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受时间约束的工作流关键路径的确定

计算机工程与应用 2004年第29期40卷 21-23页

作者：陶泽谢里阳袁锋东北大学机械工程与自动化学院沈阳110004

针对工作流模型的结构特点,建立了一种关键路径分析法,增加了对工作流常见结构的支持。该法将工作流模型中不同的控制结构转换为相应的顺序结构,并建立它们的约简规则。通过该算法,可以计算工作流完成时间的最大最小值及记录约简过程中... 详细信息

针对工作流模型的结构特点,建立了一种关键路径分析法,增加了对工作流常见结构的支持。该法将工作流模型中不同的控制结构转换为相应的顺序结构,并建立它们的约简规则。通过该算法,可以计算工作流完成时间的最大最小值及记录约简过程中的中间结果,从而确定工作流模型的关键路径。在该路径上包含了在整个流程起关键性作用的活动以及相应的时间分布,对于确保工作流计划的高效执行和提高企业的竞争力具有重要意义。

关键词：工作流时间约束工作流管理系统排队模型

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一种适用于云计算环境的跨域访问控制模型

微电子学与计算机 2017年第3期34卷 65-69页

作者：江泽涛谢朕王琦张文辉桂林电子科技大学计算机与信息安全学院广西桂林541004

使用控制模型(Usage Control,UCON)涵盖了传统的访问控制、可信管理及数字版权等复杂需求,被称为下一代访问控制模型.但是由于其授权实现较为复杂,其实际应用还处于探索阶段.将UCON模型中的义务元素删除、条件元素进拆分后使其实现大为... 详细信息

使用控制模型(Usage Control,UCON)涵盖了传统的访问控制、可信管理及数字版权等复杂需求,被称为下一代访问控制模型.但是由于其授权实现较为复杂,其实际应用还处于探索阶段.将UCON模型中的义务元素删除、条件元素进拆分后使其实现大为简化.同时提出了三种在云计算环境下将传统访问控制模型转换为支持UCON模型的方法.

关键词：使用控制模型云计算跨域访问授权

Skeletal muscle-specific Bambi deletion induces hypertrophy and oxidative switching coupling with adipocyte thermogenesis against metabolic disorders

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Science China Life Sciences 2025年

作者： Xiangping Yao Xudong Mai Ye Tian Yifan Liu Guanghui Jin ze Li Shujie Chen Xiaoshuang Dai Liujing Huang Zijing Fan Guihua Pan Xiaohan Pan Xiangmin Li Michael C Yu Jia Sun Jingxing Ou Hong Chen Liwei xie College of Life and Health Sciences Guangdong Industry Polytechnic Department of Endocrinology and Metabolism Zhujiang Hospital Southern Medical University State Key Laboratory of Applied Microbiology Southern China Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application Guangdong Open Laboratory of Applied MicrobiologyInstitute of Microbiology Guangdong Academy of Sciences Institute of Aging Research Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics School of Medical Technology Guangdong Medical University Department of Hepatic Surgery and Liver transplantation Center of the Third Affiliated Hospital Organ Transplantation Institute Sun Yat-sen University Organ Transplantation Research Center of Guangdong ProvinceGuangdong province engineering laboratory for transplantation medicine Guangdong Provincial Key Laboratory of Liver Disease Research School of Public Health Xinxiang Medical University BGI Institute of Applied Agriculture BGI-Shenzhen Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic University Department of Biological Sciences State University of New York at Buffalo Department of Internal Medicine Shunde Women and Children's Hospital (Maternity and Child Healthcare Hospital of Shunde Foshan) Guangdong Medical University

Skeletal muscle plays a significant role in both local and systemic energy metabolism. The current investigation aims to explore the role of the Bambi gene in skeletal muscle, focusing on its implications for muscle hypertrophy and systemic metabolism. We hypothesize that skeletal muscle-specific deletion of Bambi induces muscle hypertrophy, improves metabolic performance, and activates thermogenic adipocytes via the reprogramming of progenitor of i WAT, offering potential therapeutic strategies for metabolic syndromes. Leveraging the Chromatin immunoprecipitation(ChIP)-seq and bioinformatics analysis, Bambi gene is shown to be a direct target of HIF2α, which is further confirmed by ChIP-qPCR and promoter luciferase assay. Skeletal muscle-specific Bambi deletion led to significant muscle hypertrophy and improved metabolic parameters, even under high-fat diet conditions. This deletion induced metabolic reprogramming of stromal vascular fractions(SVFs) into thermogenic adipocytes, contributing to systemic metabolic improvements, potentially through the secretory ***, mice with skeletal muscle-specific Bambi deletion demonstrate resistance to high-fat diet-induced metabolic disorders, highlighting a potential therapeutic pathway for metabolic syndrome management. Thus, skeletal muscle-specific deletion of Bambi triggers muscle growth, enhances metabolic performance, and activates thermogenic adipocytes. These findings suggest Bambi as a novel therapeutic target for metabolic syndromes, providing new insights into the interaction between muscle hypertrophy and systemic metabolic improvement. The study underscores the potential of manipulating muscle physiology to regulate whole-body metabolism, offering a novel perspective on treating metabolic disorders.

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Dynamics of loose granular flow and its subsequent deposition in a narrow mountainous river

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Journal of Mountain Science 2019年第6期16卷 1367-1380页

作者： LEI Ming XU ze-xing ZHAO tao WANG xie-kang State Key Laboratory of Hydraulics and Mountain River Engineering Sichuan University

A large amount of loose debris materials were deposited on the slope of mountainous areas after the 2008 Ms 8.0 Wenchuan earthquake. During and after the earthquake, these loose debris deposits collapsed and slide into valleys or rivers, changing river sediment supply condition and channel morphology. To investigate the mechanisms of granular flow and deposition, the dynamics of slope failure and sediment transportation in typical mountainous rivers of different intersection angles were analyzed with a coupling model of Computational Fluid Dynamics and Discrete Element Method(CFD-DEM). The numerical results show that the change of intersection angle between the granular flow flume and the river channel can affect the deposit geometry and the fluid flow field significantly. As the intersection angle increases, the granular velocity perpendicular to the river channel increases, while the granular velocity parallel to the river channel decreases gradually. Compared to the test of dry granular flow, the CFD-DEM coupling tests show much higher granular velocity and larger volume of sediments entrained in the river. Due to the river flow, particles located at the edge of the deposition will move downstream gradually and the main section of sediments deposition moves from the center to the edge of the river channel. As a result, sediment supply in the downstream river will distribute unevenly. Under the erosion of fluid flow, the proportion of fine particles increases, while the proportion of coarse particles decreases gradually in the sediment deposition. The build-up of accumulated sediment mass will cause a significant increase in water level in the river channel, thus creating serious flooding hazard in mountainous rivers.

关键词： Loose debris materials Sediment supply CFD-DEM coupling method Numerical simulations

Stability analysis for a size-structured model of species in a space-limited habitat

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International Journal of Biomathematics 2016年第6期9卷 241-262页

作者： ze-Rong He Qiang-Jun xie Hai-tao Wang Institute of Operational Research and Cybernetics Hangzhou Dianzi University Hangzhou 310018 P. R. China

We investigate the stability of steady states of a size- and stage-structured population model, which is a hybrid system of ordinary and partial differential equations with global integral feedbacks. After the formulation of a criterion by spectrum method, we derive conditions for global stability of the trivial state and local stability of the positive equilibrium via the basic reproduction rate. Furthermore, some examples and simulations ure .presented to illustrate the obtained results.

关键词： Space-limitation size-dependence spectrum reproduction number stability.

扬子板块西南缘早前寒武纪地质演化:来自撮科元古宙变沉积岩碎屑锆石U-Pb年龄、Hf-O同位素的制约

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岩石学报 2025年第1期41卷 304-320页

作者：高嘉敏谢士稳刘倩王舫陶鹏龙涛中国地质大学(北京)地球科学与资源学院北京100083 中国地质科学院地质研究所北京离子探针中心北京100037 山东省第四地质矿产勘查院潍坊261021

扬子板块的太古宙-古元古代基底出露十分有限,制约了对扬子早前寒武纪地质演化的认识。本次研究对扬子板块西南缘撮科地区的大红山群和昆阳群变沉积岩开展了碎屑锆石原位U-Pb年龄、Hf-O同位素及微量元素研究。测年结果显示,大红山群谐... 详细信息

扬子板块的太古宙-古元古代基底出露十分有限,制约了对扬子早前寒武纪地质演化的认识。本次研究对扬子板块西南缘撮科地区的大红山群和昆阳群变沉积岩开展了碎屑锆石原位U-Pb年龄、Hf-O同位素及微量元素研究。测年结果显示,大红山群谐和锆石年龄分布于3092~1786Ma之间,最年轻碎屑锆石年龄为1786Ma,限定大红山群最大沉积时代为古元古代晚期。昆阳群谐和锆石年龄分布于2874~1031Ma之间,最年轻碎屑锆石年龄为1031Ma,表明昆阳群最大沉积时代为中元古代晚期。除少量较年轻锆石(<1.75Ga)外,昆阳群和大红山群具有相似的年龄分布特征,两个主要的年龄峰为2.0~1.85Ga和2.4~2.2Ga。尽管古元古代碎屑锆石的年龄峰与撮科地区已报道的古元古代岩浆活动期次一致,但仅有少部分碎屑锆石的Hf-O同位素特征与撮科古元古代岩浆岩相似,大多数碎屑锆石Hf-O同位素组成与加拿大Rae克拉通古元古代变沉积岩中碎屑锆石相似,暗示古元古代碎屑物质可能仅少部分来自撮科地区已识别的古元古代岩浆岩,而大部分可能来自与Rae克拉通发育的古元古岩浆岩相似的源区。大红山群和昆阳群中1.9~1.03Ga的碎屑锆石可能来自扬子西南缘发育的古元古代晚期-中元古代晚期岩浆岩。结合前人的资料,我们认为我国撮科和越南北部的Phan Si Pan带经历了与加拿大Rae克拉通相似的古元古代演化过程,支持2.4~2.3Ga扬子西南缘卷入Arrowsmith造山事件,并与Rae克拉通一起参与哥伦比亚超大陆聚合过程的认识。

关键词：扬子西南缘撮科地区哥伦比亚超大陆大红山群和昆阳群碎屑锆石

FHL2 deficiency aggravates Candida albicans infection through decreased myelopoiesis

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Science China Life Sciences 2025年

作者： Rongmei Gao Kanchao Chen Yimin Wang Rongxia Guo Xiaoyu Zhang Peng Wu Weili Wang Qingxiang Huang Xuemei xie Shangda Yang Yanling Lü Qian Ren Fei Liu Song Chen Fengxia Ma tao Cheng Hui Cheng State Key Laboratory of Experimental Hematology National Clinical Research Center for Blood Diseases Haihe Laboratory of Cell Ecosystem Institute of Hematology & Blood Diseases Hospital Chinese Academy of Medical Sciences & Peking Union Medical College CAMS Center for Stem Cell Medicine PUMC Department of Stem Cell and Regenerative Medicine

Hematopoiesis is a finely tuned process that generates all blood cell types through self-renewal and differentiation, which is crucial for maintaining homeostasis. Acute infections can prompt a hematopoietic response known as emergency myelopoiesis. In this study, using a Candida albicans (C. albicans) infection model, we demonstrated for the first time that disruption of Fhl2 led to increased fungal burden,heightened inflammatory response and reduced survival rates. Impaired myeloid hematopoiesis and immune cell production were evident, as proved by the decreased numbers of hematopoietic stem and progenitor cells (HSPCs) and granulocytes in the bone marrow of Fhl2-deficient mice. In conclusion, FHL2 regulated emergency myelopoiesis in response to C. albicans, affecting the host’s defense against pathogens.

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Numerical analysis of loess and weak intercalated layer failure behavior under direct shearing and cyclic loading

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Journal of Mountain Science 2020年第11期17卷 2796-2815页

作者： ZHANG ze-lin WANG tao College of Water Resources and Civil Engineering China Agricultural UniversityBeijing 100083China Institute of Geomechanics Chinese Academy of Geological SciencesBeijing 100081China

The mechanical behavior of the joints inside a loess layer is greatly important in weak intercalation studies owing to its involvement in a wide range of landslides in the loess region in *** shear behavior of the joints in the loess stratum during direct shear and cyclic loadings was investigated using the PFC2D discrete element *** mudstone and mudstone with weak intercalated layer materials were subjected to direct testing,and cyclic shear tests were conducted with consideration to the influence of normal stress and shear *** macroscopic properties and damage patterns were obtained for six numerical configurations;namely,loess-weathered mudstone with 0°,10°,and-10°joints and weathered mudstone with 0°,10°,and-10°weak intercalated *** numerical test results revealed that,in the direct shear tests,the shear stress and shear displacement of the samples increased with the normal *** the cyclic shear tests with a total cycle number N=20,the shear stress-shear strain curve of the six different configurations exhibited a hysteresis *** numerical tests also revealed that,under cyclic shear,the normal stress and shear velocity affected the shear *** degree of damage increased as the shear velocity decreased from 0.1 mm/s to 0.005 mm/s for all six numerical *** with the damage pattern of the direct shear tests,the damage of the cyclic shear tests mainly comprised shear cracks and fractures,some shaking consolidation settlement and fewer shear strain occurred around the *** the direct shear tests,more compression cracks and fractures occurred in the *** damage mainly developed along the joints,and shearing-off damage *** results obtained by this study further elucidate the failure mechanism and microscopic damage response of the joints in the loess stratum in Northwest China.

关键词： Loess Mudstone Weak intercalated layer Direct shear test Cyclic shear test PFC2D

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我国未来学习中心建设现状与路径探索

大学图书情报学刊 2025年第1期43卷 37-42,65页

作者：李小涛解玲南京航空航天大学图书馆 210016 南京航空航天大学经济与管理学院 210016

建设未来学习中心,是推进高等教育数字化转型和高校图书馆服务升级的有效途径。调研未来学习中心建设现状及存在问题,可为我国高等院校未来学习中心建设实践提供参考借鉴。文章运用文献调研和网络调查的方法,从顶层设计、建设理念、空... 详细信息

建设未来学习中心,是推进高等教育数字化转型和高校图书馆服务升级的有效途径。调研未来学习中心建设现状及存在问题,可为我国高等院校未来学习中心建设实践提供参考借鉴。文章运用文献调研和网络调查的方法,从顶层设计、建设理念、空间建设、资源建设、服务创新5个维度对全国高等院校未来学习中心建设实践进行调查,并对调查结果进行归类、统计和分析。研究发现,我国未来学习中心建设正处于起步探索期,在具体实践中存在着顶层设计不足、技术应用与教学模式融合不深等问题。针对这些问题,文章提出了相应的建设路径。

关键词：未来学习中心高校图书馆建设现状网络调研

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