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Distinct immune escape and microenvironment between RG-like and pri-OPC-like glioma revealed by single-cell RNA-seq analysis

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Frontiers of Medicine 2024年第1期18卷 147-168页

作者： Weiwei xian Mohammad Asad Shuai Wu Zhixin Bai Fengjiao Li Junfeng Lu Gaoyu Zu Erin Brintnell Hong Chen ying Mao Guomin Zhou Bo Liao Jinsong Wu Edwin Wang Linya You Department of Human Anatomy&Histoembryology School of Basic Medical SciencesFudan UniversityShanghai200032China Cumming School of Medicine University of CalgaryCalgaryAlbertaT2N 4N1Canada Glioma Surgery Division Department of NeurosurgeryHuashan HospitalFudan UniversityShanghai200040China Department of Pathology Huashan HospitalFudan UniversityShanghai200040China Department of Neurosurgery Huashan HospitalFudan UniversityShanghai200040China Shanghai Key Laboratory of Medical Imaging Computing and Computer Assisted Intervention Fudan UniversityShanghai200040China School of Mathematics and Statistics Hainan Normal UniversityHaikou570100China

The association of neurogenesis and gliogenesis with glioma remains *** conducting single-cell RNA-seq analyses on 26 gliomas,we reported their classification into primitive oligodendrocyte precursor cell(pri-OPC)-like and radial glia(RG)-like tumors and validated it in a public cohort and TCGA *** RG-like tumors exhibited wild-type isocitrate dehydrogenase and tended to carry EGFR mutations,and the pri-OPC-like ones were prone to carrying TP53 *** subclones only in pri-OPC-like tumors showed substantially down-regulated MHC-I genes,suggesting their distinct immune evasion ***,the two subgroups appeared to extensively modulate glioma-infiltrating lymphocytes in distinct *** specific genes not expressed in normal immune cells were found in glioma-infiltrating *** example,glial/glioma stem cell markers OLIG1/PTPRZ1 and B cell-specific receptors IGLC2/IGKC were expressed in pri-OPC-like and RG-like glioma-infiltrating lymphocytes,*** expression was positively correlated with those of immune checkpoint genes(e.g.,LGALS33)and poor survivals as validated by the increased expression of LGALS3 upon IGKC overexpression in Jurkat *** finding indicated a potential inhibitory role in tumor-infiltrating lymphocytes and could provide a new way of cancer immune evasion.

关键词： single-cell RNA-seq glioma radial glia primitive oligodendrocyte precursor cell immune escape

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英语教学中跨文化交际的渗透

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山西广播电视大学学报 2006年第4期11卷 76-77页

作者：李幸曾宪英湖南怀化医学高等专科学校湖南怀化418000

外语教学的主要任务是培养具有不同文化背景的人们之间进行交际的人才,那么跨文化交际的教学将是外语教学发展的必然趋势。根据现实生活中发生的事分析了跨文化交际失败的原因,对如何在教学中开展文化传授,培养学生跨文化交际的能力进... 详细信息

外语教学的主要任务是培养具有不同文化背景的人们之间进行交际的人才,那么跨文化交际的教学将是外语教学发展的必然趋势。根据现实生活中发生的事分析了跨文化交际失败的原因,对如何在教学中开展文化传授,培养学生跨文化交际的能力进行了深层次的探讨。

关键词：跨文化交际交际能力文化渗透

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乐滩水电站测量施工控制网的复测技术

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红水河 2006年第3期25卷 88-89,92页

作者：曾英先苏信广西水电工程局南宁530001

乐滩水电站开挖工程基本结束后,进入混凝土工程和金属结构、机电安装工程之时,采用TCA2003全站仪和NA3003电子水准仪,对原测量施工控制网进行全面复测,确保测量控制网点坐标和高程准确,为电站建筑物施工放样提供依据。

关键词：测量施工控制网坐标高程复核测量乐滩水电站

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急性轻,中度缺氧对左心室壁应力及心功能的影响

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中华航空医学杂志 1992年第2期3卷 65-68页

作者：曾宪英潘明达海军医学研究所上海，200433

用超声心动图法测定了正常及缺氧状态下15名健康人的左心室壁应力，同时测射血分数、平均周边纤维缩短速度及左室短轴缩短率等指标，并分析了其与室壁应力间的变化关系。结果显示，缺氧可引起左心室壁应力改变，尤以收缩期最大壁应力为... 详细信息

用超声心动图法测定了正常及缺氧状态下15名健康人的左心室壁应力，同时测射血分数、平均周边纤维缩短速度及左室短轴缩短率等指标，并分析了其与室壁应力间的变化关系。结果显示，缺氧可引起左心室壁应力改变，尤以收缩期最大壁应力为显著。室壁应力与心肌收缩力指标可同步增加，此点有别于临床对病人的观察，可能是心功能正常人的特征。

关键词：缺氧左心室壁应力心功能

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Multilocular thymic cysts can be easily misdiagnosed as malignant tumor on computer tomography:A case report

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World Journal of Clinical Cases 2024年第8期12卷 1474-1480页

作者： Jun Sun Qing-Ning Yang Yi Guo Ping zeng Long-Yan Ma Ling-Wen Kong Bo-ying Zhao Chuan-Ming Li Department of Radiology Chongqing University Central HospitalChongqing Emergency Medical CenterChongqing 400014China Department of Pathology Chongqing University Central HospitalChongqing Emergency Medical CenterChongqing 400014China Department of Cardiothoracic Surgery Chongqing University Central HospitalChongqing Emergency Medical CenterChongqing 400014China

BACKGROUND Multilocular thymic cyst(MTC)is a rare mediastinal lesion which is considered to occur in the process of acquired *** is usually characterized by well-defined cystic density and is filled with transparent *** SUMMARY We report on a 39-year-old male with a cystic-solid mass in the anterior *** tomography(CT)imaging showed that the mass was irregular with unclear *** injection of contrast agent,there was a slight enhancement of stripes and *** to CT findings,it was diagnosed as thymic *** After surgery,MTC accompanied by bleeding and infection was confirmed by pathological *** main lesson of this case was that malignant thymic tumor and MTC of the anterior mediastinum sometimes exhibit similar CT *** is necessary in clinical work to avoid misdiagnosis.

关键词： Multilocular thymic cyst Computer tomography Misdiagnosis Hemorrhage Infection Case report

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The only purple-flower species in Actaea *** pollinated by a hornet

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Journal of Plant Ecology 2024年第4期17卷 181-196页

作者： Lin-Feng Qiu Jiu-Dong Zhang ying Li Xiao-ying Liu Dan-Qing Zhang Long Huang Ya-Peng Yang Shi-Yu Wang Yue-Yi Li Zi-Wei Ma Jie Sui Lin Wang Xiao-Fen Che xian-Hua Tian Yi Ren Jian-Qiang Zhang National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest China College of Life SciencesShaanxi Normal UniversityXi’an 710119China Key Laboratory of Medicinal Plant Resource and Natural Pharmaceutical Chemistry of Ministry of Education Shaanxi Normal UniversityXi’an 710119China College of Biological and Environmental Engineering Xi’an UniversityXi’an 710065China

Examining the pollination biology of plant species is not only crucial for enhancing our understanding of their reproductive biology,but also essential for elucidating their adaptation and evolutionary ***,we investigated the breeding system and pollination biology of two closely related species in *** flower of *** is unique in the genus with purple and chartaceous(paper-like)sepals,fewer stamens with yellow anthers and purple *** three seasons of field observation and exclusion experiments,we determined that *** was primarily pollinated by a hornet species,Vespa bicolor,which also served as the most efficient *** contrast,*** was primarily pollinated by large *** purpurea exhibited a significantly higher cumulative nectar volume than ***,which could be a crucial factor in attracting ***.A control experiment further demonstrated that removing the nectar leaf(petal)significantly decreased the visiting frequency of *** system studies revealed that both species were self-compatible,yet they primarily underwent outcrossing in natural *** study presents a compelling case of possible pollinator shift in *** accompanied by morphological divergence.A more in-depth investigation of this system would offer crucial insights into the extent to which pollinators are involved in the plant speciation process and whether they contribute to reproductive isolation between closely related species.

关键词： Actaea purpurea Actaea japonica breeding system pollinator shift speciation Vespa bicolor

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Innovative coaxial high-temperature thin-film sensor with core-shell structure surpassing traditional multilayer films

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Rare Metals 2024年第8期43卷 3854-3867页

作者： Chao Wu Guo-Chun Chen Fu-Xin Zhao Fan Lin ying-Jun zeng Yan-Zhang Fu Yan-Song Zhang Li-Da Xu Qin-Nan Chen Rui Tang Dao-Heng Sun Zhen-Yin Hai Pen-Tung Sah Institute of Micro-Nano Science and Technology Xiamen UniversityXiamen 361005China AECC Shenyang Engine Institute Shenyang 110015China School of Aerospace Engineering Xiamen UniversityXiamen 361005China

High-temperature thin-film sensors(TFSs)often suffer from inadequate tolerance to elevated *** this study,an innovative approach is presented to fabricate in situ integrated TFSs with a core-shell structure on alloy components using coaxial multi-ink printing *** method replaces traditional layerby-layer(LbL) deposition and LbL sintering processes and achieves simplified one-step *** coaxial TFS includes a conductive Pt core for conducting and sensing and a dielectric shell for electrical isolation and high-temperature *** coaxial Pt resistance grid demonstrates excellent high-temperature stability,with a resistance drift rate of only 0.08%·h^(-1) at 800 ℃,significantly lower than traditional Pt *** employing this method,a Pt thin-film strain gauge(TFSG) is fabricated that boasts remarkable high-temperature electromechanical *** effectively addresses the problem of sensitivity degradation experienced by traditional LbL Pt TFSGs when subjected to high *** demonstrate the system integration potential of the technique by printing and verifying the functionality of a long-path thinfilm resistance grid on turbine blades,which can withstand butane flame up to ~1300℃.These results showcase the potential of core-shell structure of the coaxial TFS for high-temperature applications,providing a novel approach to develop high-performance TFS beyond traditional multilayer structure.

关键词： Coaxial printing Core-shell structure Thinfilm strain gauge High-temperature stability

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Weatherability and heat resistance enhanced by interaction between AG25 and Mg/AI-LDH

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Rare Metals 2024年第6期43卷 2758-2768页

作者： Pei-Yao Yang xiang-Cui Liu Yu-Chao Wang Huan-Ran Zheng Jin-xian Wang Jia-Yi Zheng Meng-Jie Liu Dan-Ni Deng Yu Bai ying-Bi Chen Tong Zhang Zhi-Ming Liu Yong-Peng Lei State Key Laboratory of Powder Metallurgy Powder Metallurgy Research InstituteCentral South UniversityChangsha 410083China Research Institute of Chemical Defense Beijing 102205China

Although inorganic pigments in common spectral tuning materials show good weatherability and heat resistance,the limited color choices,weak coloring power,poor dispersibility,and a possibility of toxicity limit their *** the basis of organic pigments which possess a wide range of colors,high coloring power,good transparency,and high safety,herein,the modified pigment and biomimetic coating with improved weatherability,especially ultraviolet(UV)resistance(from 2 to 6 days),was achieved by intercalating acid green 25(AG25)pigment into Mg/Al-layered double hydroxides(Mg/Al-LDH).Furthermore,the heat resistance of AG25 was also significantly ***,the spectral stability of pigments after heat treatment is superior with almost unchanged spectral profile and green reflection *** formation of strong N-H bonds and the S-M(Mg,Al)bonds between Mg/Al-LDH laminates and AG25 molecules contributes to the *** work shows potential for biomimetic leaf materials in respect of reflective spectra stability.

关键词： Layered double hydroxide Biomimetic Acid green 25 Interaction Weatherability Heat resistance

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Cetuximab combined with chemotherapy for simultaneous esophageal squamous cell carcinoma and colon adenocarcinoma:A case report

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World Journal of Clinical Cases 2024年第15期12卷 2649-2654页

作者： Xin-Xin Luo Yu-Xuan Du Qi-Qing Zhang Lin Zhang Shu-ying zeng Zhi-Hong Yu Peng Shen Zheng-Quan Feng The Second School of Clinical Medicine Zhejiang Chinese Medical UniversityHangzhou310053Zhejiang ProvinceChina Department of Oncology Tongde Hospital of Zhejiang ProvinceHangzhou 310012Zhejiang ProvinceChina Department of Medical Oncology The First Affiliated HospitalMedical College of Zhejiang UniversityHangzhou 310003Zhejiang ProvinceChina

BACKGROUND Multiple primary carcinomas(MPCs)are defined as two or more independent primary cancers that occur simultaneously or sequentially in the same *** MPCs are rarer than solitary cancers or metachronous *** diagnoses of synchronous MPCs and the choice of treatment are critical for successful outcomes in these *** SUMMARY A 64-year-old patient presented with dysphagia,without obvious cause.A diagnosis of synchronous esophageal squamous cell carcinoma and colon adenocarcinoma with liver metastasis was confirmed based on examination and laboratory *** multi-disciplinary consultations,combination chemotherapy(a 3-wk cycle with oxaliplatin 212 mg administered on day 1 and capecitabine 1.5 g twice daily on days 1-14)and esophageal cancer radiotherapy were *** on the results of genetic testing,we switched to a regimen of leucovorin+fluorouracil+oxaliplatin and cetuximab regimen for 8 ***,capecitabine and bevacizumab were administered until the most recent follow-up,at which the tumor remained *** Successful cetuximab chemotherapy treatment provides a reference for the nonoperative and homogeneous treatment of different pathological types of synchronous MCPs.

关键词： Synchronous multiple primary carcinoma Esophageal squamous cell carcinoma Colon adenocarcinoma Cetuximab Chemotherapy Case report

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Novel PIKfyve/Tubulin Dual-target Inhibitor as a Promising Therapeutic Strategy for B-cell Acute Lymphoblastic Leukemia

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Current Medical Science 2024年第2期44卷 298-308页

作者： Zhen LU Qian LAI Zhi-feng LI Meng-ya ZHONG Yue-long JIANG Li-ying FENG Jie ZHA Jing-wei YAO Yin LI xian-ming DENG Bing XU Department of Hematology The First Affiliated Hospital of Xiamen University and Institute of HematologySchool of MedicineXiamen UniversityXiamen361005China Key Laboratory of Xiamen for Diagnosis and Treatment of Hematological Malignancy Xiamen361005China Department of Oncology The First Affiliated Hospital of Jinan UniversityJinan UniversityGuangzhou510630China State Key Laboratory of Cellular Stress Biology Innovation Center for Cell Signaling NetworkSchool of Life SciencesXiamen UniversityXiamen361003China

Objective:In B-cell acute lymphoblastic leukemia(B-ALL),current intensive chemotherapies for adult patients fail to achieve durable responses in more than 50%of cases,underscoring the urgent need for new therapeutic regimens for this patient *** present study aimed to determine whether HZX-02-059,a novel dual-target inhibitor targeting both phosphatidylinositol-3-phosphate 5-kinase(PIKfyve)and tubulin,is lethal to B-ALL cells and is a potential therapeutic for B-ALL ***:Cell proliferation,vacuolization,apoptosis,cell cycle,and in-vivo tumor growth were *** addition,Genome-wide RNA-sequencing studies were conducted to elucidate the mechanisms of action underlying the anti-leukemia activity of HZX-02-059 in ***:HZX-02-059 was found to inhibit cell proliferation,induce vacuolization,promote apoptosis,block the cell cycle,and reduce in-vivo tumor *** of the p53 pathway and suppression of the phosphoinositide 3-kinase(PI3K)/AKT pathway and the downstream transcription factors c-Myc and NF-κB were responsible for these ***:Overall,these findings suggest that HZX-02-059 is a promising agent for the treatment of B-ALL patients resistant to conventional therapies.

关键词： B-cell acute lymphoblastic leukemia dual-target inhibitor NF-kB c-Myc PI3K/AKT p53

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