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Correlation of pressure gradient in three hepatic veins with portal pressure gradient

World Journal of Clinical Cases 2022年第14期10卷 4460-4469页

作者： Hao-Yu Wang Qing-Kun Song Zhen-dong Yue Lei Wang Zhen-hua Fan Yi-Fan Wu Cheng-Bin dong Yu zhang Ming-Ming Meng Ke zhang Li jiang hui-Guo Ding Yue-Ning zhang Yong-ping Yang Fu-Quan Liu Department of Oncology The 9^(th)Clinical Medical College&Beijing Shijitan HospitalPeking UniversityBeijing 100038China Division of Clinical Epidemiology and Evidence-Based Medicine Beijing Shijitan HospitalCapital Medical UniversityBeijing 100038China Department of Interventional Therapy Beijing Shijitan HospitalCapital Medical UniversityBeijing 100038China Department of Gastroenterology Beijing Shijitan HospitalCapital Medical UniversityBeijing 100038China Department of General Surgery Beijing Ditan HospitalCapital Medical UniversityBeijing 100102China Department of Gastroenterology and Hepatology Beijing You'an HospitalCapital Medical UniversityBeijing 100069China Department of Therapeutic Research for Liver Cancer The Fifth Medical Center of Chinese PLA General HospitalBeijing 100039China

BACKGROUND The liver is one of the most important organs in the human body,with functions such as detoxification,digestion,and blood *** terms of vascular anatomy,the liver is divided into the left and the right liver by the main portal vein,and there are three hepatic efferent veins(right,middle,and left)and two portal *** with impaired liver function have increased intrahepatic vascular resistance and splanchnic vasodilation,which may lead to an increase in the portal pressure gradient(PPG)and cause portal hypertension(PHT).In order to measure the increased pressure gradient of portal vein,the hepatic venous pressure gradient(HVPG)can be measured to reflect it in clinical *** accuracy of PPG measurements is directly related to patient *** To analyze the correlation between HVPG of three hepatic veins and PPG in patients with *** From January 2017 to December 2019,102 patients with PHT who met the inclusion criteria were evaluated during the transjugular intrahepatic portosystemic shunt procedure and *** The mean HVPG of the middle hepatic vein was 17.47±10.25 mmHg,and the mean HVPG of the right and left hepatic veins was 16.34±7.60 and 16.52±8.15 mmHg,*** average PPG was 26.03±9.24 *** correlation coefficient and coefficient of determination of the right hepatic vein,middle hepatic vein,and left hepatic vein were 0.15 and 0.02(P=0.164);0.25 and 0.05(P=0.013);and 0.14 and 0.02(P=0.013),*** mean wedged hepatic vein/venous pressure(WHVP)of the middle and left hepatic veins was similar at 29.71±12.48 and 29.1±10.91 mmHg,respectively,and the mean WHVP of the right hepatic vein was slightly lower at 28.01±8.95 *** mean portal vein pressure was 34.11±8.56 *** correlation coefficient and coefficient of determination of the right hepatic vein,middle hepatic vein,and left hepatic vein were 0.26 and 0.07(P=0.009);0.38 and 0.15(P<0.001);and 0.26 and 0.07(P=0.008),respecti

关键词： Portal hypertension Portal pressure gradient Hepatic venous pressure gradient Free hepatic venous pressure

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Machine-learning-assisted prediction of the mechanical properties of Cu–Al alloy

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International Journal of Minerals,Metallurgy and Materials 2020年第3期27卷 362-373页

作者： Zheng-hua Deng Hai-qing Yin Xue jiang Cong zhang Guo-fei zhang Bin Xu Guo-qiang Yang Tong zhang Mao Wu Xuan-hui Qu Collaborative Innovation Center of Steel Technology University of Science and Technology BeijingBeijing 100083China Chongqing Engineering Technology Research Center for Light Alloy and Processing Chongqing Three Gorges UniversityChongqing 404000China Beijing Advanced Innovation Center for Materials Genome Engineering Beijing 100083China Institute for Advanced Materials and Technology University of Science and Technology BeijingBeijing 100083China

The machine-learning approach was investigated to predict the mechanical properties of Cu–Al alloys manufactured using the powder metallurgy technique to increase the rate of fabrication and characterization of new materials and provide physical insights into their *** algorithms were used to construct the prediction models, with chemical composition and porosity of the compacts chosen as the *** results show that the sequential minimal optimization algorithm for support vector regression with a puk kernel(SMOreg/puk) model demonstrated the best prediction ability. Specifically, its predictions exhibited the highest correlation coefficient and lowest error among the predictions of the six models. The SMOreg/puk model was subsequently applied to predict the tensile strength and hardness of Cu–Al alloys and provide guidance for composition design to achieve the expected values. With the guidance of the SMOreg/puk model, Cu–12Al–6Ni alloy with a tensile strength(390 MPa) and hardness(HB 139) that reached the expected values was developed.

关键词： powder metallurgy tensile strength hardness machine learning Cu–Al alloy SMOreg/puk

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Use of the Attain Select Ⅱ catheter delivery system to improve left ventricular lead implantation in cardiac resynchronization therapy

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Chinese Medical Journal 2011年第8期124卷 1209-1212页

作者： zhou Xian-hui TANG Bao-peng LI Jin-xin zhang Yu zhang jiang-hua LI Yao-dong Heart Center First Affiliated Hospital Xinjiang MedicalUniversity Urumqi Xinjiang 830000 China

Background Despite technical advances in tools used to facilitate implantation of cardiac resynchronization therapy （CRT） devices, there are many hurdles related mainly to the variation in the anatomy of the coronary veins. One such difficulty is the presence of a very sharply-angulated or tortuous of the lateral or posterolateral cardiac *** Totally 44 patients, 28 males and 16 females, with congestive heart failure and intraventricular conduction delay were studied retrospectively. There were 23 patients who had left ventricular （LV） lead implantation using standard techniques and equipment. For the other 21 patients with LV lead implantation we used the Attain Select Ⅱ catheter delivery system. The patients were seen every 3-6 months for 12 months and the efficacy of the primary procedure, LV lead implantation time, procedure and fluoroscopy time and the complications associated with the two techniques were *** There were no significant differences in the age, gender, New York Heart Association （NYHA） functional class,ischemic etiology, QRS duration, left ventricular ejection fraction, left ventricular end-diastolic diameter, left ventricular end-systolic diameter and LV dyssynchrony between the two groups. The LV lead implantation time, procedure time and fluoroscopy time were significantly shorter in the group using the Attain Select Ⅱ catheter delivery system; LV lead implantation time from （51-7） minutes to （40±7） minutes （P ＜0.001）, procedure time from （143±17） minutes to （124±18）minutes （P=0.001）, and fluoroscopy time from （45±7） minutes to （35±6） minutes （P＜0.001）. A successful procedure of LV lead implantation was significantly improved from 17/23 （74%） patients using the standard techniques and equipment, to 20/21 （95.3%） patients using the Attain Select Ⅱ catheter delivery system （P=0.06）Conclusion It is feasible and safe to implant LV leads through the coronary sinus using the Attain Select Ⅱ catheter delivery system.

关键词： cardiac resynchronization therapy congestive heart failure the Attain Select Ⅱ catheter delivery system left ventricular lead implantation

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New tirucallane-type triterpenoids from the resin of Boswellia carterii and their NO inhibitory activities

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Chinese Journal of Natural Medicines 2021年第9期19卷 686-692页

作者： LIU Fang-Shen zhang Ting-Ting XU Jun JING Qin-Xue GONG Chi dong Bang-Jian LI Da-Hong LIU Xiao-Qiu LI zhan-Lin YUAN Zhong hua hui-Ming Key Laboratory of Structure-Based Drug Design&Discovery Ministry of EducationShenyang Pharmaceutical UniversityShenyang 110016China School of Traditional Chinese Materia Medica Shenyang Pharmaceutical UniversityShenyang 110016China State Key Laboratory of Medicinal Chemical Biology College of Pharmacyand Tianjin Key Laboratory of Molecular Drug ResearchNankai UniversityTianjin 300071China

Six new tirucallane-type triterpenoids(1-6),along with ten known triterpenoids,were isolated from methylene chloride extract of the resin of Boswellia carterii *** the application of the comprehensive spectroscopic data,the structures of the compounds were *** experimental electronic circular dichroism spectra were compared with those calculated,which allowed to assign the absolute *** 5 and 6 possesed a 2,3-seco tirucallane-type triterpenoid skeleton,which were first *** inhibitory activity against NO formation in LPS-activated BV-2 cells were *** 9 showed appreciable inhibitory effect,with an IC_(50)value of 7.58±0.87μmol·L^(-1).

关键词： Boswellia carterii Birdw seco-Tirucallane triterpenoids NO inhibition

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Transjugular intrahepatic portosystemic shunt with radioactive seed strand for main portal vein tumor thrombosis with cirrhotic portal hypertension

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World Journal of Gastrointestinal Surgery 2022年第6期14卷 567-579页

作者： Xuan-hui Yan Zhen-dong Yue Hong-Wei Zhao Lei Wang Zhen-hua Fan Yi-Fan Wu Ming-Ming Meng Ke zhang Li jiang hui-Guo Ding Yue-Ning zhang Yong-ping Yang Fu-Quan Liu Department of Interventional Therapy Peking University Ninth School of Clinical MedicineBeijing Shijitan HospitalBeijing 100038China Department of Interventional Therapy Beijing Shijitan HospitalCapital Medical UniversityBeijing 100038China Department of Interventional Therapy Beijing Tongren HospitalCapital Medical UniversityBeijing 100005China Department of Gastroenterology Beijing Shijitan HospitalCapital Medical UniversityBeijing 100038China Department of General Surgery Beijing Ditan HospitalCapital Medical UniversityBeijing 100102China Department of Gastroenterology Beijing You'an HospitalCapital Medical UniversityBeijing 100069China Department of Liver Disease Digestion Center Beijing You'an HospitalCapital Medical UniversityBeijing 100069China Department of Liver Disease The Fifth Medical Center of Chinese PLA General HospitalBeijing 100039China

BACKGROUND Patients with hepatocellular carcinoma complicated with main portal vein tumor thrombosis(mPVTT) and cirrhotic portal hypertension(CPH) have an extremely poor prognosis, and there is a lack of a clinically effective treatment *** To evaluate the efficacy and safety of transjugular intrahepatic portosystemic shunt(TIPS)combined with radioactive seed strand for the treatment of mPVTT patients with *** The clinical data of 83 consecutive patients who underwent TIPS combined with 125I seed strand placement for mPVTT and CPH from January 2015 to December 2018 were retrospectively reviewed. Procedure-related data(success rate, relief of portal vein pressure and CPH symptoms,and adverse events), PVTT response, and patient survival were assessed through a 2-year *** The success rate was 100.0% without perioperative death or procedure-related severe adverse events. The mean portal vein pressure was significantly decreased after the procedure(22.25 ± 7.33mmHg vs 35.12 ± 7.94 mmHg, t = 20.61, P < 0.001). The symptoms of CPH were all effectively relieved within 1 mo. The objective response rate of PVTT was 67.5%. During a mean follow-up of 14.5 ± 9.4 mo(range 1-37 mo), the cumulative survival rates at 6, 12 and 24 mo were 83.1%, 49.7%,and 21.8%, respectively. The median survival time was 12.0 ± 1.3 mo(95% confidence interval: 9.5-14.5). In multivariate Cox regression analysis, body mass index, Child-Pugh grade, cTNM stage,and PVTT response were independent prognostic factors(P < 0.05).CONCLUSION TIPS combined with radioactive seed strand might be effective and safe in treating mPVTT patients with CPH.

关键词： Transjugular intrahepatic portosystemic shunt Radioactive seed strand Portal vein tumor thrombosis Hepatocellular carcinoma Cirrhotic portal hypertension Cirrhosis

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Toll-like receptor 5-mediated signaling enhances liver regeneration in mice

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Military Medical Research 2021年第4期8卷 490-502页

作者： Wen zhang Lei Wang Xue-hua Sun Xian Liu Yang Xiao Jie zhang Ting Wang hui Chen Yi-Qun zhan Miao Yu Chang-hui Ge Chang-Yan Li Guang-Ming Ren Rong-hua Yin Xiao-Ming Yang Department of Pharmaceutical Engineering School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300072China. State Key Laboratory of Proteomics Beijing Proteome Research CenterNational Center for Protein Sciences(Beijing)Beijing Institute of LifeomicsBeijing 102206China. School of Basic Medical Sciences Anhui Medical UniversityHefei 230032Anhui ProvinceChina. Beijing Institute of Radiation Medicine Beijing 100850China.

Background:Toll-like receptor 5(TLR5)-mediated pathways play critical roles in regulating the hepatic immune response and show hepatoprotective effects in mouse models of hepatic ***,the role of TLR5 in experimental models of liver regeneration has not been *** study aimed to investigate the role of TLR5 in partial hepatectomy(PHx)-induced liver ***:We performed 2/3 PHx in wild-type(WT)mice,TLR5 knockout mice,or TLR5 agonist CBLB502 treated mice,as a model of liver *** flagellin content was measured with ELISA,and hepatic TLR5 expression was determined with quantitative PCR analyses and flow *** study the effects of TLR5 on hepatocyte proliferation,we analyzed bromodeoxyuridine(BrdU)incorporation and proliferating cell nuclear antigen(PCNA)expression with immunohistochemistry(IHC)*** effects of TLR5 during the priming phase of liver regeneration were examined with quantitative PCR analyses of immediate early gene mRNA levels,and with Western blotting analysis of hepatic NF-κB and STAT3 *** and growth factor production after PHx were detected with real-time PCR and cytometric bead array(CBA)*** Red O staining and hepatic lipid concentrations were analyzed to examine the effect of TLR5 on hepatic lipid accumulation after ***:The bacterial flagellin content in the serum and liver increased,and the hepatic TLR5 expression was significantly up-regulated in WT mice after ***5-deficient mice exhibited diminished numbers of BrdU-and PCNA-positive cells,suppressed immediate early gene expression,and decreased cytokine and growth factor ***,PHx-induced hepatic NF-κB and STAT3 activation was inhibited in Tlr5–/–mice,as compared with WT ***,the administration of CBLB502 significantly promoted PHx-mediated hepatocyte proliferation,which was correlated with enhanced production of proinflammatory cytokines and the recruitment of macrophages

关键词： Liver regeneration Partial hepatectomy Toll-like receptor 5 CBLB502 NF-κB

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Peroxisome proliferator-activated receptor gamma signaling in human sperm physiology

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Asian Journal of Andrology 2015年第6期17卷 942-947,I0008页

作者： Li-Li Liu hua Xian Jing-Chen Cao Chong zhang Yong-hui zhang Miao-Miao Chen Yi Qian Ming jiang Laboratory of Nuclear Receptors and Cancer Research Basic Medical Research Center Nantong University School of Medicine Nantong Jiangsu China Department of Surgery Affiliated Hospital of Nantong University Nantong Jiangsu China Division of Epidemiology Department of Medicine Vanderbilt lngram Cancer CenterVanderbilt University Medical Center Nashville TN USA .

Peroxisome proliferator-activated receptor gamma （PPARy） is a member of the PPARs, which are transcription factors of the steroid receptor superfamily. PPARy acts as an important molecule for regulating energy homeostasis, modulates the hypothalamic-pituitary-gonadal （HPG） axis, and is reciprocally regulated by HPG. In the human, PPARγprotein is highly expressed in ejaculated spermatozoa, implying a possible role of PPARγ signaling in regulating sperm energy dissipation. PPARγ protein is also expressed in Sertoli cells and germ cells （spermatocytes）. Its activation can be induced during capacitation and the acrosome reaction. This mini-review will focus on how PPARy signaling may affect fertility and sperm quality and the potential reversibility of these adverse effects.

关键词： fertilization hypothalamic-pituitary-gonadal axis insulin resistance leptin peroxisome proliferator-activated receptor gamma sperm physiology spermatogenesis spermatozoa

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On-treatment quantitative hepatitis B e antigen predicted response to nucleos(t)ide analogues in chronic hepatitis B

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World Journal of Hepatology 2016年第34期8卷 1511-1520页

作者： Yu-hua Gao Qing-hua Meng zhan-Qing zhang ping Zhao Qing-hua Shang Quan Yuan Yao Li Juan Deng Tong Li Xue-En Liu hui Zhuang Department of Microbiology and Infectious Disease Center School of Basic Medical SciencesPeking University Health Science Center Beijing YouAn Hospital Capital Medical University Shanghai Public Health Clinical Center Fudan University Department of Hepatology 302 Military Hospital of China Department of Hepatology the No.88 Hospital of the People’s Liberation Army National Institute of Diagnostic and Vaccine Development in Infectious Diseases School of Public HealthXiamen University

AIMTo investigate potential predictors for treatment response to nucleos(t)ide analogues (NAs) in hepatitis B e antigen (HBeAg)-positive chronic hepatitis B (CHB) patients. METHODSSeventy-six HBeAg-positive CHB patients received 96-wk NAs optimized therapy (lamivudine and adefovir dipivoxil) were studied retrospectively. Serum hepatitis B surface antigen, HBeAg, hepatitis B core antibody, hepatitis B virus (HBV) DNA and alanine aminotransferase levels were quantitatively measured before and during the treatment at 12 and 24 wk. Stepwise logistic regression analyses were performed to identify predictors for treatment response, and areas under the receiver operating characteristic curves (AUROC) of the independent predictors were calculated. RESULTSForty-three CHB patients (56.6%) achieved virological response (VR: HBV DNA ≤ 300 copies/mL) and 15 patients (19.7%) developed HBeAg seroconversion (SC) after the 96-wk NAs treatment. The HBeAg level (OR = 0.45, P = 0.003) as well as its declined value (OR = 2.03, P = 0.024) at 24-wk independently predicted VR, with the AUROC of 0.788 and 0.736, respectively. The combination of HBeAg titer 1.6 lg PEIU/mL at 24-wk predicted VR with a sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) of 85%, 100%, 100% and 83%, respectively, and the AUROC increased to 0.923. The HBeAg level (OR = 0.37, P = 0.013) as well as its declined value (OR = 2.02, P = 0.012) at 24-wk also independently predicted HBeAg SC, with the AUROC of 0.828 and 0.814, respectively. The HBeAg titer 2.2 lg PEIU/mL at 24-wk predicted HBeAg SC with a sensitivity, specificity, PPV, NPV of 88%, 98%, 88% and 98%, respectively, and the AUROC reached 0.928. CONCLUSIONThe combination of HBeAg level and its declined value at 24-wk may be used as a reference parameter to optimize NAs therapy.

关键词： Response predictor Quantitative detection Hepatitis B e antigen Hepatitis B virus DNA Chronic hepatitis B Nucleos(t)ide analogues

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Identification of anti-gastric cancer effects and molecular mechanisms of resveratrol: From network pharmacology and bioinformatics to experimental validation

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 493-513页

作者： Ying-Qian Ma Ming zhang Zhen-hua Sun Hong-Yue Tang Ying Wang jiang-Xue Liu zhan-Xue zhang Chao Wang Department of Oncology Hebei General HospitalShijiazhuang 050051Hebei ProvinceChina School of Graduate Studies Hebei Medical UniversityShijiazhuang 050017Hebei ProvinceChina Clinical Medical Research Center Hebei General HospitalShijiazhuang 050051Hebei ProvinceChina Department of Gastrointestinal Surgery Second Hospital of Hebei Medical UniversityShijiazhuang 050000Hebei ProvinceChina

BACKGROUND Gastric cancer(GC)is one of the most aggressive malignancies with limited therapeutic options and a poor ***,a non-flavonoid poly-phenolic compound found in a variety of Chinese medicinal materials,has shown excellent anti-GC ***,its exact mechanisms of action in GC have not been *** To identify the effects of resveratrol on GC progression and explore the related molecular *** Action targets of resveratrol and GC-related targets were screened from public *** overlapping targets between the two were confirmed using a Venn diagram,and a“Resveratrol-Target-GC”network was constructed using Cyto-scape software version *** protein-protein interaction(PPI)network was constructed using STRING database and core targets were identified by PPI network *** Database for Annotation,Visualization and Integrated A total of 378 resveratrol action targets and 2154 GC disease targets were obtained from public databases,and 181 intersection targets between the two were screened by Venn *** top 20 core targets were identified by PPI network analysis of the overlapping *** function analysis mainly involved protein binding,identical protein binding,cytoplasm,nucleus,negative regulation of apoptotic process and response to xenobiotic *** enrichment analysis suggested that the involved signaling pathways mainly included PI3K-AKT signaling pathway,MAPK signaling pathway,IL-17 signaling pathway,TNF signaling pathway,ErbB signaling pathway,*** murine osteosarcoma viral oncogene homolog(FOS)and matrix metallopeptidase 9(MMP9)were selected by differential expression analysis,and they were closely associated with immune *** docking results showed that resveratrol docked well with these two *** treatment arrested the cell cycle at the S phase,induced apoptosis,and weakened viability,migration and invasion in a dose-dependent ***,re

关键词： Resveratrol Gastric cancer Network pharmacology Bioinformatics Molecular docking

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Relationship between Phenotypic Changes of Dendritic Cell Subsets and the Onset of Plateau Phase during Intermittent Interferon Therapy in Patients with CHB

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Biomedical and Environmental Sciences 2024年第3期37卷 303-314页

作者： YANG Liu WANG Shi Yu jiang Ting Ting DENG Wen CHANG Min WU shu Ling CAO Wei hua LU Yao SHEN Ge LIU Ru Yu GAO Yuan Jiao XU Meng Jiao HU Lei ping zhang Lu XIE Yao LI Ming hui Department of Hepatology Division 2 Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China Center for Infectious Diseases Second Affiliated Hospital of Air Force Medical UniversityXi'an 710038ShaanxiChina Department of Hepatology Division 2 Peking University Ditan Teaching HospitalBeijing 100015China

Objective This study aimed to evaluate whether the onset of the plateau phase of slow hepatitis B surface antigen decline in patients with chronic hepatitis B treated with intermittent interferon therapy is related to the frequency of dendritic cell subsets and expression of the costimulatory molecules CD40,CD80,CD83,and *** This was a cross-sectional study in which patients were divided into a natural history group(namely NH group),a long-term oral nucleoside analogs treatment group(namely NA group),and a plateau-arriving group(namely P group).The percentage of plasmacytoid dendritic cell and myeloid dendritic cell subsets in peripheral blood lymphocytes and monocytes and the mean fluorescence intensity of their surface costimulatory molecules were detected using a flow *** In total,143 patients were enrolled(NH group,n=49;NA group,n=47;P group,n=47).The results demonstrated that CD141/CD1c double negative myeloid dendritic cell(DNmDC)/lymphocytes and monocytes(%)in P group(0.041[0.024,0.069])was significantly lower than that in NH group(0.270[0.135,0.407])and NA group(0.273[0.150,0.443]),and CD86 mean fluorescence intensity of DNmDCs in P group(1832.0[1484.0,2793.0])was significantly lower than that in NH group(4316.0[2958.0,5169.0])and NA group(3299.0[2534.0,4371.0]),Adjusted P all<*** Reduced DNmDCs and impaired maturation may be associated with the onset of the plateau phase during intermittent interferon therapy in patients with chronic hepatitis B.

关键词： CHB Dendritic Cells Intermittent Interferon Therapy Plateau Phase

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