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Ecological vulnerability analysis of Tibetan towns with tourism-based economy： a case study of the Bayi District

Journal of Mountain Science 2018年第5期15卷 1101-1114页

作者： KAN Ai-ke LI Guo-qing YANG Xiao zeng ye-long TESREN Luobu HE Jie College of Geophysics Chengdu University of Technology Chengdu 610059 China State Key Laboratory of Resource and Environmental Information System Institute of Geographic Sciences and Natural Resources Research Chinese Academy of Sciences Beijing 100101 China School of Resources and Environmental Engineering Ludong University Yantai 264025 China College of Forestry Guizhou University Guiyang 550025 China Institute of Science & Technology Information of Tibet Autonomous Region Lhasa 850000 China College of Tourism and Urban-RuraI Planning Chengdu University of Technology Chengclu 610059 China

This paper provides a generalizable mode for the ecological vulnerability evaluation for tourism planning and development in high mountain *** Bayi District located in southeastern Tibet is taken as a typical town to study the conflict between the protection of natural ecological environment and the exploitation of tourism resources. Based on the Sensitivity-Recovery-Pressure(SRP) framework, a set of vulnerability evaluation systems for plateau tourism regions were developed. The spatial principal component analysis(SPCA), remote sensing and GIS technologies were integrated to apply for spatial quantification of evaluation index system. The ecological vulnerability of the Bayi District was divided into five levels: potential, mild, moderate,severe, and extreme, and our results showed that significantly severe and extreme vulnerability areas were mainly distributed throughout the southwestern and central northern alpine pasture and glacial *** and mild vulnerability areas were mainly distributed in the vicinity of the Yarlung Zangbo River tributary basin. Then three tourism development and environmental protection zones were classified and appropriate measures for the protection were proposed. It also provides a reference for the spatial distribution of a range of areas that require different protection measures according to ecological vulnerability classification.

关键词： Ecological vulnerability Tourism area Tibet Spatial principal component analysis (SPCA) Moran's I model

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Mesospheric tide comparisons at low latitudes observed by two collocated meteor radars

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Earth and Planetary Physics 2025年第1期9卷 54-68页

作者： Jian Li Wen Yi XiangHui Xue Jie zeng HaiLun ye JianYuan Wang JinSong Chen Na Li TingDi Chen Chinese Academy of Sciences(CAS)Key Laboratory of Geospace Environment Department of Geophysics and Planetary SciencesUniversity of Science and Technology of ChinaHefei 230026China CAS Center for Excellence in Comparative Planetology Anhui Mengcheng Geophysics National Observation and Research StationUniversity of Science and Technology of ChinaHefei 230026China Hefei National Laboratory University of Science and Technology of ChinaHefei 230026China Collaborative Innovation Center of Astronautical Science and Technology Harbin 150001China National Key Laboratory of Electromagnetic Environment China Research Institute of Radiowave PropagationQingdao 266107China Yunnan Kunming Electromagnetic Environment National Observation and Research Station Qujing Kunming 655000China

Accurate knowledge of mesospheric winds and waves is essential for studying the dynamics and climate in the mesosphere and lower thermosphere(MLT)*** this study,we conduct a comparative analysis of the mesosphere tidal results obtained from two adjacent meteor radars at low latitudes in Kunming,China,from November 2013 to December *** two radars operate at different frequencies of 37.5 MHz and 53.1 MHz,***,overall good agreement is observed between the two radars in terms of horizontal winds and tide *** results show that the dominant tidal waves of the zonal and meridional winds are diurnal and semidiurnal ***,we conduct an exhaustive statistical analysis to compare the tidal amplitudes and vertical wavelengths recorded by the dual radar systems,which reveals a high degree of alignment in tidal *** investigation includes variances and covariances of tidal amplitudes,which demonstrate remarkable consistency across measurements from both *** finding highlights clear uniformity in the mesospheric tidal patterns observed at low latitudes by the two neighboring meteor *** of the comparative analysis specifically underscore the significant correlation in vertical wavelength measurements,validating the robustness of radar observations for tidal research.

关键词： mesosphere and lower thermosphere region meteor radar mesospheric winds tides

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Enhanced autophagic clearance of amyloid-βvia histone deacetylase 6-mediated V-ATPase assembly and lysosomal acidification protects against Alzheimer's disease in vitro and in vivo

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Neural Regeneration Research 2025年第9期20卷 2633-2644页

作者： Zhimin long Chuanhua Ge Yueyang Zhao Yuanjie Liu Qinghua zeng Qing Tang Zhifang Dong Guiqiong He Institute of Neuroscience School of Basic Medical SciencesChongqing Medical UniversityChongqingChina Department of Anatomy Chongqing Medical UniversityChongqingChina Department of Physiology Chongqing Medical UniversityChongqingChina Pediatric Research Institute Children’s Hospital of Chongqing Medical UniversityChongqingChina Ministry of Education Key Laboratory of Child Development and Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina National Clinical Research Center for Child Health and Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina

Recent studies have suggested that abnormal acidification of lysosomes induces autophagic accumulation of amyloid-βin neurons,which is a key step in senile plaque ***,resto ring normal lysosomal function and rebalancing lysosomal acidification in neurons in the brain may be a new treatment strategy for Alzheimer's *** acetylation/deacetylation plays a central role in lysosomal ***,we show that inhibiting the classic microtubule deacetylase histone deacetylase 6 with an histone deacetylase 6 shRNA or thehistone deacetylase 6 inhibitor valproic acid promoted lysosomal reacidification by modulating V-ATPase assembly in Alzheimer's *** rthermore,we found that treatment with valproic acid markedly enhanced *** clearance of amyloid-βaggregates,and ameliorated cognitive deficits in a mouse model of Alzheimer's *** findings demonstrate a previously unknown neuroprotective mechanism in Alzheimer's disease,in which histone deacetylase 6 inhibition by valproic acid increases V-ATPase assembly and lysosomal acidification.

关键词： Alzheimer's disease amyloid-β APP/PS1 mice autophagy cognitive impairment histone deacetylase 6 lysosomal acidification microtubule acetylation valproic acid V-ATPase

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La-substituted W-type barium-nickel ferrites for tunable and high-performance electromagnetic wave absorption

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International Journal of Minerals,Metallurgy and Materials 2025年第3期32卷 645-656页

作者： long Wang Jiurong Liu Shenghui Xie Yanli Deng Zhou Wang Shanyue Hou Shengying Yue Gang Wang Na Wu Zhihui zeng Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials(Ministry of Education) School of Materials Science and EngineeringShandong UniversityJinan 250061China Electronic Materials Research Laboratory Key Laboratory of the Ministry of Education and International Center for Dielectric ResearchSchool of Electronic Science and EngineeringXi’an Jiaotong UniversityXi’an 710049China Army Engineering University of PLA College of Field Engineering Nanjing 210007China Laboratory for Multiscale Mechanics and Medical Science State Key Laboratory for Strength and Vibration of Mechanical StructuresSchool of AerospaceXi’an Jiaotong UniversityXi’an 710049China Department of Electrical and Computer Engineering Beckman Institute for Advanced Science and TechnologyUniversity of Illinois at Urbana-ChampaignUrbana 61801USA School of Chemistry and Chemical Engineering Shandong UniversityJinan 250100China

W-type barium-nickel ferrite(BaNi_(2)Fe_(16)O_(27))is a highly promising material for electromagnetic wave(EMW)absorption be-cause of its magnetic loss capability for EMW,low cost,large-scale production potential,high-temperature resistance,and excellent chemical ***,the poor dielectric loss of magnetic ferrites hampers their utilization,hindering enhancement in their EMW-absorption *** efficient strategies that improve the EMW-absorption performance of ferrite is highly desired but re-mains ***,an efficient strategy substituting Ba^(2+)with rare earth La^(3+)in W-type ferrite was proposed for the preparation of novel La-substituted ferrites(Ba_(1-x)LaxNi_(2)Fe_(15.4)O_(27)).The influences of La^(3+)substitution on ferrites’EMW-absorption performance and the dissipative mechanism toward EMW were systematically explored and ***^(3+)efficiently induced lattice defects,enhanced defect-induced polarization,and slightly reduced the ferrites’bandgap,enhancing the dielectric properties of the ***^(3+)also enhanced the ferromagnetic resonance loss and strengthened magnetic *** effects considerably improved the EMW-absorption perform-ance of Ba_(1-x)LaxNi_(2)Fe_(15.4)O_(27)compared with pure W-type *** x=0.2,the best EMW-absorption performance was achieved with a minimum reflection loss of-55.6 dB and effective absorption bandwidth(EAB)of 3.44 GHz.

关键词： electromagnetic wave absorption W-type barium ferrite rare earth dielectric

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Pattern-based rapid and robust profiling of gut microbiota and its metabolism with a single fluorescent probe

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Science China Chemistry 2025年第2期68卷 781-788页

作者： Hongli Tan Meizi zeng Cong Fang Xiaohua Zhu Feng Liu Ying long Ruijie Deng Peng Yin Meiling Liu Haitao Li Youyu Zhang Shouzhuo Yao Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research(Ministry of Education) College of Chemistry and Chemical EngineeringInstitute of Interdisciplinary StudiesHunan Normal UniversityChangsha 410081China Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine Central South UniversityChangsha 410013China College of Biomass Science and Engineering Healthy Food Evaluation Research CenterSichuan UniversityChengdu 610064China

The gut microbiota and the associated metabolism play a pivotal role in maintaining human health,yet their assessment is challenging due to their inherent diversity,variety,and ***,we developed a multichannel sensor array based on a single fluorescent probe,allowing for rapid and robust profiling gut microbiota and their key metabolites including cysteine(Cys),glutathione(GSH),and homocysteine(Hcy).The assay leverages the single fluorescent probe that is with multiple binding sites and the cross-reactive sensing principle to specifically recognize different biological *** analyzing the pattern of biological thiols,the assay is capable of rapidly identifying six gut-derived bacteria including probiotics,neutral,and pathogenic strains based on fluorescent fingerprints within 5 min,and also discriminating bacteria and their mixtures with different *** the assay that enables the simultaneous measurement of multiple gut-derived bacteria and their metabolites,the designed array achieved an accuracy of 0.99 when discriminating colorectal cancer(CRC)patient feces samples from healthy ***,the as-prepared sensor array can also be used to identify various stages of *** simplicity,rapidness,and cost-effectiveness of our approach render it a robust platform for the analysis of gut microbiota.

关键词： gut microbiota biological thiols sensor array fluorescent probe

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Glutamatergic CYLD deletion leads to aberrant excitatory activity in the basolateral amygdala:association with enhanced cued fear expression

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Neural Regeneration Research 2025年第11期20卷 3259-3272页

作者： Huidong Li Faqin Li Zhaoyi Chen Erwen Wu Xiaoxi Dai Danni Li Haojie An Shiyi zeng Chunyan Wang Li Yang Cheng long School of Life Sciences South China Normal UniversityGuangzhouGuangdong ProvinceChina School of Life Sciences Guangzhou UniversityGuangzhouGuangdong ProvinceChina Guangdong Provincial Key Laboratory of Major Obstetric Diseases The Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina South China Normal University-Panyu Central Hospital Joint Laboratory of Translational Medical Research Panyu Central HospitalGuangzhouGuangdong ProvinceChina

Neuronal activity,synaptic transmission,and molecular changes in the basolateral amygdala play critical roles in fear ***(CYLD)is a deubiquitinase that negatively regulates the nuclear factor kappa-B *** is well studied in non-neuronal cells,yet underinvestigated in the brain,where it is highly *** studies have shown involvement of CYLD in the remodeling of glutamatergic synapses,neuroinflammation,fear memory,and anxiety-and autism-like ***,the precise role of CYLD in glutamatergic neurons is largely ***,we first proposed involvement of CYLD in cued fear *** next constructed transgenic model mice with specific deletion of Cyld from glutamatergic *** results show that glutamatergic CYLD deficiency exaggerated the expression of cued fear in only male ***,loss of CYLD in glutamatergic neurons resulted in enhanced neuronal activation,impaired excitatory synaptic transmission,and altered levels of glutamate receptors accompanied by over-activation of microglia in the basolateral amygdala of male ***,our study suggests a critical role of glutamatergic CYLD in maintaining normal neuronal,synaptic,and microglial *** may contribute,at least in part,to cued fear expression.

关键词： basolateral amygdala cued fear expression cylindromatosis deubiquitinase glutamate receptor 1 glutamatergic neuron microglial activation N-methyl-D-aspartate receptor 1 neuronal activation synaptic transmission

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基于遥感与GIS的青藏高原典型电网工程生态环境敏感性分析

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中国环境科学 2017年第8期37卷 3096-3106页

作者：曾业隆周全江栗张扬建俎佳星谭伟贵州大学林学院贵州贵阳550025 中国科学院地理科学与资源研究所生态系统网络观测与模拟重点实验室北京100101 国家电网公司西南分部四川成都610041 中国科学院青藏高原地球科学卓越创新中心北京100101 中国科学院大学北京100049

为了评估电网工程对生态环境的影响,以概念图的形式确定并表达了电网工程特定活动直接或间接作用于复杂自然环境带来的生态环境影响,基于RS与GIS技术,构建并定量化了敏感性评价指标体系,运用空间主成分方法对青藏高原典型电网工程开展应... 详细信息

为了评估电网工程对生态环境的影响,以概念图的形式确定并表达了电网工程特定活动直接或间接作用于复杂自然环境带来的生态环境影响,基于RS与GIS技术,构建并定量化了敏感性评价指标体系,运用空间主成分方法对青藏高原典型电网工程开展应用.结果显示:研究区的总体生态环境敏感程度很高且集聚效应显著,重度和极度敏感区集中分布(高-高空间关联模式)在研究区中部的雅鲁藏布大峡谷和东南部的高山河谷地带.依据生态环境敏感程度分布状况形成的电网工程极度敏感标段,重度敏感标段,中度敏感标段和轻度敏感标段应利用不同自然条件采取相应的措施降低工程对生态环境的影响.该方法可为复杂自然条件下其他大型工程建设的生态环境影响评价提供借鉴.

关键词：遥感 GIS 电网工程青藏高原生态环境影响评价敏感性

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Internal flow mechanism for a pump-turbine operated in pump mode under double humps condition

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Science China Technological Sciences 2025年第3期68卷 114-128页

作者： Yongshun zeng Zhaohui QIAN Weixiang ye Yuning ZHANG Diana PUGA Xianwu LUO School of Energy Power and Mechanical Engineering North China Electric Power University Department of Energy and Power Engineering State Key Laboratory of Hydroscience and Engineering Tsinghua University Institute of Nuclear and New Energy Technology Tsinghua University

The head-flow rate curve with double humps brings greater challenges to the stable operation of a pump-turbine in pump mode, and the present investigation aims to reveal the formation mechanisms behind it. We performed unsteady simulations by applying a modified partially averaged Navier-Stokes(PANS) model and the double hump phenomenon was satisfactorily captured with relative errors within 3.87% by comparing the head with the experimental data. The results showed that the rotating stall occurred in the guide vane during both the first and second hump regions and induced the dominant pressure pulsation component with an oscillating frequency 11.7% times the runner rotation frequency. The reverse flow was observed due to the propagation of rotating stall cells in the guide vane, and the first hump was attributed to the vortex in the vaneless region, with a reduction in the runner's capacity for doing work as the reverse flow reached the blade trailing *** second hump was attributed to the flow separation near the leading edge of the runner blades, which extended to the runner outlet and interacted with the rotating stall cell, leading to a rapid extension of the reverse flow into the runner. This not only reduces the runner's capacity for doing work but also significantly increases the energy loss in the blade-to-blade flow passage near the runner exit. This study enhances the understanding of the flow mechanism in the hump region, which can provide insights into the suppression of unstable flows and runner optimization.

关键词： pump-turbine double humps capacity for doing work energy loss vortex evolution

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Liquid metal catalyst for ammonia synthesis at low pressure

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Science China Materials 2025年第2期68卷 681-682页

作者： Ziyue zeng Chenyang Wang Lei Fu College of Chemistry and Molecular Sciences Wuhan UniversityWuhan 430072China The Institute for Advanced Studies Wuhan UniversityWuhan 430072China

Liquid metal(LM)has attracted immense interest as a novel catalyst in the past few years for its distinctive physicochemical properties,encompassing superior electrical and thermal conductivities,as well as exceptional fluidity characteristics at low temperatures[1].In contrast to conventional solid heterogeneous catalysts,the fluidic characteristics of liquid metal catalysts enhance the interaction between catalysts and reactants,boosting mass transfer at the reaction interface.

关键词： catalyst ammonia synthesis

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Dynamical complexity of Anosov systems driven by a quasi-periodic force

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Science China Mathematics 2025年第1期68卷 89-136页

作者： Wen Huang zeng Lian Kening Lu Department of Mathematics University of Science and Technology of ChinaHefei 230026China School of Mathematics Sichuan UniversityChengdu 610065China

Consider C^(2)Anosov systems on a compact manifold driven by a quasi-periodic *** study their dynamical complexity on various levels from the perspectives of both path-wise dynamics and stochastic *** that these systems are non-wandering(i.e.,every point in the phase space is nonwandering),we prove a set of results:(1)the existence of abundance of random periodic points;(2)a random Livsic theorem;(3)a random Mañé-Bousch-Conze-Guivarc'h lemma;(4)the existence of strong random ***,a concrete example constructed on a 2-dimensional torus is also given to uncover some interesting phenomena of the systems.

关键词： random Anosov systems Anosov system on bers entropy random periodic orbit random horseshoe cohomological equation random Livsic theorem random Bousch-Mañécohomology lemma

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