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Recent advances in understanding T cell activation and exhaustion during HBV infection

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Virologica Sinica 2023年第6期38卷 851-859页

作者： Lu Wang xiaoqing zeng Zida Wang Ling Fang Jia Liu Department of Infectious Diseases Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China Joint International Laboratory of Infection and Immunity Huazhong University of Science and TechnologyWuhan430022China Central Sterile Supply Department Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China

Chronic hepatitis B virus(HBV)infection remains a major public health concern globally,and T cell responses are widely believed to play a pivotal role in mediating HBV ***,research on the characteristics of HBV-specific T cell responses,from activation to exhaustion,has advanced ***,we summarize recent developments in characterizing T cell immunity in HBV infection by reviewing basic and clinical research published in the last five *** provide a comprehensive summary of the mechanisms that induce effective anti-HBV T cell immunity,as well as the latest developments in understanding T cell dysfunction in chronic HBV ***,we briefly discuss current novel treatment strategies aimed at restoring anti-HBV T cell responses.

关键词： Hepatitis B virus(HBV) T cell Immune therapy

Effects of Emotion on Decision-Making ofMethamphetamine Users: Based on theEmotional Iowa Gambling Task

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International Journal of Mental Health Promotion 2023年第11期25卷 1229-1236页

作者： xiaoqing zeng Song Tu Ting Liu School of Psychology Jiangxi Normal UniversityNanchang330022China Jiangxi Key Laboratory of Psychology and Cognitive Science Nanchang330022China Institute of Psychology Jiangxi Normal UniversityNanchang330022China Shenzhen Daydream Network Technology Co. Ltd.Shenzhen518000China

The relapse of methamphetamine (meth) is associated with decision-making dysfunction. The present study aims to investigate theimpact of different emotions on the decision-making behavior of meth users. We used 2 (gender: male, female) × 3 (emotion:positive, negative, neutral) × 5 (block: 1, 2, 3, 4, 5) mixed experiment design. The study involved 168 meth users who weredivided into three groups: positive emotion, negative emotion and neutral emotion group, and tested by the emotional IowaGambling Task (IGT). The IGT performance of male users exhibited a decreasing trend from Block 1 to Block 3. Female methusers in positive emotion had the best performance in IGT than females in the other two groups. In positive emotion, the IGTperformance of female meth users was significantly better than that of men. Female meth users in positive emotion had betterdecision-making than those in negative or neutral emotion. Female meth users in positive emotion had better decision-makingperformance than males in positive emotion. In negative and neutral emotions, there was no significant gender difference indecision-making.

关键词： Methamphetamine user emotion gender difference Iowa gambling task decision-making

药物性肝损伤患者的临床特征及预后相关危险因素分析

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中华肝脏病杂志 2024年第3期32卷 214-221页

作者：魏倩李蕾曾晓清阿比丹·拜合提亚尔殷杰高虹郭津生复旦大学附属中山医院消化科上海市肝病研究所上海200032

目的旨在探讨近年引起药物性肝损伤(DILI)的药物和临床特征,识别药物性肝功能衰竭和慢性DILI的危险因素,以便于早期识别和更好地管理。方法对2018年1月至2020年12月期间诊断为DILI并随访至少6个月的224例患者进行回顾性调查和分析。采... 详细信息

目的旨在探讨近年引起药物性肝损伤(DILI)的药物和临床特征,识别药物性肝功能衰竭和慢性DILI的危险因素,以便于早期识别和更好地管理。方法对2018年1月至2020年12月期间诊断为DILI并随访至少6个月的224例患者进行回顾性调查和分析。采用单因素和多因素logistic回归分析识别药物性肝功能衰竭和慢性DILI的危险因素。结果中药(占62.5%)包括草药(占中药的84.3%)和一些中成药是研究中发现引起DILI的主要原因。胆汁淤积型与严重和慢性DILI更相关。已存在胆囊疾病、初始总胆红素、初始凝血酶原时间、初始抗核抗体滴度是药物性肝功能衰竭的独立危险因素。碱性磷酸酶(ALP)、丙氨酸转氨酶(ALT)从峰值下降到峰值的50%的时间间隔(T_(0.5ALP)和T_(0.5ALT))延长为慢性DILI的独立危险因素(受试者操作特征曲线下面积=0.787,95%置信区间:0.697~0.878,P<0.001),临界值分别为12.5 d和9.5 d。结论中药是导致DILI的主要原因,发生严重DILI的风险与已存在胆囊疾病、初始总胆红素、凝血酶原时间和抗核抗体相关。T_(0.5ALP)和T_(0.5ALT)可作为预测慢性DILI的指标。

关键词：药物性肝损伤肝功能衰竭慢性化危险因素中药

溶岩、溶洞地区超长超大灌注桩施工关键技术研究

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施工技术（中英文） 2024年第19期53卷 40-45页

作者：沈登龙曾晓庆徐解清余超谭辉深圳华城国际低碳城开发建设有限公司广东深圳518000 陕西建工集团股份有限公司陕西西安710000

深圳市龙岗区低碳城片区为溶岩、溶洞地质,某项目拟建200m超高层建筑,采用超长超大灌注桩,施工难度大。经研究论证,采用泥浆护壁、分级回填溶洞和土洞处理、分级钻进和钻孔埋管后注浆等施工关键技术,有效保证了成桩质量和施工安全。通过... 详细信息

深圳市龙岗区低碳城片区为溶岩、溶洞地质,某项目拟建200m超高层建筑,采用超长超大灌注桩,施工难度大。经研究论证,采用泥浆护壁、分级回填溶洞和土洞处理、分级钻进和钻孔埋管后注浆等施工关键技术,有效保证了成桩质量和施工安全。通过1 019根桩基的施工迭代和验证,质量检测结果均满足设计和相关规范要求,证明该项目采用的超长超大桩基施工各项关键技术可行有效。

关键词：高层建筑桩基础灌注桩溶岩溶洞施工技术

MD安德森症状评估量表急性白血病模块的编制及信度和效度检验

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中国护理管理 2024年第9期24卷 1347-1350页

作者：王菲菲孟利敏曾小青张文坚祁欢曾庆威郭秀芳吴学成林栋美赣南医科大学护理学院江西省赣州市341000 深圳市宝安区石岩人民医院赣南医科大学第一附属医院广州市第一人民医院深圳市龙岗区妇幼保健院

目的:编制MD安德森症状评估量表急性白血病模块,并检验其信度和效度。方法:通过文献回顾、半结构式访谈、德尔菲专家函询和患者预调查形成预量表,选取235例成人急性白血病患者进行临床调查,检验其信度和效度。结果:MD安德森症状评估量... 详细信息

目的:编制MD安德森症状评估量表急性白血病模块,并检验其信度和效度。方法:通过文献回顾、半结构式访谈、德尔菲专家函询和患者预调查形成预量表,选取235例成人急性白血病患者进行临床调查,检验其信度和效度。结果:MD安德森症状评估量表急性白血病模块共25个条目,包括19个症状评估条目和6个症状对日常生活的困扰条目。内容效度结果显示,I-CVI和S-CVI均大于0.8。验证性因子分析结果显示,χ^(2)/df=2.230,RMSEA=0.072,GFI=0.976,CFI=0.955,IFI=0.956,NFI=0.923,TLI=0.915,模型拟合结果良好,具有良好的结构效度。MD安德森症状评估量表急性白血病模块总量表的Cronbach’sα系数为0.941,急性白血病模块的Cronbach’sα系数为0.707。结论:MD安德森症状评估量表急性白血病模块具有较好的信度和效度,可作为急性白血病患者症状的评估工具。

关键词：急性白血病 MD安德森症状评估量表症状评估工具信度效度

A novel heterogeneous reaction for generating gaseous nitrous acid

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Chinese Science Bulletin 2007年第22期52卷 3056-3060页

作者： WANG WeiGang GE MaoFa YAO Li zeng xiaoqing WANG ZiFa Beijing National Laboratory for Molecular Sciences and State Key Laboratory for Structural Chemistry of Unstable and Stable Species Institute of Chemistry Chinese Academy of Sciences Beijing 100080 China State Key laboratory of Atmospheric Boundary Layer Physics and Atmospheric Chemistry Institute of Atmospheric Physics Chi- nese Academy of Sciences Beijing 100029 China

The short-lived reactive specimen nitrous acid HONO was generated in the gas phase by the hetero-geneous reaction of gaseous HCl with AgNO2 which can generate higher concentration of HONO than other methods. We investigated the process from generation to dissociation in the gas phase under different controlled temperatures,and discussed the ionization and reaction on the solid surface by combination of the photoelectron spectroscopy and photoionization mass spectroscopy(PES-PIMS) and in situ diffuse reflectance infrared Fourier transform spectroscopy(DRIFTS) .

关键词：亚硝酸气体网络技术异构性化学结构

Synthesis,structure and superoxide dismutase activity of two self-assembly transition metal complexes containing a tridentate amino-Schiff base deviating from salicylaldehyde with glycine

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Chinese Science Bulletin 2009年第19期54卷 3508-3514页

作者： HAN Jing BAI FengYing ZHAO HaiYan XING YongHeng zeng xiaoqing GE MaoFa College of Chemistry and Chemical Engineering Liaoning Normal University Dalian 116029 China Institute of Chemistry Chinese Academy of Sciences Beijing 100080 China

Two new transition metal (Cu, Ni) complexes with amino-Schiff base ligand, (C9H7NO3)Cu(C14H12N2)-H2O (1) and (C9H7NO3)Ni(C3H4N2)3-H2O (2), have been designed and synthesized in ethanol solution at room temperature. Both of the complexes have been characterized by elemental analysis, IR spectra, UV-vis spectroscopy and X-ray single crystal diffraction. For complex 1, the coordination environment of the central copper atom is a distorted square pyramid, and one-dimensional chain is formed through the inter-molecular hydrogen bonds (O4-H2W···O3, O4-H2W···O3#1 (#1: -x+1, y, -z+3/2)) and weak interactions (π-π stacking interaction) between the phenyl rings. For complex 2, the nickel atom is 6-coordinated and in a distorted octahedral environment, and a discrete hydrogen-bond cluster (four molecules are connected by hydrogen bonds into a group) is formed via two types of intra-molecular hydrogen bonds (O-H···O, N-H···O) and inter-molecular hydrogen bonds (O-H···O, N-H···O).

关键词：过氧化物岐化酶糖胶分子组成化学

成人血液系统肿瘤患者化疗期核心症状及对生活质量的影响

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护理学杂志 2024年第12期39卷 25-30页

作者：郭秀芳孟利敏李婷曾小青魏清风刘怡王菲菲林栋美赣南医科大学护理学院江西赣州341000 赣南医科大学第一附属医院血液内科江西省肿瘤医院癌症中心办公室赣州市肿瘤医院护理部

目的构建成人血液系统肿瘤患者化疗期的症状网络,识别其核心症状及对生活质量的影响。方法便利选取400例血液系统肿瘤患者,采用一般资料调查表、中文版安德森症状评估量表和简版生活质量量表(SF-12)进行调查。使用R软件构建症状网络,分... 详细信息

目的构建成人血液系统肿瘤患者化疗期的症状网络,识别其核心症状及对生活质量的影响。方法便利选取400例血液系统肿瘤患者,采用一般资料调查表、中文版安德森症状评估量表和简版生活质量量表(SF-12)进行调查。使用R软件构建症状网络,分析中心性指标并确定核心症状;使用单因素分析和分层回归分析探讨核心症状对成人血液系统肿瘤患者生活质量的影响。结果成人血液系统肿瘤患者的核心症状是苦恼,最常见的症状是疲劳、口干和睡眠不安,最严重的症状是疲劳、睡眠不安、食欲下降和苦恼。在症状网络中,强度最大为苦恼(rs=1.2357);紧密中心性和中介中心性最高为疲劳(rc=0.0087,rb=30.0000)。分层回归分析结果显示,在控制一般资料变量后,苦恼和疲劳可解释生理领域总分31.5%的变异,以及心理领域总分31.5%的变异。结论成人血液系统肿瘤患者化疗期的核心症状为苦恼;疲劳处于症状网络的中心位置,与其他症状的接近度高;可将苦恼和疲劳作为靶点制定干预措施,提高成人血液系统肿瘤患者症状管理效能。

关键词：血液系统肿瘤网络分析核心症状生活质量症状管理苦恼疲乏化疗

Prognostic Nomogram model for the efficacy of endoscopic treatment in gastric varices caused by liver cirrhosis

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China Medical Abstracts(Internal Medicine) 2020年第2期37卷 96-97页

作者： zeng xiaoqing Dept Gastroenterol&Hepatol Zhongshan HospFudan UnivShanghai 200032

Objective To predict the efficacy of endoscopic tissue adhesives in the treatment of gastric varices in patients with liver cirrhosis by Nomogram *** From August 2014 to September 2017,158 patients with liver cirrhosis caused esophagogastric variceal bleeding and received endoscopic tissue adhesives treatment at Zhongshan Hospital,Fudan University were *** patients were followed for 12 months.

关键词： endoscopic liver treatment