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Is there an optimal time to initiate adjuvant chemotherapy to predict benefit of survival in non-small cell lung cancer?

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Chinese Journal of Cancer Research 2017年第3期29卷 263-271页

作者： Yutao Liu xiaoyu zhai Junling Li Zhiwen Li Di Ma Ziping Wang Department of Medical Oncology National Cancer Center/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Institute of Reproductive & Child Health Peking University Ministry of Health Key Laboratory of Reproductive Health Department of Epidemiology and Biostatistics School of Public Health Peking University Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing) Department of Thoracic Medical Oncology Peking University Cancer Hospital &Institute

Objective: Adjuvant chemotherapy (AC) after curative resection is known to improve the survival of patients with non-small cell lung cancer (NSCLC); however, few studies have reported the correlation between the time to initiation of AC (TTAC) and survival in NSCLC patients. Methods: The clinical data of 925 NSCLC patients who received curative resection and post-operative AC at the Cancer Hospital of Chinese Academy of Medical Sciences between 2003 and 2013 were retrospectively analyzed. TTAC was measured from the date of surgery to the initiation of AC. Disease-free survival (DFS) was defined as the duration from surgery to the time of tumor recurrence or last follow-up evaluation. The optimal cut-off value of TTAC was determined by maximally selected log-rank statistics. The DFS curve was estimated using the Kaplan-Meier method, and the Cox proportional hazards regression model was used to identify risk factors independently associated with DFS. Propensity score matching (PSM) was performed for survival analysis using the match data. Results: The optimal discriminating cut-off value of TTAC was set at d 35 after curative resection based on which the patients were assigned into two groups: group A ( 35 d). There was no significant difference in the DFS between the two groups (P=0.246), indicating that the TTAC is not an independent prognostic factor for DFS. A further comparison continued to show no significant difference in the DFS among 258 PSM pairs (P=0.283). Conclusions: There was no significant correlation between the TTAC and DFS in NSCLC patients. Studies with larger samples are needed to further verify this conclusion.

关键词： Non-small cell lung cancer (NSCLC) adjuvant chemotherapy time to adjuvant chemotherapy(TTAC) disease-free survival

Electrical and Optical Properties of Nano Aluminum Film/Particle Structure

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Journal of Wuhan University of Technology(Materials Science) 2017年第5期32卷 989-993页

作者：孟庆云 LI Siqi KANG Yixin zhai xiaoyu WEI Sitao HE Huimei 王云殷子文 Faculty of Science Beijing University of Chemical Technology Beijing 100029 China China Electronics Technology GroupCorporation No. 45 Research Institute CETC Beifing Electronic Equipment Co. Ltd. Beifing 101100 China

The electrical and optical effects of particles on the nano aluminum film deposited by thermal evaporation was investigated. From the characterization results of scanning electron microscope（SEM）, the accumulation in tens of nanometers had been observed. The current-voltage（I-V） curve of the sample indicates its nonlinear electrical characters expecting the corresponding nonlinear optical properties. By the theoretical calculation, nonlinear conduction of the carrier transportation may result from the barrier-well-barrier structure, where negative resistance and Coulomb blockade effect appears. The simulation results are approximately matched with the experimental results. By testing the fluorescence emission spectrum of the sample, peaks were found to be located at 420 and 440 nm. In addition, the full width at half maximum（FWHM） had been obviously broadened by means of adding 2, 5-diphenyloxazole（DPO）. Therefore, discrete energy levels could be estimated inside those particles.

关键词： nonlinear conduction properties fluorescence emission aluminum nano particle

Microstructure and UV Fluorescence of Amorphous I/Au Composite Nanofilms Based on LVDCS Method

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Journal of Wuhan University of Technology(Materials Science) 2019年第6期34卷 1254-1258页

作者： zhai xiaoyu DING Yufeng KANG Yixin LI Siqi PAN Liangliang ZHANG Dapeng HE Huimei JIANG Xinhua WANG Yun MENG Qingyun State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical TechnologyBeijing 100029China School of Microelectronics Tianjin UniversityTianjin 300072China

The amorphous I/Au composite nanofilms were prepared by low vacuum direct current sputtering(LVDCS) method. The optimized preparation technologies contain growth pressure, time, gaseous environment and annealing conditions. The maximum fluorescence emission(λemmax) of I/Au nanofilms was observed at wavelength of 375 nm, and the intensity of fluorescence emission peak of annealed I/Au films was smaller than that of unannealed one due to fewer amorphous Au nanoparticles, caused by annealing treatment. In the UV-Vis absorption spectra, the intensity of UV-Vis absorption peak of annealed I/Au nanofilms is larger than that of the unannealed one. This work also developed a new way to grow I/Au composite fluorescent thin films.

关键词： LVDCS method amorphous I/Au nanofilms fluorescence

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一步溶剂热法制备立方状ITO纳米粉体

稀有金属材料与工程 2019年第7期48卷 2358-2363页

作者：陈玉洁翟晓宇刘家祥北京化工大学材料电化学过程与技术北京市重点实验室

通过一步溶剂热法制备出导电性良好的立方状ITO纳米粉体。研究了不同溶剂、反应温度和反应时间对ITO粉体微观结构和电性能的影响。结果表明,以乙二醇为溶剂,在250℃下反应24h,ITO纳米粉体的电阻率最低为0.2Ω×cm,平均粒径为45.95 nm。... 详细信息

通过一步溶剂热法制备出导电性良好的立方状ITO纳米粉体。研究了不同溶剂、反应温度和反应时间对ITO粉体微观结构和电性能的影响。结果表明,以乙二醇为溶剂,在250℃下反应24h,ITO纳米粉体的电阻率最低为0.2Ω×cm,平均粒径为45.95 nm。随反应时间的延长,通过溶解-再结晶机制,棒状前驱体逐步向立方状In2O3转化。在In2O3晶体形成过程中,乙二醇和四甲基铵根离子吸附在晶体表面,使垂直于(200)晶面的生长速率降低,诱导形成立方状颗粒。

关键词：铟锡氧化物纳米粉体溶剂热法立方状电阻率

化学凝并增强湿式电除尘器捕集燃煤粉尘的研究

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中国电机工程学报 2023年第2期43卷 651-658页

作者：翟晓宇肖立春韩莹莹燕山大学环境与化学工程学院河北省秦皇岛市066004

湿式电除尘器(wet electrostatic precipitator,WESP)对细颗粒物PM2.5的捕集效率高于传统干式电除尘器。为实现烟尘趋零排放,在WESP中加入化学凝并剂,研究化学凝并剂的种类、浓度、加入点位等对燃煤粉尘凝并效果及除尘效率的影响。结果... 详细信息

湿式电除尘器(wet electrostatic precipitator,WESP)对细颗粒物PM2.5的捕集效率高于传统干式电除尘器。为实现烟尘趋零排放,在WESP中加入化学凝并剂,研究化学凝并剂的种类、浓度、加入点位等对燃煤粉尘凝并效果及除尘效率的影响。结果表明:添加化学凝并剂能够促进燃煤粉尘颗粒的凝并,添加果胶(pectin,PG)后,粉尘颗粒的中位径由28.19μm增加到45.28μm;在PG浓度为1.0×10^(-2)g/L时凝并效果最好,除尘效率达到96.42%;聚丙烯酰胺(polyacrylamide,PAM)的电晕放电性能最好,PAM与水蒸气协同作用能提高凝并效果,1.0×10^(-2)g/L的PAM与3.2kg/h的水蒸气协同作用时除尘效率达到96.68%。加入化学凝并剂后,可促进细颗粒粉尘的凝并,增强WESP对于细颗粒物的捕集效果。

关键词：湿式电除尘器细颗粒物化学凝并除尘效率

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调和γ-正规映射和调和γ-正规型映射

河北大学学报（自然科学版） 2020年第2期40卷 119-124页

作者：乔金静翟小雨河北大学数学与信息科学学院河北保定071002

作为调和γ-Bloch映射和调和γ-Bloch型映射的推广,研究了调和γ-正规映射和调和γ-正规型映射,讨论了这2类调和映射的如下性质:仿射不变性、线性不变性、包含关系、与局部一致单叶调和映射的关系以及从属原则.

关键词：调和γ-正规映射调和γ-正规型映射仿射和线形不变性局部一致单叶从属

可提取物和浸出物定性定量分析方法的发展近况

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中国医药工业杂志 2020年第4期51卷 461-466页

作者：翟小语张毅兰中国医药工业研究总院上海医药工业研究院国家食品药品监督管理总局药品包装材料科研检验中心上海201203

药品包装材料可提取物和浸出物研究是相容性研究的重要组成部分。可提取物和浸出物是一种包含痕量挥发物、半挥发物、不挥发性物及痕量元素杂质的复杂样品,必须使用正交、专属、灵敏的分析方法进行全面分析。本文系统介绍了可提取物和... 详细信息

药品包装材料可提取物和浸出物研究是相容性研究的重要组成部分。可提取物和浸出物是一种包含痕量挥发物、半挥发物、不挥发性物及痕量元素杂质的复杂样品,必须使用正交、专属、灵敏的分析方法进行全面分析。本文系统介绍了可提取物和浸出物的来源、色谱质谱联用技术在分析可提取物和浸出物中的应用,以及未知物的鉴定策略。

关键词：可提取物和浸出物色谱质谱联用技术高分辨质谱未知物分析综述

不同pH值环境下β-乳球蛋白与咖啡中3种主要多酚之间的相互作用

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食品科学 2024年第19期45卷 26-40页

作者：翟晓宇董文江于鑫欣胡荣锁华中农业大学食品科学技术学院湖北武汉430070 中国热带农业科学院香料饮料研究所海南万宁571533 海南省特色热带作物加工适宜性与品质控制重点实验室海南万宁571533 国家重要热带作物工程技术研究中心海南海口570000

利用多光谱学和分子对接技术,探究在不同pH值条件下,咖啡中的3种主要多酚(绿原酸、咖啡酸和阿魏酸)与牛乳中β-乳球蛋白间的非共价相互作用及对蛋白结构的影响。结果表明,在两种pH值环境下,3种咖啡多酚均通过静态猝灭有效地猝灭β-乳球... 详细信息

利用多光谱学和分子对接技术,探究在不同pH值条件下,咖啡中的3种主要多酚(绿原酸、咖啡酸和阿魏酸)与牛乳中β-乳球蛋白间的非共价相互作用及对蛋白结构的影响。结果表明,在两种pH值环境下,3种咖啡多酚均通过静态猝灭有效地猝灭β-乳球蛋白的荧光,在pH 7.4、温度298 K时,绿原酸、咖啡酸和阿魏酸对β-乳球蛋白的猝灭常数(K_(sv))分别为6.53×10^(4)、3.16×10^(4)L/mol及3.09×10^(4)L/mol,结合位点数分别为1.20、1.02和1.14,能量转移效率分别为34.55%、24.56%和21.35%;pH 3.0、温度298 K时,K_(sv)分别为7.18×10^(4)、5.24×10^(4)L/mol及7.12×10^(4)L/mol,结合位点数为1.28、1.18和1.25,能量转移效率分别提高至34.70%、30.42%和29.65%。在pH 7.4时,β-乳球蛋白α-螺旋含量降低,β-折叠含量增加;pH 3.0时,β-折叠含量增加,无规卷曲含量降低。分子对接结果表明,3种多酚主要通过氢键和范德华力以及疏水相互作用结合在β-乳球蛋白的疏水口袋。本研究初步揭示不同pH值条件下咖啡乳饮料中β-乳球蛋白和绿原酸、咖啡酸及阿魏酸间的相互作用机制。

关键词：多酚 β-乳球蛋白非共价相互作用多光谱技术分子对接

“互联网+传统文化教育”与线下教育相结合改进策略探析

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家电维修 2023年第11期 24-27,64页

作者：翟小语青岛恒星科技学院山东省青岛市266000

坚定文化自信,是事关民族荣辱兴衰之大事。实现中华民族伟大复兴中国梦,离不开对中华优秀传统文化的创新性继承,高校是普及中华文化的重要媒介,基于疫情期间“互联网+教育”的模式引发的相关思考及后疫情时代“互联网+”的相关教学研究... 详细信息

坚定文化自信,是事关民族荣辱兴衰之大事。实现中华民族伟大复兴中国梦,离不开对中华优秀传统文化的创新性继承,高校是普及中华文化的重要媒介,基于疫情期间“互联网+教育”的模式引发的相关思考及后疫情时代“互联网+”的相关教学研究成果层出不穷,本文立足于党的二十大后齐鲁地域传统文化的传播与教育、弘扬中华优秀传统文化的社会背景,以“互联网+传统文化教育”为研究主题,并针对民办型高校的相关特点,探析“互联网+传统文化教育”与线下教育相结合的有关改进策略,提出“3+2”教学范式,从而完成对民办高校文化自信自强路径实现等相关问题的改善与探讨。

关键词：互联网+传统文化教育线下教育 “3+2”教学范式改进策略