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Computational systems pharmacology reveals anantiplatelet and neuroprotective mechanism of Deng-Zhan-Xi-Xin injection in treatment of ischemic stroke

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中国药理学与毒理学杂志 2019年第10期 857-858页

作者： ZHAO Jing LYU Chao wu Qiu-ling zeng hua-wu GUO Xin YANG Jian TIAN Sai-sai ZHANG Wei-dong Institute of Interdisciplinary Integrative Medicine Research Shanghai University of Traditional Chinese Medicine School of Pharmacy Fujian University of Traditional Chinese Medicine School of Pharmacy Second Military Medical University

Herbs are typically prescribed in traditional Chinese medicine(TCM) to treat complex diseases. The multicomponent nature of herbal drug ingredients makes it difficult to readily understand their mode of action. To decipher their molecular mechanisms, here we proposed a novel computational systems pharmacology based approach, which consisted of transcriptome profiling,data collection, statistical analysis, network algorithm,bioinformatics analysis and pharmacological *** network algorithm called signed random walk with restart(SRWR) was used to simulate the propagation of drugs effects on networks. This algorithm could identify proteins either positively or negatively regulated(activated or inhibited) by drugs on human signaling networks. To establish proof of principle, the herbal product Deng-Zhan-XiXin injection(DZXXI), which exhibits pharmacological effects in ischemic stroke but its mechanism was unclear,was analyzed. Eighty-three targets were predicted with high confidence for DZXXI′s active compounds in plasma,and 87 differentially expressed genes(DEGs) were identified in MCF7 cells treated with DZXXI. These target genes were further found to be associatedwith pathways involved in neuronal apoptosis in ischemic stroke, such as NF-κB signaling, TNF signaling, and PI3K-Akt *** analysis between DZXXI’s putative targets with ischemic stroke-associated genes identified two important targets(PTGS1, PTGS2) corresponding to four DZXXI compounds, which were further validated using in silico and in vitro/in vivo models. The most inhibited genes identified by the SRWR algorithm were significantly enriched with ischemic stroke-associated disease genes,antiplatelet associated pathways, and their encoded proteins were enriched in brain, vascular endothelium and platelets. The CMAP analysis based on DEGs suggested that DZXXI could function as both an anti-inflammatory and anti-platelet agent. Taken together, the computational analysis suggested

关键词： ischemic stroke Deng-Zhan-Xi-Xin injection computational analysis

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矩形RC桥墩变形能力概率模型

工程力学 2015年第1期32卷 57-63,71页

作者：卓卫东曾武华福州大学土木工程学院福建福州350116

桥墩是桥梁抗侧力体系中的关键构件。为实现基于概率和性能的桥梁抗震设计的多级性能目标,有必要给出桥墩在不同性能极限状态下的概率能力。基于已有研究工作,将RC桥墩的抗震性能水平划分为五个等级,并定义了相应的性能极限状态。采用... 详细信息

桥墩是桥梁抗侧力体系中的关键构件。为实现基于概率和性能的桥梁抗震设计的多级性能目标,有必要给出桥墩在不同性能极限状态下的概率能力。基于已有研究工作,将RC桥墩的抗震性能水平划分为五个等级,并定义了相应的性能极限状态。采用等效集中塑性铰理论,推导并建立了各性能极限状态下RC墩柱变形能力的确定性计算公式;基于183个矩形RC墩柱试件的拟静力试验结果,通过多元回归分析,确定了各计算公式中与轴压比、长细比和配箍特征值等设计参数相关的待定系数。基于确定性计算模型和拟静力试验结果,考虑认知不确定性,建立了矩形RC墩柱变形能力的概率模型。通过实例分析,表明该模型可用于基于概率和性能的桥梁抗震设计和抗震评估。

关键词： RC桥墩性能极限状态拟静力试验概率能力漂移率

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Brain region-specific roles of brain-derived neurotrophic factor in social stress-induced depressive-like behavior

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Neural Regeneration Research 2025年第1期20卷 159-173页

作者： Man Han Deyang zeng Wei Tan Xingxing Chen Shuyuan Bai Qiong wu Yushan Chen Zhen Wei Yufei Mei Yan zeng Brain Science and Advanced Technology Institute Wuhan University of Science and TechnologyWuhanHubei ProvinceChina Geriatric Hospital Affiliated to wuhan University of Science and Technology WuhanHubei ProvinceChina School of Public Health Wuhan University of Science and TechnologyWuhanHubei ProvinceChina

Brain-derived neurotrophic factor is a key factor in stress adaptation and avoidance of a social stress behavioral *** studies have shown that brain-derived neurotrophic factor expression in stressed mice is brain region–specific,particularly involving the corticolimbic system,including the ventral tegmental area,nucleus accumbens,prefrontal cortex,amygdala,and *** how brain-derived neurotrophic factor participates in stress processing in different brain regions will deepen our understanding of social stress *** this review,we discuss the expression and regulation of brain-derived neurotrophic factor in stress-sensitive brain regions closely related to the pathophysiology of *** focused on associated molecular pathways and neural circuits,with special attention to the brain-derived neurotrophic factor–tropomyosin receptor kinase B signaling pathway and the ventral tegmental area–nucleus accumbens dopamine *** determined that stress-induced alterations in brain-derived neurotrophic factor levels are likely related to the nature,severity,and duration of stress,especially in the above-mentioned brain regions of the corticolimbic ***,BDNF might be a biological indicator regulating stress-related processes in various brain regions.

关键词： amygdala chronic mild stress chronic social defeat stress corticolimbic system depression hippocampus medial prefrontal cortex nucleus accumbens social stress models ventral tegmental area

Liver as a new target organ in Alzheimer's disease:insight from cholesterol metabolism and its role in amyloid-beta clearance

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Neural Regeneration Research 2025年第3期20卷 695-714页

作者： Beibei wu Yuqing Liu Hongli Li Lemei Zhu Lingfeng zeng Zhen Zhang Weijun Peng Department of Integrated Traditional Chinese&Western Medicine The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Academician Workstation Changsha Medical UniversityChangshaHunan ProvinceChina Yangsheng College of Traditional Chinese Medicine Guizhou University of Traditional Chinese MedicineGuiyangGuizhou ProvinceChina Qinhuangdao Shanhaiguan Pharmaceutical Co. LtdQinhuangdaoHebei ProvinceChina National Clinical Research Center for Mental Disorder The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina

Alzheimer's disease,the primary cause of dementia,is characterized by neuropathologies,such as amyloid plaques,synaptic and neuronal degeneration,and neurofibrillary *** amyloid plaques are the primary characteristic of Alzheimer's disease in the central nervous system and peripheral organs,targeting amyloid-beta clearance in the central nervous system has shown limited clinical efficacy in Alzheimer's disease *** abnormalities are commonly observed in patients with Alzheimer's *** liver is the primary peripheral organ involved in amyloid-beta metabolism,playing a crucial role in the pathophysiology of Alzheimer's ***,impaired cholesterol metabolism in the liver may exacerbate the development of Alzheimer's *** this review,we explore the underlying causes of Alzheimer's disease and elucidate the role of the liver in amyloid-beta clearance and cholesterol ***,we propose that restoring normal cholesterol metabolism in the liver could represent a promising therapeutic strategy for addressing Alzheimer's disease.

关键词： ABCA1 Alzheimer's disease amyloid-beta apolipoprotein E cholesterol metabolism liver liver X receptor low-density lipoprotein receptor-related protein 1 peripheral clearance tauroursodeoxycholic acid

Antioxidant activities of α-methyl-4-(3-oxo-2H-1,2-benzoisoselenazol-2-yl)benzeneacetic acid in vitro

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中国药理学与毒理学杂志 1998年第1期 68-69页

作者： zeng huawu, JIANG YuanYing1, CAI DingGuo, TAO Zhihua, LONG Kun1(The Pharmacy Center of Navy, The Navy 411 Hospital, Shanghai 200081 1 Department of Pharmacology,College of Pharmacy, The Second Military Medical University, Shangh

Ａｎｔｉｏｘｉｄａｎｔａｃｔｉｖｉｔｉｅｓｏｆα┐ｍｅｔｈｙｌ┐４┐（３┐ｏｘｏ┐２Ｈ┐１，２┐ｂｅｎｚｏｉｓｏｓｅｌｅｎａｚｏｌ┐２┐ｙｌ）ｂｅｎｚｅｎｅａｃｅｔｉｃａｃｉｄｉｎｖｉｔｒｏＺＥＮＧＨｕａ－Ｗｕ，ＪＩ... 详细信息

Ａｎｔｉｏｘｉｄａｎｔａｃｔｉｖｉｔｉｅｓｏｆα┐ｍｅｔｈｙｌ┐４┐（３┐ｏｘｏ┐２Ｈ┐１，２┐ｂｅｎｚｏｉｓｏｓｅｌｅｎａｚｏｌ┐２┐ｙｌ）ｂｅｎｚｅｎｅａｃｅｔｉｃａｃｉｄｉｎｖｉｔｒｏＺＥＮＧＨｕａ－Ｗｕ，ＪＩＡＮＧＹｕａｎ－Ｙｉｎｇ１，ＣＡＩ...

关键词： αmethyl4(3oxo2H1,2benzoisoselenazol2yl) benzeneacetic acid selenoorganic compound lipid peroxides

中空夹层钢管钢渣混凝土T形节点抗震性能研究

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振动工程学报 2024年第6期37卷 1023-1032页

作者：曾武华王伟陈庆熠王军芳吴应雄卓卫东三明学院建筑工程学院福建三明365004 工程结构智能建造与监控福建省高校重点实验室福建三明365004 同济大学土木工程防灾减灾全国重点实验室上海200092 福州大学土木工程学院福建福州350108

将钢渣混凝土灌入中空夹层钢管混凝土结构,充分利用钢渣混凝土的微膨胀性和中空夹层内外钢管对混凝土的约束作用,有效解决了钢渣混凝土工程应用中的安定性问题。以混凝土类型、空心率、支主管直径比和轴压比为参数变量,共进行了5个中空... 详细信息

将钢渣混凝土灌入中空夹层钢管混凝土结构,充分利用钢渣混凝土的微膨胀性和中空夹层内外钢管对混凝土的约束作用,有效解决了钢渣混凝土工程应用中的安定性问题。以混凝土类型、空心率、支主管直径比和轴压比为参数变量,共进行了5个中空夹层钢管混凝土T形节点试件(1个普通混凝土试件、4个钢渣混凝土试件)拟静力试验研究。试验结果表明:与灌注普通混凝土相比,灌注钢渣混凝土对试件节点承载力影响不大,但位移延性和耗能能力明显增加,提高幅度分别达69.46%和48.20%;当空心率从0.3增大到0.5时,试件位移延性系数提高9.69%;当支主管直径比从0.40增大到0.68时,位移延性系数提高82.44%;当轴压比从0.1增大到0.2时,试件位移延性系数降低17.98%。建立有限元模型对试件的滞回性能进行了模拟,模拟结果与试验结果基本符合,验证了所建有限元模型的有效性。进而开展了节点承载力影响参数分析,得到最佳空心率为70%左右。钢渣在钢管混凝土结构中应用,可大幅提高其抗震性能。

关键词：抗震性能:中空夹层钢管混凝土钢渣混凝土滞回特性拟静力试验

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皮肤羧酸酯酶代谢的立体选择性

药学学报 2005年第4期40卷 322-326页

作者：朱全刚胡晋红曾华武第二军医大学长海医院药学部上海200433

目的　研究人皮肤羧酸酯酶代谢的立体选择性,为利用前体药物方法促进透皮吸收提供分子生物学基础。方法　以酮洛芬乙酯为模型药物,利用皮肤匀浆代谢方法考察皮肤羧酸酯酶代谢的立体选择性。以人肝脏L02细胞株中羧酸酯酶的表达为对照,采... 详细信息

目的　研究人皮肤羧酸酯酶代谢的立体选择性,为利用前体药物方法促进透皮吸收提供分子生物学基础。方法　以酮洛芬乙酯为模型药物,利用皮肤匀浆代谢方法考察皮肤羧酸酯酶代谢的立体选择性。以人肝脏L02细胞株中羧酸酯酶的表达为对照,采用RT PCR方法从mRNA水平研究皮肤组织及其细胞中羧酸酯酶的表达。结果酮洛芬乙酯在人皮肤匀浆中的代谢产物以R 酮洛芬为主。人羧酸酯酶 2 (hCE 2)在皮肤组织及其细胞中都有很强的表达,而人羧酸酯酶 1(hCE 1)在皮肤组织及其细胞中的表达量很小或不表达。结论　皮肤表达的hCE 2是透皮吸收常用酯类前体药物的主要水解酶,其对手性酯类前体药物的水解具有立体选择性。

关键词：羧酸酯酶酮洛芬乙酯立体选择性逆转录聚合酶链式反应

A Facile Synthesis of 2-Aryloxy-5,6,7,8-tetrahydro benzothieno[2,3-d]pyrimidin-4(3H)-ones

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A Facile Synthesis of 2-Aryloxy-5,6,7,8-tetrahydro benzothie...

第七届全国磷化学化工暨第四届海峡化学生物学、生物技术与医药发展讨论会

作者： Xiao-hua zeng, Ming-wu Ding, Hong-wu He Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of hemistry, Central China Normal University,wuhan, 430079, P. R. China

The carbodiimides 2, obtained from aza-Wittig reactions of iminophosphorane 1 with aliphatic isocyanates, reacted with various phenols to give 2-aryloxy-3-alkyl-5,6,7,8-tetrahydro-benzothieno[2,3-d] pyrimidin-4(3H)-on... 详细信息

关键词： benzothieno[2,3-d]pyrimidin-4(3H)-ones, iminophosphorane, carbodiimide, aza-Wittig reaction, synthesis

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钢筋混凝土桥墩位移延性系数概率分析

工程抗震与加固改造 2016年第5期38卷 33-37页

作者：曾武华王逢朝卓卫东三明学院建筑工程学院福建三明365004 福州大学土木工程学院福建福州350002

为了实现桥梁结构基于性能抗震设计多等级性能目标,需要给出桥梁关键构件达到各级性能水平的概率。将钢筋混凝土桥墩抗震性能水平划分为四个等级,并从桥墩物理损伤角度给出各性能水平的控制条件。基于183个矩形和77个圆形桥墩拟静力试... 详细信息

为了实现桥梁结构基于性能抗震设计多等级性能目标,需要给出桥梁关键构件达到各级性能水平的概率。将钢筋混凝土桥墩抗震性能水平划分为四个等级,并从桥墩物理损伤角度给出各性能水平的控制条件。基于183个矩形和77个圆形桥墩拟静力试验结果,采用统计分析的方法得到各性能水平下位移延性系数统计特征值。采用K-S方法,对位移延性系数概率分布模型进行检验。结果表明,在5%重要性水平下概率分布模型服从对数正态分布。研究结果可用于钢筋混凝土桥墩易损性计算。

关键词：性能水平钢筋混凝土桥墩拟静力试验概率分析位移延性系数