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今日中国（西文版） 2024年第3期 34-35页

作者： MICHAEL zÁRATE 不详

China-Uruguay: la defensa del libre comercio

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今日中国（西文版） 2024年第1期 44-45页

作者： MlCHAEL zÁRATE

Effects of exosomes from mesenchymal stem cells on functional recovery of a patient with total radial nerve injury: A pilot study

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World Journal of Stem Cells 2024年第1期16卷 19-32页

作者： ErdinçCivelek Serdar Kabatas Eyüp Can Savrunlu Furkan Diren Necati Kaplan Demet Ofluoğlu Erdal Karaöz Department of Neurosurgery University of Health SciencesGaziosmanpaşa Training and Research HospitalGaziosmanpaşa 34255IstanbulTurkey Department of Neurosurgery University of Health Sciences TurkeyGaziosmanpaşa Training and Research HospitalGaziosmanpaşa 34255IstanbulTurkey Center for Stem Cell&Gene Therapy Research and Practice University of Health Sciences TurkeyGaziosmanpaşa 34255IstanbulTurkey Department of Neurosurgery Nevşehir State HospitalNevşehir 50300Turkey Department of Neurosurgery Istanbul Rumeli UniversityÇorlu Reyap HospitalÇorlu 59860TekirdağTurkey Department of Physical Medicine and Rehabilitation Ofluoğlu KlinikGöztepe 34728IstanbulTurkey Liv Hospital Center for Regenerative Medicine and Stem Cell Research&Manufacturing(LivMedCell)Beşiktaş34340IstanbulTurkey Department of Histology and Embryology Istinye UniversityFaculty of MedicineZeytinburnu 34010IstanbulTurkey Istinye University Center for Stem Cell and Tissue Engineering Research and PracticeBeşiktaş34340IstanbulTurkey

BACKGROUND Peripheral nerve injury can result in significant clinical complications that have uncertain ***,there is a lack of effective pharmacological interventions for nerve damage,despite the existence of several small compounds,Despite the objective of achieving full functional restoration by surgical intervention,the persistent challenge of inadequate functional recovery remains a significant concern in the context of peripheral nerve *** To examine the impact of exosomes on the process of functional recovery following a complete radial nerve *** A male individual,aged 24,who is right-hand dominant and an immigrant,arrived with an injury caused by a knife *** cut is located on the left arm,specifically below the *** neurological examination and electrodiagnostic testing reveal evidence of left radial nerve *** sural autograft was utilized for repair,followed by the application of 1 mL of mesenchymal stem cell-derived exosome,comprising 5 billion *** exosome was split into four equal volumes of 0.25 mL each and delivered microsurgically to both the proximal and distal stumps using the subepineural *** patient was subjected to a period of 180 d during which they had neurological examination and electrodiagnostic *** The duration of the patient’s follow-up period was 180 *** increasing Tinel’s sign and sensory-motor recovery were detected even at the 10th wk following nerve *** the conclusion of the 6-mo post-treatment period,an evaluation was conducted to measure the extent of improvement in motor and sensory functions of the *** assessment was based on the British Medical Research Council scale and the Mackinnon-Dellon *** results indicated that the level of improvement in motor function was classified as M5,denoting an excellent ***,the level of improvement in sensory function was classified as S3+,indicating a good *** is

关键词： Mesenchymal stem cell Exosomes Radial nerve Sural nerve

Greatly enhanced corrosion/wear resistances of epoxy coating for Mg alloy through a synergistic effect between functionalized graphene and insulated blocking layer

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Journal of Magnesium and Alloys 2024年第1期12卷 332-344页

作者： z.Y.Xue X.J.Li J.H.Chu M.M.Li D.N.zou L.B.Tong School of Metallurgical Engineering Xi’an University of Architecture and TechnologyXi’an 710055China State Key Laboratory of Advanced Design and Manufacturing for Vehicle Body Hunan UniversityChangsha 410082China

The poor corrosion and wear resistances of Mg alloys seriously limit their potential applications in various *** conventional epoxy coating easily forms many intrinsic defects during the solidification process,which cannot provide sufficient *** the current study,we design a double-layer epoxy composite coating on Mg alloy with enhanced anti-corrosion/wear properties,via the spin-assisted assembly *** outer layer is functionalized graphene(FG)in waterborne epoxy resin(WEP)and the inner layer is Ce-based conversion(Ce)*** FG sheets can be homogeneously dispersed within the epoxy matrix to fill the intrinsic defects and improve the barrier *** Ce film connects the outer layer with the substrate,showing the transition *** corrosion rate of Ce/WEP/FG composite coating is 2131 times lower than that of bare Mg alloy,and the wear rate is decreased by~90%.The improved corrosion resistance is attributed to the labyrinth effect(hindering the penetration of corrosive medium)and the obstruction of galvanic coupling *** synergistic effect derived from the FG sheet and blocking layer exhibits great potential in realizing the improvement of multi-functional integration,which will open up a new avenue for the development of novel composite protection coatings of Mg alloys.

关键词： Mg alloy Functionalized graphene Epoxy coating Corrosion/wear resistance Blocking layer

Solid-state Circuit Breaker Based on Cascaded Normally-on SiC JFETs for Medium-voltage DC Distribution Networks

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Protection and Control of Modern Power Systems 2024年第2期9卷 32-46页

作者： Dong He Haohui zhou zheng Lan Wei Wang Jinhui zeng Xueping Yu z.John Shen Chongqing University of Posts and Telecommunications ChongqingChina Henan Polytechnic University JiaozuoChina College of Electrical and Information Engineering Hunan University of TechnologyZhuzhou 412007China Hunan University ChangshaChina College of Electrical and Information Engineering Hunan UniversityChangshaChina College of Electrical Engineering Three Gorges University Rensselaer Polytechnic Institute TroyNYUSA

Solid-state circuit breakers(SSCBs)are critical components in the protection of medium-voltage DC distribution networks to facilitate arc-free,fast and reliable isolation of DC ***,limited by the capacity of a single semiconductor device,using semi-conductor-based SSCBs at high voltage is *** study presents the details of a 1.5 kV,63 A medi-um-voltage SSCB,composed primarily of a solid-state switch based on three cascaded normally-on silicon car-bide(SiC)junction field-effect transistors(JFETs)and a low-cost programmable gate drive *** and static voltage sharing among the cascaded SiC JFETs of the SSCB during fault isolation is realized using the pro-posed gate drive *** selection conditions for the key parameters of the SSCB gate driver are also ***,an improved pulse-width modulation cur-rent-limiting protection solution is proposed to identify the permanent overcurrent and transient inrush current associated with capacitive load startup in a DC distribu-tion *** the developed SSCB prototype and the fault test system,experimental results are obtained to validate the fault response performance of the *** Terms—Solid-state circuit breaker,DC distribu-tion network,SiC JFET,voltage balancing,inrush current.

关键词： Solid-state circuit breaker DC distribu-tion network SiC JFET voltage balancing inrush current

A mathematical model for a disease outbreak considering waningimmunity class with nonlinear incidence and recovery rates

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Journal of Biosafety and Biosecurity 2024年第3期6卷 170-180页

作者： Nursanti Anggriani Lazarus Kalvein Beay Meksianis z.Ndii Fatuh Inayaturohmat Sanubari Tansah Tresna Department of Mathematics Universitas PadjadjaranSumedangIndonesia Department of Mathematics Universitas PattimuraMalukuIndonesia Department of Mathematics Universitas Nusa CendanaKupangIndonesia

In the spread of infectious diseases,intervention levels play a crucial role in shaping interactions between healthy and infected individuals,leading to a nonlinear transmission ***,the availability of medical resources limits the recovery rate of infected patients,adding further nonlinear dynamics to the healing *** research introduces novelty by combining nonlinear incidence and recovery rates alongside waning immunity in an epidemic *** present a modified SIRW-type model,examining the epidemic problem with these *** analysis,we explore conditions for non-endemic and co-existing cases based on the basic reproduction *** local stability of equilibria is verified using the Routh-Hurwitz criteria,while global stability is assessed using Lyapunov functions for each ***,we investigate bifurcations around both non-endemic and co-existing ***,we give some simulations to support our analytical findings.

关键词： SIRW-type model Basic reproduction ratio Waning immunity Nonlinear incidence rate Nonlinear recovery rate Lyapunov functions Bifurcation

Feeding ecology and interactions with mammal hosts in a symbiotic genus of birds(Buphagus spp.)in Namibia

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Avian Research 2024年第3期15卷 336-344页

作者： Michael S.Lukubwe Daniel Velarde-Garcéz Fernando Sequeira Susana Lopes Adrian J.F.K.Craig Vanessa A.Mata Department of zoology and Entomology Rhodes UniversityMakhandaSouth Africa Department of Wildlife Management and Tourism Studies University of NamibiaKatima Mulilo CampusNamibia Departamento de Biologia Faculdade de CiênciasUniversidade do PortoPortoPortugal CIBIO Centro de Investigação em Biodiversidade e Recursos GenéticosInBIO Laboratório AssociadoCampus de VairãoVairãoPortugal BIOPOLIS Program in Genomics Biodiversity and Land PlanningCIBIOCampus de VairãoVairãoPortugal

As the sole obligate symbiotic birds in Africa,oxpeckers offer a unique model for studying symbiotic *** to the multitrophic level they occupy and the context dependent foraging behavior they exhibit,the type of symbiotic relationship can be *** addition to providing a cleaning service to the host by removing ticks,oxpeckers frequently feed on blood,mucus,and saliva,inflicting potential damage on the ***,we used DNA metabarcoding on faecal samples to analyze the taxonomic composition of the trophic interactions of the Yellow-billed Oxpecker(Buphagus africanus)and Red-billed Oxpecker(***)in northeastern *** contrast to conventional methods,DNA metabarcoding allows for a detailed identification of dietary resources encompassing both mammal hosts and consumed arthropods within the same *** this information,we examined differences in the diet composition between oxpecker species and localities,as well as the co-occurrence between host and arthropod *** findings revealed that oxpeckers predominantly source their diet from mammals,ticks,and flies;however,ticks and flies rarely co-occur in the diet of an *** observed variability among individuals in their feeding ecology,which is strongly correlated with locality and,to a lesser extent,with the mammal *** noted a high degree of mobility between hosts within relatively short periods,with 32%of the samples showing traces of at least two mammal *** study illustrates the dynamic foraging behavior of these specialized symbiotic birds,shedding light on their potential role in pest control services and disease transmission.

关键词： Commensalism Diet DNA metabarcoding Oxpeckers Parasitism Trophic ecology

Remodeling Tumor Immune Microenvironment by Using Polymer-Lipid-Manganese Dioxide Nanoparticles with Radiation Therapy to Boost Immune Response of Castration-Resistant Prostate Cancer

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Research 2024年第3期2023卷 83-96页

作者： Abdulmottaleb E.zetrini HoYin Lip Azhar z.Abbasi Ibrahim Alradwan Taksim Ahmed Chunsheng He Jeffrey T.Henderson Andrew M.Rauth Xiao Yu Wu Advanced Pharmaceutics and Drug Delivery Laboratory Leslie Dan Faculty of PharmacyUniversity of TorontoM5S 3M2TorontoONCanada. Departments of Medical Biophysics and Radiation Oncology University of TorontoM5G 1L7TorontoONCanada.

Despite substantial progress in the treatment of castration-resistant prostate cancer (CRPC), including radiation therapy and immunotherapy alone or in combination, the response to treatment remains poor due to the hypoxic and immunosuppressive nature of the tumor microenvironment. Herein, we exploited the bioreactivity of novel polymer–lipid manganese dioxide nanoparticles (PLMDs) to remodel the tumor immune microenvironment (TIME) by increasing the local oxygen levels and extracellular pH and enhancing radiation-induced immunogenic cell death. This study demonstrated that PLMD treatment sensitized hypoxic human and murine CRPC cells to radiation, significantly increasing radiation-induced DNA double-strand breaks and ultimately cell death, which enhanced the secretion of damage-associated molecular patterns, attributable to the induction of autophagy and endoplasmic reticulum stress. Reoxygenation via PLMDs also polarized hypoxic murine RAW264.7 macrophages toward the M1 phenotype, enhancing tumor necrosis factor alpha release, and thus reducing the viability of murine CRPC TRAMP-C2 cells. In a syngeneic TRAMP-C2 tumor model, intravenous injection of PLMDs suppressed, while radiation alone enhanced recruitment of regulatory T cells and myeloid-derived suppressor cells. Pretreatment with PLMDs followed by radiation down-regulated programmed death-ligand 1 and promoted the infiltration of antitumor CD8+ T cells and M1 macrophages to tumor sites. Taken together, TIME modulation by PLMDs plus radiation profoundly delayed tumor growth and prolonged median survival compared with radiation alone. These results suggest that PLMDs plus radiation is a promising treatment modality for improving therapeutic efficacy in radioresistant and immunosuppressive solid tumors.

关键词： RAW264.7 alone treatment

Analysis of the Impact of the Blazhko Effect Both on the Van Hoof Effect and Radial Velocity Amplitude in the Star RR Lyr

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Research in Astronomy and Astrophysics 2024年第6期24卷 253-272页

作者： Y.El jariri F.L.Sefyani A.Benhida z.Benkhaldoun K.Kolenberg K.Chafouai A.Habib M.Sabil Observatoire de l'Oukaimeden LPHEAFSSMUniversitéCadi AyyadMarrakech2390Morocco Observatoire de l'Oukaimeden LPHEAFSTGUniversitéCadi AyyadMarrakech549Morocco Département de physique Universitéd'Anvers Avenue Groenenborger 171Anvers2020Belgium LICPM ENSA-BMUniversitéSultan Moulay SlimaneBeni-Mellal23020Morocco

The Van Hoof effect is a phase shift existing between the radial velocity curves of hydrogen and metallic lines within the atmosphere of pulsating *** this article,we present a study of this phenomenon through the spectra of the brightest pulsating star RR Lyr of RR Lyrae stars recorded for 22 *** based ourselves,on the one hand,on 1268 spectra(41 nights of observation)recorded between the years 1994 and 1997 at the Observatory of Haute Provence(OHP,France)previously observed by Chadid and Gillet,and on the other hand on 1569 spectra(46nights of observation)recorded at our Oukaimeden Observatory(Morocco)between 2015 and *** this study,we have detected information on atmospheric dynamics that had not previously been ***,the Van Hoof effect which results in a clear correlation between the radial velocities of hydrogen and those of the metallic lines has been observed and analyzed at different Blazhko phases.A correlation between the radial velocities of different metallic lines located in the lower atmosphere has been observed as *** the first time,we were able to show that the amplitude of the radial velocity curves deduced from the lines of hydrogen and that of FeⅡ(λ4923.921?)increases toward the minimum of the Blazhko cycle and decreases toward the maximum of the same Blazhko ***,we found that the Van Hoof effect is also modulated by the Blazhko ***,toward the minimum of the Blazhko cycle the Van Hoof effect is more visible and at the maximum of the Blazhko cycle,this effect is *** also observed the temporal evolution of the amplitudes of the radial velocities of the lower and upper *** observed over a long time,we can interpret it as a function of the Blazhko phases.

关键词： stars:atmospheres stars:variables:RR Lyrae shock waves techniques:spectroscopic techniques:radial velocities stars:individual(RR Lyr)

ADAM8 inactivation retards intervertebral disc degeneration in mice

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Genes & Diseases 2024年第3期11卷 91-94页

作者： zuozhen Tian Frances S.Shofer Mingyue Fan Alec z.Sandroni Lutian Yao Lin Han Ling Qin Motomi Enomoto-lwamoto Yejia zhang Department of Physical Medicine&Rehabilitation Perelman School of MedicineUniversity of PennsylvaniaPhiladelphiaPA19146USA Department of Emergency Medicine Perelman School of MedicineUniversity of PennsylvaniaPhiladelphiaPA 19104USA Department of Orthopedic Surgery Perelman School of MedicineUniversity of PennsylvaniaPhiladelphiaPA 19104USA School of Biomedical Engineering Science&Health SystemsDrexel UniversityPhiladelphiaPA 19104USA Department of Orthopedics/Sports Medicine and Joint Surgery the First Hospital of China Medical UniversityShenyangLiaoning 110001China Department of Orthopedics University of Maryland School ofMedicineBaltimoreMD21201USA Section of Rehabilitation Medicine Corporal Michael J.Crescenz Veterans Affairs Medical CenterPhiladelphiaPA 19104USA

ADAM8 has been identified as the fibronectin-cleaving enzyme in human degenerative intervertebral disc(IVD)tissues.^(1)Increase of the active form of ADAM8 and its cleavage product,fibronectin fragment,correlated with an increased degree of IVD degeneration.1 Furthermore,fibronectin fragments have been shown to accelerate the progression of IVD degeneration.^(2)These findings suggest that ADAM8 may play a role in degenerative disc disease,a clinical problem with tremendous socioeconomic burdens in the United States.

关键词： ADAM8 degeneration intervertebral