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Visual dual chemodynamic/photothermal therapeutic nanoplatform based on superoxide dismutase plus Prussian blue

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Nano Research 2019年第5期12卷 1071-1082页

作者： Shan Lei Jinxing Chen kun zeng Mozhen Wang Xuewu Ge CAS Key Laboratory of Soft Matter Chemistry Department of Polymer Science and EngineeringUniversity of Science and Technology of ChinaHefei 230026China

Enzyme-based anticancer therapy is more attractive for the less side effect than conventional ***,the poor stability and low membrane permeability of enzymes during the intracellular delivery are constraints for its practical *** this work,we synthesized novel near-infrared (NIR)-responsive core-shell-structured Prussian blue@fibrous SiO2 (PBFS) nanoparticles as the carrier of superoxide dismutase (SOD) and a glutathione (GSH)-activated Fenton reagent (DiFe).The PBFS nanoparticles are further modified with aGSH-responsive cationic polymer (poly(2-(acryloyloxy)-N,N-dimethyl-N-(4-(((2-((2-(((4-methyl-2-oxo-2H-chromen-7-yl)carbamoyl)oxy)ethyl)disulfaneyl)ethoxy)carbonyl)amino)benzyl)ethan-1-aminium,PSS) containing disulfide bonds and *** SOD and DiFe are loaded on the PBFS-PSS nanoparticles,dual chemodynamic/photothermal therapeutic nanoparticulate systems (PBFS-PSS/DiFe/SOD) are *** vitro experiments show that PBFS-PSS/DiFe/SOD nanoparticles have good biocompatibility and can be tracked under fluorescence microscope during the intracellular delivery process in MCF-7 tumor cells due to the GSH-activated release of *** also exhibit high efficiency in NIR photothermal conversion and GSH-activated Fenton reaction in tumor cells,thus achieving high-efficient killing effect of tumor cells based on the combination of photothermal and chemodynamic therapeutic performance (PTT and CDT).This work offers a novel pathway to construct a visual multifunctional nanomedicine platform for future cancer therapy.

关键词： copper-zinc superoxide dismutase Fenton reagent Prussian blue near-infrared (NIR) photothermal therapy fluorescence

Synthesis of polynorbornene with pendant moiety bearing azide and terminal alkyne groups

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Chinese Chemical Letters 2011年第7期22卷 785-788页

作者： Ze Zhang Zhi Wei Peng kun zeng Fan School of Biochemical Engineering Anhui Polytechnic University Wuhu 241000 China Department of Chemistry University of Science and Technology of China Hefei 230026 China

A powerful approach to the synthesis of an unprecedented polynorbornene with pendant moiety bearing azide and terminal alkyne groups is developed. Two key intermediates, namely, 3-azido-5-（2-（trimethylsilyl）ethynyl） benzyl alcohol and 4-（4-azatricyclo [5.***.1.0^2.6]dec-8-en-4-yl） benzoic acid, were optimally synthesized for convergent synthesis of the corresponding monomer.

关键词： Polynorbomene Azide Alkyne Esterification Metathesis

Catalase-imprinted Fe3O4/Fe@fibrous SiO2/polydopamine nanoparticles： An integrated nanoplatform of magnetic targeting, magnetic resonance imaging, and dual-mode cancer therapy

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Nano Research 2017年第7期10卷 2351-2363页

作者： Jinxing Chen Shan Lei kun zeng Mozhen Wang Anila Asif Xuewu Ge CAS Key Laboratory of Soft Matter Chemistry Department of Polymer Science and Engineering University of Science and Technology of China Hefei 230016 China Interdisciplinary Research Centre in Biomedical Materials (IRCSM) COMSATS Institute of Information Technology Lahore 54000 Pakistan

Recent advances in the research on the molecular mechanism of cell death and methods for preparation of nanomaterials make the integration of various therapeutic approaches, targeting, and imaging modes into a single nanoscale complex a new trend for the development of future nanotherapeutics. Hence, a novel ellipsoidal composite nanoplatform composed of a magnetic Fe3O4/Fe nanorod core （-120 nm） enwrapped by a catalase （CAT）-imprinted fibrous SiO2/ polydopamine （F-SiO2/PDA） shell with thickness 70 nm was prepared in this work. In vitro experiments showed that the Fe3O4/Fe@F-SiO2/PDA nanoparticles can selectively inhibit the bioactivity of CAT in tumor cells by the molecular imprinting technique. As a result, the H2O2 level in tumor cells was elevated dramatically. At the same time, the Fe304FFe core released Fe ions to catalyze the conversion of H2O2 to ＊OH in tumor cells. Eventually, the concentration of ＊OH in tumor cells rapidly rose to a lethal level thus triggering apoptosis. Combined with the remarkable near-infrared light （NIR） photothermal effect of the CAT- imprinted PDA layer, the Fe3O4/Fe@F-SiO2/PDA nanoparticles can effectively kill MCF-7, HeLa, and 293T tumor cells but are not toxic to nontumor cells. Furthermore, these nanoparticles show good capacity for magnetic targeting and suitability for magnetic resonance imaging （MRI）. Therefore, the integrated multifunctional nanoplatform opens up new possibilities for high-efficiency visual targeted nonchemo therapy for cancer.

关键词： molecular imprintednanoparticles reactive oxygen species NIR photothermal therapy magnetic targeting magnetic resonanceimaging (MRI)

Synthesis of Single-stranded Polynorbornene with Pendant Group Bearing Benzenedicarboxaldehyde and Long Alkyl Chain

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Chemical Research in Chinese Universities 2012年第6期28卷 985-989页

作者： ZHANG Ze WU Hao-hao WANG Chun-shan FAN kun-zeng School of Biochemical Engineering Anhui Polytechnic University Wuhu 241000 P. R. China Department of Chemistry University of Science and Technology of China Hefei 230026 P. R. China

An unprecedented single-stranded polynorbornene with the pendant group containing benzenedicarboxaldehyde and a long alkyl chain（12） was synthesized by ring-open metathesis polymerization（ROMP） of the corresponding monomer（11）,which was obtained via the esterification of two crucial intermediates,namely,2-hexadecyloxy-5-hydroxymethyl-1,3-benzenedicarboxaldehyde（7,obtained via 6 steps） and 4-（4-aza-tricyclo[5.***.1.0 2.6 ]-dec-8en-4-yl）benzoic acid（10）.The target compound and all the intermediates were characterized by infrared（IR）,1 H NMR and high resolution mass spectroscopy（HRMS） analysis.

关键词： Polynorbornene Benzenedicarboxaldehyde Esterification Ring-open metathesis polymerization

A combination of hierarchical pore and buffering layer construction for ultrastable nanocluster Si/SiO_(x)anode

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Nano Research 2020年第11期13卷 2987-2993页

作者： kun zeng Tong Li Xianying Qin Gemeng Liang Lihan Zhang Qi Liu Baohua Li Feiyu Kang Shenzhen Key Laboratory of Power Battery Safety Research and Shenzhen Geim Graphene Center Tsinghua Shenzhen International Graduate SchoolTsinghua UniversityShenzhen518055China Tsinghua-Berkeley Shenzhen Institute(TBSI) Tsinghua UniversityShenzhen518055China School of Materials Science and Engineering Tsinghua UniversityBeijing100084China

Porous Si can be synthesized from diverse silica(SiO_(2))via magnesiothermic reduction technology and widely employed as potential anode material in lithium ion ***,concerns regarding the influence of residual silicon oxide(SiO_(x))component on resulted Si anode after reduction are still *** this work,we intentionally fabricate a cauliflower-like silicon/silicon oxide(CF-Si/SiO_(x))particles from highly porous SiO_(2)spheres through insufficient magnesiothermic reduction,where residual SiO_(x)component and internal space play an important role in preventing the structural deformation of secondary bulk and restraining the expansion of Si ***,the hierarchically structured CF-Si/SiO_(x)exhibits uniformly-dispersed channels,which can improve ion transport and accommodate large volume expansion,*** a result,the CF-Si/SiO_(x)-700 anode shows excellent electrochemical performance with a specific capacity of^1,400 mA·h·g^(−1)and a capacity retention of 98%after 100 cycles at the current of 0.2 A·g^(−1).

关键词： highly-porous Si/SiO_(x)anodes magnesiothermic reduction lithium ion battery

Surface engineering of nickel-rich single-crystal layered oxide cathode enables high-capacity and long cycle-life sulfide all-solid-state batteries

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Advanced Powder Materials

Advanced Powder Materials 2024年第5期3卷 101-110页

作者： Xuebao Li Jiasen Wang Cheng Han kun zeng Zhuangzhi Wu Dezhi Wang School of Materials Science and Engineering Central South UniversityChangsha 410083China State Key Laboratory of Powder Metallurgy Central South UniversityChangsha 410083China

Sulfide all-solid-state lithium batteries(SASSLBs)with a single-crystal nickel-rich layered oxide cathode(LiNix-CoyMn_(1-x-y)O_(2),x≥0.8)are highly desirable for advanced power batteries owing to their excellent energy density and ***,the cathode material's cracking issue and its severe interfacial problem with sulfide solid electrolytes have hindered the further *** study proposes to employ surface modification engineering to produce B-NCM cathode materials coated with boride nanostructure stabilizer in situ by utilizing NCM encapsulated with residual *** approach enhances the electrochemical performance of SASSLBs by effectively inhibiting electrochemical-mechanical degradation of the NCM cathode material on cycling and reducing deleterious side reactions with the solid sulfide *** B-NCM/LPSCl/Gr SASSLBs demonstrate impressive cycling stability,retaining 84.19%of its capacity after 500 cycles at 0.2 C,which represents a 30.13%increase ***/LPSCl/*** also exhibits a specific capacity of 170.4 mAh/g during its first discharge at 0.1 *** work demonstrates an effective surface engineering strategy for enhancing capacity and cycle life,providing valuable insights into solving interfacial problems in SASSLBs.

关键词： Lithium-ion batteries Sulfide all-solid-state electrolytes Nickel-rich Single-crystal LiNi0.8Co0.1Mn0.1O2 Nanocoating

SOLVING GENERALIZED FRACTIONAL PROGRAMMING WITH p+1-PARAMETER PROGRAMMING

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Chinese Science Bulletin 1989年第8期34卷 699-700页

作者：徐增堃 Department of Mathematics Zhejiang Normal University Jinhua

For the generalized fractional programming （P） where S is a nonempty subset of Rn, fi and gi are real-valued functions on S, and gi are positive on S, we propose the following program with p+1 parameters （α,θ）∈... 详细信息

关键词： nonempty fractional valued subset 吕才

Selective Carbon Dioxide Capture in Antifouling Indole-based Microporous Organic Polymers

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Chinese Journal of Polymer Science 2020年第2期38卷 187-194,I0008页

作者： Meng-Qi Du Yu-Zheng Peng Yuan-Chi Ma Li Yang Yuan-Lin Zhou Fan-kun zeng Xiang-Ke Wang Man-Ling Song Guan-Jun Chang State Key Laboratory of Environment-friendly Energy Materials School of Material Science and EngineeringSchool of Life Science and EngineeringSouthwest University of Science and TechnologyMianyang 621010China Department of Chemical and Biomolecular Engineering University of PennsylvaniaPennsylvania 19104United States

Intermolecular synergistic adsorption of indole and carbonyl groups induced by intermolecular hydrogen bonding makes microporous organic polymer(PTICBL)exhibit high CO2 uptake capacity(5.3 mmol·g^-1at 273 K)and selectivities(CO2/CH4=53,CO2/N2=107 at 273 K).In addition,we find that indole units in the PTICBL networks inhibit the attachment of bacteria(*** and ***)on the surface of PTICBL and extend its service life in CO2 capture.

关键词： CO2 capture Synergistic adsorption Antifouling Indole Microporous organic polymer

Design and study of a long-wavelength monolithic high-contrast grating resonant-cavity-enhanced photodetector

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Optoelectronics Letters 2019年第4期15卷 250-254页

作者： zeng kun DUAN Xiao-feng HUANG Yong-qing LIU Kai REN Xiao-min State Key Laboratory of Information Photonics and Optical Communications Beijing University of Posts and Telecommunications

Novel construction of a resonant-cavity-enhanced photodetector(RCE-PD) with monolithic high-contrast grating(HCG)is proposed to overcome the difficulty of fabricating a high reflective mirror of RCE-PD at 1 550 nm. In this structure,HCG serves as the top mirror of the RCE-PD, whereas InGaAs serves as a sacrificial layer to achieve monolithic *** the bandwidth optimization, the ratio of the thickness of the total intrinsic region and the absorption layer is introduced to realize the simultaneous optimization of the thickness of spacing layers and absorption layer. After structural optimization, the quantum efficiency of the device with diameter of 20 μm is 82% at 1 550 nm, and the 3-dB bandwidth is 34 GHz at a bias of 3 V.

关键词： Novel construction resonant-cavity-enhanced photodetector(RCE-PD) high-contrast grating(HCG)