检索结果-南通市图书馆

Characterising Mechanical Properties of Flowing Microcapsules Using a Deep Convolutional Neural Network

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advances in Applied Mathematics and Mechanics 2022年第1期14卷 79-100页

作者： T.Lin Z.wang R.X.Lu W.wang Y.Sui School of Engineering and Materials Science Queen Mary University of LondonLondon E14NSUnited Kingdom Department of Mechanical Engineering University College LondonLondon WC1E 6BTUnited Kingdom

Deformable microcapsules are widely used in industries and also serve as a mechanical model of living biological cells.In this study,we develop a novel method,by integrating a deep convolutional neural network(DCNN)with high-fidelity mechanistic capsule modelling,to identify the membrane constitutive law and estimate associated parameters of a microcapsule from its steady deformed profile in a capillary tube.Compared with conventional inverse methods,the present approach is more accurate and can increase the prediction throughput rate by a few orders of magnitude.It can process capsules with large deformation in inertial flows.Furthermore,the method can predict the capsule membrane shear elasticity,area dilatation modulus and initial inflation from a single steady capsule profile.We explore the mechanism that the DCNN makes decisions by considering its feature maps,and discuss their potential implication on the development of inverse methods.The present method provides a promising tool which may enable high-throughput mechanical characterisation of microcapsules and biological cells in microfluidic flows.

关键词： Microcapsules flow cytometry deep convolutional neural network high throughput mechanical characterisation

Numerical performance assessment of double-shell targets for z-pinch dynamic hohlraum

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Matter and Radiation at Extremes 2022年第3期7卷 10-19页

作者： Y.Y.Chu Z.wang J.M.Qi z.P.Xu z.H.Li Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China

A z-pinch dynamic hohlraum can create the high-temperature radiation field required by indirect-drive inertial confinement fusion.A dynamic hohlraum with peak radiation temperature over 300 eV can be obtained with a>50 MA z-pinch driver according to the scaling law of dynamic hohlraum radiation temperature vs drive current.Based on a uniform 300 eV radiation temperature profile with a width of 10 ns,three double-shell capsules with radii of 2,2.5,and 3 mm are proposed,and the corresponding fusion yields from a one-dimensional calculation are 28.8,56.1,and 101.6 MJ.The implosion dynamics of the 2.5 mm-radius capsule is investigated in detail.At ignition,the areal density of the fuel is about 0.53 g/cm^(2),the fuel pressure is about 80 Gbar,and the central ion temperature is about 4.5 keV,according to the one-dimensional simulation.A two-dimensional simulation indicates that the double-shell capsule can implode nearly spherically when driven by the radiation field of a z-pinch dynamic hohlraum.The sensitivities of the fusion performance to the radiation temperature profiles and to deviations in the capsule parameter are investigated through one-dimensional simulation,and it is found that the capsule fusion yields are rather stable in a quite large parameter space.A one-dimensional simulation of a capsule embedded in 50 mg/cm^(3)CH foam indicates that the capsule performance does not change greatly in the mimicked environment of a z-pinch dynamic hohlraum.The double-shell capsules designed here are also applicable to laser indirect-drive inertial fusion,if a laser facility can produce a uniform 300 eV radiation field and sustain it for about 10 ns.

关键词： dynamic double performance

Simultaneous enhancement of mechanical and shape memory properties by heat-treatment homogenization of Ti_(2)Ni precipitates in TiNi shape memory alloy fabricated by selective laser melting

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2022年第6期101卷 205-216页

作者： H.z.Lu L.H.Liu C.Yang X.Luo C.H.Song Z.wang J.wang Y.D.Su Y.F.Ding L.C.zhang Y.Y.Li National Engineering Research Center of Near-net-shape Forming for Metallic Materials South China University of TechnologyGuangzhou 510640China Musculoskeletal Oncology Department Sun Yat-Sen University Cancer CenterGuangzhouGuangdong ProvinceChina Shenyang Aircraft Design and Research Institute Shenyang 110035China Guangdong Huayi Plumbing Fittings Industry Co. Ltd.Kaiping 529321China School of Engineering Edith Cowan University270 Joondalup DriveJoondalupPerthWA 6027Australia

The excellent shape memory and mechanical properties of Ti Ni shape memory alloys(SMAs) fabricated using selective laser melting(SLM) are highly desirable for a wide range of critical applications. In this study, we examined the simultaneous enhancement of mechanical and shape memory properties using heat-treatment homogenization of Ti_(2)Ni precipitates in a Ti_(50.6)Ni_(49.4)SMA fabricated using SLM. Specifically, because of the complete solution treatment, nanoscale spherical Ti_(2)Ni precipitates were homogeneously dispersed throughout the grain interior. Interestingly, the resultant SMA exhibited an ultrahigh tensile strength of 880 ± 13 MPa, a large elongation of 22.4 ± 0.4%, and an excellent shape memory effect, with a recovery rate of > 98% and ultrahigh recoverable strain of 5.32% after ten loading–unloading cycles. These simultaneously enhanced properties are considerably superior than those of most previously reported Ti Ni SMAs fabricated using additive manufacturing. Fundamentally, the enhancement in tensile strength is ascribed to precipitation strengthening and work hardening, and the large plasticity is mainly attributed to the homogeneous nanoscale globular Ti_(2)Ni precipitates, which effectively impeded the rapid propagation of microcracks. Furthermore, the enhanced shape memory properties are derived from the suppression of dislocation movement and formation of retained stabilized martensite by the presence of high-density dislocations, nanoscale Ti_(2)Ni precipitates, and abundant interfaces. The obtained results provide insight into the enhancement of the two types of properties in Ti Ni SMAs and will accelerate the wider application of SMAs.

关键词： Shape memory alloy Selective laser melting Heat treatment Mechanical properties Shape memory properties

维普期刊数据库

A neural circuit for binding spatially localized objects from streaming visual information

在线全文

学校读者我要写书评

暂无评论

A neural circuit for binding spatially localized objects fro...

Novel immunotherapy approaches for metastatic urothelial and renal cell carcinoma

中国神经科学学会第十届全国学术会议

作者： Z.wang A.T.SORNBORGER L.TAO Sch of Life Sciences Ctr.for BioinformaticsPeking Univ. Univ.of California at Davis

Visual motion computation has long been a model for studying the computational principles of sensory information processing.Mechanisms underlying visual motion detection have been accounted for by various algorithms;however,it remains unclear how a neural circuit can generate three-dimensional,location information from two-dimensional,ocular information acquired over time.Here we study a neural circuit that accepts time-dependent angular information and outputs the three dimensional location of objects in the visual field.We take a reverse engineering approach,first constructing the conceptual components of the circuit from the top down,then implementing them in a nonlinear neural circuit.We show that,given well understood principles for constructing circuit connectivity,a simple nonlinearity can decode streaming angular information to object motion information.

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Asian Journal of Urology 2016年第4期3卷 268-277页

作者： zhiying Shao Andrew Z.wang Daniel J.George Tian zhang Department of Medical Oncology The Affiliated Hospital of Xuzhou Medical UniversityJiangsu Center for the Collaboration and Innovation of Cancer BiotherapyCancer InstituteXuzhou Medical UniversityXuzhouJiangsuChina Department of Radiation Oncology Lineberger Comprehensive Cancer CenterUniversity of North Carolina-Chapel HillChapel HillNCUSA Division of Medical Oncology Department of MedicineDivision of UrologyDepartment of SurgeryDuke Cancer InstituteDuke University Medical CenterDurhamNCUSA Division of Medical Oncology Department of MedicineDuke Cancer InstituteDuke University Medical CenterDurhamNCUSA

The treatment of metastatic renal cell carcinoma(RCC)and urothelial carcinoma(UC)remains a major challenge.Past research has implicated the immune system in tumor surveillance of both malignancies,leading to the application of immunotherapy agents for both cancers.Among them,the most promising agents are the checkpoint blockade drugs,such as antibodies targeting the cytotoxic T-lymphocyte-associated antigen 4(CTLA-4),programmed death receptor 1(PD-1),and PD-1 ligand(PD-L1).In normal physiology,these immune checkpoints act as inhibitory signals to fine-tune the duration and strength of immune reactions,which is pivotal for maintaining self-tolerance.However,tumor cells also utilize immune checkpoint pathways to evade anti-tumor immune response,leading to disease progression and metastasis.Thus,there has been intense preclinical and clinical effort focused on the application of checkpoint inhibitors in metastatic RCC and UC.To date,nivolumab(anti-PD-1)and atezolizumab(anti-PD-L1)have been approved for the treatment of metastatic RCC and UC,respectively.Despite these successes,challenges remain in how to further improve response rates to immunotherapy and how to select patients that will benefit from this approach.In this report,we review existing data and research on immunotherapy in metastatic RCC and UC.

关键词： Immune checkpoint inhibitors Nivolumab Atezolizumab Pembrolizumab Renal cell carcinoma Urothelial carcinoma

Overcoming the strength-ductility trade-off by tailoring grain-boundary metastable Si-containing phase in β-type titanium alloy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2021年第9期68卷 112-123页

作者： X.Luo L.H.Liu C.Yang H.z Lu H.W.Ma Z.wang D.D.Li L.C.zhang Y.Y.Li National Engineering Research Center of Near-net-shape Forming for Metallic Materials South China University of TechnologyGuangzhou510640China State Key Laboratory of Materials Processing and Die&Mould Technology Huazhong University of Science and TechnologyWuhan430074China Key Laboratory of Automobile Materials of MOE Department of Materials ScienceJilin UniversityChangchun130012China School of Engineering Edith Cowan University270Joondalup DriveJoondalupPerthWA 6027Australia

It is well accepted that grain-boundary phases in metallic alloys greatly deteriorate the mechanical properties.In our work,we report on a novel strategy to prepare high strength-ductility β-type(Ti69.71 Nb23.72zr4.83Ta1.74)97Si3(at.%)(TNzTS) alloys by tailoring grain-boundary metastable Si-containing phase.Specifically,the thin shell-shaped metastable S1 phase surrounding the columnar β-Ti grain was intercepted successfully via nonequilibrium rapid solidification achieved by selective laser melting(SLM).Subsequently,the thin shell-shaped metastable(Ti,Nb,zr)5 Si3(called S1) phase was transformed into globular(Ti,Nb,zr)2 Si(called S2) phase by the solution heat treatment.Interestingly,the globular S2 phases reinforced TNzTS alloy exhibits ultrahigh yield strength of 978 MPa,ultimate strength of 1010 MPa and large elongation of 10.4 %,overcoming the strength-ductility trade-off of TNzTS alloys by various methods.Especially,the reported yield strength herein is 55 % higher than that of conventionally forged TNzT alloys.Dynamic analysis indicates the globularization process of the metastable S1 phase is controlled by the model of termination migration.The quantitative analysis on strengthening mechanism demonstrates that the increase in yield strength of the heat-treated alloys is mainly ascribed to the strengthening of the precipitated silicide and the dislocations induced by high cooling rate.The obtained results provide some basis guidelines for designing and fabricating β-titanium alloys with excellent mechanical properties,and pave the way for biomedical application of TNzTS alloy by SLM.

关键词： Selective laser melting βtitanium alloys Heat treatment

维普期刊数据库

Imaging protein crystal growth behaviour in batch cooling crystallisation

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemical Engineering 2016年第1期24卷 101-108页

作者： Jing J.Liu Cai Y.Ma Xue Z.wang School of Chemistry and Chemical Engineering South China University of Technology Institute of Particle Science and Engineering School of Chemical and Process Engineering University of Leeds

The temporal and spatial growth behaviour of protein crystals, subject to different cooling strategies in protein crystallisation was investigated. Although the impact of temperature and cooling rate on crystal growth of small molecules was well documented, much less has been reported on their impact on the crystallisation of proteins. In this paper, an experimental set-up is configured to carry out such a study which involves an automatic temperature controlled hot-stage crystalliser fitted with a real-time imaging system. Linbro parallel crystallisation experiments(24-well plate) were also conducted to find the suitable initial conditions to be used in the hot-stage crystallisation experiments, including the initial concentration of HEW lysozyme solutions, precipitate concentration and pH value. It was observed that fast cooling rates at the early stage led to precipitates while slow cooling rates produced crystal nuclei, and very slow cooling rates, much smaller than for small molecules are critical to the growth of the nuclei and the crystals to a desired shape. The interesting results provide valuable insight as well as experimental proof of the feasibility and effectiveness of cooling as a means for achieving controlled protein crystallisation, compared with the evaporation approach which was widely used to grow single large crystals for X-ray diffraction study. Since cooling rate control can be easily achieved and has good repeatability, it suggests that large-scale production of protein crystals can be effectively achieved by manipulating cooling rates.

关键词：蛋白质晶体实时成像系统冷却结晶生长行为自动控制温度蛋白质结晶冷却速率间歇

维普期刊数据库

Remote Observations in China’s Ramsar Sites: Wetland Dynamics, Anthropogenic Threats, and Implications for Sustainable Development Goals

在线全文

学校读者我要写书评

暂无评论

Journal of Remote Sensing 2021年第1期2021卷 319-331页

作者： D.Mao Z.wang Y.wang C.-Y.Choi M.Jia M.V.Jackson R.A.Fuller Key Laboratory of Wetland Ecology and Environment Northeast Institute of Geography and AgroecologyChinese Academy of SciencesChangchun 130102China National Earth System Science Data Center BeijingChina Department of Natural Resources Sciences University of Rhode IslandKingstonRI 02881USA School of Environmental Science and Engineering College of EngineeringSouthern University of Science and TechnologyShenzhen 518055China School of Biological Sciences The University of QueenslandBrisbaneAustralia

The Ramsar Convention on Wetlands is an international framework through which countries identify and protect important wetlands.Yet Ramsar wetlands are under substantial anthropogenic pressure worldwide,and tracking ecological change relies on multitemporal data sets.Here,we evaluated the spatial extent,temporal change,and anthropogenic threat to Ramsar wetlands at a national scale across China to determine whether their management is currently sustainable.We analyzed Landsat data to examine wetland dynamics and anthropogenic threats at the 57 Ramsar wetlands in China between 1980 and 2018.Results reveal that Ramsar sites play important roles in preventing wetland loss compared to the dramatic decline of wetlands in the surrounding areas.However,there are declines in wetland area at 18 Ramsar sites.Among those,six lost a wetland area greater than 100 km^(2),primarily caused by agricultural activities.Consistent expansion of anthropogenic land covers occurred within 43(75%)Ramsar sites,and anthropogenic threats from land cover change were particularly notable in eastern China.Aquaculture pond expansion and Spartina alterniflora invasion were prominent threats to coastal Ramsar wetlands.The observations within China’s Ramsar sites,which in management regulations have higher levels of protection than other wetlands,can help track progress towards achieving United Nations Sustainable Development Goals(SDGs).The study findings suggest that further and timely actions are required to control the loss and degradation of wetland ecosystems.

关键词： Sustainable threat wetland

脑转移瘤的影像组学特征：EGFR突变状态的预测

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

国际医学放射学杂志 2021年第5期 607-608页

作者： G.Y.wang B.wang Z.wang W.C.Li J.J.Xiu z.Liu 李柯颖

摘要目的利用基于脑转移瘤的MR影像组学特征预测原发的肺腺癌中表皮生长因子受体(EGFR)突变状态,并探讨预测EGFR突变的最佳MR序列。方法回顾性分析52

关键词：