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Spectral and Timing Analysis of the Black Hole Transient MAxI J1631–479 During its 2019 Outburst Observed with Insight-HxMT

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Research in Astronomy and Astrophysics 2022年第11期22卷 21-33页

作者： Yu-Cong Fu L.M.Song G.Q.Ding S.N.zhang J.L.Qu S.zhang L.zhang Q.C.Bu Y.Huang x.Ma z.x.yang Y.L.Tuo x.F.Lu D.K.zhou B.Y.Wu T.M.Li Y.C.xu xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqiXinjiang 830011China University of Chinese Academy of Sciences Chinese Academy of SciencesBeijing 100049China Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Institut fur Astronomie und Astrophysik Kepler Center for Astro and Particle PhysicsEberhard Karls UniversitatSand 1D-72076 TübingenGermany

We report spectral and timing analysis of the black hole transient MAxI J1631–479 during the hard intermediate state of its 2019 outburst from the Insight-Hard x-ray Modulation Telescope(Insight-HxMT)*** find that the energy dependence of the type-C quasi-periodic oscillation(QPO)frequency evolves with time:during the initial rise of a small flare(~MJD 58526.0-58527.1),the QPO frequency increases with increasing energy from~1 to~100 ke V,and then the frequency remains constant after MJD *** discover a possible new phenomenon of Fe line’s QPO frequency jump that has never been observed for other black hole transients:during the small flare,the QPO frequency around the Fe line energy is higher than any other energy band,with the frequency difference Δf=0.25±0.08 Hz between 5.5–7.5 ke V and other energy *** spectral analysis shows that the evolution of QPOs is related to the equivalent width of the narrow Fe line,and its equivalent width increases during this small *** propose that the QPO frequency difference results from the differential precession of a vertically extended jet,and the higher QPO frequency of Fe line could be caused by the layered jet when the jet scale *** the same time,the evolution of QPOs is related to the accretion rate,while the energy dependence of QPOs supports the existence of deceleration in the vertically distributed jet.

关键词： accretion accretion disks stars:black holes x-rays:binaries

CT和MRI鉴别诊断儿童胰母细胞瘤与实性假乳头状瘤

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国际医学放射学杂志 2021年第3期44卷 370-371页

作者： z.x.yang Y.Gong M.Ji B.yang z.W.Qiao 彭鹏

摘要目的探讨CT和/或MRI特征能否鉴别儿童胰腺的胰母细胞瘤(PB)和实性假乳头状瘤(SPN)。方法回顾性分析经手术或活检证实的20例SPN和14例PB的临床及

关键词：

Chemisorption on znO/A_xB_(1-x) Composite Systems

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信阳师范学院学报（自然科学版） 1991年第3期4卷 60-66页

作者： z.x.yang and T.zhangDepartment of physics, Henan Normal University & Henan Foundational and Applied Science Institute, xinxiang, Henan 453002, People’s Republic of China

The chemisorption energy of hydrogen on semiconductor/alloy composite substrates are investigated. (?)g the conplex-energy-plane integration approach. The electronic properties of the substrate are described by using the Green function method within the framework of the tight-binding approximation. The coherent potential approximation (CPA) is used to deal with the alloys. specific calculations are performed for the H-znO/Ni_xCu_(1-x) and H-znO/Ag_xpd_(1-x) systems.

关键词：半导体合金复合材料衬底氢化学吸附能格林函数相干势近似电导率复能面积分

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扩散峰度成像评价肝细胞癌微血管浸润

国际医学放射学杂志 2018年第2期 228-228页

作者： W.T.Wang L.yang z.x.yang x.x.Hu Y.Ding x.Yan 刘春明 Department of Radiology Zhongshan HospitalFudan University and Shanghai Medical Imaging Institute

摘要目的探讨扩散峰度成像的标准单指数模型与常规MR成像的形态学特征在术前预测肝细胞癌(HCC)微血管浸润(MVI)中的潜在作用。材料与方法研究经机构伦理

关键词：扩散峰度成像肝细胞癌微血管

Polyethylene glycol fusion repair of severed rat sciatic nerves reestablishes axonal continuity and reorganizes sensory terminal fields in the spinal cord

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Neural Regeneration Research 2025年第7期20卷 2095-2107页

作者： Emily A.Hibbard Liwen zhou Cathy z.yang Karthik Venkudusamy Yessenia Montoya Alexa Olivarez George D.Bittner Dale R.Sengelaub Program in Neuroscience Indiana UniversityBloomingtonINUSA Department of Neuroscience University of Texas at AustinAustinTXUSA

Peripheral nerve injuries result in the rapid degeneration of distal nerve segments and immediate loss of motor and sensory functions;behavioral recovery is typically *** used a plasmalemmal fusogen,polyethylene glycol(PEG),to immediately fuse closely apposed open ends of severed proximal and distal axons in rat sciatic *** have previously reported that sciatic nerve axons repaired by PEG-fusion do not undergo Wallerian degeneration,and PEG-fused animals exhibit rapid(within 2–6 weeks)and extensive locomotor ***,our previous report showed that PEG-fusion of severed sciatic motor axons was non-specific,i.e.,spinal motoneurons in PEG-fused animals were found to project to appropriate as well as inappropriate target *** this study,we examined the consequences of PEG-fusion for sensory axons of the sciatic *** adult male and female rats(Sprague–Dawley)received either a unilateral single cut or ablation injury to the sciatic nerve and subsequent repair with or without(Negative Control)the application of *** action potentials recorded immediately after PEG-fusion repair confirmed conduction across the injury *** success of PEG-fusion was confirmed through Sciatic Functional Index testing with PEG-fused animals showing improvement in locomotor function beginning at 35 days *** 2–42 days postoperatively,we anterogradely labeled sensory afferents from the dorsal aspect of the hindpaw following bilateral intradermal injection of wheat germ agglutinin conjugated horseradish ***-fusion repair reestablished axonal *** to unoperated animals,labeled sensory afferents ipsilateral to the injury in PEG-fused animals were found in the appropriate area of the dorsal horn,as well as inappropriate mediolateral and rostrocaudal ***,despite having intact peripheral nerves,similar reorganizations of labeled sensory afferents were also observed contralateral to the injury and repa

关键词： axotomy dorsal horn peripheral nerve injury plasticity polyethylene glycol(PEG) sciatic nerve sensory terminals wheat germ agglutinin horseradish peroxidase

Polyethylene glycol has immunoprotective effects on sciatic allografts, but behavioral recovery and graft tolerance require neurorrhaphy and axonal fusion

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Neural Regeneration Research 2025年第4期20卷 1192-1206页

作者： Tyler A.Smith Liwen zhou Cameron L.Ghergherehchi Michelle Mikesh Cathy z.yang Haley O.Tucker JuliAnne Allgood Jared S.Bushman George D.Bittner Department of Molecular Biosciences University of Texas at AustinAustinTXUSA Department of Neuroscience University of Texas at AustinAustinTXUSA Division of Pharmaceutical Sciences University of WyomingLaramieWYUSA

Behavioral recovery using(viable)peripheral nerve allografts to repair ablation-type(segmental-loss)peripheral nerve injuries is delayed or poor due to slow and inaccurate axonal ***,such peripheral nerve allografts undergo immunological rejection by the host immune *** contrast,peripheral nerve injuries repaired by polyethylene glycol fusion of peripheral nerve allografts exhibit excellent behavioral recovery within weeks,reduced immune responses,and many axons do not undergo Wallerian *** relative contribution of neurorrhaphy and polyethylene glycol-fusion of axons versus the effects of polyethylene glycol per se was unknown prior to this *** hypothesized that polyethylene glycol might have some immune-protective effects,but polyethylene glycol-fusion was necessary to prevent Wallerian degeneration and functional/behavioral *** examined how polyethylene glycol solutions per se affect functional and behavioral recovery and peripheral nerve allograft morphological and immunological responses in the absence of polyethylene glycol-induced axonal ***-type sciatic nerve injuries in outbred Sprague–Dawley rats were repaired according to a modified protocol using the same solutions as polyethylene glycol-fused peripheral nerve allografts,but peripheral nerve allografts were loose-sutured(loose-sutured polyethylene glycol)with an intentional gap of 1–2 mm to prevent fusion by polyethylene glycol of peripheral nerve allograft axons with host *** to negative control peripheral nerve allografts not treated by polyethylene glycol and in contrast to polyethylene glycol-fused peripheral nerve allografts,animals with loose-sutured polyethylene glycol peripheral nerve allografts exhibited Wallerian degeneration for all axons and myelin degeneration by 7 days postoperatively and did not recover sciatic-mediated behavioral functions by 42 days *** morphological signs of rejection,such as col

关键词： allograft rejection axotomy macrophage myelin nerve repair polyethylene glycol(PEG) sciatic nerve T cell transplantation Wallerian degeneration

Targeting epigenetic mechanisms in amyloid-β-mediated Alzheimer’s pathophysiology:unveiling therapeutic potential

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Neural Regeneration Research 2025年第1期20卷 54-66页

作者： Jennie z.Li Nagendran Ramalingam Shaomin Li Ann Romney Center for Neurologic Diseases Brigham and Women’s Hospital and Harvard Medical SchoolBostonMAUSA

Alzheimer’s disease is a prominent chronic neurodegenerative condition characterized by a gradual decline in memory leading to *** evidence suggests that Alzheimer’s disease is associated with accumulating various amyloid-βoligomers in the brain,influenced by complex genetic and environmental *** memory and cognitive deficits observed during the prodromal and mild cognitive impairment phases of Alzheimer’s disease are believed to primarily result from synaptic *** life,environmental factors can lead to enduring changes in gene expression and the emergence of brain *** changes,known as epigenetic modifications,also play a crucial role in regulating the formation of synapses and their adaptability in response to neuronal *** this context,we highlight recent advances in understanding the roles played by key components of the epigenetic machinery,specifically DNA methylation,histone modification,and microRNAs,in the development of Alzheimer’s disease,synaptic function,and activity-dependent synaptic ***,we explore various strategies,including enriched environments,exposure to non-invasive brain stimulation,and the use of pharmacological agents,aimed at improving synaptic function and enhancing long-term potentiation,a process integral to epigenetic ***,we deliberate on the development of effective epigenetic agents and safe therapeutic approaches for managing Alzheimer’s *** suggest that addressing Alzheimer’s disease may require distinct tailored epigenetic drugs targeting different disease stages or pathways rather than relying on a single drug.

关键词： Alzheimer’s disease DNA methylation enriched environments histone modification microRNAs non-invasive brain stimulation synaptic plasticity

Polyethylene glycol fusion repair of severed sciatic nerves accelerates recovery of nociceptive sensory perceptions in male and female rats of different strains

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Neural Regeneration Research 2025年第9期20卷 2667-2681页

作者： Liwen zhou Karthik Venkudusamy Emily A.Hibbard Yessenia Montoya Alexa Olivarez Cathy z.yang Adelaide Leung Varun Gokhale Guhan Periyasamy zeal Pathak Dale R.Sengelaub George D.Bittner Department of Neuroscience University of TexasAustinTXUSA Program in Neuroscience Indiana UniversityBloomingtonINUSA Department of Molecular Biosciences University of TexasAustinTXUSA

Successful polyethylene glycol fusion(PEG-fusion)of severed axons following peripheral nerve injuries for PEG-fused axons has been reported to:(1)rapidly restore electrophysiological continuity;(2)prevent distal Wallerian Degeneration and maintain their myelin sheaths;(3)promote primarily motor,voluntary behavioral recoveries as assessed by the Sciatic Functional Index;and,(4)rapidly produce correct and incorrect connections in many possible combinations that produce rapid and extensive recovery of functional peripheral nervous system/central nervous system connections and reflex(e.g.,toe twitch)or voluntary *** preceding companion paper describes sensory terminal field reo rganization following PEG-fusion repair of sciatic nerve transections or ablations;howeve r,sensory behavioral recovery has not been explicitly explored following PEG-fusion *** the current study,we confirmed the success of PEG-fusion surgeries according to criteria(1-3)above and more extensively investigated whether PEG-fusion enhanced mechanical nociceptive recovery following sciatic transection in male and female outbred Sprague-Dawley and inbred Lewis *** nociceptive responses were assessed by measuring withdrawal thresholds using von Frey filaments on the dorsal and midplantar regions of the *** von Frey filament tests were a more reliable method than plantar von Frey filament tests to assess mechanical nociceptive sensitivity following sciatic nerve *** withdrawal thresholds of the sciatic-mediated lateral dorsal region differed significantly across strain but not *** thresholds did not change significantly from baseline in chronic Unoperated and Sham-operated *** sciatic transection,all rats exhibited severe hyposensitivity to stimuli at the lateral dorsal region of the hindpaw ipsilateral to the ***,PEG-fused rats exhibited significantly earlier return to baseline withdrawal thresholds than Negative

关键词： autophagia axotomy collateral sprouting neuropathic pain peripheral nerve repair polyethylene glycol fusion(PEG-fusion) saphenous nerve sensory neurons sex and strain Wallerian degeneration

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MR直方图预测结直肠癌肝转移化疗疗效

国际医学放射学杂志 2016年第5期 581-581页

作者： H.Y.Liang Y.Q.Huang z.x.yang Y.Ding M.S.zeng S.x.Rao 郭素引 Department of Radiology Zhongshan Hospital of Fudan University and Shanghai Medical Imaging Institute

摘要目的以实体瘤疗效评价标准（RECIST 1.1）为参考标准,探讨MRI直方图分析对预测结直肠癌肝转移病人化疗疗效的价值。方法 53例结直肠癌肝转移病人在化疗前进行常规MRI检查,包括扩散加权成像（b=0,500 s/mm;）。将表观扩散系数（ADC... 详细信息

摘要目的以实体瘤疗效评价标准（RECIST 1.1）为参考标准,探讨MRI直方图分析对预测结直肠癌肝转移病人化疗疗效的价值。方法 53例结直肠癌肝转移病人在化疗前进行常规MRI检查,包括扩散加权成像（b=0,500 s/mm;）。将表观扩散系数（ADC）图、动脉期和门静脉期强化图中的最大转移灶兴趣区（ROI）以直方图形式显示,得到上述图像中最

关键词：结直肠癌肝转移化疗疗效 MR 直方图