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Folate-chitosan-gemcitabine core-shell nanoparticles targeted to pancreatic cancer

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Chinese Journal of Cancer Research 2013年第5期25卷 527-535页

作者： Jiahua Zhou Junying Wang Qian Xu Shi Xu Jin Wen zeqian yu Detong Yang Department of General Surgery Zhongda HospitalSchool of MedicineSoutheast University Ministry of Education Key Laboratory of Environmental Medicine and Engineering Southeast University

Objective：Human pancreatic cancer is one of the most common clinical *** effect of comprehensive treatment based on surgery is *** effects of chemotherapy were not obvious mainly because of lack of targeting and chemoresistance in pancreatic *** study aimed to investigate the effects of folate receptor （FR）-mediated gemcitabine FA-Chi-Gem nanoparticles with a core-shell structure by electrostatic spray on pancreatic ***：In this study,the levels of expression of FR in six human pancreatic cancer cell lines were studied by immunohistochemical *** uptake rate of isothiocyanate-labeled FA-Chi nanoparticles in FR high expression cell line COLO357 was assessed by fluorescence microscope and the inhibition rate of FA-Chi-Gem nanoparticles on COLO357 cells was evaluated by MTT ***,the biodistribution of PEG-FA-ICGDER02-Chi in the orthotopic pancreatic tumor model was observed using near-infrared imaging and the human pancreatic cancer orthotopic xenografts were treated with different nanoparticles and normal saline ***：The expression of FR in COLO357 was the highest among the six pancreatic cancer cell *** FR mainly distributed on cell membrane and fewer in the cytoplasm in pancreatic ***,the absorption rate of the FA-Chi-Gem nanoparticles was more than the Chi nanoparticles without FA *** proliferation of COLO357 was significantly inhibited by FA-Chi-Gem *** PEG-FA-ICGDER02-Chi nanoparticles were enriched in tumor tissue in human pancreatic cancer xenografts,while non-targeted nanoparticles were mainly in normal liver ***-FA-Gem-Chi significantly inhibited the growth of human pancreatic cancer xenografts （PEG-FA-Gem-Chi ***,t=22.950,P=0.000）.Conclusions：PEG-FA-FITC-Chi nanoparticles might be an effective targeted drug for treating human FR-positive pancreatic cancer.

关键词： Pancreatic cancer folate receptor targeted nanoparticle gemcitabine

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Exosomes在肿瘤微环境中的作用

国际外科学杂志 2014年第1期41卷 54-58页

作者：任龙余泽前周家华东南大学医学院南京210009 东南大学附属中大医院普外科南京210009

肿瘤微环境是指肿瘤细胞在生长过程中,由肿瘤细胞及细胞外间质相互作用后形成的肿瘤细胞生长的特殊环境.肿瘤微环境作为保护和支持肿瘤发生、发展及转移复发的必要机构功能单元的理论已为越来越多的学者所接受.而最新的研究证据表明,exo... 详细信息

肿瘤微环境是指肿瘤细胞在生长过程中,由肿瘤细胞及细胞外间质相互作用后形成的肿瘤细胞生长的特殊环境.肿瘤微环境作为保护和支持肿瘤发生、发展及转移复发的必要机构功能单元的理论已为越来越多的学者所接受.而最新的研究证据表明,exosomes在肿瘤微环境中,参与了细胞与细胞间的沟通,对肿瘤的进展可能起到了举足轻重的作用.本文总结近年来的文献,就exosomes的性质、生物学作用以及作为肿瘤微环境的重要组成部分在肿瘤进展中的潜在作用作一综述.

关键词： Exosomes 肿瘤微环境血管生成素类肿瘤转移

Silk damping in scalar-induced gravitational waves: a novel probe for new physics

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 79-85页

作者： Yan-Heng yu Sai Wang Theoretical Physics Division Institute of High Energy Physics Chinese Academy of Sciences School of Physics University of Chinese Academy of Sciences

Silk damping is well known in the study of cosmic microwave background（CMB） and accounts for suppression of the angular power spectrum of CMB on large angular multipoles. In this article, we study the effect of Silk damping on the scalar-induced gravitational waves（SIGWs）. Resulting from the dissipation of cosmic fluid, the Silk damping notably suppresses the energydensity spectrum of SIGWs on scales comparable to a diffusion scale at the decoupling time of weakly-interacting particles. The effect offers a novel observable for probing the underlying particle interaction, especially for those mediated by heavy gauge bosons beyond the standard model of particles. We anticipate that pulsar timing arrays are sensitive to gauge bosons with mass ～10～3-10～4 GeV, while space-and ground-based interferometers to those with mass ～10～7-1012GeV, leading to essential complements to on-going and future experiments of high-energy physics.

关键词： scalar-induced gravitational waves Silk damping new physics

Interconnections between diabetic corneal neuropathy and diabetic retinopathy:diagnostic and therapeutic implications

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Neural Regeneration Research 2025年第8期20卷 2169-2180页

作者： Mingyi yu Faith Teo En Ning Chang Liu yu-Chi Liu Tissue Engineering and Stem Cell Group Singapore Eye Research InstituteSingapore Yong Loo Lin School of Medicine National University of SingaporeSingapore Department of Cornea and External Eye Disease Singapore National Eye CenterSingapore Ophthalmology and Visual Sciences Academic Clinical Program Duke-NUS Medical SchoolSingapore

Diabetic corneal neuropathy and diabetic retinopathy are ocular complications occurring in the context of diabetes *** corneal neuropathy refers to the progressive damage of corneal *** retinopathy has traditionally been considered as damage to the retinal ***,growing evidence suggests that diabetic retinopathy is a complex neurovascular disorder resulting from dysfunction of the neurovascular unit,which includes both the retinal vascular structures and neural *** retinopathy is one of the leading causes of blindness and is frequently screened for as part of diabetic ocular ***,diabetic corneal neuropathy is commonly overlooked and underdiagnosed,leading to severe ocular surface *** studies have found that these two conditions tend to occur together,and they share similarities in their pathogenesis pathways,being triggered by a status of chronic *** review aims to discuss the interconnection between diabetic corneal neuropathy and diabetic retinopathy,whether diabetic corneal neuropathy precedes diabetic retinopathy,as well as the relation between the stage of diabetic retinopathy and the severity of corneal *** also endeavor to explore the relevance of a corneal screening in diabetic eyes and the possibility of using corneal nerve measurements to monitor the progression of diabetic retinopathy.

关键词： cornea corneal nerves diabetes diabetic corneal neuropathy diabetic retinopathy retina

Attention Eraser and Quantitative Measures for Automated Bone Age Assessment

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Computers, Materials & Continua 2025年第1期82卷 627-644页

作者： Liuqiang Shu Lei yu College of Computer and Information Science Chongqing Normal UniversityChongqing401331China

Bone age assessment(BAA)aims to determine whether a child’s growth and development are normal concerning their chronological *** predict bone age more accurately based on radiographs,and for the left-hand X-ray images of different races model can have better adaptability,we propose a neural network in parallel with the quantitative features from the left-hand bone measurements for *** this study,a lightweight feature extractor(LFE)is designed to obtain the featuremaps fromradiographs,and amodule called attention erasermodule(AEM)is proposed to capture the fine-grained ***,the dimensional information of the metacarpal parts in the radiographs is measured to enhance the model’s generalization capability across images fromdifferent *** is trained and validated on the RSNA,RHPE,and digital hand atlas datasets,which include images from various racial *** model achieves a mean absolute error(MAE)of 4.42 months on the RSNA dataset and 15.98 months on the RHPE *** to ResNet50,InceptionV3,and several state-of-the-art methods,our proposed method shows statistically significant improvements(p<0.05),with a reduction in MAE by 0.2±0.02 years across different racial ***,t-tests on the features also confirm the statistical significance of our approach(p<0.05).

关键词： Bone age assessment attention eraser quantitative feature metacarpal bones

Tilting homeostatic and dyshomeostatic microglial balance in health and disease:transforming growth factor-beta1 as a critical protagonist

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Neural Regeneration Research 2025年第10期20卷 2895-2897页

作者： Nicolas Hugues yu Luo Department of Molecular and Cellular Biosciences University of CincinnatiCincinnatiOHUSA Neuroscience Graduate Program University of CincinnatiCincinnatiOHUSA Division of Immunobiology Cincinnati Children’s Hospital Medical CenterUniversity of Cincinnati College of MedicineCincinnatiOHUSA

Adult microglia,by continuously sensing changes in their environment and communicating with nearly all brain cell types,are considered to be the immune sentinels of the *** the healthy central nervous system(CNS),microglia display a unique molecular homeostatic signature(i.e.,Tmem119,P2ry12,Sall1,Siglech,Gpr34,and Hexb)(Figure 1A).

关键词： Figure signature critical

Dynamic Regulation of Hydrogen Bonding Networks and Solvation Structures for Synergistic Solar‑Thermal Desalination of Seawater and Catalytic Degradation of Organic Pollutants

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Nano-Micro Letters 2025年第2期17卷 548-565页

作者： Ming‑yuan yu Jing Wu Guang Yin Fan‑Zhen Jiao Zhong‑Zhen yu Jin Qu Beijing Key Laboratory of Advanced Functional Polymer Composites Beijing University of Chemical TechnologyBeijing 100029People’s Republic of China State Key Laboratory of Organic‑Inorganic Composites College of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029People’s Republic of China

Although solar steam generation strategy is efficient in desalinating seawater,it is still challenging to achieve continuous solar-thermal desalination of seawater and catalytic degradation of organic ***,dynamic regulations of hydrogen bonding networks and solvation structures are realized by designing an asymmetric bilayer membrane consisting of a bacterial cellulose/carbon nanotube/Co_(2)(OH)_(2)CO_(3)nanorod top layer and a bacterial cellulose/Co_(2)(OH)_(2)CO_(3)nanorod(BCH)bottom ***,the hydrogen bonding networks inside the membrane can be tuned by the rich surface–OH groups of the bacterial cellulose and Co_(2)(OH)_(2)CO_(3)as well as the ions and radicals in situ generated during the catalysis ***,both SO_(4)^(2−)and HSO_(5)−can regulate the solvation structure of Na^(+)and be adsorbed more preferentially on the evaporation surface than Cl^(−),thus hindering the de-solvation of the solvated Na^(+)and subsequent nucleation/growth of ***,the heat generated by the solar-thermal energy conversion can accelerate the reaction kinetics and enhance the catalytic degradation *** work provides a flow-bed water purification system with an asymmetric solar-thermal and catalytic membrane for synergistic solar thermal desalination of seawater/brine and catalytic degradation of organic pollutants.

关键词： Solar steam generation Seawater desalination Catalytic degradation Bacterial cellulose Cobalt hydroxycarbonate nanorods

Method for Estimating the State of Health of Lithium-ion Batteries Based on Differential Thermal Voltammetry and Sparrow Search Algorithm-Elman Neural Network

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Energy Engineering 2025年第1期122卷 203-220页

作者： yu Zhang Daoyu Zhang TiezhouWu School of Electrical and Electronic Engineering Hubei University of TechnologyWuhan430068China

Precisely estimating the state of health(SOH)of lithium-ion batteries is essential for battery management systems(BMS),as it plays a key role in ensuring the safe and reliable operation of battery ***,current SOH estimation methods often overlook the valuable temperature information that can effectively characterize battery aging during capacity ***,the Elman neural network,which is commonly employed for SOH estimation,exhibits several drawbacks,including slow training speed,a tendency to become trapped in local minima,and the initialization of weights and thresholds using pseudo-random numbers,leading to unstable model *** address these issues,this study addresses the challenge of precise and effective SOH detection by proposing a method for estimating the SOH of lithium-ion batteries based on differential thermal voltammetry(DTV)and an SSA-Elman neural ***,two health features(HFs)considering temperature factors and battery voltage are extracted fromthe differential thermal voltammetry curves and incremental capacity ***,the Sparrow Search Algorithm(SSA)is employed to optimize the initial weights and thresholds of the Elman neural network,forming the SSA-Elman neural network *** validate the performance,various neural networks,including the proposed SSA-Elman network,are tested using the Oxford battery aging *** experimental results demonstrate that the method developed in this study achieves superior accuracy and robustness,with a mean absolute error(MAE)of less than 0.9%and a rootmean square error(RMSE)below 1.4%.

关键词： Lithium-ion battery state of health differential thermal voltammetry Sparrow Search Algorithm

血清天冬氨酸-天冬酰胺β羟化酶(ASPH)分子联合AFP和GP73检测对原发性肝癌的诊断意义

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山东大学学报（医学版） 2014年第6期52卷 78-80,84页

作者：张继宗孟九大丁海易永祥余泽前周家华东南大学医学院江苏南京210009 东南大学附属南京市第二医院肝胆外科江苏南京210003 东南大学附属中大医院肝胆外科江苏南京210009

目的探讨联合检测血清天冬氨酸-天冬酰胺β羟化酶(ASPH)、甲胎蛋白(AFP)以及高尔基体糖蛋白73(GP73)对于原发性肝癌的诊断意义。方法分别检测50例原发性肝癌患者、50例肝炎肝硬化患者和50例健康人血清中AFP、GP73和ASPH的含量,分析ASPH... 详细信息

目的探讨联合检测血清天冬氨酸-天冬酰胺β羟化酶(ASPH)、甲胎蛋白(AFP)以及高尔基体糖蛋白73(GP73)对于原发性肝癌的诊断意义。方法分别检测50例原发性肝癌患者、50例肝炎肝硬化患者和50例健康人血清中AFP、GP73和ASPH的含量,分析ASPH联合AFP、GP73检测对原发性肝癌的诊断意义。结果肝炎肝硬化组和健康对照组AFP、GP73和ASPH含量明显低于原发性肝癌组,差异有统计学意义(P<0.05);单独检测AFP、GP73和ASPH对诊断原发性肝癌的灵敏度分别为76.00%、86.00%和80.00%,特异度分别为88.00%、98.00%、86.00%,准确度分别为82.00%、92.00%、87.00%;GP73灵敏度、特异度及准确度均为三项中最高。联合检测AFP、GP73和ASPH三项灵敏度为96.00%,特异度为98.00%,准确度为97.00%,均高于单项检测。结论联合检测AFP、GP73和ASPH可作为诊断原发性肝癌的重要指标,可提高早期原发性肝癌的诊断率。

关键词：血清天冬氨酸-天冬酰胺β羟化酶甲胎蛋白高尔基体糖蛋白73 原发性肝癌