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Method for rapid warning and activity concentration estimates in online waterγ-spectrometry systems

Nuclear Science and Techniques 2024年第3期35卷 1-12页

作者： Meng Wang Yi Gu Mao-Lin Xiong Liang-quan Ge Qing-Xian Zhang Guo-Qiang zeng Heng Lu Sheng-Liang Guo College of Nuclear Technology and Automation Engineering Chengdu University of TechnologyChengdu 610059China Applied Nuclear Technology in Geosciences Key Laboratory of Sichuan Province (Chengdu University of Technology)Chengdu 610059China Chengdu New Ray Technology Co.Ltd Chengdu 610052China

Onlineγ-spectrometry systems for inland waters,most of which extract samples in situ and in real time,are able to produce reliable activity concentration measurements for waterborne radionuclides only when they are distributed relatively uniformly and enter into a steady-state diffusion regime in the measurement chamber.To protect residents’health and ensure the safety of the living environment,better timeliness is required for this measurement method.To address this issue,this study established a mathematical model of the online waterγ-spectrometry system so that rapid warning and activity estimates can be obtained for water under non-steady-state(NSS)conditions.In addition,the detection efficiency of the detector for radionuclides during the NSS diffusion process was determined by applying the computational fluid dynamics technique in conjunction with Monte Carlo simulations.On this basis,a method was developed that allowed the online waterγ-spectrometry system to provide rapid warning and activity concentration estimates for radionuclides in water.Subsequent analysis of the NSS-mode measurements of^(40)K radioactive solutions with different activity concentrations determined the optimum warning threshold and measurement time for producing accurate activity concentration estimates for radionuclides.The experimental results show that the proposed NSS measurement method is able to give warning and yield accurate activity concentration estimates for radionuclides 55.42 and 69.42 min after the entry of a 10 Bq/L^(40)K radioactive solution into the measurement chamber,respectively.These times are much shorter than the 90 min required by the conventional measurement method.Furthermore,the NSS measurement method allows the measurement system to give rapid(within approximately 15 min)warning when the activity concentrations of some radionuclides reach their respective limits stipulated in the Guidelines for Drinking-water Quality of the WHO,suggesting that this method considerably enhances the warning capacity of in si

关键词： Water radioactivity monitoring Dynamic detection efficiency Rapid warning Activity estimation

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Cetuximab combined with chemotherapy for simultaneous esophageal squamous cell carcinoma and colon adenocarcinoma:A case report

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World Journal of Clinical Cases 2024年第15期12卷 2649-2654页

作者： Xin-Xin Luo Yu-Xuan Du Qi-Qing Zhang Lin Zhang Shu-Ying zeng Zhi-Hong Yu Peng Shen Zheng-quan Feng The Second School of Clinical Medicine Zhejiang Chinese Medical UniversityHangzhou310053Zhejiang ProvinceChina Department of Oncology Tongde Hospital of Zhejiang ProvinceHangzhou 310012Zhejiang ProvinceChina Department of Medical Oncology The First Affiliated HospitalMedical College of Zhejiang UniversityHangzhou 310003Zhejiang ProvinceChina

BACKGROUND Multiple primary carcinomas(MPCs)are defined as two or more independent primary cancers that occur simultaneously or sequentially in the same individual.Synchronous MPCs are rarer than solitary cancers or metachronous MPCs.Accurate diagnoses of synchronous MPCs and the choice of treatment are critical for successful outcomes in these cases.CASE SUMMARY A 64-year-old patient presented with dysphagia,without obvious cause.A diagnosis of synchronous esophageal squamous cell carcinoma and colon adenocarcinoma with liver metastasis was confirmed based on examination and laboratory results.After multi-disciplinary consultations,combination chemotherapy(a 3-wk cycle with oxaliplatin 212 mg administered on day 1 and capecitabine 1.5 g twice daily on days 1-14)and esophageal cancer radiotherapy were initiated.Based on the results of genetic testing,we switched to a regimen of leucovorin+fluorouracil+oxaliplatin and cetuximab regimen for 8 cycles.Subsequently,capecitabine and bevacizumab were administered until the most recent follow-up,at which the tumor remained stable.CONCLUSION Successful cetuximab chemotherapy treatment provides a reference for the nonoperative and homogeneous treatment of different pathological types of synchronous MCPs.

关键词： Synchronous multiple primary carcinoma Esophageal squamous cell carcinoma Colon adenocarcinoma Cetuximab Chemotherapy Case report

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Comparative study of anti-inflammatory effects of different processed products through the COX-2/PGE2 signaling pathway: based on network pharmacology and molecular docking

Pharmacology Discovery

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Pharmacology Discovery 2024年第2期4卷 32-45页

作者： Ping Chen Yun-Yun quan An-Qi zeng Ying Dai Jin zeng Translational Chinese Medicine Key Laboratory of Sichuan Province Sichuan Academy of Chinese Medicine SciencesChengdu 610041China Translational Chinese Medicine Key Laboratory of Sichuan Province Sichuan Institute for Translational Chinese MedicineChengdu 610041China

Background:Radix Aconiti Lateralis Preparata(Fu-zi)is a traditional Chinese medicinal herb,which has been widely used in the clinic and has potent anti-inflammatory activities.we aimed to explore the mechanisms of extract containing alkaloids from different Fu-zi Processed Products(FPP)in treating inflammation,especially rheumatoid arthritis(RA).Methods:Firstly,using network pharmacology technology,the ingredients,and targets of Fu-zi were obtained by searching and screening,the targets involving RA were acquired,the intersection targets were constructed a"component-target-pathway"network.A comprehensive investigation was conducted on the anti-rheumatoid arthritis mechanisms of 5 FPPs in lipopolysaccharide(LPS)induced RAW264.7 cells,which serve as a model for RA.The production of NO and inflammatory cytokines were measured by ELISA kit.quantitative Real-time PCR(qRT-PCR)was utilized to measure the mRNA levels.COX-2/PGE2 signaling pathway-associated proteins were determined by western blot.Results:According to a network pharmacological study,16 chemical components and 43 common targets were found in Fu-zi and 6 key targets including PTGS2 were closely related to the mechanism of Fu-zi in treating RA.The in vitro study revealed that the levels of NO,TNF-α,and IL-1βwere substantially decreased by the 5 FPPs.The 5 FPPs significantly suppressed the expression of proteins COX-2,iNOS,and NF-κB,with particularly notable effects observed for PFZ and XFZ.Conclusion:Altogether,these results demonstrated that the 5 PPS containing alkaloids have a good anti-RA-related inflammatory effect,and the mechanism may be related to COX-2/PGE2 signaling pathway,particularly,Fu-zi prepared utilizing a traditional Chinese technique.

关键词： Radix Aconiti Lateralis Preparata(Fu-zi) rheumatoid arthritis anti-inflammatory network pharmacology COX-2/PGE2 signaling pathway

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不同建筑环境下平均风速剖面的数值模拟

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同济大学学报（自然科学版） 2024年第4期52卷 551-556页

作者：全涌曾一凡全茜同济大学土木工程防灾减灾全国重点实验室上海200092 上海理工大学基础学院上海200093

基于计算流体力学(CFD)方法对具有不同建筑环境参数的城市上空的风场进行系统性的数值模拟,并对平均风速剖面指数的变化规律进行讨论。研究结果表明,建筑平均高度对平均风速剖面指数的影响较大,建筑密度对平均风速剖面指数的影响较小。... 详细信息

基于计算流体力学(CFD)方法对具有不同建筑环境参数的城市上空的风场进行系统性的数值模拟,并对平均风速剖面指数的变化规律进行讨论。研究结果表明,建筑平均高度对平均风速剖面指数的影响较大,建筑密度对平均风速剖面指数的影响较小。文中还给出了以建筑平均高度和建筑密度为自变量的平均风速剖面指数经验公式。

关键词：平均风速剖面指数建筑环境参数城市风场数值模拟

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quantum geometric tensor and the topological characterization of the extended Su-Schrieffer-Heeger model

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Chinese Physics B 2024年第3期33卷 260-265页

作者：曾相龙赖文喜魏祎雯马余全 School of Science Beijing Information Science and Technology UniversityBeijing 100192China

We investigate the quantum metric and topological Euler number in a cyclically modulated Su-Schrieffer-Heeger(SSH)model with long-range hopping terms.By computing the quantum geometry tensor,we derive exact expressions for the quantum metric and Berry curvature of the energy band electrons,and we obtain the phase diagram of the model marked by the first Chern number.Furthermore,we also obtain the topological Euler number of the energy band based on the Gauss-Bonnet theorem on the topological characterization of the closed Bloch states manifold in the first Brillouin zone.However,some regions where the Berry curvature is identically zero in the first Brillouin zone result in the degeneracy of the quantum metric,which leads to ill-defined non-integer topological Euler numbers.Nevertheless,the non-integer"Euler number"provides valuable insights and an upper bound for the absolute values of the Chern numbers.

关键词： quantum geometric tensor topological Euler number Chern number Berry curvature quantum metric Su-Schrieffer-Heeger(SSH)model

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基于自适应聚合距离的多目标进化算法

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控制与决策 2024年第4期39卷 1113-1122页

作者：曾亮曾维钧李燕燕全睿王珊珊湖北工业大学电气与电子工程学院武汉430068 太阳能高效利用及储能运行控制湖北省重点实验室武汉430068 襄阳湖北工业大学产业研究院湖北襄阳441100

随着目标数的增多,种群收敛性与分布性的冲突愈加激烈,传统的多目标进化算法的选择算子难以平衡种群的收敛性与分布性.对此,提出一种基于自适应聚合距离的多目标进化算法.首先,采用参考点支配关系替代原有的Pareto支配关系,以增加选择压... 详细信息

随着目标数的增多,种群收敛性与分布性的冲突愈加激烈,传统的多目标进化算法的选择算子难以平衡种群的收敛性与分布性.对此,提出一种基于自适应聚合距离的多目标进化算法.首先,采用参考点支配关系替代原有的Pareto支配关系,以增加选择压力,加强收敛性;其次,提出自适应聚合距离,通过动态变化的惩罚参数来自适应调整收敛性与分布性的比例;最后,设计一种带有淘汰算子的方法以改进小生境选择策略,根据自适应聚合距离的大小进行选择和淘汰操作.为验证算法的可行性,将所提出算法在测试问题上与其他4种优秀的多目标进化算法进行比较,并应用于两个实际应用中,仿真结果表明,所提出算法的综合性能更优,能有效平衡种群的收敛性与分布性.

关键词：多目标进化算法参考点支配自适应聚合距离淘汰算子收敛性与分布性

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不同形态氮添加对多年生高寒栽培草地土壤理化性质和微生物群落结构的影响

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环境科学 2024年第6期45卷 3595-3604页

作者：童永尚张春平董全民杨增增张小芳霍丽安曹铨张正社俞旸杨晓霞青海大学畜牧兽医科学院青海省畜牧兽医学院西宁810016 青海省高寒草地适应性管理重点实验室西宁810016 青海大学三江源区高寒草地生态教育部重点实验室西宁810016

探究不同氮素形态对多年生高寒栽培草地土壤理化性质和微生物群落结构的影响,以期为制定多年生高寒栽培草地氮添加方案提供科学依据.于2022年6月,在青海省海南藏族自治州共和县巴卡台农牧场以建植4龄的青海草地早熟禾(Poa pratensis Qin... 详细信息

探究不同氮素形态对多年生高寒栽培草地土壤理化性质和微生物群落结构的影响,以期为制定多年生高寒栽培草地氮添加方案提供科学依据.于2022年6月,在青海省海南藏族自治州共和县巴卡台农牧场以建植4龄的青海草地早熟禾(Poa pratensis Qinghai)+青海中华羊茅(Festuca sinensis Qinghai)混播草地为研究对象,以不施肥为对照(CK),设置3个不同形态氮素处理,分别为U:尿素(酰胺态氮)、A:硫酸铵(铵态氮)和N:硝酸钙(硝态氮),各处理的氮素施用量均为67.5 kg·(hm^(2)·a)^(-1),对不同处理下土壤养分和微生物群落组成及多样性进行分析.结果表明,外源铵态氮输入显著提高了NH_(4)^(+)-N含量、AP含量和EC,酰胺态氮输入显著提高了SOC含量和TN含量,硝态氮输入显著提高了NO_(3)^(-)-N含量、AN含量和TC含量.外源氮输入改变了土壤细菌和真菌群落结构以及优势菌门和属的相对丰度,但对细菌和真菌群落的Alpha多样性没有显著影响.主坐标分析(PCo A)表明,不同形态氮添加对细菌群落的Beta多样性具有显著影响,而对真菌群落影响不显著.冗余分析(RDA)表明,氮添加主要通过土壤铵态氮来改变微生物群落组成和结构.综合而言,在青藏高原多年生栽培草地土壤修复过程中,应优先考虑铵态氮肥.

关键词：氮素形态高寒栽培草地土壤养分微生物多样性土壤修复

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A von-Neumann-like photonic processor and its application in studying quantum signature of chaos

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Light(Science & Applications) 2024年第4期13卷 672-681页

作者： Shang Yu Wei Liu Si-Jing Tao Zhi-Peng Li Yi-Tao Wang Zhi-Peng Zhong Raj BPatel Yu Meng Yuan-Ze Yang Zhao-An Wang Nai-Jie Guo Xiao-Dong zeng Zhe Chen Liang Xu Ning Zhang Xiao Liu Mu Yang Wen-Hao Zhang Zong-quan Zhou Jin-Shi Xu Jian-Shun Tang Yong-Jian Han Chuan-Feng Li Guang-Can Guo CAS Key Laboratory of quantum Information University of Science and Technology of ChinaHefei 230026China. CAS Center for Excellence in quantum Information and quantum Physics University of Science and Technology of ChinaHefei 230026China. Hefei National Laboratory University of Science and Technology of ChinaHefei 230088China. Research Center for quantum Sensing Zhejiang LabHangzhou 310000China. quantum Optics and Laser Science Blackett LaboratoryImperial College LondonPrince Consort RdLondon SW72AZUK. Clarendon Laboratory Department of PhysicsOxford UniversityParks Road OX13PUOxfordUK

Photonic quantum computation plays an important role and offers unique advantages.Two decades after the milestone work of Knill-Laflamme-Milburn,various architectures of photonic processors have been proposed,and quantum advantage over classical computers has also been demonstrated.It is now the opportune time to apply this technology to real-world applications.However,at current technology level,this aim is restricted by either programmability in bulk optics or loss in integrated optics for the existing architectures of processors,for which the resource cost is also a problem.Here we present a von-Neumann-like architecture based on temporal-mode encoding and looped structure on table,which is capable of multimode-universal programmability,resource-efficiency,phasestability and software-scalability.In order to illustrate these merits,we execute two different programs with varying resource requirements on the same processor,to investigate quantum signature of chaos from two aspects:the signature behaviors exhibited in phase space(13 modes),and the Fermi golden rule which has not been experimentally studied in quantitative way before(26 modes).The maximal program contains an optical interferometer network with 1694 freely-adjustable phases.Considering current state-of-the-art,our architecture stands as the most promising candidate for real-world applications.

关键词： quantum signature chaos

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Epidemiological characteristics of varicella in Chongqing,China,2014-2021

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Medical Data Mining 2024年第2期7卷 32-38页

作者： Yong-Jiao Hu Qing Wang Mu-Nan Zhang Xin zeng quan-Hong Lu Zheng Zhang Ping Cheng Jing Deng School of Public Health Chongqing Medical UniversityChongqing 400016China Institute of Immunization Program Chongqing Center for Disease Control and PreventionChongqing 400042China

Background:To analyze the epidemiological characteristics of varicella epidemics in Chongqing Municipality from 2014 to 2021,and to provide a scientific basis for the formulation of varicella prevention and control measures.Methods:Data on the incidence of varicella outbreaks and vaccination data in Chongqing from 2014 to 2021 were collected through the China Disease Control and Prevention Information System and statistically analyzed using descriptive epidemiological methods.Results:From 2014 to 2021,213,715 cases of varicella were reported in Chongqing Municipality,with an average annual incidence rate of 86.26/100,000,with a statistically significant difference(χ^(2)=24,972.069,P<0.001);varicella incidence is seasonal,with peaks in May/June and October/December each year,presenting a“double-peak distribution”.The average annual incidence rate of varicella in municipal districts was 90.74/100,000,which was higher than that of counties 69.62/100,000 and autonomous counties 84.04/100,000;the average annual incidence rate of varicella in males was 89.37/100,000,and in females,82.22/100,000,with the difference not being statistically significant;the age of onset of the disease was mainly in the group of people under 15 years of age,with a total of 190,021 cases reported(88.9%),with 5-9 years old(35.7%)as the high incidence age group.The incidence occupation was dominated by students in 133,733 cases(62.6%).Conclusion:The overall varicella epidemic in Chongqing is on the rise,and has obvious seasonal,regional and population distribution characteristics.The prevention and control of varicella epidemic should be strengthened,the publicity of varicella vaccine should be increased,and it is recommended that varicella vaccine should be included in the national immunization program.

关键词： varicella epidemiologic characteristics vaccination preventive and control measures

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微波焙烧赤泥-稻壳压块回收铁

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中国有色金属学报 2024年第5期34卷 1702-1711页

作者：曾一钧曾奎全学军姜启彬闫春宇蒋孟芝重庆理工大学化学化工学院重庆400054

本文提出了一种利用微波体相加热还原焙烧赤泥−稻壳压块并从中回收铁的新方法,研究了进料方式、生物质用量、焙烧温度和时间等主要工艺参数对铁回收的影响。结果表明:在稻壳赤泥比为3、焙烧温度为1000℃、焙烧时间为20 min的优化条件下... 详细信息

本文提出了一种利用微波体相加热还原焙烧赤泥−稻壳压块并从中回收铁的新方法,研究了进料方式、生物质用量、焙烧温度和时间等主要工艺参数对铁回收的影响。结果表明:在稻壳赤泥比为3、焙烧温度为1000℃、焙烧时间为20 min的优化条件下,得到铁品位为60.1%、回收率为86.3%的铁精矿。利用X射线衍射和X射线荧光光谱分析研究了赤泥中铁氧化物还原过程的机理,赤泥中的含铁矿物被还原成Fe和FeO等磁性物质。

关键词：微波体相加热还原焙烧赤泥−稻壳压块铁回收

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