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Effectiveness of Zhenqi Buxue Oral Liquid Combined with Progesterone for Treatment of Oligomenorrhea and Hypomenorrhea with Qi-Blood and Kidney(Shen)Essence Deficiency:A Randomized Controlled Trial

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Chinese Journal of Integrative Medicine 2023年第11期29卷 963-970页

作者： GAN Jing-wen LV De-xin FU Jin SHI Liang-yan YUAN Chun-yan zeng xiao-qin LI Jun SUN Ai-jun National Clinical Research Center for Obstetric&Gynecologic Diseases Department of Obstetrics and GynecologyPeking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical College Address:Peking Union Medical College Hospital(East)Beijing(100730)China Department of Obstetrics and Gynecology Liuzhou Maternal and Child Health Care HospitalLiuzhouGuangxi Zhuang Autonomous Region(545001)China Department of Obstetrics and Gynecology Sichuan University West China Second University HospitalChendu(610066)China Department of Obstetrics and Gynecology Maternal and Child Health Hospital of Hubei ProvinceWuhan(430070)China Department of Obstetrics and Gynecology Southeast University Zhongda HospitalNanjing(210009)China Department of Obstetrics and Gynecology Guangzhou Women and Children's Medical CenterGuangzhou(510623)China Department of Obstetrics and Gynecology the First Hospital of Hebei Medical UniversityShijiazhuang(050000)China

Objective:To evaluate the effectiveness and safety of Zhenqi Buxue Oral Liquid(ZQ),progesterone capsules,and their combination in treating oligomenorrhea and hypomenorrhea with qi-blood and Kidney(Shen)essence ***:This was a prospective,randomized,multi-center controlled trial between June 2022 to December ***-six oligomenorrhea and hypomenorrhea patients with qi-blood and Shen essence deficiency were randomly assigned to receive ZQ(ZQ group,29 cases),progesterone capsules(PG group,32 cases),or the combined Chinese and Western medicine(COM group,31 cases)at a ratio of 1:1:*** in the ZQ or PG group took daily 10 m L twice a day of ZQ or 200 mg once a day of progesterone capsules for 10 consecutive days on day 15 of the menstrual cycle respectively,and patients in the COM group received the same ZQ combined with progesterone *** treatment course lasted for 3 months and follow-up was performed at 1 and 3 months after the end of *** endpoint was the menstrual Traditional Chinese Medicine Syndrome Scale(TCMSS)*** endpoints included pictorial blood loss assessment chart(PBAC)scores,clinical efficacy rate,36-item Short Form Health Survey(SF-36)scores,sex hormones and thickness of *** events(AEs)were ***:TCMSS scores after 1-and 3-month treatment in all groups were significantly lower than those at baseline(P<0.05).Only TCMSS scores after 3-month treatment in the ZQ and COM groups continuously decreased compared with those after 1-month treatment in the same group(P<0.01).TCMSS scores after 3-month treatment in the ZQ and COM groups were significantly lower than those in the PG group(P<0.05,P<0.01).Compared with baseline,PBAC scores in the ZQ and COM groups after 3 months of treatment were also significantly higher(both P<0.01).The total effective rates of TCM syndrome of 3-month treatment were significantly improved in all groups compared with that after 1 month of treatment(P<0.

关键词： Kidney Blood treatment

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Gene mapping and candidate gene analysis of multi-floret spikelet 3(mfs3) in rice(Oryza sativa L.)

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Journal of Integrative Agriculture 2019年第12期18卷 2673-2681页

作者： ZHENG Hao ZHANG Jun ZHUANG Hui zeng xiao-qin TANG Jun WANG Hong-lei CHEN Huan LI Yan LING Ying-hua HE Guang-hua LI Yun-feng Chongqing Key Laboratory of Application and Safety Control of Genetically Modified Crops/Rice Research Institute Southwest University

Rice(Oryza sativa L.) is one of the most important food crops worldwide and a model monocot plant for gene function analysis, so it is an ideal system for studying flower development. This study reports a mutant, named multi-floret spikelet 3(mfs3), which is related to the spikelet development in rice and derived from the ethylmethane sulfonate(EMS)-treated rice cultivar XIDA 1 B. In mfs3, the main body of palea(bop) was degenerated severely and only glume-like marginal regions of palea(mrp) remained, while other floral organs developed normally, indicating that the palea identity was seriously influenced by the mutation. It was also observed that the number of floral organs was increased in some spikelets, including 2 lemmas, 4 mrp, 4 lodicules, 8–10 stamens, and 2 pistils, which meant that the spikelet determinacy was lost to some degree in mfs3. Furthermore, genetic analysis demonstrated that the mfs3 trait was controlled by a single recessive gene. Using 426 F2 mutants derived from the cross between sterile line 56 S and mfs3, the MULTI-FLORET SPIKELET 3(MFS3) gene was mapped between the molecular markers RM19347 and RM19352 on Chr.6, with a physical distance of 106.3 kb. Sequencing of candidate genes revealed that an 83-bp fragment loss and a base substitution occurred in the LOC_Os06 g04540 gene in the mutant, confirming preliminarily that the LOC_Os06 g04540 gene was the MFS3 candidate gene. Subsequent q PCR analysis showed that the mutation caused the down-regulation of Os MADS1 and FON1 genes, and the up-regulation of Os IDS1 and SNB genes, which are all involved in the regulation of spikelet development. The MFS3 mutation also significantly reduced the transcription of the REP gene, which is involved in palea development. These results indicated that the MFS3 gene might be involved in the spikelet meristem determinacy and palea identity by regulating the expression of these related genes.

关键词： rice(Oryza sativa) multi-floret spikelet palea degeneration gene mappi ng can didate gene

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YGL9, encoding the putative chloroplast signal recognition particle 43 kDa protein in rice, is involved in chloroplast development

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Journal of Integrative Agriculture 2016年第5期15卷 944-953页

作者： WANG Zhong-wei ZHANG Tian-quan XING Ya-di zeng xiao-qin WANG Ling LIU Zhong-xian SHI Jun-qiong ZHU xiao-yan MA Ling LI Yun-feng LING Ying-hua SANG Xian-chun HE Guang-hua Chongqing Key Laboratory of Application and Safety Control of Genetically Modified Crops Rice Research Institute Southwest University Chongqing 400715 P.R. China

The nuclear-encoded light-harvesting chlorophyll a/b-binding proteins（LHCPs） are specifically translocated from the stroma into the thylakoid membrane through the chloroplast signal recognition particle（cp SRP） pathway. The cp SRP is composed of a cp SRP43 protein and a cp SRP54 protein, and it forms a soluble transit complex with LHCP in the chloroplast stroma. Here, we identified the YGL9 gene that is predicted to encode the probable rice cp SRP43 protein from a rice yellow-green leaf mutant. A phylogenetic tree showed that an important conserved protein family, cp SRP43, is present in almost all green photosynthetic organisms such as higher plants and green algae. Sequence analysis showed that YGL9 comprises a chloroplast transit peptide, three chromodomains and four ankyrin repeats, and the chromodomains and ankyrin repeats are probably involved in protein-protein interactions. Subcellular localization showed that YGL9 is localized in the chloroplast. Expression pattern analysis indicated that YGL9 is mainly expressed in green leaf sheaths and leaves. Quantitative real-time PCR analysis showed that the expression levels of genes associated with pigment metabolism, chloroplast development and photosynthesis were distinctly affected in the ygl9 mutant. These results indicated that YGL9 is possibly involved in pigment metabolism, chloroplast development and photosynthesis in rice.

关键词： Oryza sativa yellow-green leaf gene cpSRP43 light-harvesting chlorophyll a/b-binding protein

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Erythrocytic or serum hydrogen sulfide association with hypertension development in untreated essential hypertension

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Chinese Medical Journal 2011年第22期124卷 3693-3701页

作者： ZHENG Mei zeng Qiang SHI xiao-qin ZHAO Jing TANG Chao-shu SUN Ning-ling GENG Bin Department of Cardiac Center Peking University People＇s Hospital Beijing 100044 China

Background Endogenous hydrogen sulfide （H2S） plays an important role in hypertension. The aim of this study was to investigate the role of erythrocyte and serum H2S in patients with untreated essential hypertension. Methods We recruited 62 patients （age 22-74 years） with untreated prehypertension or hypertension, and 64 normotensive subjects （age 18-64 years）. We assessed the 3-mercaptopyruvate sulphurtransferase （MPST） protein expression in erythrocytes and measured the H2S production from erythrocytes and serum H2S levels, then analyzed the association of erythrocytic or serum H2S content and blood pressure or cardiovascular risk factors （e.g., age, body mass index （BMI） and dyslipidemia）. A stepwise regression analysis was used to evaluate the possible relationship of erythrocytic H2S in hypertension. Results In hypertensive patients, erythrocyte H2S production （（111.04_＋.29.20） nmol/min per 10a erythrocytes） was higher than that in controls （（78.85＋19.38） nmol/min per 108 erythrocytes）, and serum H2S was also higher. The erythrocytic H2S production was associated with increased systolic blood pressure （sBP）, diastolic blood pressure （dBP）, age, BMI, level of C-reactive protein （CRP）, as well as triglycerides （TG） and high density lipoprotein cholesterol （HDL-C） Serum H2S was not associated with age or CRP. Stepwise regression analysis showed that erythrocytic H2S production was correlated with sBP, TG, HDL-C, low density lipoprotein cholesterol （LDL-C） and blood urea nitrogen （BUN） and serum H2S was correlated with dBP and TG. Results of receiver-operating characteristic curve analysis suggested that erythrocytic H2S production was a more sensitive predictor of hypertension development than serum H2S. Conclusion Ervthrocvtic or serum H^S Production is sensitive predictor of hvDertension.

关键词： erythroeyte hydrogen sulfide 3-mercaptopyruvate sulphurtransferase hypertension

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Effect of zirconium addition on microstructure and mechanical properties of Mg_(97)Y_2Zn_1 alloy

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Transactions of Nonferrous Metals Society of China 2012年第4期22卷 773-778页

作者：陈彬卢晨林栋樑曾小勤上海交通大学材料科学与工程学院上海200240

The effects of zirconium addition on the microstructure and mechanical properties of Mg97Y2Zn1 alloy were *** microstructure of as-cast Mg97Y2Zn1 alloy is refined by the addition of *** the extrusion,the initial nucleation sites of the alloy are mainly original grain boundaries and secondary *** addition of zirconium could stimulate the DRX process because more grain boundaries are formed,which increases the dynamic recrystallization *** the strength and elongation of the alloy are increased by the addition of zirconium.

关键词： Mg97Y2Zn1 zirconium microstructure mechanical properties

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一种基于边的上下文相关图文法形式化框架

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软件学报 2008年第8期19卷 1893-1901页

作者：曾晓勤韩秀清邹阳河海大学计算机及信息工程学院江苏南京210098

围绕解决图文法中的主要问题——嵌入问题,提出了一种基于边的上下文相关图文法形式化框架,并对由此定义的文法的一些性质及相应的归约算法进行了讨论.对所提出的图文法与已有的文法进行了比较.同时,展望了今后值得进一步研究的一些问... 详细信息

围绕解决图文法中的主要问题——嵌入问题,提出了一种基于边的上下文相关图文法形式化框架,并对由此定义的文法的一些性质及相应的归约算法进行了讨论.对所提出的图文法与已有的文法进行了比较.同时,展望了今后值得进一步研究的一些问题和方向.

关键词：可视化语言形式化图文法嵌入问题产生式

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AZ31镁合金表面气相沉积不锈钢薄膜的实验研究

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材料工程 2006年第z1期34卷 43-46页

作者：吴国松曾小勤姚寿山上海交通大学轻合金精密成型国家工程研究中心上海200030

利用真空蒸发镀膜技术在镁合金表面沉积不锈钢薄膜是提高镁合金防腐性能的新尝试。本研究利用该技术在AZ31上成功制备了不锈钢薄膜。通过在5%NaCl溶液中的浸入实验和极化实验考察了腐蚀性能,发现镀膜后耐蚀性显著降低。另外,镀膜后的显... 详细信息

利用真空蒸发镀膜技术在镁合金表面沉积不锈钢薄膜是提高镁合金防腐性能的新尝试。本研究利用该技术在AZ31上成功制备了不锈钢薄膜。通过在5%NaCl溶液中的浸入实验和极化实验考察了腐蚀性能,发现镀膜后耐蚀性显著降低。另外,镀膜后的显微硬度也未有明显提高。利用AFM,SEM,EDX等分析手段对薄膜进行了观察和检测,发现耐蚀性变差的原因主要是薄膜表面存在贯穿性的微米级孔洞和Cr元素分布不均匀造成的。

关键词：镁合金不锈钢薄膜气相沉积腐蚀表面形貌

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Mg_(97)Y_2Zn_1合金高温热压缩流动行为

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上海交通大学学报 2010年第5期44卷 593-597页

作者：陈彬卢晨林栋樑曾小勤上海交通大学材料科学与工程学院上海200240

通过Gleeble-3500型热模拟机研究了Mg97Y2Zn1镁合金在热变形过程中流变应力与变形温度和应变速率等之间的关系,并建立了相应的流变应力模型.结果表明:在所采用的试验条件下,Mg97Y2Zn1合金的流变应力随变形温度的升高而降低,随应变速率... 详细信息

通过Gleeble-3500型热模拟机研究了Mg97Y2Zn1镁合金在热变形过程中流变应力与变形温度和应变速率等之间的关系,并建立了相应的流变应力模型.结果表明:在所采用的试验条件下,Mg97Y2Zn1合金的流变应力随变形温度的升高而降低,随应变速率的增加而提高;Mg97Y2Zn1合金的流动应力应变行为可用Zener-Hollomon参数表示;Mg97Y2Zn1合金在高温塑性变形过程中的平均变形激活能为137.277 kJ/mol.

关键词： Mg97Y2Zn1合金热压缩变形流变应力 Zener-Hollomon参数变形激活能

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Recent Strategies and Advances in Hydrogel‑Based Delivery Platforms for Bone Regeneration

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Nano-Micro Letters 2025年第3期17卷 389-439页

作者： xiao Wang Jia zeng Donglin Gan Kun Ling Mingfang He Jianshu Li Yongping Lu Scientific and Technological Innovation Center for Biomedical Materials and Clinical Research Guangyuan Key Laboratory of Multifunctional Medical HydrogelGuangyuan Central HospitalGuangyuan 628000People’s Republic of China Jiangsu Collaborative Innovation Center of Biomedical Functional Materials Jiangsu Key Laboratory of Bio‑Functional MaterialsSchool of Chemistry and Materials ScienceNanjing Normal UniversityNanjing 210023People’s Republic of China College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu 610065People’s Republic of China

Bioactive molecules have shown great promise for effectively regulating various bone formation processes,rendering them attractive therapeutics for bone ***,the widespread application of bioactive molecules is limited by their low accumulation and short half-lives in *** have emerged as ideal carriers to address these challenges,offering the potential to prolong retention times at lesion sites,extend half-lives in vivo and mitigate side effects,avoid burst release,and promote adsorption under physiological *** review systematically summarizes the recent advances in the development of bioactive molecule-loaded hydrogels for bone regeneration,encompassing applications in cranial defect repair,femoral defect repair,periodontal bone regeneration,and bone regeneration with underlying ***,this review discusses the current strategies aimed at improving the release profiles of bioactive molecules through stimuli-responsive delivery,carrier-assisted delivery,and sequential ***,this review elucidates the existing challenges and future directions of hydrogel encapsulated bioactive molecules in the field of bone regeneration.

关键词： Hydrogel Bone regeneration Bioactive molecules Drug delivery Nano-/microscale carriers

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基于生成对抗网络的图像修复

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计算机科学 2018年第12期45卷 229-234,261页

作者：孙全曾晓勤河海大学计算机与信息学院智能科学与技术研究所南京211100

针对现有图像修复算法存在受损区域的形状和大小受限以及修复痕迹明显、修复边缘不连续的问题,文中提出一种基于生成对抗网络的图像修复方法。该方法采用生成对抗网络(Generative Adversarial Networks,GAN)这种新的生成模型作为基本架... 详细信息

针对现有图像修复算法存在受损区域的形状和大小受限以及修复痕迹明显、修复边缘不连续的问题,文中提出一种基于生成对抗网络的图像修复方法。该方法采用生成对抗网络(Generative Adversarial Networks,GAN)这种新的生成模型作为基本架构,结合Wasserstein距离,同时融入条件对抗网络(CGAN)的思想;以破损图像作为附加条件信息,采用对抗损失与内容损失相结合的方式来训练网络模型,以修复破损区域。此方法能够修复大多数破损情况下的图像。在CelebA和LFW两个数据集上的实验结果表明,所提方法能够取得很好的修复效果。

关键词：生成对抗网络图像修复对抗学习 Wasserstein距离

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