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马鞍山长江公铁大桥z3号桥塔施工关键技术

世界桥梁 2024年第2期52卷 29-35页

作者：潘博李维刘爱林中铁大桥局集团有限公司湖北武汉430050 桥梁智能与绿色建造全国重点实验室湖北武汉430034 中国铁路上海局集团有限公司上海200071

巢马城际铁路马鞍山长江公铁大桥主航道桥为(112+392+2×1120+392+112)m三塔钢桁梁斜拉桥,z3号桥塔为超高多肢钢-混组合塔,高308 m。上塔柱钢结构高87.5 m,分13个吊装节段,最重505 t;中、下塔柱混凝土结构高217.5 m,分38个节段液压爬模... 详细信息

巢马城际铁路马鞍山长江公铁大桥主航道桥为(112+392+2×1120+392+112)m三塔钢桁梁斜拉桥,z3号桥塔为超高多肢钢-混组合塔,高308 m。上塔柱钢结构高87.5 m,分13个吊装节段,最重505 t;中、下塔柱混凝土结构高217.5 m,分38个节段液压爬模施工;钢-混结合段高3 m,内部采用PBL键+剪力钉+高强度钢锚杆+高强度混凝土结构形式。在中塔柱设置钢管临时横撑控制塔柱线形及应力;下横梁采用落地支架法分层施工,与对应塔柱同步浇筑;钢-混结合段混凝土采用C60细石补偿收缩混凝土+高强度灌浆料,保证了混凝土施工质量;采用工厂“2+1”立体匹配制造、“提升站+运输栈桥”钢塔节段转运等技术,并研制15000 t•m超大型塔吊,实现了钢塔柱大节段的制造、整体滩地运输和吊装;钢塔节段间采用栓焊组合连接形式,通过设置工艺隔板、双面坡口等措施控制了钢塔焊接变形;利用定位桁架临时锁定钢塔合龙段实现了钢塔的精确合龙,定位桁架受力及变形均满足要求。

关键词：斜拉桥钢-混组合桥塔超高多肢钢-混结合段整体吊装钢塔合龙栓焊组合连接施工技术

Preparation Process and Properties of Porous Ecological Concrete

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武汉理工大学学报 2010年第17期32卷 256-260页

作者： LIANG L M YU H F pan z F Department of Civil Engineering Nanjing University of Aeronautics &AstronauticsNanjing 210016China

By using waste bricks as aggregate,a kind of porous ecological concrete was prepared and the mixing technique and its properties were studied. Effects of the cement paste fluidity on workability of the porous ecological concrete were investigated,and influences of the water-cement ratio,the aggregate-cement ratio and the aggregate size on compressive strength and porosity of the porous ecological concrete were also discussed. Results show that for preparation of the porous ecological concrete,the aggregates should be enveloped with neat cement paste,and recommended fluidity of the cement paste is 200～235 mm. With the increasing of the aggregate-cement ratio,porosity of the porous ecological concrete increases while the 28 d compressive strength decreases. With increasing of the water-cement ratio,porosity of the porous ecological concrete decreases. And relationship between compressive strength and water-cement ratio of the porous ecological concrete does not follow Bolomey's formula. As a result of this study the porous ecological concrete is prepared,its porosity is 38.93%,the water absorption is 11.39% and the compressive strength is 1.14 MPa.

关键词： aggregate-cement ratio water-cement ratio aggregate size on fluidity of cement paste porous ecological concrete process of paste encapsulated stone porosity compressive strength

SCH合并VH患者血LncRNA XIST、miR-192水平与慢性肝炎转化间关系

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医学动物防制 2024年第1期40卷 72-77页

作者：罗庆宗潘勇黄国光莫小俊潘宏贵赵玉兰贺州市第五人民医院广西壮族自治区贺州542800 广西脑科医院贺州市妇幼保健院

目的探究精神分裂症(schizophrenia, SCH)合并病毒性肝炎(viral hepatitis, VH)患者血长链非编码RNA-X染色体失活特异转录物(long non-coding RNA X inactive-specific transcript, LncRNA XIST)、微小RNA-192(micro RNA,miR-192)水平变化,并评估VH转化为慢性肝炎的风险。方法选取2020年4月-2021年10月贺州市某医院207例SCH患者,其中合并VH患者138例(研究组)和未合并VH患者69例(对照组)。比较两组患者的LncRNA XIST和miR-192水平,统计SCH合并VH患者的慢性肝炎转化率。采用Cox回归分析SCH合并VH患者转化为慢性肝炎影响因素。采用相加模型评价血LncRNA XIST和miR-192水平对SCH合并VH患者转化为慢性肝炎的交互作用,并评估其转化为慢性肝炎的价值。结果与对照组相比,研究组LncRNA XIST水平升高、miR-192水平降低(t=4.218、4.946,Pz=2.352、4.623,P<0.05)。结论 SCH合并VH患者LncRNA XIST水平异常升高、miR-192水平有所下调,评估两者水平变化可提高预测VH患者向慢性肝炎转化的风险,对临床评估病情变化有重要意义。

关键词：病毒性肝炎精神分裂症长链非编码RNA-X染色体失活特异转录本 miR-192 慢性肝炎

替雷利珠单抗联合化疗方案治疗中晚期NSCLC疗效观察

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中国基层医药 2024年第3期31卷 347-352页

作者：刘孝凤潘鑫福卢洁舟山医院药学部舟山316021 舟山医院胸心外科舟山316021

目的探讨替雷利珠单抗注射液联合化疗方案治疗中晚期非小细胞肺癌(NSCLC)的疗效及其对患者免疫功能、生存质量的影响。方法采用病例对照研究,回顾性分析舟山医院2021年5月至2022年6月收治的中晚期NSCLC患者104例的临床资料,按照治疗方... 详细信息

目的探讨替雷利珠单抗注射液联合化疗方案治疗中晚期非小细胞肺癌(NSCLC)的疗效及其对患者免疫功能、生存质量的影响。方法采用病例对照研究,回顾性分析舟山医院2021年5月至2022年6月收治的中晚期NSCLC患者104例的临床资料,按照治疗方法不同分为A组(52例)和B组(52例)。A组采用吉西他滨+顺铂或培美曲塞+顺铂化疗方案治疗,B组采用替雷利珠单抗注射液联合吉西他滨+顺铂或培美曲塞+顺铂化疗方案治疗,21 d为1个周期,两组患者治疗3个周期。比较两组患者近期疗效,治疗前后Ⅲ期、Ⅳ期患者血清肿瘤标志物水平,免疫功能指标,生存质量评分以及不良反应发生情况。结果B组近期总有效率[51.92%(27/52)]高于A组[32.69%(17/52)](z=4.11,P<0.001)。治疗后,两组Ⅲ期、Ⅳ期患者血清肿瘤标志物水平、CD8^(+)百分比均比治疗前低,且B组均低于A组(均P<0.05);两组CD4^(+)百分比、CD4^(+)/CD8^(+)比值、功能子量表、症状子量表、总评分均高于治疗前(均P<0.05),且B组均高于A组高(均P<0.05)。B组不良反应发生率为44.23%(23/52),高于A组的21.15%(11/52)(χ^(2)=6.29,P=0.012)。结论替雷利珠单抗联合化疗方案用于NSCLC患者的治疗中,可降低血清肿瘤标志物水平,调节免疫功能,提升患者生活质量,临床疗效确切。

关键词：癌,非小细胞肺抗肿瘤药抗肿瘤联合化疗方案生物标记,肿瘤免疫,细胞生活质量替雷利珠单抗

Lipid-lowering effects of gefarnate in statin-treated patients with residual hypertriglyceridemia: a randomized controlled study

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Journal of geriatric cardiology : JGC 2024年第8期21卷 791-798页

作者： Jing Shi Ming-Lu Xu Mei-Jiao He Wan-Lan Bo Hai-Yu zhang Dang-Hui Sun Ding-Yu Wang Xiao-Yu Wang Qun Shao Yu-Jiao pan Yu zhang Chen-Guang Dai Jing-Ying Wang Lin-Wei zhang Guang-zhong Liu Yue Li Department of Cardiology the First Affiliated Hospital Harbin Medical University Harbin China. Department of Gastroenterology the Fourth Affiliated Hospital Harbin Medical University Harbin China. Department of Cardiology Harbin Medical University Cancer Hospital Harbin China. Department of Cardiology Shenzhen People's Hospital Shenzhen China. National Key Laboratory of Frigid zone Cardiovascular Diseases Harbin Medical University Harbin China. NHC Key Laboratory of Cell Transplantation Key Laboratory of Cardiovascular Disease Acousto-Optic Electromagnetic Diagnosis and Treatment in Heilongjiang Province Heilongjiang Province Clinical Medical Research Center for Hypertension the First Affiliated Hospital Harbin Medical University Harbin China. Institute of Metabolic Disease Heilongjiang Academy of Medical Science Harbin China.

BACKGROUND:The prevention of coronary artery disease (CAD) faces dual challenges: the aspirin-induced gastrointestinal injury, and the residual cardiovascular risk after statin treatment. Geraniol acetate (Gefarnate) is an anti-ulcer drug. It was reported that geraniol might participate in lipid metabolism through a variety of pathways. The aim of this study was to assess the lipid-lowering effects of gefarnate in statin-treated CAD patients with residual hypertriglyceridemia.METHODS:In this prospective, open-label, randomized, controlled trial, 69 statin-treated CAD patients with residual hypertriglyceridemia were randomly assigned to gefarnate group and control group, received gefarnate (100 mg/3 times a day) combined with statin and statin alone, respectively. At baseline and after one-month treatment, the levels of plasma triglyceride, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and total cholesterol were tested.RESULTS:After one-month gefarnate treatment, triglyceride level was significantly lowered from 2.64 mmol/L to 2.12 mmol/L ( = 0.0018), LDL-C level lowered from 2.7 mmol/L to 2.37 mmol/L ( = 0.0004), HDL-C level increased from 0.97 mmol/L to 1.17 mmol/L ( = 0.0228). Based on statin therapy, gefarnate could significantly reduce the plasma triglyceride level ( = 0.0148) and increase the plasma HDL-C level ( = 0.0307). Although the LDL-C and total cholesterol levels tended to decrease, there was no statistically significant difference.CONCLUSIONS:The addition of gefarnate to statin reduced triglyceride level and increased HDL-C level to a significant extent compared to statin alone in CAD patients with residual hypertriglyceridemia. This suggested that gefarnate might provide the dual benefits of preventing gastrointestinal injury and lipid lowering in CAD patients.

关键词： nat alone Lipid

青藏高原及其周边寒武纪综合地层、生物群与古地理演化

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中国科学：地球科学 2024年第4期54卷 968-991页

作者：孙智新孙郎赵方臣潘兵 Malik Muhammad Saud Sajid KHAN Shehryar AHMED 杨传苗兰云殷宗军李国祥朱茂炎中国科学院南京地质古生物研究所现代古生物学和地层学国家重点实验室南京210008 中国科学院大学地球与行星科学学院北京100049

青藏高原及其周边地区具有漫长且复杂的构造演化历史.印度北部、拉萨、羌塘、柴达木、中祁连等大小不同的克拉通和地块,以及位于它们之间的造山带构成了青藏高原的主体.寒武纪时期,这些克拉通和地块大多位于冈瓦纳大陆的西北缘,并以发... 详细信息

青藏高原及其周边地区具有漫长且复杂的构造演化历史.印度北部、拉萨、羌塘、柴达木、中祁连等大小不同的克拉通和地块,以及位于它们之间的造山带构成了青藏高原的主体.寒武纪时期,这些克拉通和地块大多位于冈瓦纳大陆的西北缘,并以发育与原特提斯洋有关的复杂岩浆-构造运动而与周边的阿拉伯、中伊朗、阿富汗、塔里木、阿拉善、华北、华南和滇缅马等构造单元相关联.从地层记录上看,这一时期区域内的大部分稳定陆块上发育了由陆源碎屑岩和碳酸盐岩组成的浅水陆棚沉积,其中包含面貌相近的典型浅水相三叶虫组合.而在原特提斯洋中的祁连构造带,寒武系则是一套在大洋扩张环境下形成的、以中基性火山岩和硅质岩为主的复杂地层序列,其中包含的碳酸盐岩含有斜坡相三叶虫组合.本文在广泛文献调研的基础上,结合第二次青藏高原综合科学考察中的野外观察及新获得的化石证据,对青藏高原及其周边地区不同构造单元上寒武纪地层发育的总体特征进行了概述.在此基础上,利用可获得的生物地层学和同位素年代学等资料,总结了不同构造单元上寒武纪地层的划分和年代地层对比,编制了岩石和生物地层的综合对比表.此外,从生物古地理的角度,简要讨论了寒武纪研究区内主要构造单元的古地理相关性,以及与原特提斯构造带演变有关的问题.

关键词：青藏高原寒武系地层古地理生物群冈瓦纳大陆原特提斯洋

Study of the mechanisms of acupuncture and moxibustion treatmentfor ulcerative colitis ratsinview of the gene expression of cytokines

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World Journal of Gastroenterology 1999年第6期5卷 515-517页

作者： Wu HG zhou LB pan YY Huang C Chen HP Shi z Hua XG Shanghai Inst Acupuncture Moxibust & Meridians Shanghai 200030 Peoples R China

AIM:To observe the effect of acupuncture and moxibustion on the expression of IL-1beta and IL-6 mRNA in ulcerative colitis ***:The SD rat ulcerative colitis model was created by immunological method associated with local stimulation. Colonic mucosa was prepared from human fresh surgical colonic specimens, homogenized by adding appropriate amount of normal saline and centrifuged at 3000r/min. The supernatant was collected for measurement of protein conentration and then mixed with Freund adjuvant. This antigen fluid was first injected into the plantae of the model group rats, and then into their plantae, dorsa, inguina and abdominal cavities (noFreund adjuvant for the last injection) again on the 10th, 17th, 24th and 31st day. When a certain titer of serum anti colonic antibody was reached, 2% formalin and antigen fluid (no Freund adjuvant) were administered separately by enema. The ulcerative colitis rat model was thus set up. The animals were randomly divided into four groups: model control group (MC, n = 8), electro acupuncture group (EA, n = 8), herbs partition moxibustion group (HPM 8), normal control group (NC,n = 8). HPM: Moxa cones made of refined mugwort floss were placed on the medicinal pad (medicinal pad dispensing: Radix Aconiti praeparata, cortex Cinnamomi, etc) for Qihai (RN 6) and Tianshu (ST 25, bilateral) and ignited. Two moxa cones were used for each acupoint once a day and 14 times in all. EA: Tianshu (bilateral) and Qihai were stimulated by the intermittent pulse with 2Hz frequency, 4mA intensity for 20 minutes once a day and 14 times in all. After treatment, rats of all four groups were killed simultaneously. The spleen was separated and the distal colon was dissected. Total tissue RNA was isolated by the guanidinium thiocyanate phenol chloroform extraction method. RT-PCR technique was used to study the expression of IL-1 beta and IL-6 ***:IL-1 beta and IL-6 mRNAs were not detected in the spleen and colonic mucosa of the NC rat

关键词： colitis, ulcerative/therapy acupuncture and moxibustion therapy gene expression cytokines interleukin-1 beta interleukin-6

TA2/Az31B/2024Al爆炸焊接复合板界面微观结构特征及其动态力学性能

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爆炸与冲击 2024年第4期44卷 139-156页

作者：梁汉良罗宁陈彦龙芮天安潘玉龙中国矿业大学深部岩土力学与地下工程国家重点实验室江苏徐州221116 中国矿业大学力学与土木工程学院江苏徐州221116 安徽宝泰特种材料有限公司安徽宣城242500

运用平行法爆炸焊接工艺,开展了TA2/Az31B/2024Al多层轻质金属板材爆炸焊接实验。通过扫描电镜、电子背散射衍射、分离式霍普金森压杆及三维轮廓扫描等测试技术,对多层爆炸焊接复合板界面微观结构特征、材料物相变化规律、复合板材动态... 详细信息

运用平行法爆炸焊接工艺,开展了TA2/Az31B/2024Al多层轻质金属板材爆炸焊接实验。通过扫描电镜、电子背散射衍射、分离式霍普金森压杆及三维轮廓扫描等测试技术,对多层爆炸焊接复合板界面微观结构特征、材料物相变化规律、复合板材动态力学性能及材料冲击断口特征开展了系统研究。研究结果表明:焊后多层轻质金属复合板的4个焊接界面均呈现出爆炸焊接特有的波形结构特征,结合界面处无明显缺陷,总体焊接质量良好。结合界面处晶粒发生细化并形成细晶区,1060Al过渡层内晶粒组织由于强塑性变形呈现典型的拉长层状晶粒特征,4个结合界面处均出现明显的变形织构与再结晶织构特征。沿X方向的试样最大动态抗压强度达605 MPa,分层断口界面三维形貌呈现近似水面波纹的独特结构特征。沿z方向的试样最大动态抗压强度达390 MPa,断口界面三维形貌呈现明显的纤维状韧性断裂特征。

关键词：轻质金属多层复合板爆炸焊接界面微观结构动态力学性能

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顾及多因子的中国区域加权平均温度模型

遥感信息 2024年第1期39卷 112-120页

作者：占果王盼黄嘉艇唐旭南京信息工程大学遥感与测绘工程学院南京210044 华设设计集团股份有限公司南京210014

针对中国地区地形起伏较大等情况影响T m值特别是短期T m值的高精度获取的问题,提出一种顾及多因子的大气加权平均温度模型。首先,通过探空数据利用积分法计算出加权平均温度,拟合分析选出特征因子加入建模;其次,将利用积分法计算的探... 详细信息

针对中国地区地形起伏较大等情况影响T m值特别是短期T m值的高精度获取的问题,提出一种顾及多因子的大气加权平均温度模型。首先,通过探空数据利用积分法计算出加权平均温度,拟合分析选出特征因子加入建模;其次,将利用积分法计算的探空数据与NCEP数据分别作为参考值,引入Bevis模型、GPT3-z模型和时空模型,将模型计算的预测值和参考值作对比,分析各模型精度;之后,将各模型用于水汽反演,分析反演精度。结果表明:多因子T m模型反演的T m值精度最高,且多因子T m模型中加入了日周期变化,相比全年在短期时间内提升更加明显;将各模型用于GNSS水汽计算,多因子T m模型精度最好,理论RMS误差和相对误差分别为0.23 mm和1.69%。

关键词：加权平均温度精化模型探空数据 NCEP再分析资料 GNSS水汽探测