reaction, respectively. Results: HRD reduced the weight and blood glucose of the db/db mice, and improved insulin sensitivity at the same time(P<0.05 or P<0.01). HRD also promoted mice to secrete more insulin and less glucagon(P<0.05 or P<0.01). Moreover, it also increased the number of islet β cell and decreased islet α cell mass(P<0.01). After HRD treatment, the levels of GLP-1,GLP-1R, PC1/3, PC2, MafA, and PDX1 in the pancreas and intestine significantly increased(P<0.05 or P<0.01).Conclusion: HRD can maintain the normal function and identity of islet β cell, and the underlying mechanism is related to promoting the paracrine and endocrine activation of GLP-1 in pancreas and intestine.

关键词： type 2 diabetes mellitus Huanglian-Renshen-Decoction isletβcell glucagon-like peptide-1 glucagon-like peptide-1 receptor Chinese medicine

PSA在三门与海阳核电厂SWS泵配置影响分析中的应用

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原子能科学技术 2013年第3期47卷 449-452页

作者：詹文辉颜珍上海核工程研究设计院上海200233

结合三门和海阳核电厂厂用水系统的实际设计,考虑各运行工况下的运行要求,特别是系统布置相关性的影响,通过概率安全评价(PSA)建模确定了系统可用性情况及其相应的风险结果。基于风险分析的结果,为三门核电厂的设计缺陷提出了合理的改... 详细信息

结合三门和海阳核电厂厂用水系统的实际设计,考虑各运行工况下的运行要求,特别是系统布置相关性的影响,通过概率安全评价(PSA)建模确定了系统可用性情况及其相应的风险结果。基于风险分析的结果,为三门核电厂的设计缺陷提出了合理的改进建议方案,从而提高了该电厂的安全性和经济性。同时结合海阳核电厂的实际情况,分析结果认为基本无改进必要,充分体现了PSA对设计的支持和指导作用。

关键词：概率安全评价厂用水系统 PSA应用

基于不同传热管材料的SGTR始发事件频率分析

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原子能科学技术 2015年第7期49卷 1243-1246页

作者：杨亚军詹文辉上海核工程研究设计院上海200233

基于不同材料传热管的运行经验,统计总的管临界年数以区分不同核电厂蒸汽发生器传热管数的影响,并将Jeffreys分布作为先验分布统计分析690TT以及经热处理的传热管(包含600TT和690TT)发生破裂的频率。该方法得到的蒸汽发生器传热管破裂(S... 详细信息

基于不同材料传热管的运行经验,统计总的管临界年数以区分不同核电厂蒸汽发生器传热管数的影响,并将Jeffreys分布作为先验分布统计分析690TT以及经热处理的传热管(包含600TT和690TT)发生破裂的频率。该方法得到的蒸汽发生器传热管破裂(SGTR)始发事件频率可较合理地体现传热管材料性能的改进对降低该事件导致安全壳旁通失效风险的影响及贡献,与通用数据库中未区分传热管材料对应的频率相比明显降低,且随着690TT传热管运行经验的进一步累积,预期SGTR始发事件频率会进一步降低。

关键词：始发事件频率蒸汽发生器传热管破裂 690TT

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多样化驱动系统保护功能及保护参数信号确定

原子能科学技术 2016年第9期50卷 1647-1652页

作者：詹文辉张彬彬徐珍上海核工程研究设计院上海200233

多样化驱动系统(DAS)为反应堆紧急停堆和驱动专设安全设施提供了与保护和安全监测系统(PMS)不同的多样化的后备。本文结合概率安全评价(PSA)分析工具,以功率运行内部事件PSA模型始发事件导致的堆芯损伤频率为度量,筛选出需要DAS提供保... 详细信息

多样化驱动系统(DAS)为反应堆紧急停堆和驱动专设安全设施提供了与保护和安全监测系统(PMS)不同的多样化的后备。本文结合概率安全评价(PSA)分析工具,以功率运行内部事件PSA模型始发事件导致的堆芯损伤频率为度量,筛选出需要DAS提供保护功能的系统,并通过分析事件进程确定了DAS驱动各系统的保护参数信号。结果表明:通过该方法可合理确定DAS的保护功能和参数信号。

关键词：多样化驱动系统保护功能分配保护参数信号

Steady-state and transient investigation of a small pressurized water reactor ACPR50S for different ATFs based on Bamboo-C code

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Nuclear Science and Techniques 2025年第1期36卷 192-206页

作者： Kun Zhuang Ying-Zhen Wang Li-Na Deng Yong-zhan Wang wen Shang Si-Peng Wang Department of Nuclear Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing 211106China

Small modular reactors have received widespread attention owing to their inherent safety,low investment,and *** pressurized water reactors(SPWRs)have become important candidates for SMRs owing to their high technological *** the Fukushima accident,research on accident-tolerant fuels(ATFs),which are more resistant to serious accidents than conventional fuels,has gradually *** study analyzes the neutronics and thermal hydraulics of an SPWR(ACPR50S)for different ATFs,BeO+UO_(2)−SiC,BeO+UO_(2)−FeCrAl,U_(3)Si_(2)−SiC,and U_(3)Si_(2)−FeCrAl,based on a PWR fuel management code,the Bamboo-C deterministic *** the steady state,the burnup calculations,reactivity coefficients,power and temperature distributions,and control rod reactivity worth were *** transients of the control rod ejection accident for the two control rods with the maximum and minimum reactivity worth were *** results showed that 5%B-10 enrichment in the wet annular burnable absorbers assembly can effectively reduce the initial reactivity and end-of-life reactivity *** BeO+UO2−SiC core exhibited superior neutronic characteristics in terms of burnup and negative temperature reactivity compared with the other three cases owing to the strong moderation ability of BeO+UO_(2)and low neutron absorption of ***,the U_(3)Si_(2)core had a marginally better power-flattening effect than BeO+UO_(2),and the differential worth of each control rod group was similar between different *** the transient of a control rod ejection,the changes in the fuel temperature,coolant temperature,and coolant density were *** maximum difference was less than 10℃ for the fuel temperature and 2℃ for the coolant temperature.

关键词： ACPR50S Small pressurized water reactor ATF Steady Transient

乙型肝炎病毒相关性肝癌患者的蛋白质组学研究

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中华医院感染学杂志 2010年第5期20卷 621-623页

作者：詹汇文富阳市妇幼保健院浙江富阳311400

目的初步探讨蛋白质组技术在精浆研究中的应用,建立乙型肝炎病毒相关性肝癌及健康者血清双向凝胶电泳图谱;筛查并鉴定二者间的差异表达蛋白质,期望从中发现有意义的分子标志物。方法采用双向凝胶电泳(2-DE)分离乙型肝炎病毒相关性肝癌... 详细信息

目的初步探讨蛋白质组技术在精浆研究中的应用,建立乙型肝炎病毒相关性肝癌及健康者血清双向凝胶电泳图谱;筛查并鉴定二者间的差异表达蛋白质,期望从中发现有意义的分子标志物。方法采用双向凝胶电泳(2-DE)分离乙型肝炎病毒相关性肝癌和健康者血清总蛋白,银染显色,PDQuest7.3.0软件分析,从中选取差异表达蛋白质,通过基质辅助激光解析电离飞行时间质谱(MALDI-TOF-MS)鉴定差异表达的蛋白质。结果获得分辨率较好的精浆双向凝胶电泳图谱;得到8个在乙型肝炎病毒相关性肝癌与健康者血清中差异有统计学意义的蛋白质斑点,进行鉴定,结果表明这些特异蛋白分别为肝脂肪酸结合蛋白、谷胱甘肽S转移酶A1、27×103热休克蛋白、黄素还原酶、假定蛋白、醛酮还原酶、乙二醛酶、细胞角蛋白18。结论在乙型肝炎病毒相关性肝癌与健康者血清中表达蛋白质差异有统计学意义,利用蛋白质组学这一高通量的筛查技术可望从中发现与乙型肝炎病毒相关性肝癌相关的血清标志物。

关键词：生物标志物蛋白质组学肝癌

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反应堆冷却剂系统低温超压分析

核科学与工程 2007年第2期27卷 167-172页

作者：詹文辉周全福上海核工程研究设计院上海200233

为分析巴基斯坦恰希玛核电厂2号机组反应堆冷却剂系统是否满足低温超压保护要求,应用热工水力分析程序Relap5／Mod3对其低温下的瞬态进行模拟计算分析,结果表明低温瞬态下的系统压力满足限值要求,不会发生超压。

关键词：反应堆冷却剂系统低温超压余热排出系统

Monitoring seismic velocity changes in the Dongtan Coal Mine using ambient noise correlation

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Earthquake Science 2025年第1期38卷 47-55页

作者： Chao Kong Kai zhan Xiaotao wen Ping Song Lianhai zhang Hanying Ding Shandong Keyue Technology Co. LtdJinan 250014China Chengdu University of Technology Chengdu 610059China Shandong Xiehe University Jinan 250014China

This study analyzed ambient seismic noise using the MSNoise package to monitor temporal changes in the underground seismic wave velocity in Mining Area 6 of the Dongtan Coal Mine in *** data was recorded continuously over 76 days by 7 three-component stations and 10 single-component microseismic stations deployed in Dongtan Coal Mine,with station spacing ranging from 0.1 km to approximately 3 *** the causal and non-causal components of the Z-component cross-correlation function,along with moving-window cross-spectrum analysis and cumulative calculations with a 5-day window overlay,stable seismic velocity changes were obtained in the frequency band of 0.1 to 2 *** found a correlation between the timing of average velocity changes and seismic events caused by underground mining *** particular,when the relative seismic velocity increased by 0.23%,larger energy minequakes typically *** study shows that ambient noise correlation has great potential for predicting minequakes,guiding pressure-relief production,and providing warnings about the impact of overburden pressure.

关键词： Dongtan Coal Mine MSNoise seismic ambient noise seismic wave velocity changes

组织气氛对工作倦怠的影响:工作压力的中介作用

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浙江大学学报（理学版） 2013年第1期40卷 112-118页

作者：詹文慧高金金陈毅文中国科学院心理研究所行为科学重点实验室北京100101 中国科学院研究生院北京100049

通过探讨组织气氛、工作压力、性别等人口学变量对工作倦怠的影响,以期望为企业管理者提供降低员工工作倦怠、提高员工工作效率的方法.本研究以民营企业员工为对象,通过问卷调查的方式对分属5类不同行业的270名员工的相关情况进行了调... 详细信息

通过探讨组织气氛、工作压力、性别等人口学变量对工作倦怠的影响,以期望为企业管理者提供降低员工工作倦怠、提高员工工作效率的方法.本研究以民营企业员工为对象,通过问卷调查的方式对分属5类不同行业的270名员工的相关情况进行了调查分析,得出以下结果:1)不同性别员工的工作倦怠水平差异不显著,男性的工作压力高于女性,女性感受到的组织气氛比男性要好;2)不同工作类型的员工的工作压力差异显著,压力最大的三类工作岗位依次为生产、行政和研发;3)工作压力、组织气氛与工作倦怠的玩世不恭和情绪衰竭两维度之间两两显著相关,与低成就感的相关不显著;4)工作压力中介了组织气氛对工作倦怠的玩世不恭、情绪衰竭两维度的影响.结果表明企业要针对不同的岗位采用不同的管理方法,同时要尽力营造好的组织气氛,这样有利于降低工作压力,进而降低工作倦怠的水平.

关键词：工作压力工作倦怠组织气氛中介作用