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Effects of chromium nanoparticle dosage on growth,body composition,serum hormones and tissue chromium in Sprague-Dawley rats

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2007年第5期8卷 323-330页

作者： zha long-ying xu zi-rong wang min-qi gu liang-ying Key Laboratory for Molecular Animal Nutrition of ministry of Education Feed Science Institute Zhejiang University Hangzhou 310029 China

This 6-week study was conducted to evaluate the effects of seven different levels of dietary chromium (Cr) (0,75,150,300,450,600,and 1200 ppb Cr) in the form of Cr nanoparticle (CrNano) on growth,body composition,serum hormones and tissue Cr in Sprague-Dawley (SD) rats. Seventy male SD rats (average initial body weight of (83.2±4.4) g) were randomly assigned to seven dietary treatments (n=10). At the end of the trial,body composition was assessed via dual energy X-ray absorptiometry (DEXA). All rats were then sacrificed to collect samples of blood,organs and tissues for determination of serum hormones and tissue Cr contents. The results indicated that lean body mass was significantly increased (P<0.05) due to the addition of 300 and 450 ppb Cr from CrNano. Supplementation of 150,300,450,and 600 ppb Cr decreased (P<0.05) percent body fat significantly. Average daily gain was increased (P<0.05) by addition of 75,150,and 300 ppb Cr and feed efficiency was increased (P<0.05) by supplementation of 75,300,and 450 ppb Cr. Addition of 300 and 450 ppb Cr decreased (P<0.05) the insulin level in serum greatly. Cr contents in liver and kidney were greatly increased (P<0.05) by the addition of Cr as CrNano in the dosage of from 150 ppb to 1 200 ppb. In addition,Supplementation of 300,450,and 600 ppb Cr significantly increased (P<0.05) Cr content in the hind leg muscle. These results suggest that supplemental CrNano has beneficial effects on growth performance and body composition,and increases tissue Cr concentration in selected muscles.

关键词： Rat Chromium (Cr) Nanoparticle Growth Body composition Hormone

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不同形式铬对SD大鼠生长性能、胴体组成和血清生化指标的影响

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动物营养学报 2007年第3期19卷 258-263页

作者：辜良英许梓荣查龙应王敏奇浙江大学教育部动物分子营养重点实验室杭州310029

本文旨在研究纳米铬和吡啶羧酸铬对SD大鼠生长性能、胴体组成及血清生化指标的影响。试验以30只平均体重为(80±5)g的SD雄性大鼠为研究对象,随机分为3组,每组10只。对照组饲喂基础日粮,试验1、2组分别在基础日粮中以吡啶羧酸铬和纳米铬... 详细信息

本文旨在研究纳米铬和吡啶羧酸铬对SD大鼠生长性能、胴体组成及血清生化指标的影响。试验以30只平均体重为(80±5)g的SD雄性大鼠为研究对象,随机分为3组,每组10只。对照组饲喂基础日粮,试验1、2组分别在基础日粮中以吡啶羧酸铬和纳米铬的形式添加300μg/kg铬,预试期7d,试验期36d。试验结果表明:(1)纳米铬处理使SD大鼠的日增重和饲料利用率分别提高了12.68%(P0.05);(2)纳米铬处理使SD大鼠瘦肉重增加了15.11%(P<0.05),脂肪率降低了24.42%(P<0.05);吡啶铬处理使大鼠瘦肉重增加了18.76%(P<0.05);(3)纳米铬处理使SD大鼠血清中胰岛素、葡萄糖、尿素氮和甘油三酯水平较对照组分别降低了45.38%(P<0.05)、31.84%(P<0.05)、48.75%(P<0.05)和38.46%(P<0.05);吡啶铬处理则使大鼠血清尿素氮浓度较对照组降低了57.62%(P<0.05),高密度脂蛋白浓度升高了26.15%(P<0.05)。因此,纳米铬能够促进大鼠生长,改善胴体组成。

关键词： SD大鼠生长性能纳米铬胴体组成血清生化指标

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Caco-2细胞模型及其在营养素小肠吸收机理研究中的应用

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动物营养学报 2006年第3期18卷 215-222页

作者：查龙应许梓荣王敏奇浙江大学饲料科学研究所教育部动物分子营养重点实验室杭州310029

Caco-2细胞源自人结肠癌细胞,体外培养时能自发地进行类似肠道细胞的形态学和生化学上的分化,获得许多小肠吸收细胞的特性,如形成微绒毛结构;在细胞表面形成良好的刷状缘;在细胞间形成紧密连接;分泌水解酶以及合成转运糖、氨基酸和药物... 详细信息

Caco-2细胞源自人结肠癌细胞,体外培养时能自发地进行类似肠道细胞的形态学和生化学上的分化,获得许多小肠吸收细胞的特性,如形成微绒毛结构;在细胞表面形成良好的刷状缘;在细胞间形成紧密连接;分泌水解酶以及合成转运糖、氨基酸和药物等的载体转运系统。由培养在微孔滤膜上的Caco-2细胞构建的模型为研究营养素在小肠的吸收机理提供了一个有效且易于操作的实验手段。本文主要综述了Caco-2细胞模型的建立、特征、检测及其在氨基酸、维生素、核苷和微量元素等营养素小肠吸收机理研究中的应用。

关键词： Caco-2细胞营养素吸收转运

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氯化铬和吡啶羧酸铬在Caco-2细胞中的摄取和转运

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细胞生物学杂志 2007年第1期29卷 77-80页

作者：查龙应许梓荣王敏奇辜良英浙江大学饲料科学研究所浙江大学动物分子营养学教育部重点实验室杭州310029

采用一种体外培养的人小肠上皮细胞模型Caco-2研究了时间、浓度、温度对氯化铬和吡啶羧酸铬细胞摄取和跨细胞转运的影响。旨在探讨氯化铬和吡啶羧酸铬在小肠上皮细胞中的摄取和转运特点。结果表明:Caco-2细胞对氯化铬和吡啶羧酸铬的摄... 详细信息

采用一种体外培养的人小肠上皮细胞模型Caco-2研究了时间、浓度、温度对氯化铬和吡啶羧酸铬细胞摄取和跨细胞转运的影响。旨在探讨氯化铬和吡啶羧酸铬在小肠上皮细胞中的摄取和转运特点。结果表明:Caco-2细胞对氯化铬和吡啶羧酸铬的摄取和转运随浓度、时间而成线性增加,当温育温度从37℃降到4℃时,摄取和转运有下降趋势(P>0.05)。氯化铬和吡啶羧酸铬从肠腔侧(AP侧)到基底侧(BL侧)的表观通透系数(Papp)近似于BL侧到AP侧(分别为0.95～1.41倍和0.84～1.07倍)。氯化铬和吡啶羧酸铬的摄取率分别为(0.88±0.08)%和(4.73±0.60)%,转运率分别为(2.11±0.05)%和(9.08±0.25)%。结果提示氯化铬和吡啶羧酸铬是以被动扩散为主要方式被Caco-2细胞摄取和转运。

关键词：氯化铬吡啶羧酸铬 Caco-2细胞摄取转运

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Response-guided treatment of cirrhotic chronic hepatitis B patients: Multicenter prospective study

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World Journal of Gastroenterology 2015年第2期21卷 653-660页

作者： Er-Li gu Yi-qi Yu Jia-Li wang Yan-Yan Ji Xiu-Yun Ma qing Xie Hong-ying Pan Shan-min Wu Jun Li Cheng-Wei Chen Xiao-Wei xu Yue-Er wang guang-Bi Yao Hong wang Wen-Hong zhang Department of Gastroenterology and Hepatology Jing’an District Central Hospital Jing’an Branch of Huashan Hospital Fudan University Department of Infectious Diseases Huashan HospitalFudan University Department of Infectious Diseases Ditan Hospital Department of Hepatology Department of Infectious DiseasesRuijin HospitalSchool of MedicineShanghai Jiaotong University Department of Infectious Diseases The 6th People’s Hospital of Hangzhou Shanghai Public Health Clincal Center Department of Infectious Diseases Jiangsu Provincial Hospital Department of Hepatology Shanghai Liver Disease Research Center of Nanjing Military Area Department of Infectious Diseases The 1st Affiliated Hospital of Zhejiang University MOH and MOE Key Laboratory of Medical Molecular Virology Shanghai Medical CollegeFudan University Institutes of Biomedical Sciences Fudan University

AIM: To observe the effect of response-guided add-on therapy with adefovir(ADV) and lamivudine(LAM) in cirrhotic hepatitis B(CHB) ***: A total of 100 patients with CHB and cirrhosis were divided into three arms according to hepatitis B virus(HBV) DNA level after 24 wk LAM monotherapy: Arm A(complete response, HBV DNA ≤ 60 IU/m L, n = 49), Arm B(partial response, HBV DNA: 60-2000 IU/m L, n = 31) and Arm C(inadequate response, HBV DNA > 2000 IU/m L, n = 20). ADV was added to LAM at week 48 in Arms A and B, but at week 24 in Arm C. Virological response, YMDD mutations, biochemical response, and liver function were ***: Comparison of the three arms demonstrated that early complete virologic response at week 24was associated with maintained viral suppression(undetectable rate of HBV DNA at week 144 was 95.96%, 66.67% and 35.29%, respectively, P = 0.000) and reduced YMDD mutations(mutation rate at week 144 was 0%, 3.23% and 15%, respectively, P = 0.015) after 144 wk treatment. For patients who failed to achieve complete virological response at week 24, switching to combination therapy further decreased HBV DNA level by 1 log10 IU/m L. All three arms obtained biochemical benefits including decline of alanine aminotransferase and elevation of albumin. In patients who developed HBV DNA breakthrough for YMDD mutations, ADV add-on therapy did not induce further multiple drug resistance to LAM or ***: Optimized response-guided add-on therapy of ADV and LAM maintains long-term suppression of HBV DNA and improves liver function in CHB patients with compensated liver cirrhosis.

关键词： Hepatitis B Cirrhosis Adefovir dipivoxil Lamivudin

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Measurement of the neutron total cross section of carbon at the Back-n white neutron beam of CSNS

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Nuclear Science and Techniques 2019年第9期30卷 73-82页

作者： Xing-Yan Liu Yi-Wei Yang rong Liu Jie Wen Zhong-Wei Wen zi-Jie Han Zhi-Zhou Ren qi An Huai-Yong Bai Jie Bao Ping Cao qi-Ping Chen Yong-Hao Chen Pin-Jing Cheng Zeng-qi Cui Rui-Rui Fan Chang-qing Feng min-Hao gu Feng-qin guo Chang-Cai Han guo-Zhu He Yong-Cheng He Yue-Feng He Han-Xiong Huang Wei-Ling Huang Xi-Ru Huang Xiao-Lu Ji xu-Yang Ji Hao-Yu Jiang Wei Jiang Han-Tao Jing Ling Kang ming-Tao Kang Bo Li Lun Li qiang Li Xiao Li Yang Li Yang Li Shu-Bin Liu guang-Yuan Luan ying-Lin Ma Chang-Jun Ning Bin-Bin qi Jie Ren Xi-Chao Ruan zhao-Hui Song Hong Sun Xiao-Yang Sun Zhi-Jia Sun Zhi-Xin Tan Hong-qing Tang Jing-Yu Tang Peng-Cheng wang qi wang Tao-Feng wang Yan-Feng wang zhao-Hui wang Zheng wang qing-Biao Wu Xiao-guang Wu xuan Wu Li-Kun Xie Han Yi Li Yu Tao Yu Yong-Ji Yu guo-Hui zhang Jing zhang Lin-Hao zhang Li-ying zhang qing-min zhang qi-Wei zhang Xian-Peng zhang Yu-liang zhang Zhi-Yong zhang ying-Tan zhao liang Zhou Zu-ying Zhou Dan-Yang Zhu Ke-Jun Zhu Peng Zhu Institute of Nuclear Physics and Chemistry China Academy of Engineering Physics State Key Laboratory of Particle Detection and Electronics Chinese Academy of Sciences(CAS) Department of Modern Physics University of Science and Technology of China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking University Key Laboratory of Nuclear Data China Institute of Atomic Energy Institute of High Energy Physics Chinese Academy of Sciences(CAS) Spallation Neutron Source Science Center University of South China Northwest Institute of Nuclear Technology Department of Engineering and Applied Physics University of Science and Technology of China Beihang University Xi’an Jiaotong University

To verify the performance of the neutron total cross-sectional spectrometer, the neutron total cross section of carbon is initially measured in the energy range of 1 eV to 20 MeV using the time-of-flight method. The measurement is performed at the Back-n white neutron source with a 76-m time-of-flight path using the China Spallation Neutron Source. A multilayer fast fission chamber with 235U and 238U is employed as the neutron detector. The diameter and thickness of the natural graphite sample are 70 mm and 40 mm, respectively. Signal waveforms are collected using a data acquisition system. Off-line data processing was used to obtain the neutron time-of-flight spectra and transmissions. The uncertainty of the counting statistics is generally approximately 3% for each bin in the energy range of 1–20 MeV. It is determined that the results for the neutron total cross section of carbon obtained using ^235U cells are in good agreement with the results obtained using 238U cells within limits of statistical uncertainty. Moreover, the measured total cross sections show good agreement with the broadening evaluated data.

关键词： CSNS Back-n white neutron source NTOX Neutron total cross section Carbon Multilayer fast fission chamber

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CD147-spike protein is a novel route for SARS-CoV-2 infection to host cells

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Signal Transduction and Targeted Therapy 2021年第1期6卷 95-104页

作者： Ke wang Wei Chen Zheng zhang Yongqiang Deng Jian-qi Lian Peng Du Ding Wei Yang zhang Xiu-xuan Sun Li Gong xu Yang Lei He Lei zhang Zhiwei Yang Jie-Jie Geng Ruo Chen Hai zhang Bin wang Yu-Meng Zhu Gang Nan Jian-Li Jiang Ling Li Jiao Wu Peng Lin Wan Huang liangzhi Xie zhao-Hui Zheng Kui zhang Jin-Lin Miao Hong-Yong Cui min Huang Jun zhang Ling Fu Xiang-min Yang Zhongpeng zhao Shihui Sun Hongjing gu Zhe wang Chun-Fu wang Yacheng Lu ying-ying Liu qing-Yi wang Huijie Bian Ping ZhuZhi-Nan Chen National Translational Science Center for Molecular Medicine&Department of Cell Biology Fourth Military Medical UniversityXi’an 710032China Beijing Institute of Biotechnology Beijing 100071China State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and EpidemiologyBeijing 100071China Tangdu Hospital Fourth Military Medical UniversityXi’an 710038China MOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter Xi’an Jiaotong UniversityXi’an 710049China Sino Biological Inc. Beijing 100176China Department of Clinical Immunology Xijing HospitalFourth Military Medical UniversityXi’an 710032China School of Basic Medicine Fourth Military Medical UniversityXi’an 710032China

In face of the everlasting battle toward COVID-19 and the rapid evolution of SARS-CoV-2,no specific and effective drugs for treating this disease have been reported until ***-converting enzyme 2(ACE2),a receptor of SARS-CoV-2,mediates the virus infection by binding to spike *** ACE2 is expressed in the lung,kidney,and intestine,its expressing levels are rather low,especially in the *** the great infectivity of COVID-19,we speculate that SARS-CoV-2 may depend on other routes to facilitate its ***,we first discover an interaction between host cell receptor CD147 and SARS-CoV-2 spike *** loss of CD147 or blocking CD147 in Vero E6 and BEAS-2B cell lines by anti-CD147 antibody,Meplazumab,inhibits SARSCoV-2 *** of human CD147 allows virus entry into non-susceptible BHK-21 cells,which can be neutralized by CD147 extracellular *** loads are detectable in the lungs of human CD147(hCD147)mice infected with SARS-CoV-2,but not in those of virus-infected wild type ***,virions are observed in lymphocytes of lung tissue from a COVID-19 *** T cells with a property of ACE2 natural deficiency can be infected with SARS-CoV-2 pseudovirus in a dosedependent manner,which is specifically inhibited by ***,CD147 mediates virus entering host cells by ***,our study reveals a novel virus entry route,CD147-spike protein,which provides an important target for developing specific and effective drug against COVID-19.

关键词： ACE2 CD147 intestine

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Seroprevalence of Bartonella henselae and Identification of Risk Factors in China

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Biomedical and Environmental Sciences 2020年第1期33卷 72-75页

作者： SONG Xiu Ping zhaNG Hai Bin LIU qi Yong SUN Ji min xu Lei gu Shao Hua SUN Wan Wan YUE Yu Juan REN Dong Sheng wang Jun LI Dong Mei State Key Laboratory of Infectious Disease Prevention and Control Collaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesNational Institute for Communicable Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China The qinghuangdao Municipal Center for Disease Prevention and Control Qinhuangdao 066000HebeiChina Zhejiang Provincial Center for Disease Control and Prevention Hangzhou 310051ZhejiangChina Ningbo Center for Disease Control and Prevention Ningbo 315010ZhejiangChina

Serum samples were tested for Bartonella henselae Ig G antibodies using indirect immunofluorescence *** then analyzed associated risk *** samples were considered positive when reactive at a dilution of more than 1:320.

关键词： Seroprevalence Bartonella henselae Identification Risk Factors in China

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Highly stable carbon-coated nZVI composite Fe0@RF-C for efficient degradation of emerging contaminants

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Environmental Science and Ecotechnology 2024年第6期22卷 233-244页

作者： guizhou xu Lin Sun Yizhou Tu Xiaolei Teng Yumeng qi Yaoyao wang Aimin Li Xianchuan Xie xueyuan gu State Key Laboratory of Pollution Control and Resource Reuse School of the EnvironmentNanjing UniversityNanjing210023China Key Laboratory of Poyang Lake Environment and Resource Utilization Engineering Research Center of Watershed Carbon NeutralizationMinistry of EducationSchool of Resource and EnvironmentNanchang UniversityNanchang330031China Nanjing University&Yancheng Academy of Environment Protection Technology and Engineering Nanjing210023China Jiangxi Nanxin Environmental Protection Technology Co.LTD Jiujiang CityJiangxi Province330300China

Nanoscale zerovalent iron(nZVI)has garnered significant attention as an efficient advanced oxidation activator,but its practical application is hindered by aggregation and *** nZVI with carbon can effectively addresses these issues.A simple and scalable production method for carbon-coated nZVI composite is highly *** anti-oxidation and catalytic performance of carbon-coated nZVI composite merit in-depth *** this study,a highly stable carbon-coated core-shell nZVI composite(Fe0@RF-C)was successfully prepared using a simple method combining phenolic resin embedding and carbothermal ***0@RF-C was employed as a heterogeneous persulfate(PS)activator for degrading 2,4-dihydroxybenzophenone(BP-1),an emerging *** to commercial nZVI,Fe0@RF-C exhibited superior PS activation performance and oxidation *** 95%of BP-1 was removed within 10 min in the Fe0@RF-C/PS *** carbon layer promotes the enrichment of BP-1 and accelerates its degradation through singlet oxygen oxidation and direct electron transfer *** study provides a straightforward approach for designing highly stable carbon-coated nZVI composite and elucidates the enhanced catalytic performance mechanism by carbon layers.

关键词： Nanoscale zerovalent iron Carbon-coated nZVI Persulfate BP-1 Enhanced degradation

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Therapeutic effects of hydrogen saturated saline on rat diabetic model and insulin resistant model via reduction of oxidative stress

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Chinese Medical Journal 2012年第9期125卷 1633-1637页

作者： wang qi-jin zha Xiao-juan KANG Zhi-min xu Mao-jin HUANG qin ZOU Da-jin Department of Endocrinology Changhai Hospital Second Military Medical University Shanghai 200433 China Department of Diving Medicine Faculty of Naval Medicine Second Military Medical University Shanghai 200433 China

Background Molecular hydrogen, as a novel antioxidant, has been proven effective in treating many diseases. This study aimed to evaluate the therapeutic effects of hydrogen saturated saline in treatment of a rat model of diabetes mellitus and a rat model of insulin resistant. Methods A rat diabetes mellitus model was established by feeding a high fat/high carbohydrate diet followed by injection of a small dose of streptozotocin, and an insulin resistant model was induced with a high glucose and high fat diet. Hydrogen saturated saline was administered to rats with both models conditions on a daily basis for eight weeks. A pioglitazone-treated group and normal saline-treated group served as positive and negative controls. The general condition, body weight, blood glucose, blood lipids, and serum insulin levels of rats were examined at the 8th week after treatment. The oxidative stress indices, including serum superoxide dismutase （SOD）, glutathione （GSH） and malondialdehyde （MDA） were also evaluated after eight weeks of treatment using the commercial kits.Results Hydrogen saturated saline showed great efficiency in improving the insulin sensitivity and lowering blood glucose and lipids. Meanwhile, the therapeutic effects of hydrogen saturated saline were superior to those of pioglitazone. Hydrogen saturated saline markedly attenuated the MDA level and elevated the levels of antioxidants SOD and GSH. Conclusion Hydrogen saturated saline may improve the insulin resistance and alleviate the symptoms of diabetes mellitus by reducing the oxidative stress and enhancing the anti-oxidant system.

关键词： diabetes mellitus hydrogen saturated saline oxidative stress insulin resistance

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