检索结果-南通市图书馆

Ca^(2.) signals induced from calcium stores in pancreatic islet β cells

Chinese science Bulletin 2000年第1期45卷 51-56页

作者： zeng xuhui, qu anlian,{2., xu jianhua, wang junjian, wu hongxiu & zhou zhuan1. institute of biochemistry and biophysics, huazhong university of science and technology, wuhan 430074, china 2. Pharmacology, huazhong university of science and technology, wuhan 430074, china 3. School of Life {12.s, university of {12. and technology of china, Hefei 2.002., china Correspondence should be addressed to zhou zhuan. institute of biochemistry and{2. Huazhong University of Science and Technology Wuhan China Pharmacology Huazhong University of Science and Technology Wuhan China School of Life sciences University of Science and Technology of China Hefei China

In single rat pancreatic βcells, using fura-2.microfluorometry to measure [Ca2.] response upon different stimuli, the ways of calcium regulation have been studied. When the extracellular calcium concentration was 2.5 mmol/L, either 60 mmol/L KCI, 2. mmol/L D-glucose or 0.1 mmol/L tolbutamide induced increase in [Ca2.]. Such increase in [Ca2.] was absent when the same stimuli were applied under zero extracellular calcium. These results indicate that the increase of [Ca2.] is induced by the activation of voltage-dependent calcium channels in p celis. The manifold forms of [Ca2.] change induced by glucose imply that the effects of glucose are complex. 5 mmol/L caffeine or 5 mmol/L MCh increase the [Ca2.], which is independent of the external calcium, suggesting that [Ca2.] can be regulated by Ca2. release from not only the IP3-sensitive but also the ryanodine sensitive calcium stores in p celis. The latency of Ca responses for IP3 pathway (5 s) is faster than that for ryanodine pathway (30 s), it is

关键词： pancreatic β cell [Ca2.]i calcium stores glucose fura-2.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：