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Damage analysis caused by ^(60)Co ions in functionally graded materials

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Defence Technology(防务技术) 2025年第2期44卷 248-256页

作者： zübeyde Özkan Ugur Gökmen Sema Bilge Ocak Department of Advanced Technologies Graduate School of Natural and Applied SciencesGazi UniversityAnkara06560Turkiye Department of Metallurgical and Materials Engineering Faculty of TechnologyGazi UniversityAnkara 06560Turkiye Basic and Engineering Sciences Central Laboratory Application and Research Center Gazi UniversityAnkara 06560Turkiye

Functionally graded composite/hybrid materials(FGCM/FGHCM)were produced by adding B_(4)C,TiO_(2),and B_(4)C+TiO_(2)ceramic materials at various ratios(0-50%)into the AA6082 *** analysis of the damage caused by^(60) ions'(1.173-1.1332 MeV)on the material was examined using the SRIM/TRIM Monte Carlo simulation *** the simulation,the following data regarding the atoms of the target materials were obtained:ion distribution,target ionization,total displacements,surface binding energy,lattice binding energy,and displacement *** the studied four materials,the one with the highest ion range value was found to be AA6082 with ***_(2)was found to be the reinforcement material that reduced the ion range the most in the *** to its high binding energy,B_(4)C reinforced AA6082+(0-50%)B_(4)C FGCM was found to have the least vacancy with 4782/ion.

关键词： SRIM/TRIM Damage analysis AA6082 ^(60)Co ion

Targeting epigenetic mechanisms in amyloid-β-mediated Alzheimer’s pathophysiology:unveiling therapeutic potential

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Neural Regeneration Research 2025年第1期20卷 54-66页

作者： Jennie z.Li Nagendran Ramalingam Shaomin Li Ann Romney Center for Neurologic Diseases Brigham and Women’s Hospital and Harvard Medical SchoolBostonMAUSA

Alzheimer’s disease is a prominent chronic neurodegenerative condition characterized by a gradual decline in memory leading to *** evidence suggests that Alzheimer’s disease is associated with accumulating various amyloid-βoligomers in the brain,influenced by complex genetic and environmental *** memory and cognitive deficits observed during the prodromal and mild cognitive impairment phases of Alzheimer’s disease are believed to primarily result from synaptic *** life,environmental factors can lead to enduring changes in gene expression and the emergence of brain *** changes,known as epigenetic modifications,also play a crucial role in regulating the formation of synapses and their adaptability in response to neuronal *** this context,we highlight recent advances in understanding the roles played by key components of the epigenetic machinery,specifically DNA methylation,histone modification,and microRNAs,in the development of Alzheimer’s disease,synaptic function,and activity-dependent synaptic ***,we explore various strategies,including enriched environments,exposure to non-invasive brain stimulation,and the use of pharmacological agents,aimed at improving synaptic function and enhancing long-term potentiation,a process integral to epigenetic ***,we deliberate on the development of effective epigenetic agents and safe therapeutic approaches for managing Alzheimer’s *** suggest that addressing Alzheimer’s disease may require distinct tailored epigenetic drugs targeting different disease stages or pathways rather than relying on a single drug.

关键词： Alzheimer’s disease DNA methylation enriched environments histone modification microRNAs non-invasive brain stimulation synaptic plasticity

Transport mechanism in chemically reactive hybrid nanofluid flow containing gyrotactic micro-organisms over a curved oscillatory surface

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 177-192页

作者： M.NAVEED M.IMRAN T.ASGHAR z.ABBAS Department of Mathematics Division of Science and TechnologyUniversity of Education Department of Mathematics The Islamia University of Bahawalpur

This paper examines the transport analysis, including both heat transfer and mass transfer, in hybrid nanofluid flow containing gyrotactic microorganisms towards a curved oscillatory surface. The influence of magnetic fields is also inspected in terms of their physical characteristics. To depict the phenomena of transport, modified versions of both Fick's and Fourier's laws are used. Additionally, the characteristics of both heterogeneous and homogeneous chemical reactions are also incorporated. Utilizing a curvilinear coordinate system, the flow problem is formulated as partial differential equations(PDEs)for momentum, concentration, microorganism field, and energy. An analytical solution to the obtained flow equations is achieved utilizing the homotopy analysis method(HAM).The effects of significant flow parameters on the pressure and microorganism fields, velocity, oscillation velocity, concentration, and temperature distributions are shown via graphs. Furthermore, the variations in skin friction, mass transfer rate, heat transfer rate, and local motile number due to different involved parameters are presented in tables and are analyzed in detail. Graphical results indicate that the curves of velocity and temperature fields are enhanced as the values of the solid volume fraction variables *** is also verified that the concentration rate field decreases as the values of the homogeneous reaction strength parameter and the radius of curvature parameter increase, and it increases with the Schmidt number and the heterogeneous reaction strength *** outcomes show a favorable response of the motile number to advanced values of the Peclet number, the Schmidt number, the microorganism difference parameter, and the bio-convective Lewis number.

关键词： analytical solution Cattaneo-Christov heat and mass flux chemical reaction gyrotactic microorganism hybrid nanofluid O368 oscillating curved stretchable sheet

New breakthrough:Building non-markovian environments for single-qubit systems at any time interval

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Science China(Physics,Mechanics & Astronomy) 2025年第3期68卷 189-189页

作者： H.z.Shen Center for Quantum Sciences and School of Physics Northeast Normal UniversityChangchun130024China

The proposal of quantum simulation provides a highly effective approach for experimental research on open quantum *** date,numerous quantum simulation studies pertaining to open quantum systems have been put forward,including Fanchini et al.’s simulation of a dephasing noise channel utilizing an optical system[1],and Xiong et al.’s realization of a quantum simulation for a non-rotating-wave approximation noise channel,also leveraging an optical system[2].

关键词： quantum system breakthrough

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粲夸克偶素P波态χ_（c0）宽度测量

高能物理与核物理 1996年第12期20卷 1057-1067页

作者： J.z.Bai O.Bardon I.Blum A. Breakstone T.Burnett G.Chen G.P.Chen H.F.Chen J.Chen S.M.Chen Y.Q.Chen Y.Chen Y.B.Chen B.S.Cheng R.F.Cowan X.z.Cui H.L.Ding z.z.du W.dunwoodie X.L.Fan J.Fang M.Fero C.S.Gao M.L.Gao S.Q.Gao P.Gratton J.H.Gu S.D.Gu W.X.Gu Y.F.Gu

利用北京谱仪在北京正负电子对撞机上采集的３５０万（２Ｓ）事例，通过（２Ｓ）→γπ－和γＫ＋Ｋ－反应道测量了Ｘｃ０的总宽度．由ＭｏｎｔｅＣａｒｌｏ模拟给出的质量分辨函数，利用拟合Ｘｃ２谱形得到的质量分辨作标定后，用于Ｘ... 详细信息

利用北京谱仪在北京正负电子对撞机上采集的３５０万（２Ｓ）事例，通过（２Ｓ）→γπ－和γＫ＋Ｋ－反应道测量了Ｘｃ０的总宽度．由ＭｏｎｔｅＣａｒｌｏ模拟给出的质量分辨函数，利用拟合Ｘｃ２谱形得到的质量分辨作标定后，用于Ｘｃ０宽度的拟合，得到Ｘｃ０的宽度为（１５．０）ＭｅＶ．同时定出了ＸｃＪ（Ｊ＝０，２）到π＋π＝和Ｋ＋Ｋ－的衰变分支比．结果为Ｂ（Ｘｃ０→π＋π－）＝（４．２７±０．２３±Ｏ．６０）×１０－３；Ｂ（Ｘｃ０→Ｋ＋Ｋ－）＝（３．４４±０．２１±０．４７×１０－３；Ｂ（Ｘｃ２→π＋π－）＝（１．５２±０．１７±０．２９）×１０－３和Ｂ（Ｘｃ２→Ｋ＋Ｋ－）＝（５．２±１．１±１．８）×１０－４，其中第一项误差为统计误差，第二项为系统误差。

关键词：粲夸克偶素 P波态宽度衰变分支比

Current impact in the treatment of advanced hepatocellular carcinoma:The challenge remains

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World Journal of Gastrointestinal Oncology 2025年第3期17卷 479-483页

作者： Angelo A de Mattos Cristiane V Tovo Isadora z Bombassaro Luis F Ferreira Department of Hepatology Federal University of Health Sciences of Porto AlegrePorto Alegre 90050-170Rio Grande do SulBrazil School of Electronics Electrical Engineering and Computer ScienceQueen’s University of BelfastBelfast BT95BNBelfastUnited Kingdom

Hepatocellular carcinoma remains a significant cause of mortality worldwide,particularly among patients with liver *** most cases,surveillance in cirrhotic patients is neglected,leading to a diagnosis when the neoplasm is at an advanced *** this context,zhou et al carried out a network metaanalysis to demonstrate the effectiveness of hepatic arterial infusion chemotherapy,concluding that it is a superior approach compared to sorafenib and transarterial chemoembolization in the treatment of advanced hepatocellular ***,the meta-analysis in question lacks methodological rigor,preventing the authors from making more definitive ***,we understand that transarterial chemoembolization,when properly indicated,is a highly effective therapeutic option,and that sorafenib,given the results of new therapies based on immune checkpoint inhibitors,is no longer the recommended drug for the treatment of these ***,we believe the use of hepatic arterial infusion chemotherapy is increasingly limited and lacks strong scientific support.

关键词： Hepatocellular carcinoma Meta-analysis Treatment Liver diseases Liver neoplasms

Thermal fracture analysis of two collinear cracks in a functionally graded medium based on the three-phase-lag model

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Applied Mathematics and Mechanics(English Edition) 2025年第3期46卷 501-520页

作者： zhangna XUE Huameng WANG Jianlin LIU Minjie WEN z.T.CHEN College of Pipeline and Civil Engineering China University of Petroleum(East China) School of Civil Engineering and Architecture Zhejiang Sci-Tech University Department of Mechanical Engineering University of Alberta

The three-phase-lag(TPL) heat conduction model is an accurate representation of the actual heat transfer process. It would be interesting to investigate how the TPL model affects the thermal fracture behavior when there are defects existing in the medium. This paper aims to analyze the thermoelastic responses of two collinear cracks within a functionally graded half-space under thermal loadings by means of the TPL model. The thermoelastic problem is transformed into a series of singular integral equations using the integral transformation methods. The transient temperature and stress intensity factors(SIFs) are obtained through the application of Chebyshev *** effects of crack spacing and non-homogeneous parameters on the transient thermoelastic responses are presented, and the results of the TPL model are compared with those of the Fourier model, Cattaneo and Vernotte(CV) model, and dual-phase-lag(DPL)model. It is shown that crack spacing and non-homogeneous parameters have important effects on the thermoelastic responses, and the fluctuation phenomenon under the TPL model is the most pronounced due to the existence of the thermal displacement lag term.

关键词： Chebyshev polynomials

Gastric cancer diagnosis and prevention:Detecting precancerous at community level

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World Journal of Gastrointestinal Oncology 2025年第3期17卷 19-28页

作者： Sergey M Kotelevets Sergey z Chukov Department of Propaedeutics of Internal Medicine North Caucasus State AcademyCherkessk 369000Russia Department of Pathological Anatomy Stavropol State Medical UniversityStavropol 355017Russia

The problem of gastric cancer(GC)prevention remains relevant for a long *** methods of population serological screening of atrophic gastritis and precancerous changes in the gastric mucosa have been created at *** endoscopic and morphological methods of verification of the diagnosis of precancerous diseases and changes in the gastric mucosa have been introduced into the practice of gastroenterologists and *** risk stratification systems allow the formation of risk groups that require population *** hints for population serological screening of atrophic gastritis,endoscopic and morphological verification of precancerous changes and diseases of the stomach recommend using it:When developing state programs for the prevention of stomach cancer;when implementing preventive measures for stomach cancer by doctors of all specialties;the authors also offer the possibility of use by anyone over the age of 40,provided that they seek methodological help from their doctor;in the work of health schools in any medical and preventive *** use of an assessment system of certain risk factor signatures with prognostic value would add significant assistance to preventive measures against GC.

关键词： Prevention Gastric cancer Strategy Atrophic gastritis Serological screening Precancerous changes

Polyethylene glycol fusion repair of severed rat sciatic nerves reestablishes axonal continuity and reorganizes sensory terminal fields in the spinal cord

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Neural Regeneration Research 2025年第7期20卷 2095-2107页

作者： Emily A.Hibbard Liwen zhou Cathy z.Yang Karthik Venkudusamy Yessenia Montoya Alexa Olivarez George D.Bittner Dale R.Sengelaub Program in Neuroscience Indiana UniversityBloomingtonINUSA Department of Neuroscience University of Texas at AustinAustinTXUSA

Peripheral nerve injuries result in the rapid degeneration of distal nerve segments and immediate loss of motor and sensory functions;behavioral recovery is typically *** used a plasmalemmal fusogen,polyethylene glycol(PEG),to immediately fuse closely apposed open ends of severed proximal and distal axons in rat sciatic *** have previously reported that sciatic nerve axons repaired by PEG-fusion do not undergo Wallerian degeneration,and PEG-fused animals exhibit rapid(within 2–6 weeks)and extensive locomotor ***,our previous report showed that PEG-fusion of severed sciatic motor axons was non-specific,i.e.,spinal motoneurons in PEG-fused animals were found to project to appropriate as well as inappropriate target *** this study,we examined the consequences of PEG-fusion for sensory axons of the sciatic *** adult male and female rats(Sprague–Dawley)received either a unilateral single cut or ablation injury to the sciatic nerve and subsequent repair with or without(Negative Control)the application of *** action potentials recorded immediately after PEG-fusion repair confirmed conduction across the injury *** success of PEG-fusion was confirmed through Sciatic Functional Index testing with PEG-fused animals showing improvement in locomotor function beginning at 35 days *** 2–42 days postoperatively,we anterogradely labeled sensory afferents from the dorsal aspect of the hindpaw following bilateral intradermal injection of wheat germ agglutinin conjugated horseradish ***-fusion repair reestablished axonal *** to unoperated animals,labeled sensory afferents ipsilateral to the injury in PEG-fused animals were found in the appropriate area of the dorsal horn,as well as inappropriate mediolateral and rostrocaudal ***,despite having intact peripheral nerves,similar reorganizations of labeled sensory afferents were also observed contralateral to the injury and repa

关键词： axotomy dorsal horn peripheral nerve injury plasticity polyethylene glycol(PEG) sciatic nerve sensory terminals wheat germ agglutinin horseradish peroxidase