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Integrated multi-omics analysis reveals liver metabolic reprogramming by fish iridovirus and antiviral function of alpha-linolenic acid

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Zoological Research 2024年第3期45卷 520-534页

作者： Lin Liu Ya zhang Meng-Di Yuan Dong-Miao xiao wei-Hua Xu Qi Zheng Qi-wei Qin You-Hua Huang xiao-Hong Huang College of Marine Sciences South China Agricultural UniversityGuangdong Laboratory for Lingnan Modern AgricultureGuangzhouGuangdong 510642China Nansha-South China Agricultural University Fishery Research Institute GuangzhouGuangdong 511464China Southern Marine Science and Engineering Guangdong Laboratory ZhuhaiGuangdong 519082China

Iridovirus poses a substantial threat to global aquaculture due to its high mortality rate;however,the molecular mechanisms underpinning its pathogenesis are not well ***,a multi-omics approach was applied to groupers infected with Singapore grouper iridovirus(SGIV),focusing on the roles of key *** showed that SGIV induced obvious histopathological damage and changes in metabolic enzymes within the ***,SGIV significantly reduced the contents of lipid droplets,triglycerides,cholesterol,and *** analysis indicated that the altered metabolites were enriched in 19 pathways,with a notable down-regulation of lipid metabolites such as glycerophosphates and alpha-linolenic acid(ALA),consistent with disturbed lipid homeostasis in the *** of transcriptomic and metabolomic data revealed that the top enriched pathways were related to cell growth and death and nucleotide,carbohydrate,amino acid,and lipid metabolism,supporting the conclusion that SGIV infection induced liver metabolic *** integrative transcriptomic and proteomic analysis indicated that SGIV infection activated crucial molecular events in a phagosome-immune depression-metabolism dysregulation-necrosis signaling *** note,integrative multi-omics analysis demonstrated the consumption of ALA and linoleic acid(LA)metabolites,and the accumulation of L-glutamic acid(GA),accompanied by alterations in immune,inflammation,and cell death-related *** experimental data showed that ALA,but not GA,suppressed SGIV replication by activating antioxidant and anti-inflammatory responses in the ***,these findings provide a comprehensive resource for understanding host response dynamics during fish iridovirus infection and highlight the antiviral potential of ALA in the prevention and treatment of iridoviral diseases.

关键词： Iridovirus Liver damage Metabolic reprogramming SGIV Alpha-linolenic acid Antiinflammatory

Synergistically enhanced dielectric, insulating and thermally conductive performances of sandwich PMMA based dielectric films

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Progress in Natural Science:Materials International 2024年第3期34卷 591-597页

作者： Dongmei zhang Yufan Li Yuchao Li Zhonggui Sun Hanxue Zhu Lujia Yang Yanhu zhan Yankai Li Shi Wang Jun-wei Zha School of Mathematical Sciences Liaocheng University School of Materials Science and Engineering Liaocheng University State Key Laboratory of Organic Electronics and Information Displays & Institute of Advanced Materials (IAM) Nanjing University of Posts & Telecommunications School of Chemistry and Biological Engineering University of Science and Technology Beijing

A tri-layered(B-G-B) dielectric films were simply prepared by alternatively spin-coating boron nitride/polymethylmethacrylate(BN/PMMA, B) and graphene nanosheets(GNS/PMMA, G) compound solutions. The structure, morphology, thermal conductivity, and particularly the dielectric and relaxation behaviors were systematically studied. Results showed that a good exfoliation and dispersion of BN and GNS can be simply achieved through intensive mechanical compounding with PMMA in the internal mixer. The dielectric constant and breakdown strength of the obtained 1-3-1(B-G-B) sandwich composite film reached 4.3(@1 kHz) and 458.6kV/mm, being 119 % and 113 % higher than that of pure PMMA, respectively. Furthermore, the overall thermal conductivity of sandwich 1-3-1 composite increased by 112 % due to the addition of thermally conductive BN and GNS. The sandwich design strategy provided an effective way of achieving good permittivity, high insulation, and improved thermal conductivity simultaneously, showing potential applications in the miniaturization and integration of electronic devices.

关键词： Breakdown strength Composites Dielectric constant Sandwich structure Thermal conductivity

Single Particle Colorimetric Acid Phosphatase Activity Assay with CeO_(2)-modified Gold Nanoparticles

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Chemical Research in Chinese Universities 2024年第2期40卷 320-325页

作者： ZHU Tang Jiayao YUAN Xiang MAO Guojiang wei Lin xiao Lehui Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research National and Local Joint Engineering Laboratory for New Petrochemical Materials and Fine Utilization of ResourcesCollege of Chemistry and Chemical EngineeringHunan Normal UniversityChangsha410081P.R.China Henan Key Laboratory of Organic Functional Molecule and Drug Innovation Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine ChemicalsKey Laboratory of Green Chemical Media and ReactionsMinistry of EducationSchool of Chemistry and Chemical EngineeringHenan Normal UniversityXinxiang453007P.R.China College of Chemistry and Chemical Engineering Central South UniversityChangsha410083P.R.China

Acid phosphatase(ACP)is a ubiquitous phosphatase in living *** abnormal variation of ACP is related to various ***,we propose a colorimetric method based on CeO_(2)-modified gold core shell nanoparticles(Au@CeO_(2)NPs)to analyze ACP activity with high sensitivity and *** this design,2-phospho-L-ascorbic acid trisodium salt(AAP)is dephosphorylated by ACP and produces reductive ascorbic acid(AA),which makes the CeO_(2)shell decomposition.A remarkable blue shift of localized surface plasmon resonance peak(LSPR,from yellow to green)along with the scattering intensity ratio changes from individual Au@CeO_(2)NPs are *** activity can be quantified by calculating the ratio changes of individual Au@CeO_(2)*** assay reveals limit of detection(LOD)of 0.044 mU/mL and the linear range of 0.05–5.0 mU/mL,which are much lower than most of spectroscopic measurements in bulk ***,the recovery measurements in real samples are satisfactory and the capacity for practical application is *** a consequence,Au@CeO_(2)NPs used in this assay will find new applications for the ultrasensitive detection of enzyme activity.

关键词： Single particle imaging Dark field Gold nanoparticle Enzyme activity Colorimetric detection

Evaluating effectiveness and safety of combined percutaneous transhepatic gallbladder drainage and laparoscopic cholecystectomy in acute cholecystitis patients:Meta-analysis

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World Journal of Gastrointestinal Surgery 2024年第5期16卷 1407-1419页

作者： Yu Li wei-Ke xiao xiao-Jun Li Hui-Yuan Dong Department of General Surgery No.942 Hospital of PLAYinchuan 750004Ningxia Hui Autonomous RegionChina

BACKGROUND Acute cholecystitis(AC)is a common disease in general *** cholecystectomy(LC)is widely recognized as the"gold standard"surgical procedure for treating *** low-risk patients without complications,LC is the recommended treatment plan,but there is still controversy regarding the treatment strategy for moderate AC patients,which relies more on the surgeon's experience and the medical platform of the visiting *** transhepatic gallbladder puncture drainage(PTGBD)can effectively alleviate gallbladder inflammation,reduce gallbladder wall edema and adhesion around the gallbladder,and create a"time window"for elective *** To compare the clinical efficacy and safety of LC or PTGBD combined with LC for treating AC patients,providing a theoretical basis for choosing reasonable surgical methods for AC *** In this study,we conducted a clinical investigation regarding the combined use of PTGBD tubes for the treatment of gastric cancer patients with *** performed searches in the following databases:PubMed,Web of Science,EMBASE,Cochrane Library,China National Knowledge Infrastructure,and Wanfang *** search encompassed literature published from the inception of these databases to the ***,relevant data were extracted,and a meta-analysis was conducted using RevMan 5.3 *** A comprehensive analysis was conducted,encompassing 24 studies involving a total of 2564 *** patients were categorized into two groups:1371 in the LC group and 1193 in the PTGBD+LC *** outcomes of the meta-analysis revealed noteworthy disparities between the PTGBD+LC group and the LC group in multiple dimensions:(1)Operative time:Mean difference(MD)=17.51,95%CI:9.53-25.49,P<0.01;(2)Conversion to open surgery rate:Odds ratio(OR)=2.95,95%CI:1.90-4.58,P<0.01;(3)Intraoperative bleeding loss:MD=32.27,95%CI:23.03-41.50,P<0.01;(4)Postoperative hospital stay:MD=1.44,95%CI:0.14-2.73,P=0.03;(5)Overall posto

关键词： Acute cholecystitis Laparoscopic cholecystectomy Percutaneous transhepatic gallbladder drainage Metaanalysis Efficacy

Design and application of copper/lithium composite anodes for advanced lithium metal batteries

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Rare Metals 2024年第3期43卷 942-970页

作者： Bin zhang Ji-Ping Ma Yang Zhao Tong Li Jin-Lin Yang zhan-Ling zhang Shi-Zhong wei Guang-Min Zhou School of Materials Science and Engineering Henan University of Science and TechnologyLuoyang 471003China Shenzhen Geim Graphene Center Tsinghua Shenzhen International Graduate SchoolTsinghua UniversityShenzhen 518055China School of Physical and Mathematical Sciences Nanyang Technological UniversitySingapore 637371Singapore Shenzhen Geim Graphene Center Tsinghua-Berkeley Shenzhen InstituteTsinghua Shenzhen International Graduate SchoolTsinghua UniversityShenzhen 518055China

Lithium(Li)is a promising candidate for nextgeneration battery anode due to its high theoretical specific capacity and low reduction ***,safety issues derived from the uncontrolled growth of Li dendrite and huge volume change of Li hinder its practical application.C onstructing dendrite-free composite Li anodes can significantly alleviate the above ***(Cu)-based materials have bee n widely used as substrates of the composite electrodes due to their chemical stability,excellent conductivity,and good mechanical ***/lithium(Cu/Li)composite anodes significantly regulate the local current density and decrease Li nucleation overp otential,realizing the uniform and dendrite-free Li *** this review,Cu/Li composite methods including electrodeposition,melting infusion,and mechanical rolling are systematically summarized and ***,design strategies of Cu-based current collectors for high performance Cu/Li composite anodes are *** challenges and future development for Cu/Li composite anodes are presented and *** hope that this review can provide a comprehensive understanding of Cu/Li composite methods of the latest development of Li metal anode and stimulate more research in the future.

关键词： Lithium metal batteries Cu/Li composite anode Electrodeposition Thermal melting infusion Mechanical rolling

Conservation genomics of the critically endangered Chinese pangolin

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Science China(Life Sciences) 2024年第10期67卷 2051-2061页

作者： Shichao wei Huizhong Fan Wenliang Zhou Guangping Huang Yan Hua Shibao Wu xiao wei Yiting Chen Xinyue Tan Fuwen wei Jiangxi Province Key Laboratory of Conservation Biology College of ForestryJiangxi Agricultural UniversityNanchang 330045China Center for Evolution and Conservation Biology Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou)Guangzhou 511458China Institute of Zoology Chinese Academy of SciencesBeijing 100101China Guangdong Provincial Key Laboratory of Silviculture Protection and UtilizationGuangdong Academy of ForestryGuangzhou 510520China School of Life Science South China Normal UniversityGuangzhou 510631China Terrestrial Wildlife Rescue and Epidemic Diseases Surveillance Center of Guangxi Nanning 530003China

The Chinese pangolin(Manis pentadactyla,MP)has been extensively exploited and is now on the brink of extinction,but its population structure,evolutionary history,and adaptive potential are ***,we analyzed 94 genomes from three subspecies of the Chinese pangolin and identified three distinct genetic clusters(MPA,MPB,and MPC),with MPB further divided into MPB1 and MPB2 *** divergence of these populations was driven by past climate *** MPB2 and MPC,recent human activities have caused dramatic population decline and small population size as well as increased inbreeding,but not decrease in genomic variation and increase in genetic load probably due to strong gene flow;therefore,it is crucial to strengthen in situ habitat management for these two *** contrast,although human activities have a milder impact on MPA,it is at high risk of extinction due to long-term contraction and isolation,and genetic rescue is urgently ***1 exhibited a relatively healthy population status and can potentially serve as a source ***,our findings provide novel insights into the conservation of the Chinese pangolin and biogeography of the mammals of eastern Asia.

关键词： Manis pentadactyla conservation genomics demographic history human activities conservation strategies

Facile SERS screening of melamine in bovine milk with 2D printed AgNPs/glass fabric filter paper as the flexible substrate

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Food Science and Human Wellness 2024年第5期13卷 2595-2600页

作者： Shiyao Wang Yanan Zhao xiao wei Yisheng Chen College of Food Science and Engineering Shanxi Agricultural UniversityTaigu 030801China Food Nutrition and Safety Institute Shanxi Agricultural UniversityTaiyuan 030031China School of Food Science and Technology Jiangnan UniversityWuxi 214122China

Melamine is one of the most frequently detected adulterants in dairy *** current study proposes a surface-enhanced Raman spectroscopy(SERS)-based analytical tool for fast and reliable screening of melamine in bovine milk.A hand-held Raman spectrometer was used in conjunction with a substrate composed of silver nanoparticles(AgNPs)that was 2D printed onto glass fiber(GF)filter *** optimized conditions,a sensitive and fingerprint-like signal at 674 cm^(-1) was *** AgNPs/GF substrate exhibited high sensitivity to melamine in milk down to 1.9498×10^(-5)mg/mL,which is well below the USA and EU safety limits(2.5×10^(-3)mg/mL).Remarkably,the proposed technology was also highly reproducible,showing spot-to-spot and block-to-block variations below 3.3%and 4.9%at 674 cm^(-1) in Raman intensity,*** characteristic peak intensity and concentration of melamine showed an acceptable linear relationship(R^(2)=0.9909)within the range of 0.0001-1 mg/***,the method established in this study can provide an efficient and effective method for the quantitative target screening and detection of melamine in dairy products.

关键词： 2D print Melamine Milk Surface-enhanced Raman spectroscopy(SERS) flexible substrate

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Effect of Y_(2)O_(3) on microstructure and properties of CoCrFeNiTiNb high entropy alloy coating on Ti-6Al-4V surface by laser cladding

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Journal of Rare Earths 2024年第3期42卷 586-599,I0006页

作者： Zhen Li wei Zhao Kedong Yu Ning Guo Guangchun xiao Zhiming Wang Hui zhang College of Mechanical Engineering Qilu University of Technology(Shandong Academy of Sciences)Jinan250353China Shandong Institute of Mechanical Design and Research Jinan250031China

The effects of Y_(2)O_(3) on the microstructure, microhardness, wear resistance, high-temperature oxidation resistance, hot corrosion resistance, and electrochemical corrosion behaviour of CoCrFeNiTiNb high entropy alloy coatings formed on Ti-6Al-4V alloy surfaces were studied. The results show that the addition of Y_(2)O_(3) changes the proportion of the phase but does not change its type. The average grain size is only 1/4.7 of that of the high entropy alloy(HEA) coating, and the fine-grained strengthening leads to increases in the microhardness and wear resistance of 21.8% and 26.9%, respectively. The addition of Y_(2)O_(3) enhances the denseness and bonding properties of the oxide and corrosion product layers, reducing the oxidation and hot corrosion rates by 60.3% and 40.3%, respectively. The addition of Y_(2)O_(3) doubles the corrosion resistance which is attributed to the refinement of the grains, the increased proportion of HCP and TiN, and the weakening of galvanic coupling corrosion.

关键词： Laser cladding High entropy alloy coatings Rare earths Wear properties High temperature properties Electrochemical corrosion

Study of baryon number transport dynamics and strangeness conservation effects using Ω-hadron correlations

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Nuclear Science and Techniques 2024年第7期35卷 147-156页

作者： wei-Jie Dong xiao-Zhou Yu Si-Yuan Ping Xia-Tong Wu Gang Wang Huan-Zhong Huang Zi-wei Lin Key Laboratory of Nuclear Physics and Ion-beam Application(MOE) Fudan UniversityShanghai 200433China Department of Physics and Astronomy University of CaliforniaLos AngelesCA 90095USA Department of Physics East Carolina UniversityGreenvilleNC 27858USA

In nuclear collisions at RHIC energies, an excess of Ω hyperons over ■ is observed, indicating that Ω has a net baryon number despite s and s quarks being produced in pairs. The baryon number in Ω may have been transported from the incident nuclei and/or produced in the baryon-pair production of Ω with other types of anti-hyperons such as Ξ. To investigate these two scenarios, we propose to measure the correlations between Ω and K and between Ω and anti-hyperons. We use two versions, the default and string-melting, of a multiphase transport(AMPT) model to illustrate the method for measuring the correlation and to demonstrate the general shape of the correlation. We present the Ω-hadron correlations from simulated Au+Au collisions at ■ =7.7 and 14.6 Ge V and discuss the dependence on the collision energy and on the hadronization scheme in these two AMPT versions. These correlations can be used to explore the mechanism of baryon number transport and the effects of baryon number and strangeness conservation on nuclear collisions.

关键词： Baryon number transport Strangeness conversation Correlation Gluon junction