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Association between preterm birth risk and polymorphism and expression of the DNA repair genes OGG1 and APE1 in Saudi women

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BIOCELL 2018年第1期42卷 1-6页

作者： ARWA OSAMA NEMER MOHAMMAD SAUD AL ANAZI RAMESA SHAFI BHAT ARJUMAND S.WARSY zeneb A babay MOHAMMAD HADDAR JILANI SHAIK SOOAD AL-DAIHAN Department of Biochemistry College of Science Genome Research Chair Department of BiochemistryCollege of Science Central Laboratory Female Center for Medical Studies and Scientific Section Department of Obs/Gyn College of MedicineKing Saud UniversityP.O.Box 22452Zip code 11495RiyadhSaudi Arabia

Genomic instability and mutations caused by increases in oxidative stress during pregnancy can damage the fetoplacental unit and can upshot preterm *** damage to DNA may possibly be involved in etiology of preterm birth(PTB)which can be repaired by DNA repair *** the present study,we assessed the association of base excision repair gene family by analyzing the association of single nucleotide polymorphisms and genes expression in 8-oxoguanine glycosylase-1(OGG1)and apurinic-apyrimidinic endonuclease 1(APE1)genes with risk of preterm birth in Saudi *** analyzed genotypes of four single nucleotide polymorphisms(SNPs)(rs1052133,rs293795,rs2072668 and rs2075747)in OGG1 gene and three SNPs(rs1130409,rs3136814,and rs3136817)in APE1 gene using TaqMan Genotyping assay kits in 50 pairs of preterm cases and individually matched ***,gene expression level was explored by RT-PCR in 10 pairs of preterm placental tissues and individually matched normal placental *** OGG1 SNP,rs1052133(OR=0.497;c2=1.11;p=0.292)and rs2072668(OR=0.408;c2=1.90;p=0.167)and one APE1 SNP rs3136817(OR=0.458;c2=0.40;p=0.527)showed nonsignificant protective effect against PTB *** expression of both genes under study was found lower in the PTB *** and allele frequencies of both gene SNPs did not show any association with the risk of preterm delivery in Saudi women(P˃0.05).However,synthesis and release of OGG1 and APE1 proteins decreased in preterm placental tissues compared to term delivery reflects the probability of being one of the mechanisms leading to preterm birth.

关键词： Preterm birth OGG1 and APE1 genes Oxidative stress SNPs

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Two polymorphisms in methylenetetrahydrofolate reductase gene(C677T and A1298C) frequently associated with recurrentspontaneous abortion show no association in Saudi women

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BIOCELL 2020年第4期44卷 613-621页

作者： AFRAH ALKHURIJI ATEKAH ABDULLAH MOHAMMED ALRAQIBAH AMAAL AWAD ALHARBI zeneb babay FATIMAH BASIL AL-MUKAYNIZI ARWA ALTHOMALI SONYA S.ABDEL-RAZEQ ARJUMAND S.WARSY Department of Zoology College of ScienceKing Saud UniversityRiyadh11451Saudi Arabia Department of Obs/Gyn College of MedicineKing Saud UniversityRiyadh11451Saudi Arabia Prince Naif Bin AbdulAziz Health Research Center(PNHRC) King Saud UniversityRiyadh11451Saudi Arabia Division of Maternal-Fetal Medicine Department of ObstetricsGynecologyand Reproductive SciencesYale University School of MedicineNew Haven06501USA Central Laboratory Center for Science and Medical Studies for GirlsKing Saud UniversityRiyadh11451Saudi Arabia

Methylenetetrahydrofolate reductase(MTHFR)deficiency is the most common genetic cause of hyperhomocysteinemia,which has been implicated in the etiology of recurrent spontaneous abortion(RSA).This study was designed to investigate the association between two single nucleotide polymorphisms(SNP)(rs1801133[C677T]and rs1801131[A1298C])in the MTHFR gene and RSA,in *** two SNPs were selected as these polymorphisms have a different effect on the activity and stability of the enzyme,and significantly diverse effects have been reported in relation to the association with *** approval was acquired from the IRB at King Saud University(KKUH),Saudi Arabia,and written informed consent was obtained from each *** study group comprised of 100 Saudi women with unexplained RSA and 100 age-matched controls,both attending KKUH for a routine *** was drawn in EDTA tubes,and DNA was *** was conducted using TaqMan SNP genotyping assay *** frequency of the T allele of C677T was 0.165 in patients and 0.17 in *** frequencies for CC,CT and TT genotypes were 70%,27%and 3%,respectively in RSA,and 71%,24%and 5%,respectively,in the controls(p>0.05).For the A1298C polymorphism,the C allele frequencies were 0.345 in patients and 0.28 in controls,while genotype frequencies for AA,AC and CC genotypes were 44%,43%,and 13%,respectively,in patients,and 54%,36%,and 10%,respectively,in controls(p>0.05).The frequency of CC genotype and C allele of A1298C were higher in the patients with RSA,but not significantly,while C677T genotypes and allele frequencies did not differ between patients and *** results suggested that MTHFR gene polymorphisms are population-specific and may not associate with RSA in Saudi women.

关键词： MTHFR RSA Single nucleotide polymorphism Hyperhomocystenemia

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政治风险对苏丹吸引FDI的影响基于国际国家风险指南的研究

政治风险对苏丹吸引FDI的影响基于国际国家风险指南的研究

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作者： IBRAHIM babay ELDIGELHUSSIN 江西财经大学

学位级别：硕士

外国直接投资(FDI)是经济增长的重要决定因素。大量文献探讨了其决定因素,但很少有人研究政治风险对FDI的影响。在发展中国家,文献和研究结果之间存在相似之处。该研究是关于2000-2021年期间苏丹局势的。因此,本研究考察了《国际国家风... 详细信息

外国直接投资(FDI)是经济增长的重要决定因素。大量文献探讨了其决定因素,但很少有人研究政治风险对FDI的影响。在发展中国家,文献和研究结果之间存在相似之处。该研究是关于2000-2021年期间苏丹局势的。因此,本研究考察了《国际国家风险指南》(ICRG)中的12项政治风险指标,增加了国民生产总值和经济开放度。多元回归分析是使用R编程语言完成的。调查结果提供了政治风险因素与FDI流入苏丹之间显着因果关系的证据。在这些因素中,政治状况、法律和秩序、腐败和政治军事是FDI最重要的决定因素。从实践和政策的角度来看,研究结果表明,苏丹从业者和政策制定者应提高治理效率和法治,以减轻政治风险并鼓励FDI流入苏丹,与伙伴国家保持健康的关系和合作,并制定适当的政策,并增强市场吸引外国直接投资的潜力。然而,在2023年4月15日快速支援部队(RSF)与苏丹军队(SAF)发生冲突后,吸引外国直接投资的努力将受到破坏,整个国家现在都面临内战风险。

关键词：外国直接投资政治风险经济增长治理 ICRG指数

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Intestinal carriage of methicillin resistant Staphylococcus aureus and extended-spectrum β-Lactamase-producing Enterobacteriacae in hospitalized and nonhospitalized patients and their clinical implications

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Asian Pacific Journal of Tropical Medicine 2009年第3期2卷 41-45页

作者： Hanan Ahmed Habib babay Ali Mohammed Somily Department of Pathology Microbiology Unit King Khalid University HospitalRiyadhSaudi Arabia

Objective:To determine the clinical implication of and intestinal carriage with methicillin resistant Staphylococcus aureus(MRSA) and extended spectrumβ-lactamase(ESBL)-producing ***: A total of 180 stool specimens were screened for MRSA and ESBL-producing *** of ESBL- producing Enterobacteriacae was done by MicroScan Walk Away 96 system(Dade Behring Inc.,West Sacramento,CA 95691,USA ) and confirmation by double-disc synergy *** was identified by disc diffusion using 30μg cefoxitin disc and the ***:The rate of fecal MRSA carriage was 7.8% (14/180),35.7%(5 /14) were recovered from surgical *** patients(21,4%) had MRSA recovered from other body sites,and 2(14.2%) had in addition ESBL -producing Escherichia coli(***) and Klebsiella pneumoniae(***) ***(28.5%) patients with MRSA fical carriage died. MRSA fecal carriage was recovered from both inpatients and ***(2.2%) cases carried ESBL-producing Enterobacteriacae in ***(75%) were from intensive care unit(ICU).One patient had both ESBL-producing *** and *** from stool as well as *** from tracheal *** ICU patients with fecal ESBL ***:Fecal screening for MRSA and ESBL of all patients at high risk admitted to different hospital wards and ICUs and implementing infection control measures were recommended.

关键词： Intestinal carriage Methicillin resistant Staphylococcus aureus Extended spectrumβ-lactamase Enterobacteriacae

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胃腺癌组织lncRNA HOTAIR、MEG3表达变化及其临床意义

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山东医药 2019年第19期59卷 1-4页

作者：张晓玲艾尼娃儿·巴巴依王小云无锡市中医医院江苏无锡214100 新疆维吾尔自治区人民医院无锡市第二人民医院

目的探讨胃腺癌组织长链非编码RNA(lncRNA)HOX转录反义RNA(HOTAIR)、母系印记表达基因3(MEG3)表达变化及其临床意义。方法选择胃腺癌患者142例,取手术切除的胃腺癌组织及其配对的癌旁正常组织,采用RT-qPCR法检测lncRNA HOTAIR、MEG3表... 详细信息

目的探讨胃腺癌组织长链非编码RNA(lncRNA)HOX转录反义RNA(HOTAIR)、母系印记表达基因3(MEG3)表达变化及其临床意义。方法选择胃腺癌患者142例,取手术切除的胃腺癌组织及其配对的癌旁正常组织,采用RT-qPCR法检测lncRNA HOTAIR、MEG3表达。比较胃腺癌组织与癌旁正常组织lncRNAHOTAIR、MEG3表达变化,并分析胃腺癌组织lncRNA HOTAIR表达与lncRNA MEG3表达的关系以及二者与患者临床病理特征的关系。结果与癌旁正常组织比较,胃腺癌组织lncRNAHOTAIR相对表达量明显升高,lncRNAMEG3相对表达量明显降低(P均0.05)。结论胃腺癌组织lncRNAHOTAIR表达升高、lncRNAMEG3表达降低,二者均参与胃腺癌的发生、发展。

关键词：胃腺癌长链非编码RNA HOX转录反义RNA 母系印记表达基因3

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