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MAVS Antagonizes Human Stem Cell Senescence as a Mitochondrial Stabilizer

Research 2024年第2期2023卷 239-257页

作者： cui Wang Kuan Yang Xiaoqian Liu Si Wang Moshi Song juan Carlos Izpisua Belimonte jing Qu Guang-Hui Liu Weiqi zhang CAS Key Laboratory of Genomic and Precision Medicine Beijng Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Sino-Danish College University of Chinese Academy of SciencesBeijing 101408China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Institute for Stem Cell and Regeneration Chinese Academy of Sciences Beijing 100101China Beijing Institute for Stem Cell and Regenerative Medicine Bejing 100101China Advanced Innovation Center for Human Brain Protection National Clinical Research Center for Geriatric DisordersXuanwu Hospital Capital Medical UniversityBeijing 100053China State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Altos Labs Inc.San DiegoCA 94022USA

Mitochondrial dysfunction is a hallmark feature of cellular senescence and organ ***,we asked whether the mitochondrial antiviral signaling protein(MAVS),which is essential for driving antiviral response,also regulates human stem cell *** answer this question,we used CRISPR/Cas9-mediated gene editing and directed differentiation techniques to generate various MAVS-knockout human stem cell *** found that human mesenchymal stem cells(hMSCs)were sensitive to MAVS deficiency,as manifested by accelerated senescence *** uncovered that the role of MAVS in maintaining mitochondrial structural integrity and functional homeostasis depends on its interaction with the guanosine triphosphatase optic atrophy type 1(OPA1).Depletion of MAVS or OPA1 led to the dysfunction of mitochondria and cellular senescence,whereas replenishment of MAVS or OPA1 in MAVS-knockout hMSCs alleviated mitochondrial defects and premature senescence *** together,our data underscore an uncanonical role of MAVS in safeguarding mitochondrial homeostasis and antagonizing human stem cell senescence.

关键词： CRISPR/Cas9 homeostasis Mitochondrial

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Association of DNA methylation/demethylation with the functional outcome of stroke in a hyperinflammatory state

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Neural Regeneration Research 2024年第10期19卷 2229-2239页

作者： Yubo Wang Ling zhang Tianjie Lyu Lu cui Shunying zhao Xuechun Wang Meng Wang Yongjun Wang zixiao Li Vascular Neurology Department of NeurologyBeijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina National Center for Healthcare Quality Management in Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Chinese Institute for Brain Research BeijingChina Research Unit of Artificial Intelligence in Cerebrovascular Disease Chinese Academy of Medical SciencesBeijingChina Beijing Engineering Research Center of Digital Healthcare for Neurological Diseases BeijingChina

Inflammation is closely related to stroke prognosis, and high inflammation status leads to poor functional outcome in stroke. DNA methylation is involved in the pathogenesis and prognosis of stroke. However, the effect of DNA methylation on stroke at high levels of inflammation is unclear. In this study, we constructed a hyperinflammatory cerebral ischemia mouse model and investigated the effect of hypomethylation and hypermethylation on the functional outcome. We constructed a mouse model of transient middle cerebral artery occlusion and treated the mice with lipopolysaccharide to induce a hyperinflammatory state. To investigate the effect of DNA methylation on stroke, we used small molecule inhibitors to restrain the function of key DNA methylation and demethylation enzymes. 2,3,5-Triphenyltetrazolium chloride staining, neurological function scores, neurobehavioral tests, enzyme-linked immunosorbent assay, quantitative reverse transcription PCR and western blot assay were used to evaluate the effects after stroke in mice. We assessed changes in the global methylation status by measuring DNA 5-mc and DNA 5-hmc levels in peripheral blood after the use of the inhibitor. In the group treated with the DNA methylation inhibitor, brain tissue 2,3,5-triphenyltetrazolium chloride staining showed an increase in infarct volume, which was accompanied by a decrease in neurological scores and worsening of neurobehavioral performance. The levels of inflammatory factors interleukin 6 and interleukin-1 beta in ischemic brain tissue and plasma were elevated, indicating increased inflammation. Related inflammatory pathway exploration showed significant overactivation of nuclear factor kappa B. These results suggested that inhibiting DNA methylation led to poor functional outcome in mice with high inflammation following stroke. Further, the effects were reversed by inhibition of DNA demethylation. Our findings suggest that DNA methylation regulates the inflammatory response in stroke

关键词： DNA demethylation DNA methylation DNMT3A functional outcome hyperinflammatory state interleukin neuroinflammation stroke TET2

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Atomistic Investigation of Shock-Induced Amorphization within Micro-shear Bands in Hexagonal Close-Packed Titanium

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Acta Metallurgica Sinica(English Letters) 2024年第9期37卷 1590-1600页

作者： z.C.Meng K.G.Wang T.Ali D.Li C.G.Bai D.S.Xu S.j.Li A.H.Feng G.j.Cao j.H.Yao Q.B.Fan H.Wang R.Yang Institute of Metal Research Chinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China Interdisciplinary Centre for Additive Manufacturing(ICAM) School of Materials and ChemistryUniversity of Shanghai for Science and TechnologyShanghai 200093China School of Materials Science and Engineering Tongji UniversityShanghai 201804China Key Laboratory for Light-Weight Materials Nanjing Tech UniversityNanjing 210009China National Key Laboratory of Science and Technology on Materials Under Shock and Impact School of Materials Science and EngineeringBeijing Institute of TechnologyBeijing 100081China Beijing Institute of Technology Chongqing Innovation Center Chongqing 401135China

The mechanical response of a single crystal titanium sample against(0001)α surface impact was investigated using molecular dynamics ***,non-uniform plastic deformation was observed in the *** high strain rates,amorphization occurred near the edge of the contact region where severe shear strain induced a large number of stacking faults(SFs)and *** contrast,the central part of the contact region underwent less deformation with significantly fewer ***,instead of amorphization by consuming SFs and dislocations,there was a gradual increase in the density of dislocations and SFs during the process of *** local amorphous regions eventually grew into shear bands.

关键词： Shock compression Amorphization Shear band Titanium Molecular dynamics

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Understanding the combustion behavior of electric bicycle batteries and unveiling its relationship with fire extinguishing

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journal of Energy Chemistry 2024年第4期91卷 609-618页

作者： zhanglong Yu Xueling Shen Ran Xu zheng Wang zengming Wan Mingyang Chen Yi cui Yanyan Fang Xiaoli Ma China Automotive Battery Research Institute Co. Ltd.Beijing 101407China China Grinm Group Co. Ltd.Beijing 100088China Ministry of Industry and Information Technology Equipment Industry Development CenterBeijing 100846China Hefei Guoxuan High-tech Power energy Co. Ltd.Hefei 230000AnhuiChina

In this study,a detailed analysis of the combustion behaviors of the lithium iron phosphate(LFP)and lithium manganese oxide(LMO)batteries used in electric bicycles was *** research included quantitative measurements of the combustion duration,flame height,combustion temperature,heat release rate,and total heat *** results indicated that LMO batteries exhibited higher combustion temperatures of 600–700°C,flame heights of 70–75 cm,a significantly higher heat release rate of40.1 k W(12 Ah),and a total heat release of 1.04 Mj(12 Ah)compared to LFP batteries with the same *** on these experimental results,a normalized total heat release(NORTHR)parameter was proposed,demonstrating good universality for batteries with different *** this parameter,quantitative calculations and optimization of the extinguishing agent dosage were conducted for fires involving these two types of batteries,and the method was validated by extinguishing fires for these two types of battery packs with water-based extinguishing fluids.

关键词： Combustion behavior Electric bicycle Lithium-ion battery Fire extinguishing Normalized total heat release

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Glasesterterpenoids A-C:three sesterterpenoids with 7-cyclohexyl-decahydronaphthalene carbon skeleton isolated from the root of Lindera glauca

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Chinese journal of Natural Medicines 2024年第9期22卷 864-868页

作者： HE Shiting zOU Qinghui zHANG Qi LUO Yingming YAN Die HE jingxin LIU Yena cui Hui School of Pharmaceutical Sciences Guangzhou University of Chinese MedicineGuangzhou 510006China State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineSun Yat-Sen University Cancer CenterGuangzhou 510060China

Three novel sesterterpenoids glasesterterpenoids A-C(1-3),featuring an unprecedented 7-cyclohexyldecahydronaphthalene carbon skeleton,were isolated from the root of Lindera glauca(***).Their structures were elucidated by quantum chemical calculations and spectroscopic *** biogenetic pathway for 1-3 is *** the bioassay,glasesterterpenoid C exhibited DNA topoisomerase 1(Top1)inhibitory activity compared with the positive control,*** findings represent the first examples of sesterterpenoids with a 7-cyclohexyldecahydronaphthalene carbon skeleton from the root of ***.

关键词： Sesterterpenoids Lindera glauca

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Phytoene synthases 1 modulates tomato fruit quality through influencing the metabolic flux between carotenoid and flavonoid pathways

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Horticultural Plant journal 2024年第6期10卷 1383-1397页

作者： Cao X. Du R. Xu Y. Wu Y. Ye K. Ma j. Lyu Y. Sun T. zhu X. Liu z. Yin j. zhu G. Huang z. Lyu H. Huang S. zhang j. College of Horticulture Northwest A & F University Shaanxi Yangling 712100 China State Key Laboratory of Vegetable Biobreeding Institute of Vegetables and Flowers Chinese Academy of Agricultural Sciences Beijing 100081 China Shenzhen Branch Guangdong Laboratory of Lingnan Modern Agriculture Genome Analysis Laboratory of the Ministry of Agriculture and Rural Affairs Agricultural Genomics Institute at Shenzhen Chinese Academy of Agricultural Sciences Guangdong Shenzhen 518120 China College of Horticulture Qingdao Agricultural University Shandong Qingdao 266109 China The AGISCAAS-YNNU joint Academy of Potato Sciences Yunnan Normal University Yunnan Kunming 650500 China Institute of Vegetables Shandong Academy of Agricultural Sciences Shandong Province Key Laboratory for Biology of Greenhouse Vegetables Shandong Branch of National Improvement Center for Vegetables Huang-Huai-Hai Region Scientific Observation and Experimental Station of Vegetables Ministry of Agriculture and Rural Affairs Shandong Jinan 250100 China

The deterioration in fruit quality of commercial tomatoes is a major concern of modern tomato breeding. However, the metabolism and genetics of fruit quality are poorly understood. Here, we performed transgenic and molecular biology experiments to reveal that tomato phytoene synthase 1 (SlPSY1) is responsible for the accumulation of an important flavor chemical, 6-methyl-5-hepten-2-one (MHO). To dissect the function of SlPSY1 in regulating fruit quality, we generated and analyzed a dataset encompassing over 2 000 compounds detected by GC–MS and LC-MS/MS along with transcriptomic data. The combined results illustrated that SlPSY1 deficiency imparts novel flavor to yellow tomatoes with 236 volatiles significantly changed and improves fruit firmness, possibly due to accumulation of seven cutins. Further analysis indicated SlPSY1 is essential for carotenoid-derived metabolite biosynthesis by catalyzing prephytoene-PP (PPPP) to 15-cis-phytoene. Notably, we showed that SlPSY1 can influence the metabolic flux between carotenoid and flavonoid pathways, and this metabolic flux was confirmed by silencing SlCHS1. Our study provided insights into the multiple effects of SlPSY1 on tomato fruit metabolome and highlights the potential to produce high-quality fruit by rational design of SlPSY1 expression. © 2023 Chinese Society for Horticultural Science (CSHS) and Institute of Vegetables and Flowers (IVF), Chinese Academy of Agricultural Sciences (CAAS).

关键词： Carotenoid Flavonoid Flavor Metabolome Phytoene synthase 1 Tomato

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蚕丝基生物材料精准和功能性组装的3D打印策略

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Engineering 2024年第3期34卷 92-108页

作者： Xiaoliang cui jun zhang Yan Qian Siqi Chang Benjamin j.Allardyce Rangam Rajkhowa Hui Wang Ke-Qin zhang National Engineering Laboratory for Modern Silk College of Textile and Clothing EngineeringSoochow UniversitySuzhou 215123China Institute for Frontier Materials Deakin UniversityGeelongVIC 3216Australia

In recent years,significant progress has been made in both three-dimensional(3D)printing technologies and the exploration of silk as an ink to produce biocompatible *** with the unlimited design potential of 3D printing,silk can be processed into a broad range of functional materials and devices for various biomedical *** ability of silk to be processed into various materials,including solutions,hydrogels,particles,microspheres,and fibers,makes it an excellent candidate for adaptation to different 3D printing *** review presents a didactic overview of the 3D printing of silk-based materials,major categories of printing techniques,and their prototyping mechanisms and structural *** addition,we provide a roadmap for researchers aiming to incorporate silk printing into their own work by summarizing promising strategies from both technical and material aspects,to relate state-of-the-art silk-based material processing with fast-developing 3D printing ***,our focus is on elucidating the techniques and strategies that advance the development of precise assembly strategies for silk-based *** printing(including high printing resolution,complex structure realization,and printing fidelity)is a prerequisite for the digital design capability of 3D printing technology and would definitely broaden the application era of silk,such as complex biomimetic tissue structures,vasculatures,and transdermal microneedles.

关键词： 3D printing Bioink Bioprinting Silk fibroin

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Sandwich-type composited solid polymer electrolytes to strengthen the interfacial ionic transportation and bulk conductivity for all-solid-state lithium batteries from room temperature to 120℃

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journal of Energy Chemistry 2024年第8期95卷 288-295,I0007页

作者： jiewen Tan zhen Wang jiawu cui zhanhui jia Wensheng Tian Chao Wu Chengxin Peng Chengyong Shu Kang Yang Wei Tang School of Chemical Engineering and Technology Xi'an Jiaotong UniversityXi'an 710049ShaanxiChina Center for Advancing Materials Performance from the Nanoscale(CAMP-Nano) State Key Laboratory for Mechanical Behavior of MaterialsXi'an Jiaotong UniversityXi'an 710049ShaanxiChina State Key Laboratory of Space Power-sources Technology Shanghai Institute of Space Power-SourcesShanghai 200245China School of Materials Science and Engineering University of Shanghai for Science and TechnologyShanghai 200093China Top-Energy Digital Manufacturing Technologies(Xi'an)Co. Ltd.Xi'an 710100ShaanxiChina

The insurmountable charge transfer impedance at the Li metal/solid polymer electrolytes(SPEs)interface at room temperature as well as the ascending risk of short circuits at the operating temperature higher than the melting point,dominantly limits their applications in solid-state batteries(SSBs).Although the inorganic filler such as CeO_(2)nanoparticle content of composite solid polymer electrolytes(CSPEs)can significantly reduce the enormous charge transfer impedance at the Li metal/SPEs interface,we found that the required content of CeO_(2)nanoparticles in SPEs varies for achieving a decent interfacial charge transfer impedance and the bulk ionic conductivity in *** this regard,a sandwich-type composited solid polymer electrolyte with a 10%CeO_(2)CSPEs interlayer sandwiched between two 50%CeO_(2)CSPEs thin layers(sandwiched CSPEs)is constructed to simultaneously achieve low charge transfer impedance and superior ionic conductivity at 30℃.The sandwiched CSPEs allow for stable cycling of Li plating and stripping for 1000 h with 129 mV polarized voltage at 0.1 mA cm^(-2)and 30℃.In addition,the LiFePO_(4)/Sandwiched CSPEs/Li cell also exhibits exceptional cycle performance at 30℃and even elevated120℃without short *** multi-layered CSPEs with optimized contents of the inorganic fillers can be an efficient method for developing all solid-state PEO-based batteries with high performance at a wide range of temperatures.

关键词： PEO-based solid electrolytes CeO_(2)nanoparticles Charge transfer impedance Sandwich-type composite electrolytes All-solid-state Li metal batteries

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Decoding the inconsistency of six cropland maps in China

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The Crop journal 2024年第1期12卷 281-294页

作者： Yifeng cui Ronggao Liu zhichao Li Chao zhang Xiao-Peng Song jilin Yang Le Yu Mengxi Chen jinwei Dong Institute of Geographic Sciences and Natural Resources Research Chinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Department of Geographical Sciences University of MarylandCollege ParkMD 20740USA College of Grassland Science and Technology China Agricultural UniversityBeijing 100193China Ministry of Education Ecological Field Station for East Asian Migratory Birds Department of Earth System ScienceInstitute for Global Change StudiesTsinghua UniversityBeijing 100084China Ministry of Education Ecological Field Station for East Asian Migratory Birds Beijing 100084China Tsinghua University(Department of Earth System Science)-Xi’an Institute of Surveying and Mapping joint Research Center for Next-Generation Smart Mapping Beijing 100084China Institute of Remote Sensing and Geographic Information System Peking UniversityBeijing 100871China Department of Forest and Conservation Sciences University of British ColumbiaVancouverBCV6T 1Z4Canada

Accurate cropland information is critical for agricultural planning and production,especially in foodstressed countries like *** widely used medium-to-high-resolution satellite-based cropland maps have been developed from various remotely sensed data sources over the past few decades,considerable discrepancies exist among these products both in total area and in spatial distribution of croplands,impeding further applications of these *** factors influencing their inconsistency are also *** this study,we evaluated the consistency and accuracy of six cropland maps widely used in China in circa 2020,including three state-of-the-art 10-m products(i.e.,Google Dynamic World,ESRI Land Cover,and ESA WorldCover)and three 30-m ones(i.e.,GLC_FCS30,GlobeLand 30,and CLCD).We also investigated the effects of landscape fragmentation,climate,and agricultural *** using a ground-truth sample revealed that the 10-m-resolution WorldCover provided the highest accuracy(92.3%).These maps collectively overestimated Chinese cropland area by up to 56%.Up to 37%of the land showed spatial inconsistency among the maps,concentrated mainly in mountainous regions and attributed to the varying accuracy of cropland maps,cropland fragmentation and management practices such as *** work shed light on the promotion of future cropland mapping efforts,especially in highly inconsistent regions.

关键词： Consistency and accuracy 10-and 30 m Cropland mapping Agricultural management China

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Substitution of Pb with (Li_(1/2)Bi_(1/2)) in PbzrO_(3)-based antiferroelectric ceramics

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journal of Advanced Dielectrics 2024年第1期14卷 74-81页

作者： Binzhi Liu Anand P.S.Gaur jun cui Xiaoli Tan Department of Materials Science and Engineering Iowa State University AmesIA 50011USA

PbzrO_(3)-based antiferroelectric(AFE)ceramics are promising dielectrics for high-energy-density capacitors due to their reversible phase transitions during charge-discharge *** this work,a new composition series,[Pb_(0.93-x)La_(0.02)(Li_(1/2)Bi_(1/2))_(x)Sr_(0.04)][zr_(0.57)Sn_(0.34)Ti_(0.09)]O_(3),with Li^(+)and Bi^(3+)substitution of Pb^(2+)at x=0,0.04,0.08,0.12,0.16 is investigated for the microstructure evolution,ferroelectric(FE)and dielectric *** is found that Li^(+) and Bi^(3+) substitution can significantly reduce the sintering temperature and simultaneously enhance the dielectric breakdown *** ultrahigh energy efficiency(94.0%)and a large energy density(3.22 j/cm^(3))are achieved in the composition of x=0.12 with a low sintering temperature(1075℃).

关键词： PbzrO_(3)-based antiferroelectrics LiþBi substitution energy storage energy efficiency

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