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long-Term Application of Organic Manure and Mineral Fertilizer on N_2O and CO_2 Emissions in a Red Soil from Cultivated Maize-Wheat Rotation in China

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Agricultural Sciences in China 2011年第11期10卷 1748-1757页

作者： zhai li-mei l1u hong-bin zhang ji-zong huang jing wang bo-ren Key laboratory of Nonpoint Pollution Control Ministry of Agriculture~Institute of Agricultural Resources and Regional Planning ChineseAcademy of Agricultural Sciences Beijing 100081 P.R.China

A long-term field experiment was established to determine the influence of mineral fertilizer and organic manure on soil fertility. A tract of red soil （Ferralic Cambisol） in Qiyang Red Soil Experimental Station （Qiyang County, Hunan Province, China） was fertilized beginning in 1990 and N20 and CO2 were examined during the maize and wheat growth season of 2007-2008. The study involved five treatments： organic manure （NPKM）, fertilizer NPK （NPK）, fertilizer NP （NP）, fertilizer NK （NK）, and control （CK）. Manured soils had higher crop biomass, organic C, and pH than soils receiving the various mineralized fertilizers indicating that long-term application of manures could efficiently prevent red soil acidification and increase crop productivity. The application of manures and fertilizers at a rate of 300 kg N ha-1 yr-1 obviously increased NzO and CO2 emissions from 0.58 kg N20-N ha-~ yr-~ and 10565 kg C ha-~ yr-~ in the CK treatment soil to 3.0l kg N20-N ha-~ yr-~ and 28 663 kg C ha-~ yr-I in the NPKM treatment. There were also obvious different effects on N20 and CO2 emissions between applying fertilizer and manure. More N20 and CO2 released during the 184-d maize growing season than the 125- d wheat growth season in the manure fertilized soils but not in mineral fertilizer treatments. N20 emission was significantly affected by soil moisture only during the wheat growing season, and CO2 emission was affected by soil temperature only in CK and NP treatment during the wheat and maize growing season. In sum, this study indicates the application of organic manure may be a preferred strategy for maintaining red emissions than treatments only with mineral fertilizer. soil productivity, but may result in greater N20 and CO2

关键词： red soil N fertilizer organic manure temperature WFPS

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Overproduction of OsRACK1A,an effector-targeted scaffold protein promoting OsRboHB-mediated ROS production,confers rice floral resistance to false smut disease without yield penalty

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Molecular Plant 2022年第11期15卷 1790-1806页

作者： Guo-Bang li jia-Xue He jin-long Wu He wang Xin zhang jie liu Xiao-hong Hu Yong Zhu Shuai Shen Yi-Fei Bai zong-lin Yao Xin-Xian liu jing-Hao Zhao De-Qiang li Yan li Fu huang Yan-Yan huang Zhi-Xue Zhao ji-Wei zhang Shi-Xin Zhou Yun-Peng ji mei Pu Peng Qin Shigui li Xuewei Chen jing wang Min He Weitao li Xian-Jun Wu Zheng-Jun Xu Wen-Ming wang jing Fan State Key laboratory of Crop Gene Exploration and utilization in Southwest China Sichuan Agricultural UniversityChengdu 611130China Rice Research Institute Sichuan Agricultural UniversityChengdu 611130China

Grain formation is fundamental for crop yield but is vulnerable to abiotic and biotic *** grain production is threatened by the false smut fungus ustilaginoidea virens,which specifically infects rice floral organs,disrupting fertilization and seed ***,little is known about the molecular mechanisms of the ***-rice interaction and the genetic basis of floral ***,we report that *** secretes a cytoplasmic effector,uvCBP1,to facilitate infection of rice ***,uvCBP1 interacts with the rice scaffold protein OsRACK1A and competes its interaction with the reduced nicotinamide adenine dinucleotide phosphate oxidase OsRboHB,leading to inhibition of reactive oxygen species(ROS)*** the analysis of natural variation revealed no OsRACK1A variants that could avoid being targeted by uvCBP1,expression levels of OsRACK1A are correlated with field resistance against *** in rice *** of OsRACK1A restores the OsRACK1A-OsRboHB association and promotes OsRboHB phosphorylation to enhance ROS production,conferring rice floral resistance to *** without yield *** together,our findings reveal a new pathogenic mechanism mediated by an essential effector from a flower-specific pathogen and provide a valuable genetic resource for balancing disease resistance and crop yield.

关键词： rice flower false smut fungal effector scaffold protein reactive oxygen species disease resistance

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Solar X-ray and EuV imager on board the FY-3E satellite

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light(Science & Applications) 2022年第12期11卷 2939-2951页

作者： bo Chen Xiao-Xin zhang ling-Ping He Ke-Fei Song Shi-jie liu Guang-Xing Ding jin-Ping Dun jia-Wei li Zhao-Hui li Quan-Feng Guo Hai-Feng wang Xiao-Dong wang Yun-Qi wang hong-ji zhang Guang zhang Zhen-Wei Han Shuang Dai Pei-jie zhang liang Sun Yang liu software engineer Peng wang Kun Wu Chen Tao Shi-lei Mao Gui mei liang Yang li-Heng Chen Chun-Yang Han bin huang Yang liu mechanical engineer Shuai ren Peng Zhou Ze-XiWei Xiao-Xue zhang Yue zhang Xin Zheng Yang wang Ya Chen jing-jiang Xie Fei He Qiao Song Wei-Guo zong Xiu-Qing Hu Peng zhang jing-Song wang Zhong-Dong Yang Changchun Institute of Optics Fine Mechanics and PhysicsChinese Academy of SciencesChangchunChina State Key laboratory of Applied Optics Chinese Academy of SciencesChangchunChina National Satellite Meteorological Center China Meteorological AdministrationBeijingChina Key laboratory of Space Weather National Center for Space WeatherChina Meteorological AdministrationBeijingChina Innovation Center for Fengyun Meteorological Satellite(FYSIC) BeijingChina Key laboratory of Earth and Planetary Physics Institute of Geology and GeophysicsChinese Academy of SciencesBeijingChina

The solar X-ray and Extreme ultraviolet Imager(X-EuVI),developed by the Changchun Institute of Optics,Fine Mechanics and Physics,Chinese Academy of Sciences(CIOMP),is the first space-based solar X-ray and Extreme ultraviolet(EuV)imager of China loaded on the Fengyun-3E(FY-3E)satellite supported by the China Meteorological Administration(CMA)for solar *** started work on July 11,2021,X-EuVI has obtained many solar *** instrument employs an innovative dual-band design to monitor a much larger temperature range on the Sun,which covers 0.6-8.0 nm in the X-ray region with six channels and 19.5 nm in the EuV region.X-EuVI has a field of view of 42′,an angular resolution of 2.5″per pixel in the EuV band and an angular resolution of 4.1″per pixel in the X-ray *** instrument also includes an X-ray and EuV irradiance sensor(X-EuVS)with the same bands as its imaging optics,which measures the solar irradiance and regularly calibrates the solar *** radiometric calibration of X-EuVS on the ground has been completed,with a calibration accuracy of 12%.X-EuVI is loaded on the FY-3E satellite and rotates relative to the Sun at a uniform ***-field calibration is conducted by utilizing successive rotation solar *** agreement between preliminarily processed X-EuVI images and SDO/AIA and Hinode/XRT images indicates that X-EuVI and the data processing algorithm operate properly and that the data from X-EuVI can be applied to the space weather forecast system of CMA and scientific investigations on solar activity.

关键词： image instrument Solar

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医疗机构静脉用细胞毒性药物调配质量管理工作规范

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中国药学杂志 2020年第1期55卷 77-80页

作者：余波翟青张艳华朱珠李国辉黄红兵董梅黄萍金岚徐嵘李湘平徐珽王增刘茂柏马珂夏宏武新安程宗琦张晶晶王宇张洁桂玲腾亮冯婉玉刘向红张健孙艳陈迹包健安姜玲复旦大学附属肿瘤医院复旦大学上海医学院肿瘤学系北京大学肿瘤医院北京协和医院中国医学科学院肿瘤医院中山大学附属肿瘤医院哈尔滨医科大学附属肿瘤医院浙江省肿瘤医院上海交通大学医学院附属新华医院上海市第六人民医院中南大学湘雅医院四川大学华西医院福建医科大学附属协和医院浙江大学医学院附属邵逸夫医院安徽省立医院兰州大学第一医院苏州大学附属第一医院天津医科大学肿瘤医院华中科技大学同济医学院附属同济医院新疆医科大学第一附属医院北京大学人民医院山东大学齐鲁医院中国人民解放军总医院

为规范临床静脉用细胞毒性药物调配,促进静脉用细胞毒性药物的合理使用,保障患者静脉用药安全,降低职业暴露,根据《中华人民共和国药品管理法》《医疗机构药事管理规定》《处方管理办法》和《静脉用药集中调配质量管理规范》,参考国际... 详细信息

为规范临床静脉用细胞毒性药物调配,促进静脉用细胞毒性药物的合理使用,保障患者静脉用药安全,降低职业暴露,根据《中华人民共和国药品管理法》《医疗机构药事管理规定》《处方管理办法》和《静脉用药集中调配质量管理规范》,参考国际肿瘤药师学会(ISOPP)、ASHP(美国医疗系统药师协会)、美国国立职业安全与健康机构(NIOSH)、美国药典797&800章节等国际权威指南起草,经专家讨论与德尔菲法制定本标准。《静脉用药集中调配质量管理规范》中关于细胞毒性药物调配工作未尽细节,参照本标准。

关键词：细胞毒药物调配工作规范

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CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai Yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-Jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng binglin Denis bodrov Anton bogomyagkov Serge bondarenko Stewart boogert Maarten boonekamp Marcello borri Angelo bosotti Vincent boudry Mohammed boukidi Igor boyko Ivanka bozovic Giuseppe bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai Huacheng Cai lorenzo Calibbi Junsong Cang Guofu Cao jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen Hua-Xing Chen Huirun Chen jinhui Chen ji-Yuan Chen Kai Chen Mali Chen Mingjun Chen Mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-long Chen Shaomin Chen Shiqiang Chen Tianlu Chen Wei Chen Xiang Chen Xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng Shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi ling-Yun Dai Xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis Christophe De la Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong jianin AGH university of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui university HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu university Institute of ScienceVaranasi Bandirma Onyedi Eylul university Bandirma Beihang university Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi lTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal university Beijing Brown university ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad university Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo university Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China Normal university WuhanHubei Central South university ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan China academy of engineering physics MianyangSichuan China building materials academy Beijing China Center of Advanced Science and Technology Beijing China Institute of Atomic Energy Beijing China jiliang university HangzhouZhejiang China Nuclear Instrument CO. LTDBeijing China university of Geosciences Beijing China university of Geosciences WuhanHubei China university of Mining and Technology XuzhouJiangsu China West Normal university NanchongSichuan Chongqing university Department of PhysicsChongqing Chulalongkorn university Bangkok City university of hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell university IthacaNY CPPM(AMu/IPhu&CNRS/INP) Marseille Dalian Minzu university DalianLiaoning Dalian university of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DlNP jiNR) Dubna East China university Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV linac,a 1.1 GeV Damping Ring,a booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The linac and Damping Ring are situated on the surface,while the subterranean booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the Hl-lHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise

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Feasibility and physics potential of detecting ^(8)B solar neutrinos at JuNO

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Chinese Physics C 2021年第2期45卷 93-110页

作者： Angel Abusleme Thomas Adam Shakeel Ahmad Sebastiano Aiello Muhammad Akram Nawab Ali Fengpeng An Guangpeng An Qi An Giuseppe Andronico Nikolay Anfimov Vito Antonelli Tatiana Antoshkina Burin Asavapibhop João Pedro Athayde Marcondes de André Didier Auguste Andrej Babic Wander Baldini Andrea Barresi Eric Baussan Marco Bellato Antonio Bergnoli Enrico Bernieri David Biare Thilo Birkenfeld Sylvie Blin David Blum Simon Blyth Anastasia bolshakova Mathieu bongrand Clément bordereau Dominique Breton Augusto Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano Max Buesken Mario Buscemi Jose Busto Ilya Butorov Anatael Cabrera Hao Cai Xiao Cai Yanke Cai Zhiyan Cai Antonio Cammi Agustin Campeny Chuanya Cao Guofu Cao Jun Cao Rossella Caruso Cédric Cerna jinfan Chang Yun Chang Pingping Chen Po-An Chen Shaomin Chen Shenjian Chen Xurong Chen Yi-Wen Chen Yixue Chen Yu Chen zhang Chen jie Cheng Yaping Cheng Alexander Chepurnov Davide Chiesa Pietro Chimenti Artem Chukanov Anna Chuvashova Gérard Claverie Catia Clementi Barbara Clerbaux Selma Conforti Di lorenzo Daniele Corti Salvatore Costa Flavio Dal Corso Christophe De la Taille jiawei Deng Zhi Deng Ziyan Deng Wilfried Depnering Marco Diaz Xuefeng Ding Yayun Ding Bayu Dirgantara Sergey Dmitrievsky Tadeas Dohnal Georgy Donchenko jianmeng Dong Damien Dornic Evgeny Doroshkevich Marcos Dracos Frédéric Druillole Shuxian Du Stefano Dusini Martin Dvorak Timo Enqvist Heike Enzmann Andrea Fabbri lukas Fajt Donghua Fan lei Fan Can Fang jian Fang Marco Fargetta Anna Fatkina Dmitry Fedoseev Vladko Fekete li-Cheng Feng Qichun Feng Richard Ford Andrey Formozov Amélie Fournier Haonan Gan Feng Gao Alberto Garfagnini Alexandre Göttel Christoph Genster Marco Giammarchi Agnese Giaz Nunzio Giudice Franco Giuliani Maxim Gonchar Guanghua Gong Hui Gong Oleg Gorchakov Yuri Gornushkin Marco Grassi Christian Grewing Maxim Gromov Vasily Gromov Minghao Gu Xiaofei Gu Yu Gu Mengyun Guan Nunzio Guardone Maria Gul Cong Guo jingyuan Guo Wanlei Guo Xinheng Guo Yuhang Guo Paul Hackspacher Caren Hagner Ran Han Yan Yerevan Physics Institute YerevanArmenia universitélibre de Bruxelles BrusselsBelgium universidade Estadual de londrina LondrinaBrazil Pontificia universidade Catolica do Rio de Janeiro RioBrazil Pontificia universidad Católica de Chile SantiagoChile universidad Tecnica Federico Santa Maria ValparaisoChile Beijing Institute of Spacecraft Environment Engineering BeijingChina Beijing Normal university BeijingChina China Institute of Atomic Energy BeijingChina Institute of High Energy Physics BeijingChina North China Electric Power university BeijingChina School of Physics Peking UniversityBeijingChina Tsinghua university BeijingChina university of Chinese Academy of Sciences BeijingChina jilin university ChangchunChina College of Electronic Science and Engineering National University of Defense TechnologyChangshaChina Chongqing university ChongqingChina Dongguan university of Technology DongguanChina jinan university GuangzhouChina Sun Yat-Sen university GuangzhouChina Harbin Institute of Technology HarbinChina university of Science and Technology of China HefeiChina The Radiochemistry and Nuclear Chemistry Group in university of South China HengyangChina Wuyi university JiangmenChina Shandong university JinanChina Institute of Modern Physics Chinese Academy of SciencesLanzhouChina Nanjing university NanjingChina Guangxi university NanningChina East China university of Science and Technology ShanghaiChina School of Physics and Astronomy Shanghai Jiao Tong UniversityShanghaiChina Tsung-Dao lee Institute Shanghai Jiao Tong UniversityShanghaiChina Institute of Hydrogeology and Environmental Geology Chinese Academy of Geological SciencesShijiazhuangChina Nankai university TianjinChina Wuhan university WuhanChina Xi’an jiaotong university Xi’anChina Xiamen university XiamenChina School of Physics and Microelectronics Zhengzhou UniversityZhengzhouChina Institute of Physics National Chiao-Tung university Hsinchu National united university Miao-Li Department of Physics National T

The jiangmen underground Neutrino Observatory(JuNO)features a 20 kt multi-purpose underground liquid scintillator sphere as its main *** of JuNO's features make it an excellent location for^8B solar neutrino measurements,such as its low-energy threshold,high energy resolution compared with water Cherenkov detectors,and much larger target mass compared with previous liquid scintillator *** this paper,we present a comprehensive assessment of JuNO's potential for detecting^8B solar neutrinos via the neutrino-electron elastic scattering process.A reduced 2 MeV threshold for the recoil electron energy is found to be achievable,assuming that the intrinsic radioactive background^(238)u and^(232)Th in the liquid scintillator can be controlled to 10^(-17)g/*** ten years of data acquisition,approximately 60,000 signal and 30,000 background events are *** large sample will enable an examination of the distortion of the recoil electron spectrum that is dominated by the neutrino flavor transformation in the dense solar matter,which will shed new light on the inconsistency between the measured electron spectra and the predictions of the standard three-flavor neutrino oscillation *** m^(2)_(21)=4.8times10^(-5);(7.5times10^(-5))eV^(2),JuNO can provide evidence of neutrino oscillation in the Earth at approximately the 3sigma(2sigma)level by measuring the non-zero signal rate variation with respect to the solar zenith ***,JuNO can simultaneously measureDelta m^2_(21)using^8B solar neutrinos to a precision of 20% or better,depending on the central value,and to sub-percent precision using reactor antineutrinos.A comparison of these two measurements from the same detector will help understand the current mild inconsistency between the value of Delta m^2_(21)reported by solar neutrino experiments and the KamlAND experiment.

关键词： neutrino oscillation solar neutrino JuNO

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中国高致病性禽流感A／H5N1病毒感染患者的临床与预后

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中华结核和呼吸杂志 2009年第5期32卷 335-341页

作者：李佳徐钰陈余清葛阳章隆辉徐晓玲吴同生陈愉生王静刘建南魏立平邱晨钟小宁黄美杏辛建保罗如平赵明顺李再清胡成平赵伟王虹张伟郭路生王秋月周龙女梁宗安马俊清刘跃建蒋远明谢万升盛吉芳高占成北京大学人民医院呼吸和危重症医学科 100044 北京大学人民医院急诊科 100044 安徽省蚌埠市第一人民医院安徽省阜阳市第二人民医院安徽省黄山市人民医院安徽省立医院安徽省铜陵市人民医院福建省立医院福建省三明市第一医院福建省漳州市医院广州医科大学第三附属医院深圳市人民医院广西医科大学第一附属医院广西壮族自治区中医学院附属瑞康医院华中科技大学同济医学院附属协和医院湖南省儿童医院湖南省江华瑶族自治县疾病预防控制中心湖南省邵阳市中心医院中南大学湘雅医院南京市第二医院江苏省人民医院江西省南昌大学附属第一医院江西省遂川县人民医院中国医科大学附属第一医院上海交通大学医学院附属第九人民医院四川大学华西医院四川省简阳市人民医院四川省人民医院四川省遂宁市人民医院新疆维吾尔自治区吉木萨尔县人民医院浙江大学第一附属医院

目的研究我国卫生部公布的28例高致病性禽流感A／H5N1病毒感染（简称人禽流感）病例的临床特点，评估其临床与预后的相关性。方法回顾总结我国2005年11月至2008年5月临床及实验室确诊的28例人禽流感病例的临床资料，应用EPIDATA 3．02... 详细信息

目的研究我国卫生部公布的28例高致病性禽流感A／H5N1病毒感染（简称人禽流感）病例的临床特点，评估其临床与预后的相关性。方法回顾总结我国2005年11月至2008年5月临床及实验室确诊的28例人禽流感病例的临床资料，应用EPIDATA 3．02建立数据库，并应用SPSS 13．0软件进行统计分析，计量资料采用独立样本非参数检验，计数资料应用χ^2（fisher）检验。结果我国28例人禽流感病例中，男13例，女15例，治愈10例，死亡18例。发病中位年龄为29岁（6～62岁），发热为本病最突出的临床表现（100％）。治愈患者首次血常规检测白细胞为（4．0±1．9）×10^9／l，淋巴细胞为（1．09±0．49）×10^9／l，血小板为（116±39）×10^9／l；死亡患者分别为（5．1±2．9）×10^9／l、（0．98±0．44）×10^9／l及（101±40）×10^9／l，两组比较差异均无统计学意义（P〉0．05）。治愈与死亡患者天冬氨酸转氨酶分别为（173±246）u／l和（272±263）u／l，乳酸脱氢酶（lDH）分别为（1016±568）u／l和（1512±1052）u／l，肌酸激酶分别为（1099±1590）u／l和（2534±4281）u／l，肌酸激酶同工酶分别为（28±30）u／l和（125±197）u／l。死亡患者发病初期lDH水平大于正常值上限8倍以上者6例。疾病极期均出现双侧肺部病变。22例发展为急性呼吸窘迫综合征，其中治愈患者中5例，死亡患者中17例；急性肾损伤9例，均死亡。奥司他韦抗病毒治疗的10例中，6例康复，4例死亡，康复和死亡患者开始使用奥司他韦的时间分别为（6．5±3．0）d和（11．8±3．3）d。28例患者均不同程度接受了抗生素和糖皮质激素治疗，开始应用糖皮质激素的时间和疗程治愈患者与死亡患者无差异。结论（1）发病初期lDH升高大于正常上限8倍以上者预后不良；（2）合并急性呼吸窘迫综合征及急性肾损伤者预后差；（3）发病早期应用有效抗病毒治疗可改善预后。

关键词：禽流感流感病毒A型治疗预后

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