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Anti-psoriasis molecular targets and active components discovery of Optimized Yinxieling Formula via affinity-purified strategy

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Chinese Journal of Natural Medicines 2024年第2期22卷 127-136页

作者： WANG wei LIU Lijuan YANG Zhuo LU Chuanjian TU Pengfei ZHAO Ruizhi zeng Kewu State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityBeijing 100191China State Key Laboratory of Dampness Syndrome of Chinese Medicine The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510006China

Psoriasis,a prevalent inherited skin condition,involves an inflammatory response as a key pathogenic *** Optimized Yinxieling Formula(OYF),rooted in traditional Chinese medicine,is extensively utilized in clinical settings to treat *** previous studies have demonstrated OYF’s significant anti-inflammatory effects in psoriasis,its potential molecular targets and active components remain *** study aimed to unveil the anti-psoriasis molecular targets and active components of *** findings indicated that OYF extract markedly reduced the production of several inflammatory mediators,including IL-23,nitric oxide,TNF-α,and IL-1β,in LPS-induced RAW264.7 *** synthesized OYF extract-crosslinked beads to isolate pharmacological targets from RAW264.7 lysates using an affinity purification strategy,known as Target *** enriched target proteins were subsequently identified via LC-MS/MS,followed by bioinformatics analysis to map the psoriasis-associated pathway-gene *** identified a total of 76 potential target proteins,which were highly associated with mRNA transcription *** particular,pathway-gene network analysis revealed that the IL-23 inflammatory pathway was involved in the anti-psoriasis effect of OYF *** further utilized a target protein-based affinity capture strategy,combined with LC-MS and SPR analysis,to globally screen OYF’s active components,focusing on the mRNA transcription regulator,fused in sarcoma(FUS).This process led to the identification of umbelliferone,vanillic acid,protocatechuic acid,gentisic acid,and echinacoside as key compounds targeting FUS to inhibit IL-23 ***,we formulated a compound cocktail(CpdC),which significantly reduced psoriasis area and severity index(PASI)scores and the expressions of IL-23 and Ki67 in an imiquimod(IMQ)-induced psoriasis mouse ***,our study elucidates the primary molecular targets and active components of OYF,offeri

关键词： Psoriasis Optimized Yinxieling Formula(OYF) FUS protein Molecular targets Affinity-purified strategy

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Elevating the comprehensive thermal properties of rare-earth cerates through high-entropy design

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Journal of Materiomics 2024年第5期10卷 1126-1136页

作者： Zhaoxuan Zhang Yiling Huang Fan Peng wei Zheng Caifen Jiang Xuemei Song Yi zeng School of Microelectronics Shanghai UniversityShanghai201800China The State Key Lab of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of ScienceShanghai200050China

In the rapidly evolving aerospace sector,the quest for sophisticated thermal barrier coating(TBC)materials has *** materials are primarily sought for their superior comprehensive thermal characteristics,which include a low thermal conductivity coupled with a high coefficient of thermal expansion(CTE)that synergizes with the *** our study,we adopt a solid-state method to synthesize a series of high-entropy rare-earth cerates:La_(2)Ce_(2)O_(7)(1RC),(La_(1/2)Nd_(1/2))2Ce_(2)O_(7)(2RC),(La_(1/3)Nd_(1/3)Sm_(1/3))_(2)Ce_(2)O_(7)(3RC),(La_(1/4)Nd_(1/4)Sm_(1/4)Eu_(1/4))_(2)Ce_(2)O_(7)(4RC),and(La_(1/5)Nd_(1/5)Sm_(1/5)Eu_(1/5)Gd_(1/5))2Ce2O7(5RC),all sintered at 1,600℃ for 10 *** thoroughly examine their phase structure,morphology,elemental distribution,and thermal *** in-depth analysis of the phonon scattering mechanisms reveals that 4RC and 5RC exhibit exceptional thermal properties:high CTEs of 13.00×10^(−6) K^(−1) and 12.77×10^(−6) K^(−1) at 1,400℃,and low thermal conductivities of 1.55 W/(m·K)and 1.68 W/(m·K)at 1,000℃,*** to other TBC systems,4RC and 5RC stand out for their excellent thermal *** study significantly contributes to the development of high-entropy oxides for TBC applications.

关键词： Thermal barrier coatings(TBCs) Comprehensive thermal properties Coefficient of thermal expansion Thermal conductivity Phonon scattering mechanisms

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Main controlling factor and mechanism of gas-in-place content of the Lower Cambrian shale from different sedimentary facies in the western Hubei area, South China

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Petroleum Science 2024年第3期21卷 1488-1507页

作者： Gang Li Xian-Ming Xiao Bo-wei Cheng Chen-Gang Lu Yue Feng Dong-sheng Li School of Energy Resources China University of Geosciences(Beijing)Beijing100083China Frontiers Science Center for Deep-time Digital Earth China University of Geosciences(Beijing)Beijing100083 China

The Lower Cambrian shale gas in the western Hubei area,South China has a great resource prospect,but the gas-in-place(GIP)content in different sedimentary facies varies widely,and the relevant mechanism has been not well *** the present study,two sets of the Lower Cambrian shale samples from the Wells YD4 and YD5 in the western Hubei area,representing the deep-water shelf facies and shallowwater platform facies,respectively,were investigated on the differences of pore types,pore structure and methane adsorption capacity between them,and the main controlling factor and mechanism of their methane adsorption capacities and GIP contents were *** results show that the organic matter(OM)pores in the YD4 shale samples are dominant,while the inorganic mineral(IM)pores in the YD5 shale samples are primary,with underdeveloped OM *** pore specific surface area(SSA)and pore volume(PV)of the YD4 shale samples are mainly from micropores and mesopores,respectively,while those of the YD5 shale samples are mainly from micropores and macropores,*** methane adsorption capacity of the YD4 shale samples is significantly higher than that of the YD5 shale samples,with a maximum absolute adsorption capacity of 3.13 cm^(3)/g and 1.31 cm^(3)/g in average,*** with the shallow-water platform shale,the deep-water shelf shale has a higher TOC content,a better kerogen type and more developed OM pores,which is the main mechanism for its higher adsorption *** GIP content models based on two samples with a similar TOC content selected respectively from the Wells YD4 and YD5 further indicate that the GIP content of the deep-water shelf shale is mainly 34 m^(3)/t within a depth range of 1000—4000 m,with shale gas exploration and development potential,while the shallow-water platform shale has normally a GIP content of<1 m^(3)/t,with little shale gas *** the geological and geochemical conditions of shale gas formation a

关键词： Lower Cambrian shale Deep-water shelf facies Shallow-waterplat form facies Pore structure Methane adsorption Gas-in-place content Controlling factor

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Energy saving analysis for CO_(2)–O_(2)mixed injection technology in converter steelmaking

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Journal of Iron and Steel Research International 2024年第5期31卷 1095-1103页

作者： Bao-chen Han Chun-liang Gao Ya-qiang Li Dan Liu Guang-sheng wei Rong Zhu Hebei Key Laboratory of Material Near-Net Forming Technology School of Material Science and EngineeringHebei University of Science and TechnologyShijiazhuang050018HebeiChina Department of Automotive Engineering Hebei Vocational University of Technology and EngineeringXingtai054000HebeiChina School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing100083China

Energy-saving in China's iron and steel industry still relies on the development and improvement of short-term energy saving ***,a special converter smelting technology incorporating energy saving was *** evaluate the energy-saving potential of the CO_(2)–O_(2)mixed injection(COMI)technology,collected production data were used to develop an improved techno-economic *** reveal that the technology can save energy through auxiliary material consumption,sensible heat of solid by-product,iron loss reduction,and energy *** application of COMI technology in an enterprise is cost effective,involving the energy saving potential of 0.206 GJ/t,the cost of conserved energy of−48.83 yuan/GJ,and a simple payback period of 0.35 year for a 60-million-yuan *** analysis shows that the investment cost and discount rate primarily influence the cost of conserved energy of the *** the discount rate increased,the cost of conserved energy also gradually ***,the COMI technology is an energy-saving technology with good development prospects.

关键词： Converter steelmaking COMI technology Energy saving Techno-economic model Investment cost

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A pair of nuclear factor Y transcription factors act as positive regulators in jasmonate signaling and disease resistance in Arabidopsis

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Journal of Integrative Plant Biology 2024年第9期66卷 2042-2057页

作者： Chuyu Lin Chenghao Lan Xiaoxiao Li wei Xie Fucheng Lin Yan Liang zeng Tao Ministry of Agriculture Key Laboratory of Molecular Biology of Crop Pathogens and Insects Institute of BiotechnologyZhejiang UniversityHangzhou 310058China State Key Laboratory for Managing Biotic and Chemical Treats to the Quality and Safety of Agro‐products Institute of BiotechnologyZhejiang UniversityHangzhou 311400China

The plant hormone jasmonate(JA)regulates plant growth and immunity by orchestrating a genome-wide transcriptional *** the resting stage,JASMONATE-ZIM DOMAIN(JAZ)proteins act as main repressors to regulate the expression of JA-responsive genes in the JA signaling ***,the mechanisms underlying de-repression of JA-responsive genes in response to JA treatment remain ***,we report two nuclear factor Y transcription factors NF-YB2 and NF-YB3(thereafter YB2 and YB3)play key roles in such de-repression in ***2 and YB3 function redundantly and positively regulate plant resistance against the necrotrophic pathogen Botrytis cinerea,which are specially required for transcriptional activation of a set of JA-responsive genes following ***,YB2 and YB3 modulated their expression through direct occupancy and interaction with histone demethylase Ref6 to remove repressive histone ***,YB2 and YB3 physically interacted with JAZ repressors and negatively modulated their abundance,which in turn attenuated the inhibition of JAZ proteins on the transcription of JA-responsive genes,thereby activating JA response and promoting disease ***,our study reveals the positive regulators of YB2 and YB3 in JA signaling by positively regulating transcription of JA-responsive genes and negatively modulating the abundance of JAZ proteins.

关键词： histone demethylase jasmonate response JAZ repressor necrotrophic resistance nuclear factor

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Insights into photocatalytic mechanism over a novel Cu_(2)WS_(4)/MoS_(2) S-scheme heterojunction

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Rare Metals 2024年第7期43卷 3118-3133页

作者： wei Zhao Ji-Hui Cao Jun-Jie Liao Yun Liu Xiao-Jun zeng Jun-Yu Shen Xue-Kun Hong Yang Guo He-Hua zeng Ya-Zi Liu School of Materials Engineering Jiangsu Key Laboratory of Advanced Functional MaterialsSchool of Electronic and Information EngineeringChangshu Institute of TechnologyChangshu215500China School of Chemistry and Chemical Engineering Changji UniversityChangji 831100China State Environmental Protection Key Laboratory of Soil Environmental Management and Pollution Control Ministry of Ecology and EnvironmentNanjing Institute of Environmental SciencesNanjing 210023China School of Environment Jiangsu Engineering Lab of Water and Soil Eco-RemediationNanjing Normal UniversityNanjing 210023China Department of Chemical Engineering Curtin UniversityPerthWA6845Australia

A novel efficient Cu_(2)WS_(4)/MoS_(2) step-scheme(S-scheme)heterojunction photocatalyst was constructed for the first time and applied in the removal of environmental *** the as-prepared photocatalysts,the Cu_(2)WS_(4)/MoS_(2)-8%heterojunc tion photoc atalyst demonstrates the optimal photocatalytic performance,with the catalytic oxidation efficiency of tetracycline(TC)and the catalytic reduction efficiency of Cr^(6+)reaching 93.3%and 82.1%,*** excellent catalytic properties of Cu_(2)WS_(4)/MoS_(2) heterojunction photocatalysts are attributed to the effective separation pathways of charges and the presence of S-scheme heterojunctions,together with stronger redox *** is speculated that the photogenerated carrier migration path of the Cu_(2)WS_(4)/MoS_(2) catalyst follows the typical S-scheme photocatalytic mechanism,which is verified by the in-depth experimental study and simulated calculations including the electron paramagnetic resonance(EPR)analysis,free radical quenching experiments,charge density distribution,and simulated built-in electric field formation at the interface,which acts as driving force to promote the separation of photoinduced electrons and ***,the photocatalytic mechanism of S-scheme photogenerated carrier migration for the Cu_(2)WS_(4)/MoS_(2) catalyst is revealed based on the systematic experimental techniques and simulated calculations,accounting for its superior photocatalytic oxidation and reduction *** study provides inspiring implications to develop high-efficient S-scheme photocatalytic systems for versatile applications in solarenergy conversion.

关键词： Cu_(2)WS_(4)/MoS_(2) S-scheme Heterojunction Photocatalysis

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利用机载激光雷达技术估测东北林区典型针叶林的蓄积量

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应用生态学报 2021年第3期32卷 836-844页

作者：袁钰娜彭道黎王威曾伟生北京林业大学林学院北京100083 国家林业和草原局调查规划设计院北京100714

为了推广激光雷达技术在森林蓄积量估测计量方面的应用,本研究以东北林区云冷杉林、落叶松林、红松林和樟子松林4种典型针叶林为对象,基于机载激光雷达获取的点云数据提取特征变量,结合800块地面样地数据,采用逐步回归方法和偏最小二乘... 详细信息

为了推广激光雷达技术在森林蓄积量估测计量方面的应用,本研究以东北林区云冷杉林、落叶松林、红松林和樟子松林4种典型针叶林为对象,基于机载激光雷达获取的点云数据提取特征变量,结合800块地面样地数据,采用逐步回归方法和偏最小二乘方法,建立4种针叶林的蓄积量模型。结果表明:偏最小二乘法建立的模型精度优于逐步回归方法(ΔR^(2)=0.05~0.15,ΔRRMSE=2.6%~4.2%);在参与建模的3类点云特征变量中,贡献最大的是点云高度变量(被选择26次),其他变量有一定的辅助作用(分别被选择12次和11次);使用偏最小二乘方法建立的林分蓄积量模型中,红松林(R^(2)=0.79,RMSE=60.92,RRMSE=22.9%)和落叶松林(R^(2)=0.76,RMSE=28.39,RRMSE=25.8%)的精度最高,云冷杉林(R^(2)=0.81,RMSE=46.96,RRMSE=27.7%)次之,樟子松林(R^(2)=0.50,RMSE=55.49,RRMSE=30.4%)的精度稍低。研究结果为东北林区4种典型针叶林蓄积量估测提供了一种有效的方法。

关键词：机载激光雷达针叶林林分蓄积偏最小二乘法

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“In-N-out” design enabling high-content triethyl phosphate-based non-flammable and high-conductivity electrolytes for lithium-ion batteries

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Science China Chemistry 2024年第2期67卷 724-731页

作者： Mengchuang Liu Fenfen Ma Zicheng Ge Ziqi zeng Qiang Wu Hui Yan Yuanke Wu sheng Lei Yanli Zhu Shijie Cheng Jia Xie State Key Laboratory of Advanced Electromagnetic Engineering and Technology School of Electrical and Electronic EngineeringHuazhong University of Science and TechnologyWuhan430074China School of Chemistry and Chemical Engineering Huazhong University of Science and TechnologyWuhan430074China GuSu Laboratory of Materials Suzhou215123China Institute of Metal Research Chinese Academy of SciencesShenyang110000China State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing100081China

Safety issues related to flammable electrolytes in lithium-ion batteries(LIBs) remain a major challenge for their extended *** use of non-flammable phosphate-based electrolytes has proved the validity in inhibiting the combustion of ***,the strong interaction between Li^(+) and phosphate leads to a dominant solid electrolyte interphase(SEI) with limited electronic shielding,resulting in the poor Li^(+) intercalation at the graphite(Gr) anode when using high-phosphate-content *** mitigate this issue and improve Li^(+) insertion,we propose an “In-N-Out” strategy to render phosphates “noncoordinative”.By employing a combination of strongly polar solvents for a “block effect” and weakly polar solvents for a “drag effect”,we reduce the Li^(+)–phosphate *** a result,phosphates remain in the electrolyte phase(“In”),minimizing their impact on the incompatibility with the Gr electrode(“Out”).We have developed a non-flammable electrolyte with high triethyl phosphate(TEP) content(>60 wt.%),demonstrating the excellent ion conductivity(5.94 mS cm^(-1) at 30 ℃) and reversible Li^(+) intercalation at a standard concentration(~1 mol L^(-1)).This approach enables the manipulation of multiple electrolyte functions and holds the promise for the development of safe electrochemical energy storage systems using non-flammable electrolytes.

关键词： lithium-ion batteries graphite anode high-phosphate-content electrolytes non-flammable electrolyte excellent ion conductivity standard concentration

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Advances in multi-scale design and fabrication processes for thick electrodes in lithium-ion batteries

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Energy Reviews 2024年第2期3卷 14-30页

作者： Xiuxue Liu Yubin zeng wei Yuan Guanhua Zhang Huai Zheng Zhongxue Chen Key Laboratory of Hydraulic Machinery Transients Ministry of EducationSchool of Power and Mechanical EngineeringWuhan UniversityWuhan430072China School of Mechanical and Automotive Engineering South China University of TechnologyGuangzhou510640GuangdongChina State Key Laboratory of Advanced Design and Manufacturing for Vehicle Body College of Mechanical and Vehicle EngineeringHunan UniversityChangsha410082China Greater Bay Area Institute for Innovation Hunan UniversityGuangzhou511300China

In the contemporary era,lithium-ion batteries have gained considerable attention in various industries such as 3C products,electric vehicles and energy storage systems due to their exceptional *** the rapid progress in the energy storage sector,there is a growing demand for greater energy density in lithium-ion *** the use of thick electrodes is a straightforward and effective approach to enhance the energy density of battery,it is hindered by the sluggish reaction dynamics and insufficient mechanical ***,we comprehensively review recent advances in the field of thick electrodes for lithium-ion batteries to overcome the bottlenecks in the development of thick electrodes and achieve efficient fabrication for high-performance lithium-ion ***,a systematic analysis is performed to identify the factors affecting the performance of the thick *** correlation between electrode materials,structural parameters,and performance is also ***,the viable strategies for constructing thick electrodes with improved properties are summarize,including high throughput,high conductivity and low tortuosity,in both material development and structural *** addition,recent advances in efficient fabrication methods for thick electrode fabrication are reviewed,with a comprehensive assessment of their merits,limitations,and applicable ***,a comprehensive overview of the multiscale design and manufacturing process for thick electrodes in lithium-ion batteries is provided,accompanied by valuable insights into design considerations that are crucial for future advances in this area.

关键词： Lithium-ion battery Thick electrode High energy density Electrode structure Multi-scale design Material development

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Lung imaging characteristics in a patient infected with Elizabethkingia miricola following cerebral hemorrhage surgery: A case report

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World Journal of Clinical Cases 2024年第1期12卷 169-175页

作者： Ping-Qiang Qi Yi-Jun zeng wei Peng Juan Kuai Department of Neurosurgery The Third Affiliated Hospital of Chengdu Medical College Pidu District People’s HospitalChengdu 611730Sichuan ProvinceChina

BACKGROUND Elizabethkingia miricola is a non-fermenting gram-negative bacterium,which was first isolated from the condensate of the Russian peace space station in *** studies on this bacterium have been carried out in the laboratory,and clinical case studies are *** date,a total of 6 clinical cases have been reported *** SUMMARY We present the first case of postoperative pulmonary infection in a patient with intracerebral hemorrhage due to Elizabethkingia *** imaging character-istics of pulmonary infection were identified and the formulation and selection of the clinical treatment plan for this patient are *** Elizabethkingia miricola infection is *** pulmonary infection occurs,computed tomography imaging may show diffuse distribution of a ground glass density shadow in both lungs,the air containing bronchial sign in local areas,thickening of bronchial vascular bundle,and pleural effusion.

关键词： Elizabethkingia miricola Cerebral hemorrhage surgery Postoperative pulmonary infection Imaging features Case report

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