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Applied Mathematics and Mechanics(English Edition) 2024年第2期45卷 373-388页

作者： M.RAHMAN M.TURKYILMAzOGLU z.mushtaq Department of Mathematics Mirpur University of Science and TechnologyMirpur 10250Pakistan Department of Mathematics Hacettepe UniversityBeytepeAnkara 06532Turkiye

In this study,we examine the effects of various shapes of nanoparticles in a steady flow of hybrid nanofluids between two stretchable rotating *** steady flow of hybrid nanofluids with transformer oil as the base fluid and Fe_(3)O_(4)+TiO_(2)as the hybrid nanofluid is *** shapes of Fe_(3)O_(4)+TiO_(2)hybrid nanofluids,including sphere,brick,blade,cylinder,and platelet,are *** shape exists in the same volume of a *** leading equations(partial differential equations(PDEs))are transformed to the nonlinear ordinary differential equations(ODEs)with the help of similarity *** system of equations takes the form of ODEs depending on the boundary conditions,whose solutions are computed numerically by the bvp4c MATLAB *** outputs are compared with the previous findings,and an intriguing pattern is discovered,such that the tangential velocity is increased for the rotation parameter,while it is decreased by the stretching values because of the lower *** the reaction rate parameter,the concentration boundary layer becomes shorter,and the activation energy component increases the rate at which mass transfers come to the higher disk but have the opposite effect on the bottom *** ranges of various parameters taken into account are Pr=6.2,Re=2,M=1.0,φ_(1)=φ_(2)=0.03,K=0.5,S=-0.1,Br=0.3,Sc=2.0,α_(1)=0.2,γ=0.1,E_(n)=2.0,and q=1.0,and the rotation factor K is within the range of 0 to 1.

关键词： transformer oil Brinkman number skin friction coefficient double rotating disk Nusselt number Sherwood number

Targeting epigenetic mechanisms in amyloid-β-mediated Alzheimer’s pathophysiology:unveiling therapeutic potential

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Neural Regeneration Research 2025年第1期20卷 54-66页

作者： Jennie z.Li Nagendran Ramalingam Shaomin Li Ann Romney Center for Neurologic Diseases Brigham and Women’s Hospital and Harvard Medical SchoolBostonMAUSA

Alzheimer’s disease is a prominent chronic neurodegenerative condition characterized by a gradual decline in memory leading to *** evidence suggests that Alzheimer’s disease is associated with accumulating various amyloid-βoligomers in the brain,influenced by complex genetic and environmental *** memory and cognitive deficits observed during the prodromal and mild cognitive impairment phases of Alzheimer’s disease are believed to primarily result from synaptic *** life,environmental factors can lead to enduring changes in gene expression and the emergence of brain *** changes,known as epigenetic modifications,also play a crucial role in regulating the formation of synapses and their adaptability in response to neuronal *** this context,we highlight recent advances in understanding the roles played by key components of the epigenetic machinery,specifically DNA methylation,histone modification,and microRNAs,in the development of Alzheimer’s disease,synaptic function,and activity-dependent synaptic ***,we explore various strategies,including enriched environments,exposure to non-invasive brain stimulation,and the use of pharmacological agents,aimed at improving synaptic function and enhancing long-term potentiation,a process integral to epigenetic ***,we deliberate on the development of effective epigenetic agents and safe therapeutic approaches for managing Alzheimer’s *** suggest that addressing Alzheimer’s disease may require distinct tailored epigenetic drugs targeting different disease stages or pathways rather than relying on a single drug.

关键词： Alzheimer’s disease DNA methylation enriched environments histone modification microRNAs non-invasive brain stimulation synaptic plasticity

Thermally Radiative Viscous Fluid Flow Over Curved Moving Surface in Darcy-Forchheimer Porous Space

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Communications in Theoretical Physics 2019年第3期71卷 259-266页

作者： A.Rauf z.Abbas S.A.Shehzad T.mushtaq Department of Mathematics The Islamia University of Bahawalpur Department of Mathematics COMSATS University Islamabad

A numerical analysis is developed for incompressible hydromagnetic viscous fluid passed through a curved stretching surface. Fluid saturated by porous space is bounded by curved surface. Term of porous medium is characterized by implementation of Darcy-Forchheimer theory. Adequate similarity variables are implemented to develop a system of non-linear ordinary differential system of equations, which govern the flow behavior. The impact of radiation constraint and Eckert number is incorporated in the energy equation. Numerical scheme based on RKF45 technique is implemented to solve the derived flow model. Prescribed heat flux(PHF) and prescribed surface temperature(PST) boundary conditions are utilized on temperature with Prescribed Surface Concentration(PSC) and Prescribed Mass Flux(PMF)on concentration. Flow behavior is discussed for both the slip and no-slip conditions. Dimensionless physical quantities are presented through graphs and tables.

关键词： viscous fluid porous medium curved stretching sheet radiation Joule heating

Transport mechanism in chemically reactive hybrid nanofluid flow containing gyrotactic micro-organisms over a curved oscillatory surface

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 177-192页

作者： M.NAVEED M.IMRAN T.ASGHAR z.ABBAS Department of Mathematics Division of Science and TechnologyUniversity of Education Department of Mathematics The Islamia University of Bahawalpur

This paper examines the transport analysis, including both heat transfer and mass transfer, in hybrid nanofluid flow containing gyrotactic microorganisms towards a curved oscillatory surface. The influence of magnetic fields is also inspected in terms of their physical characteristics. To depict the phenomena of transport, modified versions of both Fick's and Fourier's laws are used. Additionally, the characteristics of both heterogeneous and homogeneous chemical reactions are also incorporated. Utilizing a curvilinear coordinate system, the flow problem is formulated as partial differential equations(PDEs)for momentum, concentration, microorganism field, and energy. An analytical solution to the obtained flow equations is achieved utilizing the homotopy analysis method(HAM).The effects of significant flow parameters on the pressure and microorganism fields, velocity, oscillation velocity, concentration, and temperature distributions are shown via graphs. Furthermore, the variations in skin friction, mass transfer rate, heat transfer rate, and local motile number due to different involved parameters are presented in tables and are analyzed in detail. Graphical results indicate that the curves of velocity and temperature fields are enhanced as the values of the solid volume fraction variables *** is also verified that the concentration rate field decreases as the values of the homogeneous reaction strength parameter and the radius of curvature parameter increase, and it increases with the Schmidt number and the heterogeneous reaction strength *** outcomes show a favorable response of the motile number to advanced values of the Peclet number, the Schmidt number, the microorganism difference parameter, and the bio-convective Lewis number.

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Numerical and statistical approach for Casson-Maxwell nanofluid flow with Cattaneo-Christov theory

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Applied Mathematics and Mechanics(English Edition) 2021年第7期42卷 1063-1076页

作者： T.mushtaq A.RAUF S.A.SHEHzAD F.MUSTAFA M.HANIF z.ABBAS Department of Mathematics COMSATS University IslamabadVehari CampusVehari 61100Pakistan Department of Mathematics COMSATS University IslamabadSahiwal CampusSahiwal 57000Pakistan Department of Mathematics The Islamia University of BahawalpurBahawalpur 63100Pakistan

The rheological features of an incompressible axi-symmetric Casson-Maxwell nanofluid flow between two stationary disks are *** lower permeable disk is located at z=-a,while the upper disk is placed at z=*** the disks are porous and subjected to uniform *** fluid properties such as thermal conductivity vary with *** Cattaneo-Christov thermal expression is implemented along with the Buongiorno nanofluid *** operating the similarity functions,the reduced form of the fluid model in terms of ordinary differential equations is obtained and solved by the bvp4 c numerical *** physical quantities are demonstrated graphically on the velocity and temperature ***-dimensional flow arrangements and twodimensional contour patterns against several dimensionless variables are also *** numerical values of the local Nusselt and Sherwood numbers for various quantities are presented in tabular *** intensity of the linear relationship between the Nusselt and Sherwood numbers is assessed through Pearson’s product-moment correlation *** statistical implication of the linear association between variables is also examined by the t-test statistic approach.

关键词： Casson-Maxwell fluid porous disk Buongiorno theory variable thermal conductivity Cattaneo-Christov model uniform injection

Advances in the treatment of autism spectrum disorder:Wharton jelly mesenchymal stem cell transplantation

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World Journal of Methodology 2025年第1期15卷 72-79页

作者： Serdar Kabatas ErdinçCivelek Eyüp Can Savrunlu Umut Karaaslan Özlem Yıldız Erdal Karaöz Department of Neurosurgery University of Health Sciences TurkeyGaziosmanpaşa Training and Research HospitalIstanbul 34255Türkiye Department of Pediatric Allergy-Immunology Institute of Health Sciences Marmara UniversityIstanbul 34865Türkiye Center for Stem Cell&Gene Therapy Research and Practice University of Health Sciences TurkeyIstanbul 34255Türkiye Department of Child and Adolescent Psychiatry University of Health SciencesGaziosmanpaşa Training and Research HospitalIstanbul 34255Türkiye Department of Child and Adolescent Psychiatry Kocaeli University Faculty of MedicineKocaeli 41001Türkiye Center for Regenerative Medicine and Stem Cell Research&Manufacturing Liv HospitalIstanbul 34340Türkiye Department of Histology and Embryology Istinye UniversityFaculty of MedicineIstanbul 34010Türkiye Center for Stem Cell and Tissue Engineering Research and Practice Istinye UniversityIstanbul 34340Türkiye

BACKGROUND Autism spectrum disorder(ASD)is a complex neurodevelopmental disorder with multifaceted *** recent studies,neuroinflammation and immune dysregulation have come to the forefront in its *** are studies suggesting that stem cell therapy may be effective in the treatment of *** To evolve the landscape of ASD treatment,focusing on the potential benefits and safety of stem cell *** A detailed case report is presented,displaying the positive outcomes observed in a child who underwent intrathecal and intravenous Wharton’s jelly-derived mesenchymal stem cells(WJ-MSCs)transplantation combined with *** The study demonstrates a significant improvement in the child’s functional outcomes(Childhood Autism Rating Scale,Denver 2 Developmental Screening Test),especially in language and gross motor *** serious side effects were encountered during the 2-year *** The findings support the safety and effectiveness of WJ-MSC transplantation in managing ASD.

关键词： Autism spectrum disorder Neurorehabilitation Stem cell transplantation Wharton jelly mesenchymal stem cells Inflammation

Dynamics of bioconvection flow of micropolar nanoparticles with Cattaneo-Christov expressions

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Applied Mathematics and Mechanics(English Edition) 2020年第9期41卷 1333-1344页

作者： S.A.SHEHzAD T.mushtaq z.ABBAS A.RAUF S.U.KHAN I.TLILI Department of Mathematics COMSATS University IslamabadSahiwal 57000Pakistan Department of Mathematics COMSATS University IslamabadVehari 61100Pakistan Department of Mathematics The Islamia University of BahawalpurBahawalpur 63100Pakistan Institute of Research and Development Duy Tan UniversityDa Nang 550000Vietnam Faculty of Civil Engineering Duy Tan UniversityDa Nang 550000Vietnam

A numerical analysis is performed to analyze the bioconvective double diffusive micropolar non-Newtonian nanofluid flow caused by stationary porous *** consequences of the current flow problem are further extended by incorporating the Brownian and thermophoresis *** energy and mass species equations are developed by utilizing the Cattaneo and Christov model of heat-mass *** flow equations are converted into an ordinary differential model by employing the appropriate *** numerical solution is reported by using the MATLAB builtin bvp4c *** consequences of engineering parameters on the flow velocity,the concentration,the microorganisms,and the temperature profiles are evaluated *** numerical data for fascinating physical quantities,namely,the motile density number,the local Sherwood number,and the local Nusselt number,are calculated and executed against various parametric *** microrotation magnitude reduces for increasing magnetic *** intensity of the applied magnetic field may be utilized to reduce the angular rotation which occurs in the lubrication processes,especially in the suspension of *** the account of industrial applications,the constituted output can be useful to enhance the energy transport efficacy and microbial fuel cells.

关键词： bioconvection flow micropolar fluid nanoparticle Cattaneo-Christov theory porous disk

Coset Diagram for the Action of Picard Group on Q（i, √3）

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Algebra Colloquium 2016年第1期23卷 33-44页

作者： Qaiser mushtaq Saima Anis Department of Mathematics Quaid-i-Azam University Islamabad Pakistan Department of Mathematics COMSATS Institute of Information Technology Abbottabad Pakistan

In this paper coset diagrams, propounded by Higman, are used to investigate the behavior of elements as words in orbits of the action of the Picard group F = PSL（2, z[i]） on Q（i, √3）. Graphical interpretation of amalgamation of the components of F is also given. Some elements a＋b√3/c of Q（i, √3） and their conjugates a-b√3/c a c over Q（i） have different signs in the orbits of the biquadratic field Q（i, √3） when acted upon by F. Such real quadratic irrational numbers are called ambiguous numbers. It is shown that ambiguous numbers in these coset diagrams form a unique pattern. It is proved that there are a finite number of ambiguous numbers in an orbit Fa, and they form a closed path which is the only closed path in the orbit Гa. We also devise a procedure to obtain ambiguous numbers of the form a-b√3/c, where b is a positive integer.

关键词： Picard group biquadratic field coset diagrams and ambiguous numbers

Polyethylene glycol fusion repair of severed rat sciatic nerves reestablishes axonal continuity and reorganizes sensory terminal fields in the spinal cord

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Neural Regeneration Research 2025年第7期20卷 2095-2107页

作者： Emily A.Hibbard Liwen zhou Cathy z.Yang Karthik Venkudusamy Yessenia Montoya Alexa Olivarez George D.Bittner Dale R.Sengelaub Program in Neuroscience Indiana UniversityBloomingtonINUSA Department of Neuroscience University of Texas at AustinAustinTXUSA

Peripheral nerve injuries result in the rapid degeneration of distal nerve segments and immediate loss of motor and sensory functions;behavioral recovery is typically *** used a plasmalemmal fusogen,polyethylene glycol(PEG),to immediately fuse closely apposed open ends of severed proximal and distal axons in rat sciatic *** have previously reported that sciatic nerve axons repaired by PEG-fusion do not undergo Wallerian degeneration,and PEG-fused animals exhibit rapid(within 2–6 weeks)and extensive locomotor ***,our previous report showed that PEG-fusion of severed sciatic motor axons was non-specific,i.e.,spinal motoneurons in PEG-fused animals were found to project to appropriate as well as inappropriate target *** this study,we examined the consequences of PEG-fusion for sensory axons of the sciatic *** adult male and female rats(Sprague–Dawley)received either a unilateral single cut or ablation injury to the sciatic nerve and subsequent repair with or without(Negative Control)the application of *** action potentials recorded immediately after PEG-fusion repair confirmed conduction across the injury *** success of PEG-fusion was confirmed through Sciatic Functional Index testing with PEG-fused animals showing improvement in locomotor function beginning at 35 days *** 2–42 days postoperatively,we anterogradely labeled sensory afferents from the dorsal aspect of the hindpaw following bilateral intradermal injection of wheat germ agglutinin conjugated horseradish ***-fusion repair reestablished axonal *** to unoperated animals,labeled sensory afferents ipsilateral to the injury in PEG-fused animals were found in the appropriate area of the dorsal horn,as well as inappropriate mediolateral and rostrocaudal ***,despite having intact peripheral nerves,similar reorganizations of labeled sensory afferents were also observed contralateral to the injury and repa

关键词： axotomy dorsal horn peripheral nerve injury plasticity polyethylene glycol(PEG) sciatic nerve sensory terminals wheat germ agglutinin horseradish peroxidase

Grids of stellar models including second harmonic and colors:solar composition(z = 0.0172,X = 0.7024)

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Research in Astronomy and Astrophysics 2015年第12期15卷 2244-2262页

作者： Mutlu Y?ld?z Ege University Department of Astronomy and Space Sciences

Grids of stellar evolution omy/astrophysics, such as planet hosting are required in many fields of astron- stars, binaries, clusters, chemically peculiar stars, etc. In this study, a grid of stellar evolution models with updated ingredients and recently determined solar abundances is presented. The solar values for the initial abundances of hydrogen, heavy elements and mixing-length parameter are 0.0172, 0.7024 and 1.98, respectively. The mass step is small enough （0.01 M） that interpolation for a given star mass is not required. The range of stellar mass is 0.74 to 10.00M. We present results in different forms of tables for easy and general appli- cation. The second stellar harmonic, required for analysis of apsidal motion of eclips- ing binaries, is also listed. We also construct rotating models to determine the effect of rotation on stellar structure and derive fitting formulae for luminosity, radius and the second harmonic as a function of rotational parameter. We also compute and list colors and bolometric corrections of models required for transformation between theo- retical and observational results. The results are tested for the Sun, the Hyades cluster, the slowly rotating chemically peculiar Am stars and eclipsing binaries with apsidal motion. The theoretical and observational results along isochrones are in good agree- ment. The grids are also applicable to rotating stars provided that equatorial velocity is given.

关键词： stars: interior -- stars: evolution -- binaries: eclipsing -- stars: chemi-cally peculiar