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感恩拓延-建构理论干预在抑郁症患者延续性护理中的价值

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中国医药导报 2024年第9期21卷 161-165页

作者：王俞帆徐涌陈叶浙江省绍兴市第七人民医院焦虑障碍科浙江绍兴312000 浙江省绍兴市第七人民医院老年精神科浙江绍兴312000

目的探讨感恩拓延-建构理论干预在抑郁症患者延续性护理中的价值。方法选取2021年5月至2022年5月浙江省绍兴市第七人民医院收治的抑郁症患者600例,按照随机数字表法将其分为对照组和研究组,各300例。对照组采用常规延续性护理,研究组... 详细信息

目的探讨感恩拓延-建构理论干预在抑郁症患者延续性护理中的价值。方法选取2021年5月至2022年5月浙江省绍兴市第七人民医院收治的抑郁症患者600例,按照随机数字表法将其分为对照组和研究组,各300例。对照组采用常规延续性护理,研究组采用感恩拓延-建构理论指导的延续性护理。比较两组干预前后抑郁改善情况[抑郁症状群量表(PHQ-9)、汉密尔顿抑郁量表(HAMD)]、功能失调情况[功能失调态度量表(DAS)]、幸福感[总体幸福感量表(GWB)]、医学应对方式[医学应对方式问卷(MCMQ)]、生活质量(世界卫生组织生活质量-100量表)。结果干预后,两组PHQ-9、HAMD评分均低于干预前,且研究组低于对照组(P<0.05);干预后,两组DAS评分低于干预前、GWB评分高于干预前,且研究组DAS评分低于对照组、GWB评分高于对照组(P<0.05);干预后,两组屈服应对、回避应对得分低于干预前,面对应对得分高于干预前;且研究组屈服应对、回避应对得分低于对照组,面对应对得分高于对照组(P<0.05);干预后,两组心理、独立性、社会关系及总分高于干预前,且研究组高于对照组(P<0.05)。结论在抑郁症患者中应用感恩拓延-建构理论指导的延续性护理能够改善抑郁症状及生活质量,优化患者医学应对方式,干预效果显著,值得临床推广应用。

关键词：抑郁症延续性护理感恩拓延-建构理论生活质量

Advances in extracellular vesicle functionalization strategies for tissue regeneration

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Bioactive Materials 2023年第7期25卷 500-526页

作者： Dandan zheng Huitong Ruan Wei chen Yuhui zhang Wenguo Cui Hao chen Hongxing Shen Department of Spine Surgery Renji HospitalShanghai JiaoTong University School of Medicine160 Pujian RoadShanghai200127PR China Department of Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint DiseasesShanghai Institute of Traumatology and OrthopaedicsRuijin HospitalShanghai Jiao Tong University School of Medicine197 Ruijin 2nd RoadShanghai200025China

Extracellular vesicles(EVs)are nano-scale vesicles derived by cell secretion with unique advantages such as promoting cell proliferation,anti-inflammation,promoting blood vessels and regulating cell differentiation,which benefit their wide applications in regenerative ***,the in vivo therapeutic effect of EVs still greatly restricted by several obstacles,including the off-targetability,rapid blood clearance,and undesired *** address these issues,biomedical engineering techniques are vastly *** review summarizes different strategies to enhance EV functions from the perspective of drug loading,modification,and combination of biomaterials,and emphatically introduces the latest developments of functionalized EV-loaded biomaterials in different diseases,including cardio-vascular system diseases,osteochondral disorders,wound healing,nerve *** and future directions of EVs are also discussed.

关键词： Extracellular vesicle Regenerative medicine Biomaterials Modification Drug delivery

RAD51AP1基因表达在三阴性乳腺癌脑转移中的生物信息分析

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诊断学理论与实践 2024年第2期23卷 146-154页

作者：欧丹蔡钢陈佳艺上海交通大学医学院附属瑞金医院放射治疗科上海200025

目的:采用生物信息分析筛选三阴性乳腺癌脑转移相关差异性表达基因(differentially expressed genes,DEG),并探索影响预后的潜在作用机制。方法:在基因表达数据库(Gene Expression Omnibus, GEO)检索获得GSE76250(三阴性乳腺癌组织与正... 详细信息

目的:采用生物信息分析筛选三阴性乳腺癌脑转移相关差异性表达基因(differentially expressed genes,DEG),并探索影响预后的潜在作用机制。方法:在基因表达数据库(Gene Expression Omnibus, GEO)检索获得GSE76250(三阴性乳腺癌组织与正常乳腺组织)和GSE125989(三阴性乳腺癌脑转移病灶组织与三阴性乳腺癌原发灶组织) 2个数据集,筛选DEG。采用GO(Gene Ontology)分析和KEGG(Kyoto Encyclopedia of Genes and Genomes)分析寻找潜在的三阴性乳腺癌脑转移相关基因。通过癌症基因组图谱(The Cancer Genome Atlas, TCGA)数据库中的临床组织样本,验证相关基因表达水平与乳腺癌预后间的关系,并使用KEGG的基因集进行基因富集分析,评估DEG可能参与的信号通路。结果:在GSE125989和GSE76250数据集中共筛选出52个DEG,蛋白质相互作用网络(protein-protein interaction, PPI)分析提示RAD51AP1为三阴性乳腺癌脑转移的重要相关基因。TCGA数据分析显示,相较于癌旁组织RAD51AP1在乳腺癌组织中高表达;不同分子分型中,基底样型中乳腺癌PAD51AP1高表达。以RAD51AP1在癌组织表达中位数[log2(TPM+1)=3.85],将乳腺癌患者分为高表达和低表达组,生存分析显示,高表达患者的中位生存期差于低表达者[3 873 d比3 945 d,P<0.05,HR=1.40(1.01~1.94)]。通过GO、KEGG、基因富集分析(gene set enrichment analysis, GSEA)发现,RAD51AP1在细胞周期、DNA复制、错配修复等信号通路中有富集明显。基于细胞周期和DNA损伤修复信号通路相关蛋白信息构建PPI,筛选与RAD51AP1直接相互作用的蛋白质,其中增殖细胞核抗原(proliferating cell nuclear antigen,PCNA)与RAD51AP1的相关性较强(R=0.715,P<0.001)。结论:RAD51AP1在三阴性乳腺癌及其脑转移组织中高表达,可能作为潜在的诊断三阴性乳腺癌及预后不良的生物标志物,且其异常表达介导乳腺癌脑转移进程可能与PCNA相关。

关键词：三阴性乳腺癌脑转移生物信息学分析 RAD51AP1

Polymetallaynes and Molecular Metallaynes Containing Platinum,Mercury and Gold for Optoelectronic and Magnetic Applications

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Chinese Journal of Chemistry 2023年第17期41卷 2159-2178页

作者： chen zhang Linli Xu Wai-Yeung Wong Departmentof Applied Biology and Chemical Technology The Hong Kong Polytechnic UniversityHung HomHong Kongchina

omprehensive Summary,Polymetallaynes are a promising branch of metallopolymers,in which the introduction of metal building blocks to organic conjugated backbones leads to their unique skeletons and versatile ***,the chemical structures,geometric configurations and functional properties in these organometallic systems can be adjusted flexibly by the appropriate selection of metal centers,auxiliary ligands,or bridging *** recent years,both one-dimensional and two-dimensional polymetallaynes have attracted considerable attention owing to their excellent electronic,optical and magnetic ***,the studies on molecular metallaynes provide substantial insights for the exploration of the structure-property-activity relationships in these organometallic acetylide-containing *** recent research progress of polymeric and molecular metallaynes containing platinum,mercury and gold is discussed in this article.A series of functional properties have been realized in these acetylide-containing compounds by the rational structural design and refined synthetic strategies,leading to their emerging applications including energy conversion,nonlinear optics,data storage and memory,as well as chemo/biosensing.

关键词： Polymetallayne Molecular metallayne Metallated graphyne Platinum Mercury Gold

小冲杆技术及其在材料与铅铋脆化效应研究中的应用

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中国腐蚀与防护学报 2024年第3期44卷 567-575页

作者：和雅洁陈灵芝阮章顺付晓刚纪琤龙斌中国原子能科学研究院、反应堆工程技术研究所北京102413

第四代反应堆中铅冷快堆是一种非常有发展前景的堆型。在铅冷快堆包壳材料设计时,需要重点考虑包壳材料与高温铅铋的相容性,关注其抗液态金属腐蚀能力,尤其是腐蚀介质与应力耦合时材料性能的变化。小冲杆实验(SPT)是一种使用小尺寸样品... 详细信息

第四代反应堆中铅冷快堆是一种非常有发展前景的堆型。在铅冷快堆包壳材料设计时,需要重点考虑包壳材料与高温铅铋的相容性,关注其抗液态金属腐蚀能力,尤其是腐蚀介质与应力耦合时材料性能的变化。小冲杆实验(SPT)是一种使用小尺寸样品评估材料服役条件下力学性能变化的实验方法,这种方法可以直接在正在使用的材料中提取样品而不损害其完整性,因此小冲杆测试非常适用于所研究材料数量有限或研究在役材料的情况。本文简要介绍了小冲杆测试技术,归纳了小冲杆测试与标准尺寸测试实验的相关性,阐述了使用小冲杆技术进行的关键材料力学性能研究,特别阐述了小冲杆测试在研究结构材料液态金属脆化效应(LME)方面的应用。结果可为小冲杆技术应用于研究材料液态铅铋脆化效应提供技术方法及理论支持。

关键词：小冲杆测试结构材料力学性能液态金属脆化效应

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裂隙水作用下岩质边坡平面滑动力学模型

公路交通科技 2024年第2期41卷 88-95,104页

作者：姜楠张安然张芳陈明晖曹晓伟黄河水利职业技术学院河南开封475004 河南省跨流域区域引调水运行与生态安全工程研究中心河南开封475004 中国建筑第八工程局有限公司华北分公司天津300450 昊鼎地基基础工程有限公司河南郑州450008

在降雨等水力条件作用下沿岩层层面的平面滑动是顺层岩质边坡最常见的一种破坏模式,而目前关于该类边坡的稳定性计算方法几乎很少考虑裂隙面粗糙度对地下水渗流力及滑面抗剪强度的影响,进而导致其稳定性计算结果误差较大。为此,首先对... 详细信息

在降雨等水力条件作用下沿岩层层面的平面滑动是顺层岩质边坡最常见的一种破坏模式,而目前关于该类边坡的稳定性计算方法几乎很少考虑裂隙面粗糙度对地下水渗流力及滑面抗剪强度的影响,进而导致其稳定性计算结果误差较大。为此,首先对地下水作用下的顺层岩质边坡受力特征进行分析,认为地下水将对滑动岩体产生3个方面的力学作用:张裂隙中的静水压力、滑面上的扬压力和渗流力,由此建立了相应的边坡稳定性计算模型。其次,通过引入裂隙面粗糙度对裂隙抗剪强度及地下水渗流力的影响,提出了考虑裂隙粗糙及地下水渗流力的顺层岩质边坡稳定性计算模型。而后,通过对含一条贯通粗糙裂隙的岩质边坡稳定性为例,验证了该模型计算结果的合理性,同时计算结果表明裂隙面粗糙度系数JRC对边坡稳定性有重要影响,必须予以考虑。最后,基于参数敏感性分析研究了主要参数如裂隙面粗糙度系数、裂隙基本摩擦角、裂隙宽度、裂隙壁面岩石抗压强度及地下水位高度等对边坡稳定性的影响,结果表明:仅裂隙宽度对边坡稳定性影响很小,而其他参数对边坡稳定性影响则相对较大,不容忽视。且裂隙面粗糙度对边坡稳定性的影响与裂隙壁面岩石抗压强度密切相关,随着其增加,裂隙面粗糙度对边坡稳定性的影响程度逐渐变大。

关键词：道路工程岩质边坡平面滑动力学模型裂隙水粗糙裂隙裂隙抗剪强度准则

新工科背景下微项目式新能源专业实验教学——锂离子电池实验案例

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实验室研究与探索 2024年第4期43卷 121-124页

作者：吴珏陈昕成锦强庄智鹏王显赫珠海科技学院应用化学与材料学院广东珠海519041

秉持“以学生为中心,理论联系实际”教学理念,对微项目式的实验教学模式展开初步探索。教师结合生活热点设定驱动性问题,引导学生半自主拟定项目课题;学生通过团队合作制定实验方案,开展“线上线下混合式”预实验;教师与学生进行多维度... 详细信息

秉持“以学生为中心,理论联系实际”教学理念,对微项目式的实验教学模式展开初步探索。教师结合生活热点设定驱动性问题,引导学生半自主拟定项目课题;学生通过团队合作制定实验方案,开展“线上线下混合式”预实验;教师与学生进行多维度互动,培养学生高阶思维能力和科学素养。通过微项目式实验教学,有效提升新能源材料与器件专业学生的综合实践能力,为培养电池行业工科专业人才提供借鉴。

关键词：微项目式实验教学探索式教学锂离子电池

Plowing-Extrusion Processes and Performance of Functional Surface Structures of Copper Current Collectors for Lithium-Ion Batteries

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Nanomanufacturing and Metrology 2022年第4期5卷 336-353页

作者： Chun Wang Wei Yuan Yu chen Bote zhao Yong Tang Shiwei zhang Xinrui Ding Jun He Songmao chen Baoyou Pan Mingyue chen School of Mechanical and Automotive Engineering South China University of TechnologyGuangzhou510640China School of Environment and Energy South China University of TechnologyGuangzhou510006China

Most copper current collectors for commercial lithium-ion batteries(LIBs)are smooth copper foils,which cannot form a stable and effective combination with electrode *** are likely to deform or fall off after long-term operation,resulting in a sharp decline in battery *** is worse is that this condition inevitably causes internal short circuits and thus brings about security *** this study,a process route of fabricating the functional surface structures on the surface of a copper collector for LIBs by twice-crisscross micro-plowing(TCMP)is proposed,which provides a new idea and an efficient method to solve the above problems from the perspective of *** finite element simulation of TCMP combined with the cutting force test and morphological characterization is conducted to verify the forming mechanism of the surface structures on a copper sheet and its relationship with the processing *** influence of several key processing parameters on the surface characteristics of the copper sheet is comprehensively explored.A series of functions is tested to obtain the optimal parameters for performance improvement of the current *** show that the structured copper sheet with the cutting distance of 250μm,cutting depth of 80μm,and cutting crossing angle of 90°enables the best surface features of the current collector;the contact angle reaches 0°,the slurry retention rate is up to 89.2%,and the friction coefficient reaches *** battery using the as-prepared structured copper sheet as the current collector produces a specific capacity of 318.6 mAh/g after 50 cycles at a current density of 0.2 C,which is 132.7%higher than the one based on a smooth *** capacity reversibility of the sample with the new current collector is much better than that of the traditional samples,yielding a lower impedance.

关键词： Plowing-extrusion Current collector Lithium-ion batteries Functional surface structures Contact angle Specific capacity

Distribution and phenogenetic diversity of Synechococcus in the Bohai Sea, China

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Journal of Oceanology and Limnology 2022年第2期40卷 592-604页

作者： Ting WANG Xi chen Jialin LI Song QIN College of Environmental Science and Engineering Ocean University of ChinaQingdao 266100China Key Lab of Coastal Biology and Biological Resource Utilization Yantai Institute of Coastal Zone ResearchChinese Academy of SciencesYantai 264003China College of Marine Life Science Ocean University of ChinaQingdao 266005China Center for Ocean Mega-Science Chinese Academy of SciencesQingdao 266071China

Synechococcus is one of the most abundant picocyanobacteria in marine ecosystem,and the absence of Prochlorococcus would make it indispensable as a primary producer in the Bohai Sea,North ***,the abundance distribution and genetic diversity of Synechococcus in this region have rarely been *** this study,the distribution pattern of Synechococcus abundance was investigated during four cruises in April,June,August,and November from 2018 to 2019,moreover,its phenogenetic diversity was studied based on high-throughput sequencing of the cpe BA *** results demonstrate that phycoerythrin-containing Synechococcus was most abundant in August when temperature was high and oxygen saturation was *** this period,Synechococcus pigment type(PT)2 was abundant in the Bohai Bay and Laizhou Bay under conditions of high nutrient concentration,temperature,and *** comparison,PT3,especially those clusters characterized with high or variable ratio of phycourobilin and phycoerythrobilin,was predominant in the Bohai Strait and Liaodong Bay under conditions of high salinity,pH,and oxygen ***,co-occurrence correlations using network analysis revealed that Synechococcus PTs were related to 15.37%-43.48%of the prokaryotic *** PT3c/PT3d and PT2 were the most important PTs in the *** hierarchical clustering revealed that taxa co-occurred with Synechococcus PTs diff ered among *** could be attributed to the substance exchange and the environmental impact,which calls for more studies in the future.

关键词： Synechococcus phenogenetic diversity co-occurrence network coastal ecosystem Bohai Sea