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Flatness,plateau limit and limit length of single-plateau functions

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Science China Mathematics 2021年第8期64卷 1757-1770页

作者： yingying zeng Tayyab Mahmood Yinhe Lin Weinian Zhang School of Mathematical Sciences Sichuan Normal UniversityChengdu 610068China Department of Mathematics COMSATS Institute of Information TechnologyWah Cantt 47040Pakistan College of Engineering and Design Lishui UniversityLishui 323000China Department of Mathematics Sichuan UniversityChengdu 610064China

In this paper we consider iteration of single-plateau functions,an important class of continuous functions with infinitely many forts,and investigate changes of number and length of plateaux under *** use the indices flatness,plateau limit and limit length to formulate those ***,we compute the flatness,plateau limit and limit length for all the nine types of single-plateau functions.

关键词： plateau iteration forts flatness limit length

Experimental researches on mass and heat transfer in new typical cross-flow rotating packed bed

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化工进展 2006年第Z1期25卷 452-457页

作者： CHEN Haihui zeng yingying GAO Wenshuai School of Mechanical Engineering Nanhua UniversityHengyang 421001

New typical cross-flow Rotating Packed Bed(RPB)called multi-pulverizing RPB was *** is enough void in multi-pulverizing RPB,where liquid easily flows and is repeatedly pulverized by light packing,which decreases the material consumed,lightens the weight,and compacts the *** and heat transfer property in the new type PRB were studied by two experimental *** the mass transfer model,the axial fan pumping gas press is only 100 Pa,mass transfer coefficient and volumetric mass transfer coefficient are similar to countercurrent RPB,which are an order quantity lager than that in the conventional packed *** the heat transfer experiment,the axial fan pumping gas press is only 120 Pa;volumetric heatwhich especially suits the treatment of large gas flow and lower gas pressure drop.

关键词： multi-pulverizing rotating packed bed mass transfer heat transfer

Mechanism of Capacity Fading Caused by Mn(Ⅱ)Deposition on Anodes for Spinel Lithium Manganese Oxide Cell

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Journal of Wuhan University of Technology(Materials Science) 2017年第1期32卷 1-10页

作者：陈海辉 MA Tianyi zeng yingying GUO Xiuyan 邱新平 College of Chemistry&Chemical Engineering Jinggangshan UniversityJi'An 343009China Department of Chemistry Tsinghua UniversityBeijing 100008China School of Mechanical&Electrical Engineering Jinggangshan UniversityJi'an 343009China

The capacity fade of spinel lithium manganese oxide in lithium-ion batteries is a bottleneck challenge for the large-scale *** traditional opinion is that Mn（Ⅱ） ions in the anode are reduced to the metallic manganese that helps for catalyzing electrolyte *** could poison and damage the solid electrolyte interface（SEI） film,leading to the the capacity fade in Li-ion *** propose a new mechanism that Mn（Ⅱ） deposites at the anode hinders and/or blocks the intercalation/de-intercalation of lithium ions,which leads to the capacity fade in Li-ion *** on the new mechanism assumption,a kind of new structure with core-shell characteristic is designed to inhabit manganese ion dissolution,thus improving electrochemical cycle performance of the *** the way,this mechanism hypothesis is also supported by the results of these *** LiMn2-xTixO4 shell layer enhances cathode resistance to corrosion attack and effectively suppresses dissolution of Mn,then improves battery cycle performance with LiMn_2O_4 cathode,even at high rate and elevated temperature.

关键词： capacity fade manganese deposition lithium manganese oxide core-shell structure

Characterization of functional transposable element enhancers in acute myeloid leukemia

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Science China(Life Sciences) 2020年第5期63卷 675-687页

作者： yingying zeng Yaqiang Cao Rivka Sukenik Halevy Picard Nguyen Denghui Liu Xiaoli Zhang Nadav Ahituv Jing-Dong JHan CAS Key Laboratory of Computational Biology CAS-MPG Partner Institute for Computational BiologyShanghai Institute of Nutrition and HealthChinese Academy of Sciences Center for Excellence in Molecular Cell ScienceCollaborative Innovation Center for Genetics and Developmental BiologyShanghai Institutes for Biological SciencesChinese Academy of SciencesShanghai 200031China Department of Bioengineering and Therapeutic Sciences University of California San FranciscoSan Francisco 94158USA Institute for Human Genetics University of California San FranciscoSan Francisco 94143USA Sackler School of Medicine Tel-Aviv UniversityTel Aviv 6997801Israel Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesCenter for Quantitative BiologyPeking UniversityBeijing 100871China

Transposable elements(TEs)have been shown to have important gene regulatory functions and their alteration could lead to disease *** myeloid leukemia(AML)develops as a consequence of a series of genetic changes in hematopoietic precursor cells,including mutations in epigenetic ***,we set out to study the gene regulatory role of TEs in *** first explored the epigenetic landscape of TEs in AML patients using ATAC-seq *** show that a large number of TEs in general,and more specifically mammalian-wide interspersed repeats(MIRs),are more enriched in AML cells than in normal blood *** obtained a similar finding when analyzing histone modification data in AML *** Ontology enrichment analysis showed that genes near MIRs in open chromatin regions are involved in *** functionally validate their regulatory role,we selected 19 MIR regions in AML cells,and tested them for enhancer activity in an AML cell line(Kasumi-1)and a chronic myeloid leukemia(CML)cell line(K562);the results revealed several MIRs to be functional *** together,our results suggest that TEs are potentially involved in myeloid leukemogenesis and highlight these sequences as potential candidates harboring AML-associated variation.

关键词： transposable element enhancer promoter MIR acute myeloid leukemia

Research on Problems and Countermeasures of Patent Evaluation System in Pharmaceutical Enterprises

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Asian Journal of Social Pharmacy 2022年第3期17卷 236-242页

作者： zeng yingying Shen Manzhu Yuan Hongmei Han Xu School of Business Administration Shenyang Pharmaceutical UniversityShenyang 110016China

Objective To provide some suggestions and countermeasures for improving the patent evaluation system in pharmaceutical *** Literature research method was used to collect the relevant documents of pharmaceutical enterprises and patent evaluation system,and then the problems of traditional patent evaluation methods for pharmaceutical patents were *** and Conclusion The evaluation of pharmaceutical patents plays an important role for pharmaceutical ***,it is urgent to improve the pharmaceutical patent evaluation system because there are many difficulties in evaluating pharmaceutical patents,such as large fluctuation of patent value,strong subjective interference,the incomplete pharmaceutical information,unapplicable traditional evaluation method,and the insufficient role of evaluation ***,some suggestions are put forward:(1)The application of the real option method;(2)Developing evaluation institutions and training evaluation personnel;(3)Improving the laws and policies related to the evaluation of pharmaceutical patents;(4)Building a pharmaceutical patent evaluation database.

关键词： pharmaceutical enterprise patent evaluation system

The Development of DTP Pharmacy and Its Impact on Pharmaceutical Enterprises

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Asian Journal of Social Pharmacy 2022年第2期17卷 159-166页

作者： Shen Manzhu zeng yingying Yuan Hongmei Fu Shuyong School of Business Administration Shenyang Pharmaceutical UniversityShenyang 110016China

Objective To summarize the development status of direct to patient(DTP)pharmacy and its impact on pharmaceutical enterprises in China and to provide a reference for the pharmaceutical *** Literature research method was used to research domestic and foreign journals and ***,all sorts of data were collected to make a comprehensive *** with relevant national policies,the current situation and advantages of the DTP pharmacy were analyzed to study its impact on pharmaceutical *** and Conclusion Although DTP pharmacies are in the exploratory stage in China,with the advancement of comprehensive medical and health reforms,several national policies have created a good environment for the development of DTP ***,DTP pharmacies are accelerating their construction with better market *** DTP pharmacies gradually become mature,some pharmaceutical enterprises have deepened cooperation with DTP pharmacies to open new channels for drug ***,from the perspective of some generic drug enterprises,DTP pharmacies have certain adverse effects on them.

关键词： DTP pharmacy prescription outflow pharmaceutical enterprise new channel

Analysis of Technical Intelligence of Tumor Cell Therapy Based on Patent Map

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Asian Journal of Social Pharmacy 2024年第2期19卷 191-201页

作者： Liu Yue zeng yingying Li Xue Yuan Hongmei School of Business Administration Shenyang Pharmaceutical UniversityShenyang 110016China

Objective To analyze the technical information in the field of tumor cell therapy in China,and to provide reference for identifying technical trends and predicting technical *** Based on the patent data in the field of tumor cell therapy in China,the patent map method was used to construct a scientific technical information analysis ***,the technical status of new drug research and development in this field was explored to identify technical *** and Conclusion Studies have found that China’s tumor immunotherapy is in the growth *** technical innovation regions are mainly distributed in the east and innovative entities are *** hotspots are concentrated in areas such as A61P35,C12N5,and the patented technical efficacy is ***,the technical research and development opportunities identified are closely related to the background in this *** better promote the development of the industry,enterprises and research institutions should strengthen cooperation in technological innovation Meanwhile,they should pay attention to technical efficacy analysis to identify more technical opportunities,thereby effectively guiding innovation strategic decisions.

关键词： patent map tumor immunotherapy technical intelligence analysis technical opportunity

Research on the Identification of Core Technologies of China’s Pharmaceutical Cold Chain Based on Patent Analysis

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Asian Journal of Social Pharmacy 2021年第2期16卷 128-138页

作者： Yuan Hongmei Zhang Wenfeng Ma Junhong zeng yingying Meng Lingquan School of Business Administration Shenyang Pharmaceutical UniversityShenyang 110016China

Objective To study the identification method that aims at the research and development target and makes the limited resources be *** the frequent occurrence of potential drug safety hazards and the vigorous development of biomedicine,China’s pharmaceutical cold chain is facing huge opportunities and *** this background,it’s vital to promote the research and development of Chinese pharmaceutical cold chain *** First,China’s pharmaceutical cold chain patents were sorted out through the literature research method and patent analysis method,de-noises and cleans the data,uses the international patent classification(IPC)numbers as the pharmaceutical cold chain ***,the IPC number co-occurrence matrix was ***,UCINET was used to visualize,draw the IPC number co-occurrence *** that,K-cores analysis was applied to initially screen the core technology so as to build a comprehensive evaluation index system to evaluate the core ***,Condorcet voting method was used to integrate the evaluation results to identify the core *** and Conclusion Based on this method,it can provide theoretical guidance for the development and decision-making of Chinese pharmaceutical cold chain enterprises,helping them break through technical barriers and improving the efficiency of Chinese pharmaceutical cold chain logistics.

关键词： pharmaceutical cold chain patent analysis IPC number co-occurrence K-cores analysis condorcet voting method

Analysis of Patent Application Status of Scutellaria Barbata Industrial Chain Based on Patent Data

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Asian Journal of Social Pharmacy 2024年第1期19卷 89-97页

作者： zeng yingying Liu Tong Liu Yue Song Aiwei Yuan Hongmei School of Business Administration Shenyang Pharmaceutical University2.Liaoning Institute for Drug ControlShenyang Shenyang 110016China

Objective To analyze patent application status of Scutellaria Barbata industrial chain and provide some suggestions for its patent application and product *** Patent data were collected through IncoPat patent analysis ***,the patent analysis method combined with text mining method was adopted to analyze the situation and development trend of patent application in China’s Scutellaria Barbata industrial chain by using pie chart,bubble chart,trend chart and other visual charts to display the *** and Conclusion The patent application of Scutellaria Barbata in China mainly experienced three stages:Slow development,rapid development,and recession *** number of patents is large,but the authorization rate is *** and enterprises are the main applicants for patent *** development is involved in the whole industrial chain,but it basically focuses on its efficacy in downstream drugs,health food and other ***,government should enhance the awareness of patent protection,encourage collaborative innovation in industry-university-research to promote the combination of basic research and market ***,it should provide theoretical support to tackle the problem of short board products,which can promote the transformation of scientific and technological achievements and contribute to the upgrading of Scutellaria Barbata industrial chain.

关键词： Scutellaria Barbata patent industrial chain