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Antitumor effects of a novel photosensitizer-mediated photodynamic therapy and its influence on the cell transcriptome

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Oncology Research 2024年第5期32卷 911-923页

作者： JINGJING CHEN DAN wang zequn wang MENGYUAN HAN HOUQING YIN WENTING ZHOU RIBAI YAN YAN PAN Department of Pharmacology School of PharmacyChangzhi Medical CollegeChangzhiChina2 Department of PharmacologySchool of Basic Medical SciencesHealth Science CenterPeking UniversityBeijingChina3 Beijing Key Laboratory of Tumor Systems BiologyPeking UniversityBeijingChina4 Department of PharmacologyXinjiang Medical UniversityUrumqiChina5 School of Pharmaceutical SciencesPeking UniversityBeijingChina

Photodynamic therapy(PDT)is a promising cancer *** study investigated the antitumor effects and mechanisms of a novel photosensitizer meso-5-[ρ-diethylene triamine pentaacetic acid-aminophenyl]−10,15,20-triphenyl-porphyrin(DTP)mediated PDT(DTP-PDT).Cell viability,reactive oxygen species(ROS),and apoptosis were measured with a Cell Counting Kit-8 assay,DCFH-DA fluorescent probe,and Hoechst staining,*** apoptosis-and autophagy-related proteins were examined using western *** sequencing was used to screen differentially expressed mRNAs(DERs),and bioinformatic analysis was performed to identify the major biological events after *** results show that DTP-PDT inhibited cell growth and induced ROS generation in MCF-7 and SGC7901 *** ROS scavenger N-acetyl-L-cysteine(NAC)and the P38 MAPK inhibitor SB203580 alleviated DTP-PDT-induced ***-PDT induced cell apoptosis together with upregulated Bax and downregulated Bcl-2,which could also be inhibited by NAC or *** level of LC3B-Ⅱ,a marker of autophagy,was increased by DTP-PDT.A total of 3496 DERs were obtained after *** Ontology and Kyoto Encyclopedia of Genes and Genomes analyses indicated that DERs included those involved in cytosolic ribosomes,the nuclear lumen,protein binding,cell cycle,protein targeting to the endoplasmic reticulum,and ribosomal DNA *** Ontology and Reactome enrichment analyses indicated that DERs were associated with a variety of cancers and cell cycle ***-protein interaction results demonstrated that cdk1 and rps27a ranked in the top 10 interacting ***,DTP-PDT could inhibit cell growth and induce cell apoptosis and autophagy,partly through ROS and the P38 MAPK signaling *** associated with the cell cycle,ribosomes,DNA replication,and protein binding may be the key changes in DTP-PDT-mediated cytotoxicity.

关键词： Photodynamic therapy ROS Apoptosis Autophagy Bioinformatic analysis

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Chromosomal in situ hybridization of Cyprinus carpio genomic DNA repetitive sequence CR1

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Chinese Science Bulletin 1999年第24期44卷 2242-2246页

作者： zequn wang Zuoyan Zhu Chinese Acad Sci Inst Hydrobiol State Key Lab Freshwater Ecol & Biotechnol Wuhan 430072 Peoples R China

Common carp Cyprinus carpio genomic DNA repetitive sequence CR1 has been DIG-labeled and hybridized in situ against chromosomes of red common carp ( Cyprinus carpio L. Xingguo red var.). It is found that the repetitive sequence CR1 is mainly localized at the cen-tromeric regions of chromosomes of the red common carp. The application of the

关键词： common carp repetitive sequences chromosomal in situ hybridization DIG-labeling.

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Picture-Induced EEG Signal Classification Based on CVC Emotion Recognition System

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Computers, Materials & Continua 2020年第11期65卷 1453-1465页

作者： Huiping Jiang zequn wang Rui Jiao Shan Jiang Brain Cognitive Computing Lab School of Information EngineeringMinzu University of ChinaBeijing100081China Information School The University of SheffieldSheffieldUK

Emotion recognition systems are helpful in human-machine interactions and Intelligence Medical ***(EEG)is closely related to the central nervous system activity of the *** with other signals,EEG is more closely associated with the emotional *** is essential to study emotion recognition based on EEG *** the research of emotion recognition based on EEG,it is a common problem that the results of individual emotion classification vary greatly under the same scheme of emotion recognition,which affects the engineering application of emotion *** order to improve the overall emotion recognition rate of the emotion classification system,we propose the CSP_VAR_CNN(CVC)emotion recognition system,which is based on the convolutional neural network(CNN)algorithm to classify emotions of EEG ***,the emotion recognition system using common spatial patterns(CSP)to reduce the EEG data,then the standardized variance(VAR)is selected as the parameter to form the emotion feature ***,a 5-layer CNN model is built to classify the EEG *** classification results show that this emotion recognition system can better the overall emotion recognition rate:the variance has been reduced to 0.0067,which is a decrease of 64%compared to that of the CSP_VAR_SVM(CVS)*** the other hand,the average accuracy reaches 69.84%,which is 0.79%higher than that of the CVS *** shows that the overall emotion recognition rate of the proposed emotion recognition system is more stable,and its emotion recognition rate is higher.

关键词： Deep learning convolutional neural network electroencephalogram emotional classification

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混合纳米结构增强水蒸发的分子机制

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工程热物理学报 2024年第9期45卷 2773-2778页

作者：王泽群安盟孙旭辉陈东升施俊文袁越锦陕西科技大学机电工程学院西安710021 轻工业西安机械设计研究院有限公司西安710086

本文通过分子动力学模拟研究了亲疏水混合纳米结构表面对水蒸发的分子尺度影响机制。分子动力学模拟结果表明混合润湿性纳米结构表面可有效提升水的蒸发速率。通过分析水分子与纳米结构表面之间的相互作用,发现混合纳米结构表面可以调... 详细信息

本文通过分子动力学模拟研究了亲疏水混合纳米结构表面对水蒸发的分子尺度影响机制。分子动力学模拟结果表明混合润湿性纳米结构表面可有效提升水的蒸发速率。通过分析水分子与纳米结构表面之间的相互作用,发现混合纳米结构表面可以调节水分子的蒸发屏障。本文有助于理解纳米结构表面水蒸发的物理机制,为设计高效的界面蒸发结构提供有效指导。

关键词：界面蒸发润湿性分子动力学模拟蒸发势垒

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东滩煤矿四采南部三号带式输送机设计改造

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煤矿现代化 2024年第4期33卷 5-8页

作者：王泽群张召毅满乐兖矿能源集团股份有限公司东滩煤矿山东邹城273500

近年来随着煤炭开采技术的发展,高速、长距离、智能化、大运量带式运输机的应用也越来越多。其中,下运运输方式不但可以减少巷道开采量,并能很大程度的减少基础建设费用以及缩短了施工的时间周期。所以,尤其是下运带式输送机的应用越来... 详细信息

近年来随着煤炭开采技术的发展,高速、长距离、智能化、大运量带式运输机的应用也越来越多。其中,下运运输方式不但可以减少巷道开采量,并能很大程度的减少基础建设费用以及缩短了施工的时间周期。所以,尤其是下运带式输送机的应用越来越广泛。本文以东滩煤矿四采南部三号带式输送机为例,分析研究下运工况下带式输送机的选型。通过对输送机运行阻力计算,研究结果得出,当圆周驱动力为负值时,驱动单元受力方向与设备运行方向相反,提供输送机向下运行所需的控制力,确定输送机运行功率为2×400 kW,一用一备。又通过对输送机进行各点张力计算,确定带式输送机下运工况下输送带、制动器等型号参数。对于企业井下输送机选用及选型有一定的参考意义。

关键词：圆周驱动力张力驱动形式运行阻力

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A Thermochromic, Viscoelastic Nacre-like Nanocomposite for the Smart Thermal Management of Planar Electronics

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Nano-Micro Letters 2023年第10期15卷 182-196页

作者： Jiemin wang Tairan Yang zequn wang Xuhui Sun Meng An Dan Liu Changsheng Zhao Gang Zhang Weiwei Lei College of Biomedical Engineering Sichuan UniversityChengdu 610064People’s Republic of China Institute for Frontier Materials Deakin UniversityWaurn Ponds CampusLocked Bag 20000GeelongVictoria 3220Australia College of Mechanical and Electrical Engineering Shaanxi University of Science and TechnologyXi’an 710021People’s Republic of China State Key Laboratory of Polymer Materials Engineering College of Polymer Science and EngineeringSichuan UniversityChengdu 610065People’s Republic of China Institute of High Performance Computing A*STAR Singapore 138632Singapore

Cutting-edge heat spreaders for soft and planar electronics require not only high thermal conductivity and a certain degree of flexibility but also remarkable self-adhesion without thermal interface materials, elasticity, arbitrary elongation along with soft devices, and smart properties involving thermal self-healing, thermochromism and so on. Nacre-like composites with excellent in-plane heat dissipation are ideal as heat spreaders for thin and planar electronics. However, the intrinsically poor viscoelasticity, i.e., adhesion and elasticity, prevents them from simultaneous self-adhesion and arbitrary elongation along with current flexible devices as well as incurring high interfacial thermal impedance. In this paper, we propose a soft thermochromic composite(STC) membrane with a layered structure, considerable stretchability, high in-plane thermal conductivity(~30 Wm^(-1) K^(-1)), low thermal contact resistance(~12 mm^2 KW^(-1), 4–5 times lower than that of silver paste), strong yet sustainable adhesion forces(~4607 Jm^(-2), 2220 Jm^(-2) greater than that of epoxy paste) and self-healing efficiency. As a self-adhesive heat spreader, it implements efficient cooling of various soft electronics with a temperature drop of 20℃ than the polyimide case. In addition to its self-healing function, the chameleon-like behavior of STC facilitates temperature monitoring by the naked eye, hence enabling smart thermal management.

关键词： Boron nitride nanosheets Nacre-inspired composites Viscoelastic Thermochromic Smart thermal management

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基于YOLOv5的复杂信号发现检测与分类

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航天电子对抗 2024年第4期40卷 44-51页

作者：王泽群徐璐时睿张一嘉浙江理工大学信息科学与工程学院浙江杭州310018

随着无线通信技术的发展,电磁环境变得越来越复杂,各种类型的信号与噪声同时存在于频谱中,这对接收机的信号检测技术提出了更大的挑战。对通信信号的检测是无线对抗过程中非常重要的一环,只有实现对信号的正确检测才能够完成后续的信号... 详细信息

随着无线通信技术的发展,电磁环境变得越来越复杂,各种类型的信号与噪声同时存在于频谱中,这对接收机的信号检测技术提出了更大的挑战。对通信信号的检测是无线对抗过程中非常重要的一环,只有实现对信号的正确检测才能够完成后续的信号识别、参数估计、解调等步骤。信号的发现检测最主要的目的,是通过宽带频谱数据判断是否有信号存在。此外,实际的战场环境下可能同时充斥着跳频、猝发以及定频等信号,不同的信号对应着不同的处理方式。传统算法通常采用的是能量检测的方式,但在信噪比较低的情况下很难区分噪声与信号。而实际情况是可以在时频图中发现信号,并观察出类别。因此,通过对时频瀑布图的特征提取,提出一种基于深度学习的更高精度的信号发现检测和分类方法。

关键词：信号检测深度学习信号分类 YOLOv5

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Exploring the potential of olivine-containing copper-nickel slag for carbon dioxide mineralization in cementitious materials

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International Journal of Minerals,Metallurgy and Materials 2024年第3期31卷 562-573页

作者： Qianqian wang zequn Yao Lijie Guo Xiaodong Shen College of Materials Science and Engineering Nanjing Tech UniversityNanjing 211816China State Key Laboratory of Materials-Oriented Chemical Engineering Nanjing 211816China BGRIMM Technology Group Beijing 100160China

Water-quenched copper-nickel metallurgical slag enriched with olivine minerals exhibits promising potential for the production of CO_(2)-mineralized cementitious *** this work,copper-nickel slag-based cementitious material(CNCM)was synthesized by using different chemical activation methods to enhance its hydration reactivity and CO_(2) mineralization *** water curing ages and carbonation conditions were explored related to their carbonation and mechanical properties ***,thermogravimetry differential scanning calorimetry and X-ray diffraction methods were applied to evaluate the CO_(2) adsorption amount and carbonation products of *** development of carbonated CNCM blocks was examined by backscattered electron imaging(BSE)with energy-dispersive X-ray *** showed that among the studied samples,the CNCM sample that was subjected to water curing for 3 d exhibited the highest CO_(2) sequestration amount of 8.51wt%at 80℃and 72 h while presenting the compressive strength of 39.07 *** result indicated that 1 t of this CNCM can sequester 85.1 kg of CO_(2) and exhibit high compressive *** the addition of citric acid did not improve strength development,it was beneficial to increase the CO_(2) diffusion and adsorption amount under the same carbonation conditions from BSE *** work provides guidance for synthesizing CO_(2)-mineralized cementitious materials using large amounts of metallurgical slags containing olivine minerals.

关键词： copper-nickel slag fayalite CO_(2)sequestration cementitious material admixtures carbonation conditions

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Carbon nanotube: Controlled synthesis determines its future

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Science China Materials 2020年第1期63卷 16-34页

作者： Shuchen Zhang Liu Qian Qiuchen Zhao zequn wang Dewu Lin Weiming Liu Yabin Chen Jin Zhang Center for Nanochemistry Beijing Science and Engineering Center for NanocarbonsBeijing National Laboratory for Molecular SciencesCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China School of Aerospace Engineering Beijing Institute of TechnologyBeijing 100081China

Carbon nanotubes(CNTs) have received broad attention in the past decades due to their excellent physical and chemical properties and thus been regarded as a powerful candidate for future star-materials. Although various CNT products and their related applications have been demonstrated recently, their performance can hardly meet the researchers’ expectations compared with their theoretical properties. The current predicament is caused by the immature synthesis method, including the basic science and the producing technology. As the synthesis with controlled structures determines its future, this review summarizes the progress on the basic research and industrialization of CNTs in the past decades, including the fine structure control, aggregation status design and scale-up production, and further points out the way for the future development of CNTs combining with specific applications.

关键词： carbon nanotubes structure-controlled synthesis scale-up synthesis applications

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QARF: A Novel Malicious Traffic Detection Approach via Online Active Learning for Evolving Traffic Streams

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Chinese Journal of Electronics 2024年第3期33卷 645-656页

作者： zequn NIU Jingfeng XUE Yong wang Tianwei LEI Weijie HAN Xianwei GAO School of Computer Science and Technology Beijing Institute of Technology School of Space Information Space Engineering University

In practical abnormal traffic detection scenarios,traffic often appears as drift,imbalanced and rare labeled streams,and how to effectively identify malicious traffic in such complex situations has become a challenge for malicious traffic *** have extensive studies on malicious traffic detection with single challenge,but the detection of complex traffic has not been widely *** adaptive random forests(QARF) is proposed to detect traffic streams with concept drift,imbalance and lack of labeled *** is an online active learning based approach which combines adaptive random forests method and adaptive margin sampling *** achieves querying a small number of instances from unlabeled traffic streams to obtain effective *** conduct experiments using the NSL-KDD dataset to evaluate the performance of *** is compared with other state-of-the-art *** experimental results show that QARF obtains 98.20% accuracy on the NSL-KDD *** performs better than other state-of-the-art methods in comparisons.

关键词： Training Streams Random forests

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