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Rociletinib(CO-1686) enhanced efficacy of chemotherapeutic agents in ABCG2-overexpressing cancer cells in vitro and in vivo

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中国药理学与毒理学杂志 2019年第10期 891-892页

作者： zeng fan-pu WANG fang ZHENG Zong-heng CHEN Zhen Kenneth Kin Wah To ZHANG Hong HAN Qian FU Li-wu State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangdong Esophageal Cancer Institute Sun Yat-Sen University Cancer Center

The abnormal expression and function of ATP-binding cassette subfamily G member 2(ABCG2) is correlated with development of multidrug resistance(MDR), and lead to lower response to ***, there is no FDA-approved commercial MDR modulator for clinical use. Here, We found rociletinib(CO-1686), a mutant-selective epidermal growth factor receptor(EGFR) tyrosine kinase inhibitor(TKI), significantly improved the efficacy of substrate chemotherapeutic agents in ABCG2-overexpressing cancer cells and also in ABCG2-overexpressing S1-MI-80 cell xenografts in nude mice, without incurring additional toxicity. Mechanistic studies revealed that in ABCG2-overexpressing cancer cells, rociletinib inhibited ABCG2-mediated drug efflux, and increased intracellular accumulation of ABCG2 probe substrates. Moreover, rociletinib, inhibited the ATPase activity, and competed with [125 I] iodoarylazidoprazosin(IAAP) photolabeling of ABCG2. The expression of ABCG2 at protein and m RNA levels was not altered when ABCG2-overexpressing cells were treated with rociletinib. In addition, rociletinib did not inhibit Erb B downstream signaling of AKT and ERK and their phosphorylations. The all results showed that rociletinib increased the accumulation of substrates in cells by inhibiting the efflux function of ABCG2, and reversed ABCG2-related MDR. Therefore, rociletinib might be useful in developing combination chemotherapy in the patients with ABCG2-overexpressing MDR tumors.

关键词： rociletinib combination chemotherapy chemotherapeutic agents

Effects of formal credit on pastoral household expense: Evidence from the Qinghai-Xizang Plateau of China

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Journal of Integrative Agriculture 2024年第5期23卷 1774-1785页

作者： Yan Zhang Yi Huang fan Zhang zeng Tang State Key Laboratory of Herbage Improvement and Grassland Agro-ecosystems College of Pastoral Agriculture Science and TechnologyLanzhou UniversityLanzhou 730020China

Formal credit is critical in agricultural production,allowing more expenditure and productive input,thereby improving farmers'*** pastoral China,formal financial institutions are gradually ***,a limited understanding remains of how formal credit affects herders'household *** on a survey of 544 herders from the Qinghai-Xizang Plateau of China,this study adopted the propensity score matching approach to identify the effect of formal credit on herders'total household expenses,daily expenses,and productive *** results found that average age,grassland mortgage,and other variables significantly affected herders'participation in formal *** credit could significantly improve household expenses,especially productive expenses.A heterogeneity analysis showed that formal credit had a greater impact on the household total expense for those at higher levels of wealth;however,it significantly affected the productive expense of herders at lower wealth ***,the mediating effect indicated that formal credit could affect herders'household income,thus influencing their household ***,this study suggests that policies should improve herders'accessibility to formal credit.

关键词： formal credit herders expense Qinghai-Xizang Plateau

Development of a novel Eu^(3+)-doped tantalate red-emitting phosphor for w-LEDs application

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Journal of Rare Earths 2024年第8期42卷 1479-1488,I0003页

作者： fan zeng Jingjing Ru Bing Zhao Feiyun Guo Jianzhong Chen College of Chemistry and Materials Fujian Province University Key Laboratory of Green Energy and Environment CatalysisNingde Normal University.Ningde352100China School of Environment and Resources School of Carbon Neutral and Modern IndustryFujian Normal UniversityFuzhou350007China College of Information and Mechanical&Electrical Engineering Ningde Normal UniversityNingde352100China College of Chemistry Fuzhou UniversityFuzhou350108China

Two novel phosphors LiBa_(4(1-x))Eu_(4x)Ta_(3)O_(12)(H-LBTO:xEu^(3+)) and Li_(0.25)Ba_(1-x)Eu_(x)Ta_(0.75)O_(3)(C-LBTO:xEu^(3+))were prepared successfully by a molten salt *** transformation between these two structures was realized by changing the sintering temperature or changing the Eu^(3+) ions concentration,which was also demonstrated by the X-ray diffraction(XRD),scanning electron microscopy(SEM),diffuse reflectance spectra(DRS),and photoluminescence excitation(PLE) analyses,Both the sintering temperature and the Eu^(3+)ions doping concentration have significant impact on the formation of the crystal *** these phosphors sintered at 1023 K exhibit two major luminescence lines at 594 and 614 nm under nearUV light of 395 nm excitation,corresponding to Eu^(3+)ions typical transitions of ^(5)D_(0)→^(7)F_(1) and ^(5)D_(0)→^(7)F_(2).The optimum concentration of Eu^(3+) ions is 9 mol% for C-LBTO:xEu^(3+) samples and the quenching interaction type is the nearest-neighbor ion *** thermal stability of the C-LBTO:0.09Eu^(3+)sample was investigated in detail and the device application further suggests that C-LBTO:0.09Eu^(3+) can be used as a red phosphor for near-UV excited w-LEDs in lighting.

关键词： Phosphor Tantalate LED device Rare earths

Polycomb and trithorax:Their yin-yang dynamics in plants

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Molecular Plant 2024年第6期17卷 845-847页

作者： fan Xu Daolei Zhang Liang Le Li pu Biotechnology Research Institute Chinese Academy of Agricultural SciencesBeijing 100081China School of Life Science Inner Mongolia UniversityHohhot 010021China

Polycomb(PcG)and trithorax(trxG)are two groups of conserved epigenetic complexes that maintain active and repressive states of target genes by altering their chromatin states to regulate plant development and stress *... 详细信息

关键词： maintain complexes states

Unsupervised Multi-Expert Learning Model for Underwater Image Enhancement

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IEEE/CAA Journal of Automatica Sinica 2024年第3期11卷 708-722页

作者： Hongmin Liu Qi Zhang Yufan Hu Hui zeng Bin fan the School of Intelligence Science and Technology and the Institute of Artificial Intelligence University of Science and Technology BeijingBeijing 100083China the School of Automation and Electrical Engineering University of Science and Technology BeijingBeijing 100083China IEEE

Underwater image enhancement aims to restore a clean appearance and thus improves the quality of underwater degraded *** methods feed the whole image directly into the model for ***,they ignored that the R,G and B channels of underwater degraded images present varied degrees of degradation,due to the selective absorption for the *** address this issue,we propose an unsupervised multi-expert learning model by considering the enhancement of each color ***,an unsupervised architecture based on generative adversarial network is employed to alleviate the need for paired underwater *** on this,we design a generator,including a multi-expert encoder,a feature fusion module and a feature fusion-guided decoder,to generate the clear underwater ***,a multi-expert discriminator is proposed to verify the authenticity of the R,G and B channels,*** addition,content perceptual loss and edge loss are introduced into the loss function to further improve the content and details of the enhanced *** experiments on public datasets demonstrate that our method achieves more pleasing results in vision *** metrics(PSNR,SSIM,UIQM and UCIQE) evaluated on our enhanced images have been improved obviously.

关键词： Multi-expert learning underwater image enhancement unsupervised learning

Laser-Induced Methanol Decomposition for Ultrafast Hydrogen Production

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Research 2024年第1期2023卷 131-137页

作者： Weiwei Cao Yinwu Li Bo Yan Zhiping zeng pu Liu Zhuofeng Ke Guowei Yang State Key Laboratory of Optoelectronic Materials and Technologies Nanotechnology Research CenterSun Yat-sen UniversityGuangzhou 510275P.R.China School of Materials Science and Engineering Sun Yat-sen UniversityGuangzhou 510275P.R.China

Methanol(CH_(3)OH)is a liquid hydrogen(H_(2))source that effectively releases H_(2) and is convenient for *** thermocatalytic CH_(3)OH reforming reaction is used to produce H_(2),but this process needs to undergo high reaction temperature(e.g.,200℃)along with a catalyst and a large amount of carbon dioxide(CO_(2))*** photocatalysis and photothermal catalysis under mild conditions are proposed to replace the traditional thermal catalysis to produce H_(2) from CH_(3)OH,they still inevitably produce CO_(2) emissions that are detrimental to carbon ***,we,for the first time,report an ultrafast and highly selective production of H_(2) without any catalysts and no CO_(2) emission from CH_(3)OH by laser bubbling in liquid(LBL)at room temperature and atmospheric pressure.

关键词： catalysis reforming replace

A Study on the Performances of Solar Air Collectors Having a Hemispherical Dimple on the Absorber Plate

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Fluid Dynamics & Materials Processing 2024年第5期20卷 939-955页

作者： Shuilian Li fan zeng Xinli Wei School of Architecture and Environmental Engineering Zhengzhou Technical CollegeZhengzhou450121China School of Mechanical and Power Engineering Zhengzhou UniversityZhengzhou450001China

In order to increase the efficiency of solar air collectors,a new variant with a protrusion is proposed in this study,and its performances are analyzed from two points of view,namely,in terms of optics and thermodynamics *** comparing and analyzing the light paths of the protrusion and the dimple,it can be concluded that when sunlight shines on the dimple,it is reflected and absorbed multiple times,whereas for the sunlight shining on the protrusion,there is no secondary reflection or absorption of *** the lighting area and the properties of the surfaces are the same,the absorption rate of the dimple is 10.3 percentage points higher than that of the *** the range of Reynolds number from 3000 to 11000,numerical simulations about the effects of the relative height(e/Dh=0.033–0.1)and relative spacing(p/e=4.5–8.5)of protrusions on air heat transfer and flow resistance show that,in terms of comprehensive evaluation coefficient(PF),the best relative height is 0.085,when the relative spacing is 5.A correlation of Nu and f with Re,e/Dh and p/e is obtained by linear regression of the results,in order to provide a useful reference for the design and optimization of this kind of solar air collector.

关键词： Heat transfer hemispherical protrusion dimple solar air collector correlation

Social Radars: Finding Targets in Cyberspace for Cybersecurity

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IEEE/CAA Journal of Automatica Sinica 2024年第2期11卷 279-282页

作者： Lili fan Changxian zeng Yutong Wang Jiaqi Ma Fei-Yue Wang School of Information and Electronics Beijing Institute of TechnologyBeijing 100081China School of Science Dalian Minzu UniversityDalian 116600China State Key Laboratory for Management and Control of Complex Systems Institute of AutomationChinese Academy of SciencesBeijing 100190China Department of Civil and Environmental Engineering University of CaliforniaLos AngelesCA 90024 USA IEEE State Key Laboratory for Management and Control of Complex Systems Chinese Academy of SciencesBeijing 100190 Faculty of Innovation Engineering Macao University of Science and TechnologyMacao 999078China

INSPIRED by the insight from American political scientist Lasswell, who summarized the environmental role in societal surveillance [1], Schramm coined the term “social radar” [2] as it resembles the activities of radar in collecting and processing information, playing a crucial role in helping humans perceive changes in the internal and external environment and promptly adjusting adaptive behaviors.

关键词： prompt summarized insight

Type Synthesis of Self-Alignment Parallel Ankle Rehabilitation Robot with Suitable Passive Degrees of Freedom

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Chinese Journal of Mechanical Engineering 2024年第1期37卷 160-175页

作者： Ya Liu Wenjuan Lu Dabao fan Weijian Tan Bo Hu Daxing zeng School of Mechanical Engineering Yanshan UniversityQinhuangdao 066004China School of Mechanical Engineering Dongguan University of TechnologyDongguan 523808China Dongguan Engineering Technology Research Center for Parallel Robot Dongguan 523808China The DGUT Innovation Center of Robotics and Intelligent Equipment Dongguan 523808China

The current parallel ankle rehabilitation robot(ARR)suffers from the problem of difficult real-time alignment of the human-robot joint center of rotation,which may lead to secondary injuries to the *** study investigates type synthesis of a parallel self-alignment ankle rehabilitation robot(PSAARR)based on the kinematic characteristics of ankle joint rotation center drift from the perspective of introducing"suitable passive degrees of freedom(DOF)"with a suitable number and ***,the self-alignment principle of parallel ARR was proposed by deriving conditions for transforming a human-robot closed chain(HRCC)formed by an ARR and human body into a kinematic suitable constrained system and introducing conditions of"decoupled"and"less limb".Second,the relationship between the self-alignment principle and actuation wrenches(twists)of PSAARR was analyzed with the velocity Jacobian matrix as a"bridge".Subsequently,the type synthesis conditions of PSAARR were ***,a PSAARR synthesis method was proposed based on the screw theory and type of PSAARR synthesis ***,an HRCC kinematic model was established to verify the self-alignment capability of the *** this study,93 types of PSAARR limb structures were synthesized and the self-alignment capability of a human-robot joint axis was verified through kinematic analysis,which provides a theoretical basis for the design of such an ARR.

关键词： Ankle rehabilitation robot Self-alignment Parallel mechanism Type synthesis Screw theory