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Modeling of multiphase flow in low permeability porous media:Effect of wettability and pore structure properties

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第4期16卷 1127-1139页

作者： Xiangjie Qin Yuxuan Xia Juncheng qiao Jiaheng Chen Jianhui zeng Jianchao Cai National Key Laboratory of Petroleum Resources and Engineering China University of PetroleumBeijing102249China Research Institute of Petroleum Exploration and Development Beijing10083China

Multiphase flow in low permeability porous media is involved in numerous energy and environmental applications.However,a complete description of this process is challenging due to the limited modeling scale and the effects of complex pore structures and wettability.To address this issue,based on the digital rock of low permeability sandstone,a direct numerical simulation is performed considering the interphase drag and boundary slip to clarify the microscopic water-oil displacement process.In addition,a dual-porosity pore network model(PNM)is constructed to obtain the water-oil relative permeability of the sample.The displacement efficiency as a recovery process is assessed under different wetting and pore structure properties.Results show that microscopic displacement mechanisms explain the corresponding macroscopic relative permeability.The injected water breaks through the outlet earlier with a large mass flow,while thick oil films exist in rough hydrophobic surfaces and poorly connected pores.The variation of water-oil relative permeability is significant,and residual oil saturation is high in the oil-wet system.The flooding is extensive,and the residual oil is trapped in complex pore networks for hydrophilic pore surfaces;thus,water relative permeability is lower in the water-wet system.While the displacement efficiency is the worst in mixed-wetting systems for poor water connectivity.Microporosity negatively correlates with invading oil volume fraction due to strong capillary resistance,and a large microporosity corresponds to low residual oil saturation.This work provides insights into the water-oil flow from different modeling perspectives and helps to optimize the development plan for enhanced recovery.

关键词： Low permeability porous media Water-oil flow Wettability Pore structures Dual porosity pore network model(PNM) Free surface model

Two-dimensional precise figuring of 500 mm-long X-ray mirror using one-dimensional ion beam system

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Advances in Manufacturing 2024年第1期12卷 177-184页

作者： Qiu-Shi huang Han-Dan huang qiao-Yu Wu Jun Yu Zhong Zhang Zhan-Shan Wang MOE Key Laboratory of Advanced Micro-Structured Materials Institute of Precision Optical Engineering(IPOE)School of Physics Science and EngineeringTongji UniversityShanghai200092People’s Republic of China Shanghai Professional Technical Service Platform for Full-Spectrum and High-Performance Optical Thin Film Devices and Applications Tongji UniversityShanghai200092People’s Republic of China Shanghai Frontiers Science Center of Digital Optics Tongji UniversityShanghai200092People’s Republic of China

In this study,a new method was developed to realize two-dimensional(2D)figure correction of grazing-incidence X-ray mirrors using a one-dimensional(1D)ion-beam figuring system.A mask of holes was specifically designed to generate removal functions at different widths and extend the figuring capability over a wide area.Accordingly,a long mirror could be manufactured.Using this method,the surface height root-mean-square(RMS)error of the center area of 484 mm×16 mm was reduced from 11.49 nm to 2.01 nm,and the 1D meridional RMS error reached 1.0 nm.The proposed method exhibits high precision and cost effectiveness for production of long X-ray mirrors.

关键词： Long-size mirrors Ion beam figuring Two-dimensional figure correction Mask

Dynamic response of mountain tunnel,bridge,and embankment along the Sichuan-Tibet transportation corridor to active fault based on model tests

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Journal of Mountain Science 2024年第1期21卷 182-199页

作者： huang Beixiu qiao Sijia CHEN Xulei LI Lihui QI Shengwen Key Laboratory of Shale Gas and Geoengineering Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China Innovation Academy for Earth Science Chinese Academy of SciencesBeijing 100029China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China

The Sichuan-Tibet transportation corridor is prone to numerous active faults and frequent strong earthquakes.While extensive studies have individually explored the effect of active faults and strong earthquakes on different engineering structures,their combined effect remains unclear.This research employed multiple physical model tests to investigate the dynamic response of various engineering structures,including tunnels,bridges,and embankments,under the simultaneous influence of cumulative earthquakes and stick-slip misalignment of an active fault.The prototype selected for this study was the Kanding No.2 tunnel,which crosses the Yunongxi fault zone within the Sichuan-Tibet transportation corridor.The results demonstrated that the tunnel,bridge,and embankment exhibited amplification in response to the input seismic wave,with the amplification effect gradually decreasing as the input peak ground acceleration(PGA)increased.The PGAs of different engineering structures were weakened by the fault rupture zone.Nevertheless,the misalignment of the active fault may decrease the overall stiffness of the engineering structure,leading to more severe damage,with a small contribution from seismic vibration.Additionally,the seismic vibration effect might be enlarged with the height of the engineering structure,and the tunnel is supposed to have a smaller PGA and lower dynamic earth pressure compared to bridges and embankments in strong earthquake zones crossing active faults.The findings contribute valuable insights for evaluating the dynamic response of various engineering structures crossing an active fault and provide an experimental reference for secure engineering design in the challenging conditions of the Sichuan-Tibet transportation corridor.

关键词： Dynamic response Engineering structure Sichuan-Tibet transportation corridor Active fault Earthquake Model test

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NLRP3/1-mediated pyroptosis:beneficial clues for the development of novel therapies for Alzheimer’s disease

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Neural Regeneration Research 2024年第11期19卷 2400-2410页

作者： Bo Hu Jiaping Zhang Jie huang Bairu Luo Xiansi zeng Jinjing Jia Department of Pathology and Municipal Key-Innovative Discipline of Molecular Diagnostics Jiaxing Hospital of Traditional Chinese MedicineJiaxing UniversityJiaxingZhejiang ProvinceChina Research Center of Neuroscience Jiaxing University Medical CollegeJiaxingZhejiang ProvinceChina Department of Clinical Pathology Jiaxing University Master Degree Cultivation BaseZhejiang Chinese Medical UniversityJiaxingZhejiang ProvinceChina

The inflammasome is a multiprotein complex involved in innate immunity that mediates the inflammatory response leading to pyroptosis,which is a lytic,inflammatory form of cell death.There is accumulating evidence that nucleotide-binding domain and leucine-rich repeat pyrin domain containing 3(NLRP3)inflammasome-mediated microglial pyroptosis and NLRP1 inflammasome-mediated neuronal pyroptosis in the brain are closely associated with the pathogenesis of Alzheimer’s disease.In this review,we summarize the possible pathogenic mechanisms of Alzheimer’s disease,focusing on neuroinflammation.We also describe the structures of NLRP3 and NLRP1 and the role their activation plays in Alzheimer’s disease.Finally,we examine the neuroprotective activity of small-molecule inhibitors,endogenous inhibitor proteins,microRNAs,and natural bioactive molecules that target NLRP3 and NLRP1,based on the rationale that inhibiting NLRP3 and NLRP1 inflammasome-mediated pyroptosis can be an effective therapeutic strategy for Alzheimer’s disease.

关键词： Alzheimer’s disease caspase-1 GSDMD inflammasome neuroinflammation NLRP1 NLRP3 pyroptosis therapeutic strategies

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Urban Flood Mitigation Strategies with Coupled Gray–Green Measures: A Case Study in Guangzhou City, China

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International Journal of Disaster Risk Science 2024年第3期15卷 467-479页

作者： Jiayue Li Jiajun zeng Guoru huang Wenjie Chen School of Civil Engineering and Transportation South China University of Technology School of Architecture South China University of Technology State Key Laboratory of Subtropical Building and Urban Science South China University of Technology College of Water Conservancy and Civil Engineering South China Agricultural University

The integration of gray and green infrastructure has proven to be a feasible approach for managing stormwater in established urban areas. However, evaluating the specific contributions of such coupled strategies is challenging. This study introduced a novel integrated hydrological-hydrodynamic model that takes into account the layout of low-impact development(LID)facilities along with pipeline alignment and rehabilitation. Reliable results from modeling were used to assess the individual contribution of LID and improved drainage facilities to urban flooding mitigation. We selected a natural island in Guangzhou City, China, as the study site. The results indicate that combining three LID measures, namely green roofs, sunken green spaces, and permeable pavements, can reduce total runoff by 41.7% to 25.89% for rainfall recurrence periods ranging from 1year to 100 years, and decrease the volume of nodal overflow by nearly half during rainfall events of less than 10-year return period. By integrating LID measures with the upgraded gray infrastructure, the regional pipeline overloading condition is substantially alleviated, resulting in a significant improvement in pipeline system resilience. For urban flooding control, it is recommended to integrate sufficient green space and avoid pipe-laying structural issues during urban planning and construction. The findings may assist stakeholders in developing strategies to best utilize gray and green infrastructure in mitigating the negative eff ects of urban flooding.

关键词： Coupled hydrodynamic model Gray–green approach Guangzhou City LID Pipe renovation Urban inundation

Recycling of waste aluminum scraps to fabricate sulfidated zero-valent iron-aluminum particles for enhanced chromate removal

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Journal of Environmental Sciences 2024年第4期138卷 650-659页

作者： Yahui Zhang Liguo Zhang Jiajia zeng Shuqun Xu Jianyu Pan Wenzhuo huang Jianliang Sun Feng Jiang Guangdong Provincial Key Laboratory of Chemical Pollution and Environmental Safety&MOE Key Laboratory of Theoretical Chemistry of Environment School of EnvironmentSouth China Normal UniversityGuangzhou 510006China Guangdong Provincial Key Lab of Environmental Pollution Control and Remediation Technology School of Environmental Science&EngineeringSun Yat-Sen UniversityGuangzhou 510275China

Massive waste aluminum scraps produced from the spent aluminum products have high electron capacity and can be recycled as an attractive alternative to materials based on zerovalent iron(Fe^(0))for the removal of oxidative contaminants from wastewater.This study thus proposed an approach to fabricate micron-sized sulfidated zero-valent iron-aluminum particles(S-Al^(0)@Fe^(0))with high reactivity,electron selectivity and capacity using recycled waste aluminum scraps.S-Al^(0)@Fe^(0)with a three-layer structure contained zero-valent aluminum(Al^(0))core,Fe^(0) middle layer and iron sulfide(FeS)shell.The rates of chromate(Cr(Ⅵ))removal by S-Al^(0)@Fe^(0)at pH 5.0-9.0 were 1.6-5.9 times greater than that by sulfidated zero-valent iron(S-Fe^(0)).The Cr(Ⅵ)removal capacity of S-Al^(0)@Fe^(0)was 8.2-,11.3-and 46.9-fold greater than those of S-Fe0,zero-valent iron-aluminum(Al^(0)-Fe^(0))and Fe^(0),respectively.The chemical cost of S-Al^(0)@Fe^(0) for the equivalent Cr(Ⅵ)removal was 78.5%lower than that of S-Fe^(0).Negligible release of soluble aluminum during the Cr(Ⅵ)removal was observed.The significant enhancement in the reactivity and capacity of S-Al^(0)@Fe^(0)was partially ascribed to the higher reactivity and electron density of the Al0core than Fe^(0).More importantly,S-Al^(0)@Fe^(0) served as an electric cell to harness the persistent and selective electron transfer from the Al^(0)-Fe^(0) core to Cr(Ⅵ)at the surface via coupling Fe^(0)-Fe^(2+)-Fe^(3+)redox cycles,resulting in a higher electron utilization efficiency.Therefore,S-Al^(0)@Fe^(0) fabricated using recycled waste aluminum scraps can be a cost-effective and environmentally-friendly alternative to S-Fe^(0) for the enhanced removal of oxidative contaminants in industrial wastewater.

关键词： Recycled waste aluminum scraps Oxidative contaminants Cr(Ⅵ)reduction Sulfidated Al^(0)@Fe^(0)particle Electron transfer

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Fabrication of surface passivated two-dimensional MFI zeolite for alkylation between toluene with methanol

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Frontiers of Chemical Science and Engineering 2024年第4期18卷 115-124页

作者： Zhenyuan Zou Shengzhi Gan Ting Pu Xingxing zeng Yi huang Baoyu Liu School of Chemical Engineering and Light Industry Guangdong University of TechnologyGuangzhou 510006China School of Engineering Institute for Materials&Processesthe University of EdinburghEdinburgh EH93FBUnited Kingdom

The fabrication of suitable MFI zeolites to effectively produce para-xylene through the alkylation between toluene and methanol is highly desired.Here,the two-dimensional pillared MFI zeolite was modified by silicalite-1,and its morphology and structure were systematically investigated by tuning the concentration of Si species during the secondary crystallization process.The MFI zeolites were characterized by X-ray diffraction,transmission electron microscopy,pyridine-infrared and N_(2) adsorption-desorption isotherms.The characterization results showed that the external Brønsted acid sites of surface passivated P-MFI-x samples have been successfully shielded.Interestingly,the P-MFI-23 showed long lifetime and high selectivity of para-xylene(about 35%)based on the cooperation between opened interlamellar structure and passivated silicalite-1 layer.It was found that the accumulated hard coke in the interior of MFI zeolites not only blocked the channels of zeolites but also covered the acidic sites,resulting in the deactivation of catalyst.Furthermore,the highest selectivity of para-xylene(about 48%)can be achieved for P-MFI-30 under harsh reaction condition,which also exhibited excellent regeneration property in the alkylation reaction between toluene and methanol.The strategy described in present research may open a window for the design of other advanced materials.

关键词： alkylation MFI nanosheets catalysis

Investigation of Quantum Dot Color Filter Micro-LED Display

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Photonic Sensors 2024年第1期14卷 40-47页

作者： Xuhui PENG Yang zeng Sitao HUO Zhenyuan YANG Xiaoping huang Qing ZHAO School of Resources and Environment University of Electronic Science and Technology of ChinaChengdu 611731China Yangtze Delta Region Institute(Huzhou) University of Electronic Science and Technology of ChinaHuzhou 313001China Shanghai Tianma Microelectronics Shanghai 201201China

In this work,we present the investigation of the quantum dot color filter(QDCF)micro-light emitting diode(micro-LED)display.Green and red quantum dot photoresist(QDPR)materials are patterned into a pixelated array and precisely bonded with an all-blue micro-light emitting diode(micro-LED)substrate,forming a red,green,and blue(RGB)full color display through color conversion.A few factors that influence the achievable color gamut are further investigated.The resulting 1.1-inch 228-pixels per inch(ppi)display demo shows the good performance.The findings in this paper pave a way to the future industrialization of the micro-LED display.

关键词： Quantum dot color filter(QDCF) color conversion micro-light emitting diode(micro-LED) color gamut

Thymic carcinoid with multiple bone metastases:A case report

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World Journal of Clinical Cases 2024年第13期12卷 2275-2280页

作者： Chun-qiao Chen Ming-Yue huang Min Pan Qiu-Qiu Chen Fei-Fei Wei Hui huang Department of Oncology People’s Hospital of GuilinGuilin 541000Guangxi Zhuang Autonomous RegionChina

BACKGROUND Thymic carcinoid(TC)is a rare entity among anterior mediastinal malignancies.TCs are neuroendocrine carcinomas that constitute approximately 2%–5%of all thymic epithelial tumors.CASE SUMMARY The study reported a rare TC with multiple bone metastases.A 77-year-old man presented with a 2-month history of lower back pain and weight loss of 5 kg.Magnetic resonance imaging scans revealed damage to the lumbar spine,sacrocaudal vertebrae and iliac crest,suggesting bone metastasis;computed tomography(CT)scan of the thorax showed a calcified anterior mediastinal mass;positron emission tomography-CT demonstrated multiple abnormal bone signals;and laboratory work-up showed no endocrine abnormalities.Fine-needle aspiration biopsy revealed predominantly single small,round to oval cells with scant cytoplasm and some loose clusters,suggesting endocrine manifestations.The pathological diagnosis was atypical carcinoid,which tend to originate from the thymus and was classified as intermediate-highly invasive.The patient underwent anlotinib-targeted therapy.Anlotinib(12 mg)was administered daily for 2 wk,after which the patient was allowed to rest for 21 d.Follow-up CT after one year demonstrated that the tumor had shrunk by approximately 29%after therapy.Treatment has a long stable disease benefit of more than 2.5 years.CONCLUSION These findings demonstrated that anlotinib is a promising treatment regimen for patients with TC and multiple bone metastases.

关键词： Thymic carcinoid Anlotinib Multitargeted tyrosine kinase inhibitor Bone metastasis Case report