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新型抗精神病药研究进展

中国新药与临床杂志 2024年第5期43卷 339-343页

作者：刘鑫翟金国济宁医学院精神卫生学院山东济宁272067

近年来发现一些新的药物治疗靶点,为抗精神病药的精准治疗提供了相关依据,推动了新作用机制抗精神病药的研发。微量胺相关受体1激动剂、甘氨酸转运蛋白-1抑制剂、外周限制性毒蕈碱受体拮抗剂、5-羟色胺2A/2C受体反向激动剂等新药的问世... 详细信息

近年来发现一些新的药物治疗靶点,为抗精神病药的精准治疗提供了相关依据,推动了新作用机制抗精神病药的研发。微量胺相关受体1激动剂、甘氨酸转运蛋白-1抑制剂、外周限制性毒蕈碱受体拮抗剂、5-羟色胺2A/2C受体反向激动剂等新药的问世,为精神病性症状的治疗提供了新的可能,其因显著的疗效及较轻的不良反应而备受关注。

关键词：抗精神病药临床试验药理作用机制药物不良反应

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女性三联征的发病及治疗概况

中国处方药 2024年第2期22卷 171-175页

作者：翟金今张兰辽宁中医药大学沈阳110847 辽宁中医药大学附属医院沈阳110032

女性三联征的概念首先由仝小林教授提出,女性三联征是对甲状腺结节、乳腺增生、子宫肌瘤三病的概括,三种疾病都属于内分泌疾病,多见于女性,临床治疗中三种疾病常相继或两种疾病合并出现。通过对近年来文献进行分析,总结出中西医对女性... 详细信息

女性三联征的概念首先由仝小林教授提出,女性三联征是对甲状腺结节、乳腺增生、子宫肌瘤三病的概括,三种疾病都属于内分泌疾病,多见于女性,临床治疗中三种疾病常相继或两种疾病合并出现。通过对近年来文献进行分析,总结出中西医对女性三联征病因的认识、治疗方法的综合描述。西医对女性三联征的认识多和内分泌水平及激素有关,因此在治疗上也以调节激素水平和手术治疗为主;中医对三病的认识多从脏腑、经络、体质出发,以“异病同治”为理念,从中药复方、中成药、针灸等方面入手,且疗效显著。中西医治疗在女性三联征中相辅相成,获得了良好的疗效。

关键词：三联征甲状腺结节乳腺增生子宫肌瘤异病同治

公安高等教育助力新质公安战斗力提升的实践路径

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江苏警官学院学报 2024年第3期39卷 11-18页

作者：张维凯翟金鹏中国人民公安大学警体战训学院

新质公安战斗力是推进公安工作现代化和高质量发展的重要引擎,是推动新质生产力发展、实现中国式现代化和中华民族伟大复兴的重要保障。在探讨新质公安战斗力提出背景与本质内涵的基础上,通过分析公安高等教育在提升新质公安战斗力中所... 详细信息

新质公安战斗力是推进公安工作现代化和高质量发展的重要引擎,是推动新质生产力发展、实现中国式现代化和中华民族伟大复兴的重要保障。在探讨新质公安战斗力提出背景与本质内涵的基础上,通过分析公安高等教育在提升新质公安战斗力中所具有的科技支撑、智力支撑和人才支撑等作用,探寻出公安高等教育助力提升新质公安战斗力的实践路径,即在党的领导下,坚定立德树人的根本任务,通过深化教育改革、优化学科专业、强化职业能力塑造、推进校局合作等措施,不断提升公安专业人才培养质量,从而赋能新质公安战斗力的形成、创新、提质、增效。

关键词：公安高等教育新质公安战斗力公安工作现代化路径

豌豆淀粉的改性及其在产品开发应用领域的研究进展

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粮食与饲料工业 2024年第4期 27-29页

作者：温琦何阳翟金星蒋微无锡中粮工程科技有限公司江苏无锡214035 中粮工科(无锡)国际生化有限公司江苏无锡214035

中国是豌豆生产大国,豌豆中淀粉含量约占50%,豌豆淀粉价格低廉,具有抗剪切稀化、高回生率、低血糖指数、高凝胶弹性和高抗性淀粉含量等特点,是一种优良的食品工业原料。然而,豌豆淀粉因在冷水中溶解性差、易老化、储藏稳定性差等特性限... 详细信息

中国是豌豆生产大国,豌豆中淀粉含量约占50%,豌豆淀粉价格低廉,具有抗剪切稀化、高回生率、低血糖指数、高凝胶弹性和高抗性淀粉含量等特点,是一种优良的食品工业原料。然而,豌豆淀粉因在冷水中溶解性差、易老化、储藏稳定性差等特性限制了其应用。全文介绍了近年来国内外豌豆淀粉的改性方法,综述了改性豌豆淀粉在食品等工业中的应用,旨在为豌豆淀粉资源的开发利用提供参考。

关键词：豌豆淀粉改性方法研究进展

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LogGPO:An accurate communication model for performance prediction of MPI programs

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Science in China(Series F) 2009年第10期52卷 1785-1791页

作者： CHEN WenGuang zhai JiDong ZHANG jin ZHENG WeiMin Tsinghua National Laboratory for Information Science and Technology Department of Computer Science and Technology TsinghuaUniversity Beijing 100084 China

Message passing interface （MPI） is the de facto standard in writing parallel scientific applications on distributed memory systems. Performance prediction of MPI programs on current or future parallel systems can help to find system bottleneck or optimize programs. To effectively analyze and predict performance of a large and complex MPI program, an efficient and accurate communication model is highly needed. A series of communication models have been proposed, such as the LogP model family, which assume that the sending overhead, message transmission, and receiving overhead of a communication is not overlapped and there is a maximum overlap degree between computation and communication. However, this assumption does not always hold for MPI programs because either sending or receiving overhead introduced by MPI implementations can decrease potential overlap for large messages. In this paper, we present a new communication model, named LogGPO, which captures the potential overlap between computation with communication of MPI programs. We design and implement a trace-driven simulator to verify the LogGPO model by predicting performance of point-to-point communication and two real applications CG and Sweep3D. The average prediction errors of LogGPO model are 2.4% and 2.0% for these two applications respectively, while the average prediction errors of LogGP model are 38.3% and 9.1% respectively.

关键词： performance prediction communication model LogP LogGPO MPI

Characterization of Mass Spectra of Aluminum Anion Clusters Generated by Laser Vaporization and Pulsed Molecular Beam Techniques

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Chinese Physics Letters 1996年第11期13卷 829-832页

作者： NI Guo-quan ZHOU Ru-fang zhai Hua-jin WANG Yu-zhu Shanghai Institute of Optics and Fine Mechanics Joint Laboratory for Quantum OpticsChinese Academy of SciencesShanghai 201800

Aluminum anion clusters are generated by laser vaporization and molecular beam *** abundance spectra exhibit a pronounced odd-even alternation for clusters ranging from n=5 to n=17,which is related to the presence of trace oxygen and water resident in He carrier gas and explained by electron pairing *** addition,confirmation of jellium model predictions is revealed at peaked A113-,and for the first time at Al_(7)O^(-).A local maximum Al7-is also observed.

关键词： confirmation pairing Molecular

A new sesquiterpene from hairy root culture of Artemisia annua

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Chinese Chemical Letters 2010年第5期21卷 590-592页

作者： Dan Dan zhai[a], Hui Zi jin[b] Jian Jiang Zhong[a][c] [a] State Key Laboratory of Bioreactor Engineering School of Biotechnology East China University of Science Technology Shanghai 200237 China [b] School of Pharmacy Shanghai Jiaotong University Shanghai 200240 China [c] Key Laboratory of Microbial Metabolism Ministry of Education School of Life Sciences & Biotechnology Shanghai Jiaotong University Shanghai 200240 China

A new sesquiterpene（Z）-7-acetoxy-methyl-11-methyl-3-methylenedodeca-1,6,10-triene（AMDT） was isolnted and identified from the methanol extract of the hairy root culture of Artemisia *** structure of AMDT was determined based on the analysis of spectroscopic data,notably of the 2D NMR *** new compound showed cytotoxicity against human tumor cell lines 95-D and HeLa with IC50 values of 27.08 and 20.12μmol/L,respectively.

关键词： Artemisia annua Sesquiterpene Cytotoxicity

Effects of Transcutaneous Electrical Acupoint Stimulation on Ovarian Responses and Pregnancy Outcomes in Patients Undergoing IVF-ET:A Randomized Controlled Trial

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Chinese Journal of Integrative Medicine 2022年第5期28卷 434-439页

作者： zhai Zhi-jin LIU Jia-en LEI Ling-ling WANG Shu-yu Department of Reproductive Medicine Beijing Obstetrics and Gynecology HospitalCapital Medical UniversityBeijing Maternal and Child Health Care HospitalBeijing(100026)China Center for Reproductive Medicine Beijing Jia-En De Yun HospitalBeijing(100089)China

Objective:To evaluate the influence of different transcutaneous electrical acupoint stimulation(TEAS)modes on ovarian responses and pregnancy outcomes in patients with infertility undergoing in vitro fertilization and embryo transfer(IVF-ET).Methods:Two hundred infertility patients undergoing IVF-ET were divided randomly into experimental groups(TEAS groups:E-Ⅰ,E-Ⅱ,E-Ⅲ,and E-Ⅳ,40 cases each group)and a control group(mock TEAS group,40 patients)using the random number *** patients in the experimental groups received TEAS treatment of 20,30,40 and 50 m A for the E-Ⅰ,E-Ⅱ,E-Ⅲand E-Ⅳgroups,*** control group received a treatment of 5 m *** was applied at acupoints of Guanyuan(RN 4),Zhongji(RN 3),Sanyinjiao(SP 6),Zigong(EX-CA 1),and Taixi(KI 13),once a day for 30 min each time for a treatment period of 10-13 *** effect was assessed using the following indicators:endometrial thickness on the 6 th day of gonadotropin treatment(GN6 day),endometrial thickness on the day on chorionic gonadotropin administration(HCG day),number of ovarian follicles on HCG day,number of ova captured,amount of estrogen required for each harvested ova,number of mature ova divided by the total number of ova,percentage of high-quality embryos,and clinical ***:Endometrial thickness in the experimental groups on the HCG day was significantly better than that of the control group after TEAS stimulation(P=0.01).TEAS exhibited a greater impact on the number of ova captured(P=0.003).However,the effect of TEAS stimulation on the high-quality embryo rate and clinical pregnancy in patients was not statistically significant(P>0.05).Conclusions:TEAS is an effective method in improving the ovarian *** the stimulus intensity was at 40 m A and above,it could be helpful to improve the patient’s endometrial condition and endometrial receptivity and to retrieve more oocytes.(Trial registration *** CTR-TRC-11001780)

关键词： acupuncture transcutaneous electrical acupoint stimulation in vitro fertilization and embryo transfer pregnancy outcome infertility controlled ovarian hyperstimulation

Multispectral Plasmon of Anisotropic Core-shell Gold Nanorods@SiO2： Dual-band Absorption Enhancement with Coupling Dye Molecules

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Chemical Research in Chinese Universities 2018年第5期34卷 772-780页

作者： CHE Yuping WANG Yang YOU Tingting CHANG Huaiqiu YIN Penggang zhai jin Key Laboratory of Bio-inspired Smart Interfacial Science and Technology Ministry of Educate'on Beijing Key Laboratory of Bio-inspired Energy Materials and Devices School of Chemistry Beihang University Beijing 100191 R R. China Institute of Chemistry Chinese Academy of Sciences Beijing 100190 P. R. China National Center for Nanoscience and Technology Beijing 100190 P. R. China

Direct evidence of effects of surface plasmon resonance（SPR） of gold naaorods（GNRs） on dual-band light absorption enhancement with coupling dye molecules was reported by introducing gold nanorod@SiO2（GNR@SiO2） core-shell nanoparticles into a photoelectric conversion system. GNR with asymmetric shape had unusual anisotropic SPR[transversal surface plasmon resonance（TSPR） and longitudinal surface plasmon resonance（LSPR）]. The excel- lent SPR of GNR made it a promising candidate as enhancing light absorption material to increase power conversion efflciency（PCE）. The PCE was improved nearly 17.2% upon incorporating GNRs, mostly due to the increase in Jsc, while Vo~ and FF were unchanged. The improvement was mostly contributed by the SPR of the GNRs with coupling of N719. And there was also a complementary to N719 in visible light range. Therefore, SPR is an effective tool in improving the photocurrent and consequently enhancement of PCE. The TSPR and LSPR effects of GNRs on light harvesting were reflected in the increased monochromatic incident photon-to-electron conversion efficiency（IPCE）. We also utilized finite-difference tirne-domain（FDTD） to investigate the light coupling of GNRs with TiO2. Compare to the base anode, the IPCE of optimized electrode showed significant improvement and peaks broadening at 500--600 nm and 610--710 nm. We got an increase in overall conversion efficiency from 6.4% to 7.5%.

关键词： Gold nanorod Plasmon Dual-band absorption Dye-sensitized solar cell(DSSC) N719