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Amplitude analysis of the decays D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)

Chinese Physics C 2024年第8期48卷 6-33页

作者： M.Ablikim M.N.Achasov P.Adlarson O.Afedulidis X.C.Ai R.Aliberti A.Amoroso Q.An Y.Bai O.Bakina I.Balossino Y.Ban h.-R.Bao V.Batozskaya K.Begzsuren N.Berger M.Berlowski M.Bertani D.Bettoni F.Bianchi E.Bianco A.Bortone I.Boyko R.A.Briere A.Brueggemann h.Cai X.Cai A.Calcaterra G.F.Cao N.Cao S.A.Cetin J.F.Chang w.L.Chang G.R.Che G.Chelkov C.Chen C.h.Chen Chao Chen G.Chen h.S.Chen M.L.Chen S.J.Chen S.L.Chen S.M.Chen T.Chen X.R.Chen X.T.Chen Y.B.Chen Y.Q.Chen z.J.Chen z.Y.Chen S.K.Choi X.Chu G.Cibinetto F.Cossio J.J.Cui h.L.Dai J.P.Dai A.Dbeyssi R.E.de Boer D.Dedovich C.Q.Deng z.Y.Deng A.Denig I.Denysenko M.Destefanis F.De Mori B.Fang S.S.Fang w.X.Fang Y.Fang Y.Q.Fang R.Farinelli L.Fava F.Feldbauer G.Felici C.Q.Feng J.h.Feng Y.T.Feng K.Fischer M.Fritsch C.D.Fu J.L.Fu Y.w.Fu h.Gao Y.N.Gao Yang Gao S.Garbolino I.Garzia P.T.Ge z.w.Ge C.Geng E.M.Gersabeck B.Ding X.X.Ding Y.Ding Y.Ding J.Dong L.Y.Dong M.Y.Dong X.Dong M.C.Du S.X.Du z.h.Duan P.Egorov Y.h.Fan J.Fang JA.Gilman K.Goetzen L.Gong w.X.Gong w.Gradl S.Gramigna M.Greco M.h.Gu Y.T.Gu C.Y.Guan z.L.Guan A.Q.Guo L.B.Guo M.J.Guo R.P.Guo Y.P.Guo A.Guskov J.Gutierrez K.L.han T.T.han X.Q.hao F.A.harris K.K.he K.L.he F.h.heinsius C.h.heinz Y.K.heng C.herold T.holtmann P.C.hong G.Y.hou X.T.hou Y.R.hou z.L.hou B.Y.hu h.M.hu J.F.hu T.hu Y.hu G.S.huang K.X.huang L.Q.huang X.T.huang Y.P.huang T.hussain F.h\"olzken N.h\"usken N.in der wiesche M.Irshad J.Jackson S.Janchiv J.h.Jeong Q.Ji Q.P.Ji w.Ji X.B.Ji X.L.Ji Y.Y.Ji X.Q.Jia z.K.Jia D.Jiang h.B.Jiang P.C.Jiang S.S.Jiang T.J.Jiang X.S.Jiang Y.Jiang J.B.Jiao J.K.Jiao z.Jiao S.Jin Y.Jin M.Q.Jing X.M.Jing T.Johansson S.Kabana N.Kalantar-Nayestanaki X.L.Kang X.S.Kang M.Kavatsyuk B.C.Ke V.Khachatryan A.Khoukaz R.Kiuchi O.B.Kolcu B.Kopf M.Kuessner X.Kui A.Kupsc w.K\"uhn J.J.Lane P.Larin L.Lavezzi T.T.Lei z.h.Lei h.Leithoff M.Lellmann T.Lenz C.Li C.Li C.h.Li Cheng Li D.M.Li F.Li G.Li h.Li h.B.Li h.J.Li h.N.Li hui Li J.R.Li J.S.Li K.Li L.J.Li L.K.Li Lei Li M.h.Li P.R.Li Q.M.Li Q.X.Li R.Li S.X.Li T.Li w.D.Li w.G.Li X.Li X.h.Li X.L.Li X.Y.Li Y Institute of high Energy Physics Chinese Academy of SciencesBeijing 100049China Beihang University Beijing 100191China Bochum Ruhr-University D-44780 BochumGermany Budker Institute of Nuclear Physics SB RAS(BINP) Novosibirsk 630090Russia Carnegie Mellon University PittsburghPennsylvania 15213USA Central China Normal University Wuhan 430079China Central South University Changsha 410083China China Center of Advanced Science and Technology Beijing 100190China China University of Geosciences Wuhan 430074China Chung-Ang University Seoul06974Republic of Korea COMSATS University Islamabad Lahore CampusDefence RoadOff Raiwind Road54000 LahorePakistan Fudan University Shanghai 200433China GSI helmholtzcentre for heavy Ion Research Gmbh D-64291 DarmstadtGermany Guangxi Normal University Guilin 541004China Guangxi University Nanning 530004China hangzhou Normal University Hangzhou 310036China hebei University Baoding 071002China helmholtz Institute Mainz Staudinger Weg 18D-55099 MainzGermany henan Normal University Xinxiang 453007China henan University Kaifeng 475004China henan University of Science and Technology Luoyang 471003China henan University of Technology Zhengzhou 450001China huangshan College Huangshan 245000China hunan Normal University Changsha 410081China hunan University Changsha 410082China Indian Institute of Technology Madras Chennai 600036India Indiana University BloomingtonIndiana 47405USA INFN Laboratori Nazionali di Frascati INFN Laboratori Nazionali di FrascatiI-00044FrascatiItaly INFN Laboratori Nazionali di Frascati INFN Sezione di PerugiaI-06100PerugiaItaly INFN Laboratori Nazionali di Frascati University of PerugiaI-06100PerugiaItaly INFN Sezione di Ferrara INFN Sezione di FerraraI-44122FerraraItaly INFN Sezione di Ferrara University of FerraraI-44122FerraraItaly Inner Mongolia University Hohhot 010021China Institute of Modern Physics Lanzhou 730000China Institute of Physics and Technology Peace Avenue 54BUlaanbaatar 13330Mongolia Instituto de A

Using e^(+)e^(−)annihilation data corresponding to an integrated luminosity of 2.93 fb^(−1)taken at the center-of-mass energy√s=3.773 GeV with the BESIII detector,a joint amplitude analysis is performed on the decays D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)(non-η).The fit fractions of individual components are obtained,and large interferences among the dominant components of the decays D^(0)→a_(1)(1260)π,D^(0)→π(1300)π,D^(0)→ρ(770)ρ(770),and D^(0)→2(ππ)_(S)are observed in both *** the obtained amplitude model,the CP-even fractions of D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)(non-η)are determined to be(75.2±1.1_(stat).±1.5_(syst.))%and(68.9±1.5_(stat).±2.4_(syst.))%,*** branching fractions of D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)(non-η)are measured to be(0.688±0.010_(stat.)±0.010_(syst.))%and(0.951±0.025_(stat.)±0.021_(syst.))%,*** amplitude analysis provides an important model for the binning strategy in measuring the strong phase parameters of D^(0)→4πwhen used to determine the CKM angleγ(ϕ_(3))via the B^(−)→DK^(−)decay.

关键词： BESIII D^(0)meson decays amplitude analysis CP-even fraction

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The Lambert-G Family:Properties,Inference,and Applications

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Computer Modeling in Engineering & Sciences 2024年第7期140卷 513-536页

作者： Jamal N.Al Abbasi Ahmed z.Afify Badr Alnssyan Mustafa S.Shama Accounting Department Ashur UniversityBaghdad10011Iraq Department of Statistics Mathematics and InsuranceBenha UniversityBenha13511Egypt Department of Management Information Systems and Production Management College of Business and EconomicsQassim UniversityBuraydah51452Saudi Arabia Department of Basic Sciences Common First Year(CFY)King Saud UniversityRiyadh11362Saudi Arabia Department of Mathematics and Statistics Osim Higher Institute of Administrative ScienceOsim12961Egypt

This study proposes a new flexible family of distributions called the Lambert-G *** Lambert family is very flexible and exhibits desirable *** three-parameter special sub-models provide all significantmonotonic and non-monotonic failure rates.A special sub-model of the Lambert family called the Lambert-Lomax(LL)distribution is *** expressions for the LL statistical properties are *** of the LL distribution are addressed mathematically based on its hazard *** estimation of the LL parameters is discussed using six estimation *** performance of this estimation method is explored through simulation *** usefulness and flexibility of the LL distribution are demonstrated empirically using two real-life data *** LL model better fits the exponentiated Lomax,inverse power Lomax,Lomax-Rayleigh,power Lomax,and Lomax distributions.

关键词： Lambert function Lomax distribution maximum likelihood hazard function statistical model simulation

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Rational molecular design of efficient yellow-red dendrimer TADF for solution-processed OLEDs: a combined effect of substitution position and strength of the donors

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Science China Chemistry 2024年第5期67卷 1613-1623页

作者： Changfeng Si Dianming Sun Tomas Matulaitis David B.Cordes Alexandra M.z.Slawin Eli zysman-Colman Organic Semiconductor Centre EaStCHEM School of ChemistryUniversity of St AndrewsSt AndrewsKY169STUK

The development of high-performance solution-processed red organic light-emitting diodes(OLEDs) remains a challenge,particularly in terms of maintaining efficiency at high luminance. here, we designed and synthesized four novel orange-red thermally activated delayed fluorescence(TADF) dendrimers that are solution-processable: 2GCz BP, 2DPACz BP, 2FBP2GCz and 2FBP2DPACz. we systematically investigated the effect of substitution position and strength of donors on the optoelectronic properties. The reverse intersystem crossing rate constant(kRISC) of the emitters having donors substituted at positions 11and 12 of the dibenzo[a,c]phenazine(BP) is more than 10-times faster than that of compounds substituted having donors substituted at positions 3 and 6. Compound 2DPACz BP, containing stronger donors than 2GCz BP, exhibits a red-shifted emission and smaller singlet-triplet energy splitting, ΔE_(ST), of 0.01 e V. The solution-processed OLED with 10 wt% 2DPACz BP doped in m CP emitted at 640 nm and showed a maximum external quantum efficiency(EQE_(max)) of 7.8%, which was effectively maintained out to a luminance of 1,000 cd m-2. Such a device's performance at relevant display luminance is among the highest for solution-processed red TADF OLEDs. The efficiency of the devices was improved significantly by using 4Cz IPN as an assistant dopant in a hyperfluorescence(hF) configuration, where the 2DPACz BP hF device shows an EQEmaxof 20.0% at λEL of 605 nm and remains high at 11.8% at a luminance of 1,000 cd m-2, which makes this device one of the highest efficiency orange-to-red hF SP-OLEDs to date.

关键词： thermally activated delayed fluorescence solution-processing red OLEDs dibenzo[a,c]phenazine dendrimers

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Electromagnetic Performance Analysis of Variable Flux Memory Machines with Series-magnetic-circuit and Different Rotor Topologies

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CES Transactions on Electrical Machines and Systems 2024年第1期8卷 3-11页

作者： Qiang wei z.Q.zhu Yan Jia Jianghua Feng Shuying Guo Yifeng Li Shouzhi Feng Department of Electronic and Electrical Engineering The University of SheffieldSheffield S13JDU.K. IEEE the CRRC zhuzhou Institute Company Ltd. Zhuzhou 412001China

In this paper,the electromagnetic performance of variable flux memory(VFM)machines with series-magnetic-circuit is investigated and compared for different rotor *** on a V-type VFM machine,five topologies with different interior permanent magnet(IPM)arrangements are evolved and optimized under same *** on two-dimensional(2-D)finite element(FE)method,their electromagnetic performance at magnetization and demagnetization states is *** reveals that the iron bridge and rotor lamination region between constant PM(CPM)and variable PM(VPM)play an important role in torque density and flux regulation(FR)***,the global efficiency can be improved in VFM machines by adjusting magnetization state(MS)under different operating conditions.

关键词： Memory machine Permanent magnet Rotor topologies Series magnetic circuit Variable flux

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Communication-less Management Strategy for Electric Vehicle Charging in Droop-controlled Islanded Microgrids

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Journal of Modern Power Systems and Clean Energy 2024年第4期12卷 1227-1238页

作者： Abdullah Azhar Al-Obaidi Mohammed zaki El-Sharafy hany E.z.Farag Saifullah Shafiq Ali Al-Awami Independent Electricity System Operator(IESO) MississaugaCanada Department of Electrical Engineering and Computer Science York UniversityTorontoCanada University of Queensland StLucia QLD 4067Australia Department of Electrical Engineering King Fahd University of Petroleum&MineralsDhahranSaudi Arabia

Adopting high penetration levels of electric vehicles(EVs)necessitates the implementation of appropriate charging management systems to mitigate their negative impacts on pow-er distribution ***,most of the proposed Ev charging management techniques rely on the availability of high-bandwidth communication *** techniques are far from realization due to①the lack of utility-grade communica-tion systems in many cases such as secondary(low-voltage)pow-er distribution systems to which EVs are connected,rural ar-eas,remote communities,and islands,and②existing fears and concerns about the data privacy of EV users and cyber-physical *** these cases,appropriate local control schemes are needed to ensure the adequate management of EV charging without violating the grid operation ***,this paper introduces a new communication-less management strategy for EV charging in droop-controlled islanded *** proposed strategy is autonomous,as it is based on the measurement of system frequency and local bus *** proposed strategy implements a social charging fairness policy during periods when the microgrid distributed genera-tors(DGs)are in short supply by allocating more system capaci-ty to the EVs with less charging in the ***,a novel communication-less EV load shedding scheme is incorpo-rated into the management strategy to provide relief to the mi-crogrid during events of severe undervoltage or underfrequency occurrences due to factors such as high loading or DG *** simulations demonstrate the superiority of the pro-posed strategy over the state-of-the-art controllers in modulat-ing the EV charging demand to counteract microgrid instability.

关键词： Charging battery management communication-less control droop control electric vehicle islanded microgrid

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Distinct Electrical and Mechanical Responses of a Cu-10Fe Composite Prepared by hot-Pressed Sintering and Post Treatment

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Acta Metallurgica Sinica(English Letters) 2024年第2期37卷 255-265页

作者： X.Y.Yue S.Y.Peng X.zhang C.N.he Y.z.Tian Key Laboratory for Anisotropy and Texture of Materials(Ministry of Education) School of Materials Science and EngineeringNortheastern UniversityShenyang110819China School of Materials Science and Engineering and Tianjin Key Laboratory of Composite and Functional Materials Tianjin UniversityTianjin300350China Research Centre for Metallic wires Northeastern UniversityShenyang110819China

A Cu-10wt%Fe composite was prepared through hot-pressed sintering,and the material was subsequently solution *** hot-pressed sintered and solution treated materials were rolled and *** precipitation behavior and performance changes were systematically studied by using scanning electron microscopy and transmission electron *** contrast to the hot-pressed sintered specimen,the solution treatment significantly affects the thermal stability and properties of the Cu-10wt%Fe *** Cu-10wt%Fe composite was prepared after solid solution,cold rolling and aging at 773 K for 1 h,and it obtained excellent tensile strength of 494 MPa,uniform elongation of 16.3%,electrical conductivity of 51.1%IACS and softening temperature of 838 *** for the distinct difference in thermal stability and properties between hot-pressed sintered and solution treated specimens were *** findings provide a theoretical basis for designing high-performance Cu-based in-situ composites by post treatment.

关键词： Cu-Fe composite hot-pressed sintering Thermal stability Strength Electrical conductivity

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Evidence for particle acceleration approaching PeV energies in the w51 complex

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Science Bulletin 2024年第18期69卷 2833-2841页

作者： LhAASO Collaboration zhen Cao F.Aharonian Axikegu Y.X.Bai Y.w.Bao D.Bastieri X.J.Bi Y.J.Bi w.Bian A.V.Bukevich Q.Cao w.Y.Cao zhe Cao J.Chang J.F.Chang A.M.Chen E.S.Chen h.X.Chen Liang Chen Lin Chen Long Chen M.J.Chen M.L.Chen Q.h.Chen S.Chen S.h.Chen S.z.Chen T.L.Chen Y.Chen N.Cheng Y.D.Cheng M.Y.Cui S.w.Cui X.h.Cui Y.D.Cui B.z.Dai h.L.Dai z.G.Dai Danzengluobu X.Q.Dong K.K.Duan J.h.Fan Y.z.Fan J.Fang J.h.Fang K.Fang C.F.Feng h.Feng L.Feng S.h.Feng X.T.Feng Y.Feng Y.L.Feng S.Gabici B.Gao C.D.Gao Q.Gao w.Gao w.K.Gao M.M.Ge L.S.Geng G.Giacinti G.h.Gong Q.B.Gou M.h.Gu F.L.Guo X.L.Guo Y.Q.Guo Y.Y.Guo Y.A.han M.hasan h.h.he h.N.he J.Y.he Y.he Y.K.hor B.w.hou C.hou X.hou h.B.hu Q.hu S.C.hu D.h.huang T.Q.huang w.J.huang X.T.huang X.Y.huang Y.huang X.L.Ji h.Y.Jia K.Jia K.Jiang X.w.Jiang z.J.Jiang M.Jin M.M.Kang I.Karpikov D.Kuleshov K.Kurinov B.B.Li C.M.Li Cheng Li Cong Li D.Li F.Li h.B.Li h.C.Li Jian Li Jie Li K.Li S.D.Li w.L.Li w.L.Li X.R.Li Xin Li Y.z.Li zhe Li zhuo Li E.w.Liang Y.F.Liang S.J.Lin B.Liu C.Liu D.Liu D.B.Liu h.Liu h.D.Liu J.Liu J.L.Liu M.Y.Liu R.Y.Liu S.M.Liu w.Liu Y.Liu Y.N.Liu Q.Luo Y.Luo h.K.Lv B.Q.Ma L.L.Ma X.h.Ma J.R.Mao z.Min w.Mitthumsiri h.J.Mu Y.C.Nan A.Neronov L.J.Ou P.Pattarakijwanich z.Y.Pei J.C.Qi M.Y.Qi B.Q.Qiao J.J.Qin A.Raza D.Ruffolo A.Sáiz M.Saeed D.Semikoz L.Shao O.Shchegolev X.D.Sheng F.w.Shu h.C.Song Yu.V.Stenkin V.Stepanov Y.Su D.X.Sun Q.N.Sun X.N.Sun z.B.Sun J.Takata P.h.T.Tam Q.w.Tang R.Tang z.B.Tang w.w.Tian C.wang C.B.wang G.w.wang h.G.wang h.h.wang J.C.wang Kai wang Kai wang L.P.wang L.Y.wang P.h.wang R.wang w.wang X.G.wang X.Y.wang Y.wang Y.D.wang Y.J.wang z.h.w.ng z.X.wang zhen wang zheng wang D.M.wei J.J.wei Y.J.wei T.wen C.Y.wu h.R.wu Q.w.wu S.wu X.F.wu Y.S.wu S.Q.Xi J.Xia G.M.Xiang D.X.Xiao G.Xiao Y.L.Xin Y.Xing D.R.Xiong z.Xiong D.L.Xu R.F.Xu R.X.Xu w.L.Xu L.Xue D.h.Yan J.z.Yan T.Yan C.w.Yang C.Y.Yang F.Yang F.F.Yang L.L.Yang M.J.Yang R.z.Yang w.X.Yang Y.h.Yao z.G.Yao L.Q.Yin N.Yin X.h.You z.Y.You Y.h.Yu Q.Yuan h.Yue h.D.zeng T.X.zeng w.zeng M.zha B.B.zhang F.zhang h.zhang 不详 Key Laboratory of Particle Astrophysics&Experimental Physics Division&Computing Center Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China TIANFU Cosmic Ray Research Center ChengduChina Dublin Institute for Advanced Studies 31 Fitzwilliam Place2 DublinIreland Max-Planck-Institut for Nuclear Physics P.O.Box 103980Heidelberg 69029Germany School of Physical Science and Technology&School of Information Science and Technology Southwest Jiaotong UniversityChengdu 610031China School of Astronomy and Space Science Nanjing UniversityNanjing 210023China Center for Astrophysics Guangzhou UniversityGuangzhou 510006China Tsung-Dao Lee Institute&School of Physics and Astronomy Shanghai Jiao Tong UniversityShanghai 200240China Institute for Nuclear Research of Russian Academy of Sciences Moscow 117312Russia hebei Normal University Shijiazhuang 050024China University of Science and Technology of China Hefei 230026China State Key Laboratory of Particle Detection and Electronics China Key Laboratory of Dark Matter and Space Astronomy&Key Laboratory of Radio Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210023China Research Center for Astronomical Computing Zhejiang LaboratoryHangzhou 311121China Key Laboratory for Research in Galaxies and Cosmology Shanghai Astronomical ObservatoryChinese Academy of SciencesShanghai 200030China School of Physics and Astronomy Yunnan UniversityKunming 650091China Key Laboratory of Cosmic Rays(Tibet University) Ministry of EducationLhasa 850000China National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China School of Physics and Astronomy(zhuhai)&School of Physics(Guangzhou)&Sino-French Institute of Nuclear Engineering and Technology(zhuhai) Sun Yat-sen UniversityZhuhai 519000&Guangzhou 510275GuangdongChina Institute of Frontier and Interdisciplinary Science Shandong UniversityQingdao 266237China APC UniversitéParis Cité

Theγ-ray emission from the w51 complex is widely acknowledged to be attributed to the interaction between the cosmic rays(CRs)accelerated by the shock of supernova remnant(SNR)w51C and the dense molecular clouds in the adjacent star-forming region,***,the maximum acceleration capability of w51C for CRs remains *** on observations conducted with the Large high Altitude Air Shower Observatory(LhAASO),we report a significant detection ofγrays emanating from the w51 complex,with energies from 2 to 200 *** LhAASO measurements,for the first time,extend theγ-ray emission from the w51 complex beyond 100 TeV and reveal a significant spectrum bending at tens of *** combining the"π^(0)-decay bump"featured data from Fermi-LAT,the broadbandγ-ray spectrum of the w51 region can be well-characterized by a simple pp-collision *** observed spectral bending feature suggests an exponential cutoff at~400 TeV or a power-law break at~200 TeV in the CR proton spectrum,most likely providing the first evidence of SNRs serving as CR accelerators approaching the PeV ***,two young star clusters within w51B could also be theoretically viable to produce the most energeticγrays observed by *** findings strongly support the presence of extreme CR accelerators within the w51 complex and provide new insights into the origin of Galactic CRs.

关键词： UhE c-ray Cosmic rays SNR w51C Star clusters

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由超拍电子伏特加速器产生的超高能伽马射线气泡

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Science Bulletin 2024年第4期69卷 449-457页

作者： LhAASO Collaboration zhen Cao Chuandong Gao Cong Li Ruo-Yu Liu Ruizhi Yang 不详 Key Laboratory of Particle Astrophyics&Experimental Physics Division&Computing Center Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China TIANFU Cosmic Ray Research Center ChengduChina Institute of Frontier and Interdisciplinary Science Shandong UniversityQingdao 266237China School of Astronomy and Space Science Nanjing UniversityNanjing 210023China University of Science and Technology of China Hefei 230026China

we report the detection of aγ-ray bubble spanning at least 100deg2 in ultra-high energy(UhE)up to a few PeV in the direction of the star-forming region Cygnus X,implying the presence super PeVatron(s)accelerating protons to at least 10 PeV.A log-parabola form with the photon indexΓ(E)=(2.71±0.02)+(0.11±0.02)×log10(E/10 TeV)is found fitting the gamma-ray energy spectrum of the bubble *** sources,“hot spots”correlated with very massive molecular clouds,and a quasi-spherical amorphousγ-ray emitter with a sharp central brightening are observed in the *** the core of~0.5°,spatially associating with a region containing massive OB association(Cygnus OB2)and a microquasar(Cygnus X-3),as well as previously reported multi-TeV sources,an enhanced concentration of UhEγ-rays is observed with 2 photons at energies above 1 *** general feature of the bubble,the morphology,and the energy spectrum,are reasonably reproduced by the assumption of a particle accelerator in the core,continuously injecting protons into the ambient medium.

关键词： Cosmic rays γ-rays Interstellar medium Star cluster

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Targeting epigenetic mechanisms in amyloid-β-mediated Alzheimer’s pathophysiology:unveiling therapeutic potential

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Neural Regeneration Research 2025年第1期20卷 54-66页

作者： Jennie z.Li Nagendran Ramalingam Shaomin Li Ann Romney Center for Neurologic Diseases Brigham and Women’s Hospital and Harvard Medical SchoolBostonMAUSA

Alzheimer’s disease is a prominent chronic neurodegenerative condition characterized by a gradual decline in memory leading to *** evidence suggests that Alzheimer’s disease is associated with accumulating various amyloid-βoligomers in the brain,influenced by complex genetic and environmental *** memory and cognitive deficits observed during the prodromal and mild cognitive impairment phases of Alzheimer’s disease are believed to primarily result from synaptic *** life,environmental factors can lead to enduring changes in gene expression and the emergence of brain *** changes,known as epigenetic modifications,also play a crucial role in regulating the formation of synapses and their adaptability in response to neuronal *** this context,we highlight recent advances in understanding the roles played by key components of the epigenetic machinery,specifically DNA methylation,histone modification,and microRNAs,in the development of Alzheimer’s disease,synaptic function,and activity-dependent synaptic ***,we explore various strategies,including enriched environments,exposure to non-invasive brain stimulation,and the use of pharmacological agents,aimed at improving synaptic function and enhancing long-term potentiation,a process integral to epigenetic ***,we deliberate on the development of effective epigenetic agents and safe therapeutic approaches for managing Alzheimer’s *** suggest that addressing Alzheimer’s disease may require distinct tailored epigenetic drugs targeting different disease stages or pathways rather than relying on a single drug.

关键词： Alzheimer’s disease DNA methylation enriched environments histone modification microRNAs non-invasive brain stimulation synaptic plasticity

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Numerical Study of Flow Features Around Submerged Circular and Square Piles at Flat and Scoured Beds Using OpenFOAM

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Journal of Ocean University of China 2024年第4期23卷 897-914页

作者： wAng Chaolin wU Guoxiang wAng Dianhe DU Shengtao zhAng zhiyong JIN heng zhU David z. LIAng Bingchen Donghai Academy School of Civil&Environmental Engineering and Geography ScienceNingbo UniversityNingbo 315211China Key Laboratory of Estuary and Coast of zhejiang Province and Zhejiang Institute of Hydraulics and EstuaryHangzhou 310020China Shandong Provincial Key Laboratory of Ocean Engineering and College of EngineeringOcean University of ChinaQingdao 266100China Shandong water Conservancy Vocational College Rizhao 276826China School of Mechanical and Energy Engineering Ningbotech UniversityNingbo 315211China

Elucidating the flow features around piles in local scouring processes is crucial for studies of local scouring mechanisms and scour depth *** study details the flow turbulence characteristics of two submerged piles that are determined by solving the Navier-Stokes equations with the improved delayed detached eddy simulation *** model is verified by comparing experimental and numerical results for hydrodynamic parameters with the literature for both square-crossing piles(SCPs)and circular-crossing piles(CCPs).Original topographies of flat and scoured beds(i.e.,the initial and equilibrium scouring stages)are based on experimental results obtained by the authors in the present *** and CCP flow features in the scouring process are *** results indicate that during the scouring process,the time-averaged drag coefficient and root mean square(rms)of the lift coefficient increase linearly in the CCP test,while the rms of the lift coefficient in the SCP test decreases ***,the minimum pressure coefficient is always located in the upstream corners in the SCP case but moves from 72.5°to 79.5°when the scour hole is completely developed in the CCP *** flow behind the pile,which is generated by separated boundary layers above the top face of the pile,can reach the sand bed and turn the separated shear layers into patches of small vortices in the near-wake ***,the high shear stress zones are mainly at the scour edges under scoured-bed conditions.

关键词： flat bed scoured bed local scour OpenFOAM bed shear stress

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