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No effect of acylpeptide hydrolase polymorphisms on pharmacokinetics of sodium valproate in healthy Chinese male volunteers

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中国药理学与毒理学杂志 2019年第10期 816-817页

作者： wen Zhi-peng zeng wen-jing XIAO Jian CHEN Xiao-ping Department of Clinical Pharmacology Xiangya HospitalCentral South University Institute of Clinical Pharmacology Hunan Key Laboratory of Pharmacogenetic Central South University National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South University Department of Pharmacy Xiangya Hospital Central South University

OBJECTIVE Sodium valproate（VPA） is one of the most common prescribed antiepileptic drugs（AEDs）. Genetic variation in genes encoding drug-metabolizing enzymes may contribute the inter-individual variability in VPA pharmacokinetics. Our previous study showed that acylpeptide hydrolase（APEH） polymorphisms might affect the VPA plasma concentration in Chinese epilepsy patients by increasing the urinary excretion of valproate-glucuronide（VPA-G）, the major metabolite of VPA. This study aimed to investigate the effects of APEH rs3816877 on the pharmacokinetics of VPA in healthy Chinese male volunteers. METHODS Thirteen subjects enrolled in this clinical trial were genotyped for APEH rs3816877 by polymerase chain reactionrestriction fragment length polymorphism（PCR-RFLP）.All volunteers received an oral dose of 1000 mg of VPA sustain tablets（Depakine, Sanofi）. The peripheral venous blood and urine were sampled for up to 72 h and 24 h post dose, respectively. The concentration of VPA and VPA-G in plasma and urine were determined by the high performance liquid chromatography-tandem mass spectrometry（HPLC-MS/MS） system. The pharmacokinetic parameters were calculated using standard non-compartmental model. RESULTS No significantly different C;,T;, t;, CL, Vd, AUC;, and AUC;were observed between APEH rs3816877 C/C group and C/T ***, the subjects carrying rs3816877 C/C genotype were characteristics with significantly higher urinary excretion of VPA-G than those with C/T genotype. CONCLUSION Our study suggested that APEH rs3816877 may have no effect on the pharmacokinetics of VPA in healthy Chinese male volunteers.

关键词： sodium valproate acylpeptide hydrolases pharmacokintics pharmacogenetics

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DDAH1-V3 transcript might act as miR-21 sponge to maintain balance of DDAH1-V1 in cultured HUVECs

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中国药理学与毒理学杂志 2016年第10期30卷 1007-1008页

作者： KUANG Da-bin ZHOU Ji-peng YULin-yu zeng wen-jing XIAO Jian ZHANG Zan-lin CHEN Xiao-ping Department of Clinical Pharmacology Xiangya HospitalCentral South University Institute of Clinical Pharmacology Central South UniversityHunan Key Laboratory of Pharmacogenetics Cooperative Innovation Center for Molecular Target New Drug Study University of South China Department of Cardiovascular Medicine Xiangya HospitalCentral South University Department of Pharmacy Xiangya HospitalCentral South University

OBJECTIVE To investigate whether micro RNA(mi RNA)mi R-21 regulates dimethylarginine dimethylaminohydrolase 1(DDAH1)expression through binding 3′-UTR regiondirectly in human umbilical venous endothelial cells(HUVECs)and to explore whether DDAH1-V2/V3 transcripts can function as micro RNA sponge,thereby modulating DDAH1-V1 *** The DDAH13′-UTR containing mi R-21 recognizing sequence was cloned into Pmir GLO dual-luciferase mi RNA target expression plasmid to construct PmirGLO-mi *** plasmid and mi R-21(at concentrations of 25,50,100 nmol·L-1,respectively)or negative control(100 nmol·L-1)were co-transfected into HUVECs,luciferase activity was detected at 24 *** were incubated with 2μg·m L-1actinomycin D for the indicated time after mi R-21(25 nmol.L-1)transfection,half-lives of DDAH1 m RNA were *** were transfected with Pmir GLO-mi R-21 alone or co-transfected with mi R-21 for 24 h,DDAH1 transcripts m RNA and DDAH1protein expression were *** Mi R-21decreased luciferase activity of Pmir GLO-mi R-21 in a dose-dependent manner(P<0.05 for 25 nmol·L-1mi R-21,P<0.01 for 50 nmol·L-1and 100 nmol·L-1mi R-21),and mi R-21 inhibitor increased reporter activity of PmirGLO-mi R-21 and m RNA expression of all DDAH1 three transcript variants significantly(P<0.05,respectively).The degree of increase in endogenous DDAH1 m RNA expression by mi R-21 inhibitor was more obvious for *** of mi R-21 decreased m RNA expression and m RNA half-life time of all DDAH1 transcripts significantly(P<0.05),and DDAH1-V2 displayed significantly decreased half-life time than DDAH1-V1and-V3 with or without mi R-21 transfection(P<0.05,respectively).Mi R-21(100 nmol·L-1)decreased DDAH1protein expression significantly(P<0.05),which was reversed by Pmir GLO-mi R-21 transfection(P<0.05).Transfection of Pmir GLO-mi R-21 alone increased intracellular mi R-21 expression by approximately 5.6-fold,but only showed a trend of increase in DDAH1 pr

关键词： DDAH1 miR-21 microRNA sponge

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Vision-Based System of AUV for An Underwater Pipeline Tracker

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China Ocean Engineering 2012年第3期26卷 547-554页

作者：张铁栋曾文静万磊秦再白 National Key Laboratory of Science and Technology on Autonomous Underwater Vehicle Harbin Engineering University

This paper describes a new framework for detection and tracking of underwater pipeline, which includes software system and hardware system. It is designed for vision system of AUV based on monocular CCD camera. First, the real-time data flow from image capture card is pre-processed and pipeline features are extracted for navigation. The region saturation degree is advanced to remove false edge point group after Sobel operation. An appropriate way is proposed to clear the disturbance around the peak point in the process of Hough transform. Second, the continuity of pipeline layout is taken into account to improve the efficiency of line extraction. Once the line information has lbeen obtained, the reference zone is predicted by Kalman filter. It denotes the possible appearance position of the pipeiine in the image. Kalman filter is used to estimate this position in next frame so that the information of pipeline of each frame can be known in advance. Results obtained on real optic vision data in tank experiment are displayed and discussed. They show that the proposed system can detect and track the underwater pipeline online, and is effective and feasible.

关键词： A UV navigation pipeline detection Hough transform reference zone

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江西九江-瑞昌地震序列震源位置和发震构造再研究

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地震地质 2016年第2期38卷 342-351页

作者：罗丽吕坚曾文敬汤兰荣江西省地震局南昌330039

选取江西九江-瑞昌MS5.7地震序列2005年11月26日至2006年6月30日228次ML≥1.0的地震,利用基于波形互相关技术的Hypodd定位方法进行了重新定位,最终获得224次地震的精确震源参数。统计定位误差（2倍标准偏差）在水平方向上为0.5km左右,... 详细信息

选取江西九江-瑞昌MS5.7地震序列2005年11月26日至2006年6月30日228次ML≥1.0的地震,利用基于波形互相关技术的Hypodd定位方法进行了重新定位,最终获得224次地震的精确震源参数。统计定位误差（2倍标准偏差）在水平方向上为0.5km左右,垂直方向上〈2km。重定位后地震序列的震源深度主要集中在8~14km,震中在NW和NE 2个方向展布,其中又以NW向条带地震居多。结合几个主要地震的震源机制解、地震序列展布方向和震区的构造背景,我们推断NW向断裂错动产生了MS5.7主震,在右旋兼逆推过程中触发NE向断裂,产生了MS4.8最大余震。NE向断裂的地震活动经过短时间应力调整后进入相对平静期,之后则是NW向断裂在长时间的应力释放过程中引发了一系列余震。MS5.7主震的发震构造可能是NW向的洋鸡山-武山-通江岭隐伏断裂,而MS4.8最大余震的发震构造可能是NE向的刘家-范家铺-城门山断裂。

关键词：九江-瑞昌地震 Hypodd方法波形互相关发震构造

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制度学视角下我国高中选课走班制的审思

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教学与管理 2020年第22期 13-15页

作者：曾文静北京师范大学教育学部北京100875

选课走班制本质上是学校教育制度的变革,需要从制度学的视角上进行探讨。本文基于制度学理论,依据制度评价的合理性、合情性和现实性标准,提出高中学校决定是否实施选课走班制应思考的三大问题:一是选课走班制的价值功能定位是否准确;... 详细信息

选课走班制本质上是学校教育制度的变革,需要从制度学的视角上进行探讨。本文基于制度学理论,依据制度评价的合理性、合情性和现实性标准,提出高中学校决定是否实施选课走班制应思考的三大问题:一是选课走班制的价值功能定位是否准确;二是能否获得学生、教师、家长的认同;三是能否处理选课走班制实施时面临的矛盾,即学生有限的自我认知水平与较大的自主选择权的矛盾、师资稳定性与学生选课不确定性的矛盾、原有的课程建设水平与现需的课程建设能力的矛盾、学校设备资源有限与精细化管理需求的矛盾。

关键词：选课走班制合理性合情性现实性

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Dynamical complexity of Anosov systems driven by a quasi-periodic force

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Science China Mathematics 2025年第1期 89-136页

作者： wen Huang zeng Lian Kening Lu Department of Mathematics University of Science and Technology of China School of Mathematics Sichuan University

Consider C2Anosov systems on a compact manifold driven by a quasi-periodic *** study their dynamical complexity on various levels from the perspectives of both path-wise dynamics and stochastic *** that these systems are non-wandering（i.e.,every point in the phase space is nonwandering）,we prove a set of results:（1） the existence of abundance of random periodic points;（2） a random Liv?ic theorem;（3） a random Ma?é-Bousch-Conze-Guivarc'h lemma;（4） the existence of strong random ***,a concrete example constructed on a 2-dimensional torus is also given to uncover some interesting phenomena of the systems.

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Aberrant FoxM1 expression increases ASPM transcription and promotes progression of gliomas

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中国药理学与毒理学杂志 2019年第10期 892-892页

作者： zeng wen-jing wen Zhi-peng GONG Zhi-cheng CHEN Xiao-ping Department of Clinical Pharmacology Xiangya HospitalCentral South University Institute of Clinical Pharmacology Central South UniversityHunan Key Laboratory of Pharmacogenetics Department of Pharmacy Xiangya HospitalCentral South University

OBJECTIVE Gliomas is the most common form ofmalignant tumorincentral nervous system. However,the molecular mechanism of the tumorigenesis and progression of gliomas remains unclear. METHODS In this study, we used GEO database to identify genes differentially expressed in gliomas and predict the prognosis of glioma. Then we investigated the effects of ASPM on the biological functions of glioma cells, as well as the role of FoxM1 in up-regulating ASPM expression in *** ASPM mRNA was increased obviously in glioma tissue, and higher ASPM mRNA expressionpredicted worse disease prognosis. ASPM was highly expressed in gliomacell lines U87-MG and U251,and knockdown of ASPM expression in these cells significantly repressed the proliferation, migration and invasion ability,and induced G;/G;phase arrest. In addition, downregulation of ASPM suppressed the growth of glioma in nude mice. Five potential binding sites for transcription factor FoxM1 are predicted in the ASPM promoter. FoxM1 overexpression significantly increased the expression of ASPM and promoted the proliferation and migration of glioma cells, which was abolished by ASPM ablation. ChIP and dual luciferase reporter analysis confirmed that FoxM1 bound to the ASPM promoter at-236～-230 bp and-1354～-1348 bp and activated the transcription of ASPM directly. CONCLUSION Our results demonstrated for the first time that FoxM1 can directly activate the expression of ASPM at transcription level, and thereby regulating malignant properties of glioma cells.

关键词： glioma FoxM1 ASPM biomarker

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乡村青年教师何以留任——基于全国18省35县调查数据的回归分析

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教师教育研究 2019年第3期31卷 45-51,69页

作者：付昌奎曾文婧教育部人文社科重点研究基地东北师范大学中国农村教育发展研究院

乡村青年教师的留任意愿基本决定着乡村教师队伍的相对稳定性。本研究利用18省35县15048份乡村青年教师调查问卷,对乡村青年教师留任意愿的影响因素进行了多元线性回归分析。结果表明:年龄、年工资、社会地位、学校内部工作环境、学校... 详细信息

乡村青年教师的留任意愿基本决定着乡村教师队伍的相对稳定性。本研究利用18省35县15048份乡村青年教师调查问卷,对乡村青年教师留任意愿的影响因素进行了多元线性回归分析。结果表明:年龄、年工资、社会地位、学校内部工作环境、学校周边环境对乡村青年教师留任意愿有显著正向影响;工作量、学校距县城距离、工作压力、教学效能、职业倦怠对其有显著负向影响;配偶跨县工作、男性、毕业于省属普通本科及以上层次院校、参加过市级及以上级别培训的乡村青年教师留任意愿更低。为增强乡村青年教师留任意愿,稳定乡村教师队伍,需提升乡村教师工资收入水平及合理性,改善乡村青年教师生活条件与便利性,创设积极且温馨的学校内部工作环境,并关注高能力青年教师职业预期的实现。

关键词：乡村教师青年教师留任意愿职业期待

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速度矢量坐标系下水下机器人动态避障方法

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哈尔滨工程大学学报 2010年第2期21卷 159-164页

作者：毛宇峰庞永杰李晔曾文静哈尔滨工程大学水下智能机器人技术国防科技重点实验室黑龙江哈尔滨150001

针对水下机器人能力有限问题设计了一种适应水下机器人能力的动态避障方法.以水下机器人对运动障碍物的相对速度信息建立速度矢量坐标系,在坐标系内,根据水下机器人速度矢量和障碍物速度矢量的相互关系以及水下机器人的能力,确定理论上... 详细信息

针对水下机器人能力有限问题设计了一种适应水下机器人能力的动态避障方法.以水下机器人对运动障碍物的相对速度信息建立速度矢量坐标系,在坐标系内,根据水下机器人速度矢量和障碍物速度矢量的相互关系以及水下机器人的能力,确定理论上能够避开障碍物的期望速度解集,然后按照满足碰撞时间条件的最小转艏避障原则求解水下机器人最优期望速度的大小和方向,使水下机器人能够以相对小的代价安全避开动态障碍物.仿真研究验证了此规划方法对躲避动态障碍物的有效性,该研究大幅度提高了水下机器人的智能水平.

关键词：水下机器人动态避障速度矢量坐标系避障策略

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The potential mechanism and clinical application value of remote ischemic conditioning in stroke

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Neural Regeneration Research 2025年第6期20卷 1613-1627页

作者： Yajun Zhu Xiaoguo Li Xingwei Lei Liuyang Tang Daochen wen Bo zeng Xiaofeng Zhang Zichao Huang Zongduo Guo The First Affiliated Hospital of Chongqing Medical University ChongqingChina

Some studies have confirmed the neuroprotective effect of remote ischemic conditioning against stroke. Although numerous animal researches have shown that the neuroprotective effect of remote ischemic conditioning may be related to neuroinflammation, cellular immunity, apoptosis, and autophagy, the exact underlying molecular mechanisms are unclear. This review summarizes the current status of different types of remote ischemic conditioning methods in animal and clinical studies and analyzes their commonalities and differences in neuroprotective mechanisms and signaling pathways. Remote ischemic conditioning has emerged as a potential therapeutic approach for improving stroke-induced brain injury owing to its simplicity, non-invasiveness, safety, and patient tolerability. Different forms of remote ischemic conditioning exhibit distinct intervention patterns, timing, and application range. Mechanistically, remote ischemic conditioning can exert neuroprotective effects by activating the Notch1/phosphatidylinositol 3-kinase/Akt signaling pathway, improving cerebral perfusion, suppressing neuroinflammation, inhibiting cell apoptosis, activating autophagy, and promoting neural regeneration. While remote ischemic conditioning has shown potential in improving stroke outcomes, its full clinical translation has not yet been achieved.

关键词： Akt apoptosis autophagy cerebral perfusion cerebral vascular stenosis clinical transformation hemorrhagic stroke ischemic stroke neuroinflammation neuroprotection Notch1 PI3K remote ischemic conditioning stroke

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