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Preliminary Application of High-Frequency Ultrasound in the Differentiation of Pemphigus and Bullous Pemphigoid: An Observational Study

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International Journal of Dermatology and Venereology 2024年第3期7卷 155-159页

作者： Liu Y.-A. Cao R. Da M.-H. Dong z.-B. Wang F. Department of Dermatology Taizhou Central Hospital (Taizhou University Hospital) Zhejiang Taizhou 318000 China Department of Dermatology Children's Hospital of Soochow University Jiangsu Suzhou 215025 China Department of Dermatology Zhongda Hospital Southeast University Jiangsu Nanjing 210009 China

Objective: Ultrasonography is a diagnostic imaging technique used to visualize subcutaneous body structures for identification of possible pathologies. In this study, we aimed to explore the clinical significance of high-frequency ultrasound in differentiating the location of blisters between pemphigus and bullous pemphigoid. Methods: Eighteen patients were recruited in Department of Dermatology, zhongda Hospital from 2020 to 2021 and divided into a pemphigus group (n = 8) and a bullous pemphigoid group (n = 10) according to the diagnostic criteria for each. Ultrasonographic images were collected using a 50-MHz high-frequency ultrasound system. The indexes of ultrasonic evaluation were the layer (epidermis or dermis), size, shape, internal echo, and boundary of the blister. Categorical variables are expressed as n (%), and differences were compared using Fisher's exact test. Results: The ultrasonographic images in the pemphigus group showed an intraepidermal semi-arc or irregular anechoic or hypoechoic areas. The inferior borders were situated above the characteristic thin linear hyperechoic bands of the epidermis. A linear hypoechoic band was present at the dermoepidermal junction in some cases. In the ultrasonographic images of the bullous pemphigoid group, the linear hyperechoic bands of the epidermis were continuous and intact. An oval fluid anechoic area (subepidermal blister) was present immediately below the bands. The location of the blisters in the ultrasonographic images was significantly different between the 2 groups (P < 0.001). Conclusion: High-frequency ultrasound can be used as an auxiliary means to differentiate the location of blisters between pemphigus and bullous pemphigoid. © 2022 Hospital for Skin Diseases (Institute of Dermatology), Chinese Academy of Medical Sciences, and Chinese Medical Association, published by Wolters Kluwer, Inc.

关键词： bullous pemphigoid high-frequency ultrasound pemphigus

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Effectiveness of serological markers of gastric mucosal atrophy in the gastric precancer screening and in cancer prevention

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World Journal of Gastrointestinal Endoscopy 2024年第8期16卷 462-471页

作者： Sergey M Kotelevets Sergey A Chekh Sergey z Chukov Department of Therapy North Caucasus State AcademyCherkessk 369000Karachay-Cherkess RepublicRussia Department of Mathematics North Caucasus State AcademyCherkessk 369000Karachay-Cherkess RepublicRussia Department of Pathological Anatomy Stavropol State Medical UniversityStavropol 355017Russia

BACKGROUND New markers are needed to improve the effectiveness of serological screening for atrophic *** To develop a cost-effective method for serological screening of atrophic gastritis with a high level of *** Of the 169 patients with atrophic gastritis,selected by the visual endoscopic Kimura-Takemoto method,165 showed histological mucosal atrophy using the updated Kimura-Takemoto *** 169 patients were examined for postprandial levels of gastrin-17(G17)and pepsinogen-1(PG1)using Gastro-Panel®(Biohit Plc,Helsinki,Finland).RESULTS We used the histological standard of five biopsies of the gastric mucosa,in accordance with the Kimura-Takemoto classification system to assess the sensitivity of G17 in detecting gastric mucosal *** also compared the morphofunctional relationships between the detected histological degree of gastric mucosal atrophy and the serological levels of G17 and PG1,as the markers of atrophic *** sensitivity of postprandial G17 was 62.2%for serological levels of G17(range:0-4 pmol/L)and 100%for serological G17(range:0-10 pmol/L)for the detection of monofocal severe atrophic *** strong correlation was found between the levels of PG1 and degree of histological atrophy determined by the Kimura-Takemoto classification system to identify the severity of mucosal atrophy of the gastric *** the presented clinical case of a 63-year-old man with multifocal atrophic gastritis,there is a pronounced positive long-term dynamics of the serological marker of atrophy-postprandial G17,after five months of rennet replacement *** Serological screening of multifocal atrophic gastritis by assessment of postprandial G17 is a cost-effective method with high *** G17 is an earlier marker of regression of atrophic gastritis than a morphological examination of a gastric biopsy in accordance with the Sydney ***,postprandial G17 is recommended for dynamic monitorin

关键词： Updated Sydney system Kimura-Takemoto classification Prevention Gastric cancer Atrophic gastritis Gastrin-17 Pepsonogen-1

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Rituximab Induced Vasculitis: Dose the Antigen-Antibody Complex of Rituximab Play a Role in Developing Leukocytoclastic Vasculitis?—A Case Report and Review of the Literature

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Journal of Biosciences and Medicines 2024年第9期12卷 89-94页

作者： Ahmed A. AlTaroti zahra z. Alzahir Salah Abohelaika Department of Internal Medicine Qatif Central Hospital Qatif Saudi Arabia Research Centre Qatif Central Hospital Qatif Saudi Arabia

Rituximab is a monoclonal antibody that targets CD20, which is a specific B-cell surface antigen. It was the first monoclonal antibody that was approved for the treatment of non-Hodgkin lymphoma, rheumatoid arthritis, and other cutaneous lymphoid malignancies. There are many off-label uses of rituximab, such as systemic lupus erythematosus, autoimmune hemolytic anemia, multiple sclerosis, graft-versus-host disease, chronic lymphocytic leukemia, and chronic immune-mediated thrombocytopenia. Among the rare side effects associated with rituximab treatment is vasculitis, more specifically, leukocytoclastic vasculitis. Here, we describe a 21-year-old Saudi female with leukocytoclastic vasculitis occurring three months after treatment with rituximab.

关键词： Rheumatoid Arthritis Rituximab Vasculitis Leukocytoclastic Vasculitis

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Cholesterol and Sericin as First Aid for Damaged Cells

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Journal of Biosciences and Medicines 2024年第4期12卷 79-88页

作者： Denız Aksoy Doga Naz Turan zeki Berkay Bayraktar Basak College Anatolian High School Aydin Turkey Bornova Anatolian High School Bornova Turkey Izmir Science High School Izmir Turkey

Cells are surrounded by a double-layered phospholipid cell membrane responsible for the isolation of intracellular contents, active regulation of uptake from the extracellular environment, and intercellular connection and communication. These cell membranes must be intact and functionally active for cell survival and biological functioning. Compromised damage repair mechanisms usually result in impaired cellular homeostasis, leading to early or late problems. Chronic myopathies, certain myocardial diseases, aging, and acute or chronic neurodegenerative diseases (like Parkinson and Alzheimer) are directly related to cell membrane damage. This study examined the effect of a cholesterol-loaded nanoparticle (methyl-beta cyclodextrin) or the silk protein sericin on cell membrane and DNA integrity and cell viability in an in vitro cell damage model (frozen-thawed rabbit sperm cells). The cells were stored in liquid nitrogen (-196°C), thawed in small batches, and treated with cholesterol-loaded cyclodextrin or sericin before incubation at 35°C for 4 hours. Cell membrane integrity, DNA damage, and viability rates were assessed immediately after thawing and after the incubation period. The administration of sericin and cholesterol in a cell damage model increased cell survival and reduced DNA damage over a 4-hour post-thaw incubation period, suggesting their potential use as a “first aid” intervention at the cellular level.

关键词： Cell Membrane DNA Survival Damage Cholesterol Sericin Spermatozoa

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Generation of polarized electron beams through self-injection in the interaction of a laser with a pre-polarized plasma

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High Power Laser Science and Engineering 2024年第3期12卷 62-68页

作者： L.R.Yin X.F.Li Y.J.Gu N.Cao Q.Kong M.Büscher S.M.Weng M.Chen z.M.Sheng Key Laboratory of Nuclear Physics and Ion-beam Application(MoE) Institute of Modern PhysicsDepartment of Nuclear Science and TechnologyFudan UniversityShanghaiChina State Key Laboratory of High Field Laser Physics Shanghai Institute of Optics and Fine MechanicsChinese Academy of SciencesShanghaiChina SANKEN(Institute of Scientific and Industrial Research) Osaka UniversityOsakaJapan Sichuan Research Institute Shanghai Jiao Tong UniversityChengduChina Peter Grünberg Institut(PGI-6) Forschungszentrum JülichJülichGermany Institut für Laser-und Plasmaphysik Heinrich-Heine-Universität DüsseldorfDüsseldorfGermany Key Laboratory for Laser Plasmas(MoE) School of Physics and AstronomyShanghai Jiao Tong UniversityShanghaiChina Collaborative Innovation Center of IFSA Shanghai Jiao Tong UniversityShanghaiChina Tsung-Dao Lee Institute Shanghai Jiao Tong UniversityShanghaiChina

Polarized electron beam production via laser wakefield acceleration in pre-polarized plasma is investigated by particlein-cell *** evolution of the electron beam polarization is studied based on the Thomas±Bargmann±Michel±Telegdi equation for the transverse and longitudinal self-injection,and the depolarization process is found to be influenced by the injection *** the case of transverse self-injection,as found typically in the bubble regime,the spin precession of the accelerated electrons is mainly influenced by the ***,in the case of longitudinal injection in the quasi-1D regime(for example,*** et al.,***.110,135002(2013)),the direction of electron spin oscillates in the laser *** the electrons move around the laser axis,the net influence of the laser field is nearly zero and the contribution of the wakefield can be ***,an ultra-short electron beam with polarization of 99%can be obtained using longitudinal self-injection.

关键词： laser wakefield acceleration longitudinal self-injection particle-in-cell simulation polarized electron beam

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Outcomes of long-acting injectable antipsychotics use in pregnancy:A literature review

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World Journal of Psychiatry 2024年第4期14卷 582-599页

作者： Ana V Pejčić Srdjan M Stefanović MilošN Milosavljević Vladimir S Janjić Marko M Folić Nevena D Folić Jovana z Milosavljević Department of Pharmacology and Toxicology Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia Department of Pharmacy Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia Department of Clinical Pharmacology University Clinical Center KragujevacKragujevac 34000Serbia Department of Psychiatry Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia Clinic for Psychiatry University Clinical Center KragujevacKragujevac 34000Serbia Center for Pharmaceutical and Pharmacological Research Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia Department of Pediatrics Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia Pediatric Clinic University Clinical Center KragujevacKragujevac 34000Serbia Department of Anatomy Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia

BACKGROUND Women with a history of serious psychotic disorders are at increased risk of disease relapse during ***-acting injectable(LAI)antipsychotics have been widely used to improve adherence and prevent relapse in patients with various severe psychotic disorders,but there is a lack of high-quality data from previous research on the safety of LAI antipsychotics during *** To summarize relevant data on maternal,pregnancy,neonatal,and developmental outcomes from published cases of LAI antipsychotic use in *** A literature search was performed through November 11,2023,using three online databases:PubMed/MEDLINE,Scopus,and Web of *** reports or case series that reported information about the outcomes of pregnancy in women who used LAI antipsychotics at any point in pregnancy,with available full texts,were *** statistics,narrative summation,and tabulation of the extracted data were *** A total of 19 publications satisfied the inclusion criteria:3 case series,15 case reports,and 1 conference *** reported the outcomes of LAI antipsychotic use in 74 women and 77 *** use of secondgeneration LAI antipsychotics was reported in the majority(n=47;61.0%)of ***-generation LAI antipsychotics were administered during 30 pregnancies(39.0%).Most of the women(approximately 64%)had either satisfactory control of symptoms or no information about relapse,while approximately 12%of them had developed gestational diabetes mellitus.A minority of cases reported adverse outcomes such as stillbirth,spontaneous abortion,preterm birth,low birth weight,congenital anomalies,and neurological manifestations in ***,there were no reports of negative long-term developmental *** Currently available data seem reassuring,but further well-designed studies are required to properly evaluate the risks and benefits of LAI antipsychotic use during pregnancy.

关键词： Antipsychotic agents Long-acting injectable Pregnancy Outcome Review

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Machine Learning Analysis of Impact of Western US Fires on Central US Hailstorms

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Advances in Atmospheric Sciences 2024年第7期41卷 1450-1462页

作者： Xinming LIN Jiwen FAN Yuwei zHANG zJason HOU Pacific Northwest National Laboratory RichlandWA 99354USA Argonne National Laboratory LemontIL 60439USA

Fires,including wildfires,harm air quality and essential public services like transportation,communication,and *** fires can also influence atmospheric conditions,including temperature and aerosols,potentially affecting severe convective ***,we investigate the remote impacts of fires in the western United States(WUS)on the occurrence of large hail(size:≥2.54 cm)in the central US(CUS)over the 20-year period of 2001–20 using the machine learning(ML),Random Forest(RF),and Extreme Gradient Boosting(XGB)*** developed RF and XGB models demonstrate high accuracy(>90%)and F1 scores of up to 0.78 in predicting large hail occurrences when WUS fires and CUS hailstorms coincide,particularly in four states(Wyoming,South Dakota,Nebraska,and Kansas).The key contributing variables identified from both ML models include the meteorological variables in the fire region(temperature and moisture),the westerly wind over the plume transport path,and the fire features(i.e.,the maximum fire power and burned area).The results confirm a linkage between WUS fires and severe weather in the CUS,corroborating the findings of our previous modeling study conducted on case simulations with a detailed physics model.

关键词： wildfire severe convective storm hailstorm machine learning

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Thermodynamic Analysis and Optimization of Flat Plate Solar Collector Using TiO_(2)/Water Nanofluid

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Journal of Harbin Institute of Technology(New Series) 2024年第4期31卷 61-73页

作者： Firas F.Qader Falah z.Mohammed Barhm Mohamad Technical Engineering College-Kirkuk Northern Technical UniversityKirkuk 36001Iraq Medical Device Technology Engineering AL-Qalam University CollegeKirkuk 36001Iraq Department of Petroleum Technology Koya Technical InstituteErbil Polytechnic UniversityErbil 44001Iraq

To research solar energy's efficiency and environmental benefits,the thermal efficiency,exergy,and entropy of solar collectors were *** experiment involved two glass-topped collectors,fluid transfer tubes,and aluminum heat-absorbing *** wool insulation minimized heat loss.A 0.5% TiO_(2)/Water nanofluid was created using a mechanical and ultrasonic *** showed that solar radiation increased thermal efficiency until midday,reaching 48.48% for water and 51.23% for the *** increasing mass flow rates from 0.0045 kg/s to 0.02 kg/s,thermal efficiency improved from 16.26% to 47.37% for water and from 20.65% to 48.76% for the *** water provided 380 W and 395 W of energy in March and April,while the nanofluid increased it to 395 W and 415 W during these *** flow generated energy,and the Reynolds number raised *** noon exergy efficiency for nanofluids was 50%-55%,compared to 30% for *** noon,the broken exergy measured 877.53 W for the nanofluid and 880.12 W for *** Kirkuk,Iraq,the 0.5% TiO_(2)/Water nanofluid outperformed water in solar collectors.

关键词： energy exergy entropy generation nanofluid flat plate solar collector

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Pyronaridine combined with diminazene aceturate inhibits Babesia in vitro and in vivo

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Asian Pacific Journal of Tropical Biomedicine 2024年第3期14卷 93-99页

作者： Shimaa Abd El-Salam El-Sayed Mohamed z.Sayed-Ahmed Shaimaa Ahmed Awad Ali Nourah Alsadaan Nawazish Alam Mahmoud S.Alkhoudary Ikuo Igarashi Mohamed Abdo Rizk National Research Center for Protozoan Diseases Obihiro University of Agriculture and Veterinary MedicineInada-ChoObihiroHokkaido 080-8555Japan Department of Biochemistry and Chemistry of Nutrition Faculty of Veterinary MedicineMansoura UniversityMansoura 35516Egypt Department of Clinical Pharmacy College of PharmacyJazan UniversityJazan 45142Saudi Arabia Medical-Surgical Department College of NursingJouf UniversitySakaka 72388Saudi Arabia Critical Care and Emergency Nursing Faculty of NursingMansoura UniversityEgypt College of Nursing Jouf UniversitySakaka 72388Saudi Arabia Faculty of Pharmacy Mansoura UniversityMansoura 35516DakahliaEgypt Department of Internal Medicine and Infectious Diseases Faculty of Veterinary MedicineMansoura UniversityMansoura 35516Egypt

Objective:To evaluate the combination therapy of pyronaridine tetraphosphate and diminazene aceturate against Babesia in vitro and in ***:Bioinformatic analysis was performed using atom pair *** in vitro combination test was performed against Babesia bovis and Theileria ***,the in vivo chemotherapeutic efficacy of pyronaridine tetraphosphate in combination with diminazene aceturate was investigated against the growth of Babesia microti in mice using a fluorescence inhibitory ***:Pyronaridine tetraphosphate and diminazene aceturate exhibited nearly similar molecular *** in vitro combination of pyronaridine tetraphosphate and diminazene aceturate was synergistic on Babesia bovis and additive on Theileria *** addition,5 mg/kg pyronaridine tetraphosphate combined with 10 mg/kg diminazene aceturate inhibited Babesia microti growth significantly compared with those observed after treatment with 25 mg/kg diminazene aceturate alone from day 6 post treatment to day 12 post *** combination therapy also normalized the hematological parameters of infected ***:An oral dose of pyronaridine tetraphosphate combined with a subcutaneous dose of diminazene aceturate inhibits Babesia in vitro and in mice,suggesting it might be a new paradigm for the treatment of babesiosis.

关键词： Babesia Pyronaridine tetraphosphate Diminazene aceturate Babesiosis Theileria

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Exploiting open source omics data to advance pancreas research

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Journal of Pancreatology 2024年第1期7卷 21-27页

作者： Gayathri Swaminathan Toshie Saito Sohail z.Husain Division of Gastroenterology Hepatology and NutritionDepartment of PediatricsStanford University School of MedicineStanfordCA

The"omics"revolution has transformed the biomedical research landscape by equipping scientists with the ability to interrogate complex biological phenomenon and disease processes at an unprecedented *** volume of"big"data generated by the different omics studies such as genomics,transcriptomics,proteomics,and metabolomics has led to the concurrent development of computational tools to enable in silico analysis and aid data *** the intensive resources and high costs required to generate and analyze big data,there has been centralized,collaborative efforts to make the data and analysis tools freely available as"Open Source,"to benefit the wider research *** research studies have contributed to this"big data rush"and have additionally benefitted from utilizing the open source data as evidenced by the increasing number of new research findings and publications that stem from such *** this review,we briefly introduce the evolution of open source omics data,data types,the"FAIR"guiding principles for data management and reuse,and centralized platforms that enable free and fair data accessibility,availability,and provide tools for omics data *** illustrate,through the case study of our own experience in mining pancreatitis omics data,the power of repurposing open source data to answer translationally relevant questions in pancreas research.

关键词： Gene expression Omics Open source data Pancreatitis

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