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Effects of mode of reproduction on genetic polymorphism and divergence in wild yams(Dioscoreaceae:Dioscorea)

Plant Diversity 2025年第1期47卷 136-147页

作者： Xin Wang Qing-Hong Feng Zhi-hua zeng Zhi-Qiang Zhang Jie Cai Gao Chen De-Zhu Li Hong Wang Wei Zhou Germplasm Bank of Wild Species&Yunnan Key Laboratory of Crop Wild Relatives Omics Kunming Institute of BotanyChinese Academy of SciencesKunmingYunnan 650201China University of Chinese Academy of Sciences Beijing 100049China Yunnan Key Laboratory of Plant Reproductive Adaptation and Evolutionary Ecology Institute of BiodiversitySchool of Ecology and Environmental ScienceYunnan UniversityKunmingYunnan 650504China Research Institute of Tropical Forestry Yunnan Academy of Forestry and GrasslandXishuangbannaYunnan 666102China CAS Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of SciencesKunmingYunnan 650201China Key Laboratory of Phytochemistry and Natural Medicines Kunming Institute of BotanyChinese Academy of SciencesKunmingYunnan 650201China Lijiang Forest Biodiversity National Observation and Research Station Kunming Institute of BotanyChinese Academy of SciencesLijiangYunnan 674100China

Evolutionary transitions from sexual to asexual reproduction should have significant influences on genetic divergence and polymorphism at the genome *** lineages with diverse reproductive systems provide opportunities to investigate this question using comparative approaches and studies of molecular *** investigated evidence for differences among the transcriptomes of 19 Dioscorea species(wild yams)with diverse reproductive *** included sexual species,those that propagate primarily by bulbils,and those with mixed sexual and asexual reproductive *** examined how transitions between these reproductive systems affected between-species divergence and within-species *** asexual species exhibited a reduced efficacy of natural selection and accumulation of deleterious mutations for both divergence and *** contrast,species with mixed reproductive strategies involving both seed and clonal reproduction showed no evidence of an increased fixation of harmful mutations at the divergence level,while an accumulation of genetic load present in polymorphism was *** study indicates that the genetic consequences of evolutionary transitions from sexual to predominantly clonal reproduction is likely to depend on both the duration and extent of asexuality occurring in populations.

关键词： Asexual Deleterious mutations Dioscorea Molecular evolution Selection

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基于PERK-eIF2α-NF-κB信号通路研究苁蓉散治疗阿尔茨海默病的作用机制

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中国药理学通报 2025年第1期41卷 80-87页

作者：王曦龙清华蔡元钦王政喻陈显兵曾楚华湖北民族大学医学部湖北恩施445000 湖北民族大学风湿性疾病发生与干预湖北省重点实验室湖北恩施445000 云南中医药大学基础医学院云南昆明650000

目的基于PERK-eIF2α-NF-κB信号通路研究苁蓉散治疗阿尔茨海默病(Alzheimer’s disease,AD)的作用机制。方法将60只SD大鼠分为正常组,模型组、苁蓉散组(4.62、9.24、18.48 g·kg-1)和安理申组,每组10只。除正常组外其余大鼠组予双侧海... 详细信息

目的基于PERK-eIF2α-NF-κB信号通路研究苁蓉散治疗阿尔茨海默病(Alzheimer’s disease,AD)的作用机制。方法将60只SD大鼠分为正常组,模型组、苁蓉散组(4.62、9.24、18.48 g·kg-1)和安理申组,每组10只。除正常组外其余大鼠组予双侧海马注射Aβ1-42建立AD模型。灌胃结束后进行水迷宫行为学检测学习记忆能力;尼氏染色观察神经元及尼氏小体变化;免疫荧光检测NF-κB核转移情况;透射电镜观察大鼠海马区内质网形态;酶免疫测定Aβ1-42及炎症因子含量;Western blot检测PERK、eIF2α、NF-κB的蛋白表达水平。结果水迷宫结果显示,苁蓉散能提高AD大鼠的逃避潜伏期时间、增加穿越求生平台次数、延长目标象限停留时间(P<0.05或P<0.01);尼氏染色结果显示,苁蓉散各剂量组神经元细胞排列较整齐,胞核存在,尼氏小体较为丰富;免疫荧光表明,苁蓉散可降低AD大鼠脑内NF-κB入核表达(P<0.05或P<0.01);透射电镜结果显示,苁蓉散各剂量组内质网形态整齐、未见明显扩张,结构正常;ELISA结果表明,苁蓉散可降低AD海马中的Aβ1-42,IL-1,TNF-α的含量;Western blot结果显示,苁蓉散各剂量组p-PERK/PERK,p-eIF2α/eIF2α,p-NF-κB p65/NF-κB p65的蛋白比值明显下降(P<0.05或P<0.01)。结论苁蓉散可通过抑制PERK-eIF2α-NF-κB信号通路的活化,缓解神经元细胞ERS状态下免疫炎症反应,以改善AD大鼠的认知功能。

关键词：阿尔兹海默病苁蓉散内质网应激 PERK-eIF2α-NF-κB信号通路炎症 Aβ1-42

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Short-range disorder in MOF glasses

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National Science Review 2021年第5期8卷 13-14页

作者： Ming-hua zeng Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources School of Chemistry and Pharmaceutical SciencesGuangxi Normal University Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional MoleculesHubei University

Glass appears to be an ordinary material with wide applications in daily life and industry; however, its formation mechanism, phase transition and microscopic structure remain mysterious. It is accepted to be an amorphous solid exhibiting glass transition, with short-range(20?A)disorder structures [1]. Experimental determination of the structure of glass is crucial to understand its dynamic and physical properties.‘What is the nature of glass?’ is one of the most fundamental and challenging scientific questions [1].

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基于LKB1/AMPK/mTOR通路调节自噬探讨固本健脑液对阿尔茨海默病的作用机制

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中国中药杂志 2025年第2期50卷 293-300页

作者：张婧凡龙清华曾楚华陈益敏谢喆尧蔡元钦王曦湖北民族大学医学部湖北恩施445000 云南中医药大学基础医学院云南昆明650500 湖北民族大学风湿性疾病发生与干预湖北省重点实验室湖北恩施445000 湖北民族大学附属民大医院湖北恩施445000

基于肝激酶B1(liver kinase B1,LKB1)/腺苷酸活化蛋白激酶(adenosine monophosphate-activated protein kinase,AMPK)/哺乳动物雷帕霉素靶蛋白(mammalian target of rapamycin,mTOR)通路调节自噬探讨固本健脑液对阿尔茨海默病(Alzheimer's disease,AD)的作用机制。雄性SD大鼠随机分为空白组、模型组、固本健脑液低剂量组、固本健脑液高剂量组和雷帕霉素组,每组10只。除空白组外,其余组大鼠均双侧海马注射β-淀粉样蛋白(β-amyloid,Aβ)1-42建立AD模型。固本健脑液低剂量组(6.21 g·kg^(-1))、固本健脑液高剂量组(12.42 g·kg^(-1))、雷帕霉素组(1 mg·kg^(-1))给予相应药物灌胃,空白组、模型组给予等体积生理盐水灌胃,持续4周。Morris水迷宫检测各组大鼠学习记忆能力;苏木精-伊红(hematoxylin-eosin,HE)染色、尼氏染色观察大鼠海马CA1区神经元及尼氏体形态数量变化;免疫组化检测大鼠海马CA1区Aβ阳性细胞表达;透射电镜观察大鼠海马组织超微结构变化;Western blot检测大鼠海马组织LKB1、p-AMPK/AMPK、p-mTOR/mTOR、Beclin1、p62、LC3-Ⅱ的蛋白表达水平。结果显示,与空白组比较,模型组大鼠逃避潜伏期升高,穿越平台次数、在平台象限停留时间减少;海马区神经元数量减少、形态受损,Aβ阳性细胞表达升高;LKB1、p-AMPK/AMPK、Beclin1、LC3-Ⅱ表达水平降低,p-mTOR/mTOR、p62表达水平升高。与模型组比较,固本健脑液低、高剂量组大鼠逃避潜伏期降低,穿越平台次数、在平台象限停留时间升高,神经元数量增多,Aβ阳性细胞表达减少,海马组织自噬溶酶体数量增加;固本健脑液低剂量组大鼠海马LKB1、Beclin1、LC3-Ⅱ表达水平升高;固本健脑液高剂量组大鼠海马组织LKB1、p-AMPK/AMPK、Beclin1、LC3-Ⅱ表达水平升高,p-mTOR/mTOR、p62表达水平降低。以上结果显示,固本健脑液可以改善AD大鼠认知障碍,其作用机制可能与激活LKB1/AMPK/mTOR信号通路,上调自噬水平有关。

关键词：阿尔茨海默病固本健脑液自噬 LKB1/AMPK/mTOR信号通路

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综合型高分子化学实验设计：亲水海绵擦的制备

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应用化学 2025年第1期42卷 117-123页

作者：徐守萍曾丽花皮丕辉文秀芳程江华南理工大学化学与化工学院

聚乙烯醇缩醛海绵具有亲水性、高强度、高回弹以及可降解性，在很多领域均具有广泛的应用。本实验采用聚乙烯醇和醛作为主要原料，通过表面活性剂发泡制备聚乙烯醇缩醛亲水海绵擦，并探索用相对低毒性的乙醛、丙醛代替传统工艺中高毒性... 详细信息

聚乙烯醇缩醛海绵具有亲水性、高强度、高回弹以及可降解性，在很多领域均具有广泛的应用。本实验采用聚乙烯醇和醛作为主要原料，通过表面活性剂发泡制备聚乙烯醇缩醛亲水海绵擦，并探索用相对低毒性的乙醛、丙醛代替传统工艺中高毒性的甲醛。实验设计分组研究甲醛、乙醛和丙醛缩醛反应能力的差异，从而更好地理解缩醛反应的机理；测试方面运用傅里叶红外光谱（FT-IR）、扫描电子显微镜（SEM）、万能拉力仪表征聚合物和材料结构，引导学生分析聚合物性能与结构之间的联系，培养学生深入思考的能力；成品海绵可作为工作台清洁工具，增加实验的趣味性。本实验是集合文献查阅、基础实验操作、材料性能表征以及应用性能为一体的综合研究型实验，有助于学生加深理解，同时锻炼主动分析问题、探究解决方案的能力，可以有效培养学生的实验技能和科学思维。

关键词：聚乙烯醇海绵缩醛反应高分子化学综合型实验

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Self-trapped spatially localized states in combined linear-nonlinear periodic potentials

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Frontiers of physics 2020年第1期15卷 17-24页

作者： Jin-Cheng Shi Jian-hua zeng State Key Laboratory of Transient Optics and Photonics Xi’an Institute of Optics and Precision Mechanics of CASXi’an 710119China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory for Physical Electronics and Devices of the Ministry of Education&Shaanxi Key Lab of Information Photonic Technique Xi’an Jiaotong UniversityXi’an 710049China

We analyze the existence and stability of two kinds of self-trapped spatially localized gap modes,gap solitons and truncated nonlinear Bloch waves,in one-and two-dimensional optical or matter-wave media with self-focusing nonlinearity,supported by a combination of linear and nonlinear periodic lattice *** former is found to be stable once placed inside a single well of the nonlinear lattice,it is unstable *** to the case with constant self-focusing nonlinearity,where the latter solution is always unstable,here,we demonstrate that it nevertheless can be stabilized by the nonlinear lattice since the model under consideration combines the unique properties of both the linear and nonlinear *** practical possibilities for experimental realization of the predicted solutions are also discussed.

关键词： gap solitons and gap waves Bose-Einstein condensates linear and nonlinear periodic potentials

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Four-Party Quantum Broadcast Scheme Based on Aharonov State

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Communications in Theoretical Physics 2008年第8期50卷 371-374页

作者： LI Yuan zeng Gui-hua Laboratory of Coding and Communication Security Department of Electronic Engineering Shanghai Jiao Tong University Shanghai 200240 China

In this paper,we propose a solution based on four-qubit Aharonov state to an old problem by using the property of *** proposed scheme may realize the broadcast among four participants,therefore,it makes progress to the three-party broadcast realized *** pairwise quantum channels and entangled qubits,the detection between these players also can be ***,the feasibility of the protocol and the analysis of security are illustrated.

关键词： broadcast scheme Aharonov state liar detection problem congruence

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Quantum BCH Codes Based on Spectral Techniques

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Communications in Theoretical Physics 2006年第2期45卷 283-286页

作者： GUO Ying zeng Gui-hua Department of Electronic Engineering Shanghai Jiao Tong University Shanghai 200030 China

When the time variable in quantum signal processing is discrete, the Fourier transform exists on the vector space of n-tuples over the Galois field F2, which plays an important role in the investigation of quantum signals. By using Fourier transforms, the idea of quantum coding theory can be described in a setting that is much different from that seen that far. Quantum BCH codes can be defined as codes whose quantum states have certain specified consecutive spectral components equal to zero and the error-correcting ability is also described by the number of the consecutive zeros. Moreover, the decoding of quantum codes can be described spectrally with more efficiency.

关键词： Fourier transform BCH code quantum error-correction code

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Deterministic Quantum Key Distribution Using Two Non-orthogonal Entangled States

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Communications in Theoretical Physics 2007年第3期47卷 459-463页

作者： GUO Ying zeng Gui-hua Department of Communication Engineering Central South University Changsha 410083 China Department of Electronic Engineering Shanghai Jiao Tong University Shanghai 200030 China

A deterministic quantum key distribution scheme using two non-orthogonal entangled states is proposed. In the proposed scheme, communicators share key information by exchanging one travelling photon with two random and secret polarization angles. The security of the distributed key is guaranteed by three checking phases in three-way channel and the communicators＇ secret polarization angles.

关键词： quantum key distribution quantum entanglement state

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Chloride Ion Transmission Model under the Drying-wetting Cycles and Its Solution

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Journal of Wuhan University of Technology(Materials Science) 2014年第3期29卷 445-450页

作者：黄滢卫军 DONG Rongzhen zeng hua School of Civil Engineering Central South University College of Architecture and Civil Engineering Jiangxi Science & Technology Normal University Nation Engineering Laboratory for High Speed Railway Construction

The chloride ion transmission model considering diffusion and convection was established respectively for different zones in concrete by analyzing chloride ion transmission mechanism under the dryingwetting cycles. The finite difference method was adopted to solve the model. The equation of chloride ion transmission model in the convection and diffusion zone of concrete was discreted by the group explicit scheme with right single point （GER method） and the equation in diffusion zone was discreted by FTCS difference scheme. According to relative humidity characteristics in concrete under drying-wetting cycles, the seepage velocity equation was formulated based on Kelvin Equation and Darcy＇s Law. The time-variant equations of chloride ion concentration of concrete surface and the boundary surface of the convection and diffusion zone were established. Based on the software MATLAB the numerical calculation was carried out by using the model and basic material parameters from the experiments. The calculation of chloride ion concentration distribution in concrete is in good agreement with the drying-wetting cycles experiments. It can be shown that the chloride ion transmission model and the seepage velocity equation are reasonable and practical. Studies have shown that the chloride ion transmission in concrete considering convection and diffusion under the drying-wetting cycles is the better correlation with the actual situation than that only considering the diffusion.

关键词： under the drying-wetting cycles the chloride ion transmission model the group explicit scheme seepage velocity

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