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Simulation of the impact of the South to North Water Transfer Project on groundwater in the beijing plain

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Simulation of the impact of the South to North Water Transfe...

Identification of a natural PLA2.inhibitor from the marine fungus Aspergillus sp.c1 for MAFLD treatment that suppressed lipotoxicity by inhibiting the IRE-1a/XBP-1s axis and JNK signaling

中国科学院地质与地球物理研究所第十届(2.10年度)学术年会

作者： YANG YONG~1,LI GUO-MIN~1,DONG YAN-HUI~1,LI MING~1, YANG jiang-QING~2.ZHOU DONG~3 & YANG ZHONG-SHAN~3 1 institute of Geology and Geophysics {2. academy of sciences,beijing 10002.,china 2.Ministry of Water Resources,Department of Hydrological Analysis,beijing 100053,china 3 beijing Hydraulic Center,beijing 100039,china

In the beijing plain,the groundwater level has been gradually descending due to extensive groundwater pumping in consecutive drought *** the implementation of the South to North Water Transfer Project, an opportunity has been provided for restoration of groundwater under over-exploitation *** the basis of hydrogeology conditions of the beijing plain,as well as the high performance parallel computing platforms,a numerical groundwater flow model was *** results show that several obvious depression cones of groundwater have been formed because of the rapid decline of groundwater levels in the beijing plain in recent years. After the implementation of the South to North Water Transfer Project and due to the restrictions on groundwater exploitation,the area of the cone of depression will be reduced to different degrees,and the centre level of depression cone will rise *** is a benefit to relieve water shortage and control the development of land subsidence and the deterioration of the ecological environment.

关键词： South to North Water Transfer Project groundwater dynamic change beijing plain numerical model parallel computing

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Acta Pharmaceutica Sinica B 2024年第1期14卷 304-318页

作者： Yong Rao Rui Su Chenyan Wu Xingxing Chai Jinjian Li Guanyu Yang Junjie Wu Tingting Fu Zhongping jiang Zhikai Guo Congjun Xu Ling Huang Key Laboratory of Tropical Biological Resources of Ministry of Education School of Pharmaceutical SciencesHainan UniversityHaikou 570200China Hainan Key Laboratory of Tropical Microbe Resources Institute of Tropical Bioscience and BiotechnologyChinese Academy of Tropical Agricultural Sciences&Key Laboratory for Biology and Genetic Resources of Tropical Crops of Hainan ProvinceHainan Institute for Tropical Agricultural ResourcesHaikou 571101China School of Pharmaceutical Sciences Guangdong Provincial Key Laboratory of New Drug Design and EvaluationSun Yat-sen UniversityGuangzhou 510275China Laboratory Animal Center of Guangdong Medical University Dongguan 523808China

Lipotoxicity is a pivotal factor that initiates and exacerbates liver injury and is involved in the development of metabolic-associated fatty liver disease(MAFLD).However,there are few reported lipotoxicity ***,we identified a natural anti-lipotoxicity candidate,HN-001,from the marine fungus Aspergillus ***-001 dose-and time-dependently reversed palmitic acid(PA)-induced hepatocyte *** protection was associated with IRE-1a-mediated XBP-1 splicing inhibition,which resulted in suppression of XBP-1s nuclear translocation and transcriptional *** of XBP-1s attenuated lipotoxicity,but no additional ameliorative effect of HN-001 on lipotoxicity was observed in XBP-1s knockdown ***,the ER stress and lipotoxicity amelioration was associated with *** HN-001 and the PLA2.inhibitor MAFP inhibited PLA2.activity,reduced lysophosphatidylcholine(LPC)level,subsequently ameliorated *** contrast,overexpression of PLA2.caused exacerbation of lipotoxicity and weakened the anti-lipotoxic effects of ***,HN-001 treatment suppressed the downstream pro-apoptotic JNK *** vivo,chronic administration of HN-001(i.p.)in mice alleviated all manifestations of MAFLD,including hepatic steatosis,liver injury,inflammation,and *** effects were correlated with PLA2.IRE-1a/XBP-1s axis and JNK signaling *** data indicate that HN-001 has therapeutic potential for MAFLD because it suppresses lipotoxicity,and provide a natural structural basis for developing anti-MAFLD candidates.

关键词： Lipotoxicity MAFLD ER stress IRE-1a XBP-1s JNK PLA2

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四川野生红豆杉资源的保护与可持续利用

四川林业科技 2003年第1期24卷 43-47页

作者：罗建勋孙启武黄晓江四川省林业科学研究院四川成都610081 中国林业科学研究院林业研究所北京100091 四川省九寨沟县林业局四川九寨沟623400

在分析四川野生红豆杉的资源量、分布和利用现状的基础上 ,探讨现有野生资源的保护与可持续利用途径。

关键词：四川野生红豆杉资源保护可持续利用

Single-atom Pd anchored in the porphyrin-center of ultrathin 2.-MOFs as the active center to enhance photocatalytic hydrogen-evolution and NO-removal

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chinese Chemical Letters 2024年第9期35卷 364-368页

作者： Xingyan Liu Chaogang Jia Guangmei jiang Chenghua Zhang Mingzuo Chen Xiaofei Zhao Xiaocheng Zhang Min Fu Siqi Li Jie Wu Yiming Jia Youzhou He Chongqing Key Laboratory of Catalysis and New environmental Materials College of Environment and ResourcesChongqing Technology and Business UniversityChongqing 400067China School of Pharmacy North Sichuan Medical CollegeNanchong 637100China Carbon Neutrality Technology Application research Center College of River and Ocean EngineeringChongqing Jiaotong UniversityChongqing 400074China State Key Joint Laboratory of environment Simulation and Pollution Control School of EnvironmentTsinghua UniversityBeijing 100084China National Local Joint Engineering research Center for Road Engineering and Disaster Prevention and Reduction Technology in Mountainous Areas China Merchants Chongqing Communications Technology Research and Design Institute Co.Ltd.Chongqing 400067China Chongqing Culture Relics and Archaeology research institute Chongqing 400013China

Single-atom catalysts were widely used to treat atmospheric pollution and alleviate energy crises through ***,how to prevent the aggregation of single atoms during the preparation and catalytic processes remained a great ***,a novel ultrathin two-dimensional porphyrin-based single-atom photocatalyst Ti-MOF(abbreviated as TMPd)obtained through a simple hydrothermal synthesis strategy was used for photocatalytic hydrogen evolution and NO removal,in which the singleatom Pd tightly anchored in the center of porphyrin to ensure single-atom Pd stable *** with most reported MOFs-based photocatalysts,the TMPd showed an excellent hydrogen evolution rate(1.32.mmol g^(-1)h^(-1))and the NO removal efficiency(62.)under visible light *** high-angle annular dark-field scanning transmission electron microscope(HAADF-STEM)and synchrotron-radiation-based X-ray absorption fine-structure spectroscopy(XAFS)proved that pd in TMPd existed in an isolated state,and the atomic force microscope(AFM)proved the ultrathin morphology of *** calculations had demonstrated that single-atom Pd could serve as the active center and more effectively achieve electron transfer,indicating that single-atom Pd played a vital role in photocatalytic hydrogen *** addition,a possible photocatalytic pathway of NO removal was proposed based on ESR and in-situ infrared spectra,in which the catalysts anchored with single-atom Pd could produce more active substances and more effectively oxidize NO to NO_(2.^(-)or NO_(3)^(-).The results suggested that coordinating single-atom metal species as the active site in the center of porphyrin could be a feasible strategy to obtain various ultrathin porphyrin-based single-atom photocatalysts to acquire excellent photocatalytic performance further.

关键词： Porphyrin-based MOFs Single-atom Pd Ultrathin 2. nanosheets Hydrogen evolution NO removal

体育事业发展中重点领域、新兴领域、涉外领域立法论纲——以高质量的体育立法助推体育强国建设

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成都体育学院学报 2024年第1期50卷 72-82页

作者：姜熙上海政法学院体育法治研究院上海201701

加强体育事业发展中重点领域、新兴领域、涉外领域立法是中国体育法治建设的重要任务,也是体育强国建设的重要保障。文章运用文献资料法、逻辑分析法等方法,就加强体育事业发展中重点领域、新兴领域、涉外领域立法的战略意义、基本遵循... 详细信息

加强体育事业发展中重点领域、新兴领域、涉外领域立法是中国体育法治建设的重要任务,也是体育强国建设的重要保障。文章运用文献资料法、逻辑分析法等方法,就加强体育事业发展中重点领域、新兴领域、涉外领域立法的战略意义、基本遵循、主要立法内容进行了探讨。研究认为,体育事业发展中重点领域的立法主要应该加强全民健身保障立法、青少年与学校体育配套立法、竞技体育领域立法、体育产业促进立法、职业体育立法、体育市场监管立法、体育组织治理的立法;体育事业发展中新兴领域的立法主要应该重视数字体育立法、体育领域市场竞争立法、体育投融资立法、打击操纵比赛的立法;涉外体育领域的立法应该重点围绕建立起在国际体育活动中保护国家利益的法律制度来展开,并就各类涉外体育事务建立起法治化的规章制度。

关键词：体育强国体育法体育法治立法

Targeting the adenosine A2. receptor for neuroprotection and cognitive improvement in traumatic brain injury and Parkinson's disease

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chinese Journal of Traumatology 2024年第3期27卷 125-133页

作者： Yan Zhao Yuan-Guo Zhou jiang-Fan Chen Department of Army Occupational Disease State Key Laboratory of TraumaBurns and Combined InjuryResearch Institute of SurgeryDaping HospitalArmy Medical University.Chongqing400042China The Molecular Neuropharmacology Laboratory and the Eye-Brain research Center The State Key Laboratory of OphthalmologyOptometry and Vision ScienceWenzhou Medical UniversityWenzhou325035Zhejiang ProvinceChina Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)Wenzhou325035Zhejiang ProvinceChina

Adenosine exerts its dual functions of homeostasis and neuromodulation in the brain by acting at mainly 2.G-protein coupled receptors,called A1 and A2. *** adenosine A2. receptor(A2.R)antagonists have been clinically pursued for the last 2.decades,leading to final approval of the istradefylline,an A2.R antagonist,for the treatment of OFF-Parkinson's disease(PD)*** approval paves the way to develop novel therapeutic methods for A2.R antagonists to address 2.major unmet medical needs in PD and traumatic brain injury(TBI),namely neuroprotection or improving *** this review,we first consider the evidence for aberrantly increased adenosine signaling in PD and TBI and the sufficiency of the increased A2.R signaling to trigger neurotoxicity and cognitive *** further discuss the increasing preclinical data on the reversal of cognitive deficits in PD and TBI by A2.R antagonists through control of degenerative proteins and synaptotoxicity,and on protection against TBI and PD pathologies by A2.R antagonists through control of ***,we provide the supporting evidence from multiple human prospective epidemiological studies which revealed an inverse relation between the consumption of caffeine and the risk of developing PD and cognitive decline in aging population and Alzheimer's disease ***,the convergence of clinical,epidemiological and experimental evidence supports the validity of A2.R as a new therapeutic target and facilitates the design of A2.R antagonists in clinical trials for disease-modifying and cognitive benefit in PD and TBI patients.

关键词： Receptor,Adenosine A2. Adenosine A2.receptor antagonists Parkinson's disease Brain injuries,traumatic

Spatiotemporal Characteristics of Atmospheric Brown Carbon Emission from Combustion Sources in china

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chinese Geographical Science 2024年

作者： OUYANG Shuyu jiang Ke XIONG Rui MEN Yatai LUO Zhihan XING Ran SHEN Guofeng College of Urban and environmental Sciences Peking University College of ecology and environment Zhengzhou University institute of Carbon Neutrality Peking University

Atmospheric Brown Carbon(BrC) with strong wavelength-dependence light-absorption ability can significantly affect radiative forcing. Highly resolved emission inventories with lower uncertainties are important premise and essential in scientifically evaluating impacts of emissions on air quality, human health and climate change. This study developed a bottom-up inventory of primary BrC from combustion sources in china from 1960 to 2.16 with a spatial resolution at 0.1° × 0.1°, based on compiled emission factors and detailed activity data. The primary BrC emission in china was about 593 Gg(500–735 Gg as interquartile range) in 2.16, contributing to 7%(5%–8%) of a previously estimated global total BrC emission. Residential fuel combustion was the largest source of primary BrC in china, with the contribution of 67% as the national average but ranging from 2.% to 99% among different provincial regions. Significant spatial disparities were also observed in the relative shares of different fuel types. Coal combustion contribution varied from 8% to99% across different regions. Heilongjiang and North china Plain had high emissions of primary BrC. Generally, on the national scale,spatial distribution of BrC emission density per area was aligned with the population distribution. Primary BrC emission from combustion sources in china have been declined since a peak of ～1300 Gg in 1980, but the temporal trends were distinct in different *** high-resolution inventory developed here enables radiative forcing simulations in future atmospheric models so as to promote better understanding of carbonaceous aerosol impacts in the Earth's climate system and to develop strategies achieving co-benefits of human health protection and climate change.

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地下水污染源解析方法研究进展

地质通报 2024年第1期43卷 153-162页

作者：冉泽宇贾永锋姜永海史浙明尚长健臧永歌陈帆廉新颖中国环境科学研究院/环境基准与风险评估国家重点实验室北京100012 中国地质大学(北京)水资源与环境学院北京100083 中国环境科学研究院/国家环境保护地下水污染模拟与控制重点实验室北京100012 中国核电工程有限公司北京100840

地下水污染具有隐蔽性,污染过程缓慢且难以治理,近年来中国高度重视地下水环境保护工作,作为支撑“以防为主”保护理念的地下水污染源解析技术研究已成为地下水污染防治领域的研究热点。介绍了国内外地下水污染源解析方面的主要技术方法... 详细信息

地下水污染具有隐蔽性,污染过程缓慢且难以治理,近年来中国高度重视地下水环境保护工作,作为支撑“以防为主”保护理念的地下水污染源解析技术研究已成为地下水污染防治领域的研究热点。介绍了国内外地下水污染源解析方面的主要技术方法,包括同位素法、荧光光谱法、地质统计学法、主成分分析法、正定矩阵因子分析模型、自组织映射技术6种常用方法的基本原理及在地下水污染识别领域的应用和研究动态,总结了这些方法的优缺点与适用性,并就上述方法在地下水污染研究中的应用前景和发展趋势进行了展望。

关键词：地下水污染源解析同位素法正定矩阵因子分析模型自组织映射技术

Phosphoproteomics Reveals the AMPK Substrate Network in Response to DNA Damage and Histone Acetylation

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Genomics, Proteomics & Bioinformatics 2022年第4期20卷 597-613页

作者： Yuejing jiang Xiaoji Cong Shangwen jiang Ying Dong Lei Zhao Yi {2. Minjia Tan Jia Li National Center for Drug Screening State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Chemical Proteomics Center State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China University of chinese academy of Sciences Beijing 100049China Open Studio for Druggability research of Marine Natural Products Pilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao 266237China

AMP-activated protein kinase(AMPK)is a conserved energy sensor that plays roles in diverse biological processes via phosphorylating various *** studies have demonstrated the regulatory roles of AMPK in DNA repair,but the underlying mechanisms remain to be fully ***,using mass spectrometry-based proteomic technologies,we systematically investigate the regulatory network of AMPK in DNA damage response(DDR).Our system-wide phosphoproteome study uncovers a variety of newly-identified potential substrates involved in diverse biological processes,whereas our system-wide histone modification analysis reveals a link between AMPK and histone *** with these findings,we discover that AMPK promotes apoptosis by phosphorylating apoptosis-stimulating of p53 protein 2.ASPP2.in an irradiation(IR)-dependent manner and regulates histone acetylation by phosphorylating histone deacetylase 9(HDAC9)in an IR-independent ***,we reveal that disrupting the histone acetylation by the bromodomain BRD4 inhibitor JQ-1 enhances the sensitivity of AMPKdeficient cells to ***,our study has provided a resource to investigate the interplay between phosphorylation and histone acetylation underlying the regulatory network of AMPK,which could be beneficial to understand the exact role of AMPK in DDR.

关键词： AMPK Phosphoproteomics Histone modification DNA damage Apoptosis