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Copper-catalyzed C–H bond functionalization enabled by programmed alternating current

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Science China Chemistry 2025年第1期68卷 10-11页

作者： zhoumei Tan Kun xu Chengchu zeng Beijing Key Laboratory of Environmental and Viral Oncology College of Chemistry and Life Science Beijing University of Technology

Synthetic electrochemistry has been selected as one of the Top Ten Emerging Technologies in Chemistry in 2023 by International Union of Pure and Applied Chemistry (IUPAC)[1]. It has emerged as a sustainable platform for organic synthesis and has exhibited a wide range of applications from academia to industry [2]. However, electrosynthesis has been predominantly performed by using direct current (DC).

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Advances in the treatment of autism spectrum disorder:Wharton jelly mesenchymal stem cell transplantation

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World Journal of Methodology 2025年第1期15卷 72-79页

作者： Serdar Kabatas ErdinçCivelek Eyüp Can Savrunlu Umut Karaaslan Özlem yıldız Erdal Karaöz Department of Neurosurgery University of Health Sciences TurkeyGaziosmanpaşa Training and Research HospitalIstanbul 34255Türkiye Department of Pediatric Allergy-Immunology Institute of Health Sciences Marmara UniversityIstanbul 34865Türkiye Center for Stem Cell&Gene Therapy Research and Practice University of Health Sciences TurkeyIstanbul 34255Türkiye Department of Child and Adolescent Psychiatry University of Health SciencesGaziosmanpaşa Training and Research HospitalIstanbul 34255Türkiye Department of Child and Adolescent Psychiatry Kocaeli University Faculty of MedicineKocaeli 41001Türkiye Center for Regenerative Medicine and Stem Cell Research&Manufacturing Liv HospitalIstanbul 34340Türkiye Department of Histology and Embryology Istinye UniversityFaculty of MedicineIstanbul 34010Türkiye Center for Stem Cell and Tissue Engineering Research and Practice Istinye UniversityIstanbul 34340Türkiye

BACKGROUND Autism spectrum disorder(ASD)is a complex neurodevelopmental disorder with multifaceted *** recent studies,neuroinflammation and immune dysregulation have come to the forefront in its *** are studies suggesting that stem cell therapy may be effective in the treatment of *** To evolve the landscape of ASD treatment,focusing on the potential benefits and safety of stem cell *** A detailed case report is presented,displaying the positive outcomes observed in a child who underwent intrathecal and intravenous Wharton’s jelly-derived mesenchymal stem cells(WJ-MSCs)transplantation combined with *** The study demonstrates a significant improvement in the child’s functional outcomes(Childhood Autism Rating Scale,Denver 2 Developmental Screening Test),especially in language and gross motor *** serious side effects were encountered during the 2-year *** The findings support the safety and effectiveness of WJ-MSC transplantation in managing ASD.

关键词： Autism spectrum disorder Neurorehabilitation Stem cell transplantation Wharton jelly mesenchymal stem cells Inflammation

Recombinant chitinase-3-like protein 1 alleviates learning and memory impairments via M2 microglia polarization in postoperative cognitive dysfunction mice

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Neural Regeneration Research 2025年第9期20卷 2727-2736页

作者： yujia Liu xue Han yan Su yiming zhou Minhui xu Jiyan xu zhengliang Ma Xiaoping Gu Tianjiao Xia Department of Anesthesiology Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina Medical School Nanjing UniversityNanjingJiangsu ProvinceChina Jiangsu Key Laboratory of Molecular Medicine Nanjing UniversityNanjingJiangsu ProvinceChina State Key Laboratory of Pharmaceutical Biotechnology Nanjing UniversityNanjingJiangsu ProvinceChina Department of Anesthesiology Zhongshan HospitalFudan UniversityShanghaiChina

Postoperative cognitive dysfunction is a seve re complication of the central nervous system that occurs after anesthesia and surgery,and has received attention for its high incidence and effect on the quality of life of *** date,there are no viable treatment options for postoperative cognitive *** identification of postoperative cognitive dysfunction hub genes could provide new research directions and therapeutic targets for future *** identify the signaling mechanisms contributing to postoperative cognitive dysfunction,we first conducted Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses of the Gene Expression Omnibus GSE95426 dataset,which consists of mRNAs and long non-coding RNAs differentially expressed in mouse hippocampus3 days after tibial *** dataset was enriched in genes associated with the biological process"regulation of immune cells,"of which Chill was identified as a hub ***,we investigated the contribution of chitinase-3-like protein 1 protein expression changes to postoperative cognitive dysfunction in the mouse model of tibial fractu re *** were intraperitoneally injected with vehicle or recombinant chitinase-3-like protein 124 hours post-surgery,and the injection groups were compared with untreated control mice for learning and memory capacities using the y-maze and fear conditioning *** addition,protein expression levels of proinflammatory factors(interleukin-1βand inducible nitric oxide synthase),M2-type macrophage markers(CD206 and arginase-1),and cognition-related proteins(brain-derived neurotropic factor and phosphorylated NMDA receptor subunit NR2B)were measured in hippocampus by western *** with recombinant chitinase-3-like protein 1 prevented surgery-induced cognitive impairment,downregulated interleukin-1βand nducible nitric oxide synthase expression,and upregulated CD206,arginase-1,pNR2B,and brain-derived neurotropic factor expr

关键词： Chil1 hippocampus learning and memory M2 microglia neuroinflammation postoperative cognitive dysfunction(POCD) recombinant CHI3L1

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Lenalidomide regulates the CCL21/CCR7/ERK1/2 axis to inhibit migration and proliferation in diffuse large B-cell lymphoma

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Oncology Research 2025年第1期33卷 199-212页

作者： WEN yANG BIN TANG DAN xu WENXIU yANG Department of Pathology Guizhou Medical UniversityThe Affiliated Hospital of Guizhou Medical UniversityGuiyang550004China

Background:The prognostic significance of the chemokine receptor CCR7 in diffuse large B-cell lymphoma(DLBCL)has been reported ***,the detailed mechanisms of CCR7 in DLBCL,particularly regarding its interaction with lenalidomide treatment,are not fully ***:Our study utilized bioinformatics approaches to identify hub genes in SU-DHL-2 cell lines treated with lenalidomide compared to control *** data and clinical information from 122 patients with DLBCL were analyzed to assess the correlation of CCR7 and p-ERK1/2 expression with the prognosis of ***,in vitro and in vivo experiments were conducted to clarify the role of CCR7 in the response of DLBCL to lenalidomide ***:Our bioinformatics analysis pinpointed CCR7 as a hub gene in the context of lenalidomide treatment in ***,31.14%and 36.0%(44/122)of DLBCL cases showed positive expression for CCR7 and ERK1/2 respectively,establishing them as independent prognostic factors for adverse outcomes in DLBCL via multivariate Cox regression ***,our studies demonstrated that the external application of the protein CCL21 promoted proliferation,migration,invasion,and activation of the ERK1/2 pathway in SU-DHL-2 and OCI-Ly3 cell lines with high levels of CCR7 *** effect was mitigated by CCR7 silencing through siRNA,application of ERK inhibitors,or lenalidomide *** vivo experiments reinforced the efficacy of lenalidomide,significantly reducing tumor growth rate,tumor mass,serum total LDH levels,and expression of CCR7 and p-ERK1/2 in a SUDHL-2 xenograft model in nude mice(py clarifies the potential role of the CCL21/CCR7/ERK1/2 axis in the therapeutic effects of lenalidomide in DLBCL treatment.

关键词： CCR7 CCL21 ERK1/2 Lenalidomide Diffuse large B-cell lymphoma(DLBCL)

Antithetical impacts of deleterious LRP1B mutations in non-squamous and squamous NSCLCs on predicting benefits from immune checkpoint inhibitor alone or with chemotherapy over chemotherapy alone: retrospective analyses of the POPLAR/OAK and CHOICE-01 trial

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Science China Life Sciences 2025年第1期68卷 249-262页

作者： Jinliang Wang Wenyong zhou yu xu Jianchun Duan Qiaoxia zhou Guoqiang Wang Leo Li Chunwei xu Wenxian Wang Shangli Cai zhijie Wang Jie Wang Department of Oncology The Fifth Medical Center of Chinese PLA General Hospital Department of Thoracic Surgery Shanghai Chest HospitalSchool of MedicineShanghai Jiao Tong University Burning Rock Biotech CAMS Key Laboratory of Translational Research on Lung Cancer State Key Laboratory of Molecular OncologyDepartment of Medical OncologyNational Cancer Center/National Clinical Research Center for ancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical College Institute of Basic Medicine and Cancer (IBMC) Chinese Academy of Sciences Department of Clinical Trial The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital)

In non-small cell lung cancers,the non-squamous and squamous subtypes（nsqNSCLC and sqNSCLC） exhibit disparities in pathophysiology,tumor immunology,and potential genomic correlates affecting responses to immune checkpoint inhibitor（ICI）-based *** our inhouse training cohort（n=85）,the presence of the LRP1B deleterious mutation（LRP1B-del） was associated with longer and shorter progression-free survival（PFS） on ICIs alone in nsqNSCLCs and sqNSCLCs,respectively(Pinteraction=0.008).These results were validated using a larger public ICI cohort(n=208,Pinteractionzolizumab over docetaxel(hazard ratio（HR）=0.70,P=0.046),whereas this benefit was negligible in those without LRP1B-del（HR=1.05,P=0.64）.Conversely,sqNSCLCs without LRP1B-del benefited more from atezolizumab（HR=0.60,P=0.002） than those with LRP1B-del（HR=1.30,P=0.31）.Consistent results were observed in the in-house CHOICE-01 cohort,in which nsqNSCLCs with LRP1B-del and sqNSCLCs without LRP1B-del benefited more from toripalimab plus chemotherapy than from chemotherapy alone(Pinteraction=0.008).This multi-cohort study delineates the antithetical impacts of LRP1B-del in nsqNSCLCs and sqNSCLCs on predicting the benefits from ICI alone or with chemotherapy over chemotherapy *** findings highlight the distinct clinical utility of LRP1B-del in guiding treatment choices for nsqNSCLCs and sqNSCLCs,emphasizing the necessity for a detailed analysis based on pathological subtypes when investigating biomarkers for cancer therapeutics.

关键词： non-squamous NSCLC squamous NSCLC LRP1B deleterious mutations predictive biomarker immune checkpoint inhibitor

Status and Strategy of Fusion Materials Development in China

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Status and Strategy of Fusion Materials Development in China

Constructing 2D bismuth-based heterostructure for highly efficient photocatalytic CO2 reduction

第十二届反应堆数值计算与粒子输运学术会议

作者： Q.y.Huang~1 y.C.Wu~1 J.G.Li~1 F.R.Wan~2 J.L.Chen~1 G.N.Luo~1 X.Liu~3 J,M,Chen~3 z.y.xu~3 X.G.zhou~4 X.Ju~2 y.y.Shan~5 J.N.yu~6 S.y.zhu~6 P.y.zhang~6 J.F.yang~7 X.J.Chen~8 S.M.Dong~9 (1.Institute of Plasma Physics,Chinese Academy of Sciences,Hefei,Anhui,230031,China 2.University of Science and Technology Beijing,Beijing 100083,China 3.Southwestern Institute of Physics,Chengdu,Sichuan,610041,China 4 National University of Defense Technology,Changsha,Hunan,410073,China 5.Institute of Metal Research,Chinese Academy of Sciences,Shenyang,Liaoning,110016,China 6.China Institute of Atomic Energy,Beijing,102413,China 7.Xi’an Jiaotong University,Xi’an,Shanxi,710049,China 8 China Academy of Engineering Physics,Mianyang,Sichuan,621900,China 9.Shanghai Institute of Ceramics,Chinese Academy of Sciences,Shahghai,200050,China)

The liquid metal and solid ceramic pebble breeder blankets have become the most promising blankets for ITER-TBMs or DEMO reactors in China and the world due to their potential advantages. In recent years the corresponding research work on fusion reactor materials are mainly focus on structural materials,plasma facing materials and the functional materials for the blanket such as breeder, coating and flow channel insert *** push work on fusion materials and then for the successful application of fusion *** R&D on those materials in the two kinds of blankets is being carried out widely in China,including fabrication and manufacturing techniques,physical/mechanical properties assessment before and after irradiation,joining techniques for structural materials, compatibility evaluation,and the development and verification of the criteria for fusion material *** progress on main R&D activities of fusion reactor materials in China is introduced and prospected in the paper.

关键词： Fusion reactor Blanket Materials R&D

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Tungsten 2025年第1期7卷 71-79页

作者： Ruo-Hang xu Hao-yu Jiang Dan-Dan Cui Kun-Rong Du Hong-Run zhang Sheng-Jie xu ya-Qi Li zhi-zhen Ren Liang Wang Wei-Chang Hao yi Du School of Physics and BUAA-UOW Joint Research Centre Beihang University Shenzhen Institute of Beihang University Centre for Catalysis and Clean Energy School of Environment and Science Griffith University

Reforming carbon dioxide（CO2） into fuels and valuable chemicals using solar energy holds significant potential for emission reduction and addressing energy supply *** recombination of photocarriers remains a major obstacle,however,to enhancing solar energy conversion efficiency in the photocatalytic reaction *** two-dimensional materials,constructing heterogeneous structures has emerged as an effective strategy to enhance the separation of photoexcited carriers by leveraging the internal electric field at the heterogeneous ***,we present a facile strategy for preparing Bi4NbO8Br/Bi2WO6plate-on-plate z-scheme junctions with a strong internal electric field by in situ *** unique heterostructure facilitates efficient separation and transport of photoexcited charges by harnessing the internal electric field induced by chemical bonding at the lateral ***,the Bi4NbO8Br/Bi2WO6heterostructure exhibits enhanced CO2photoreduction properties,along with a CO yield rate of approximately 35 μmol·g-1·h-1under full light *** work offers novel insights into the synthesis of unique hetero structures intended to enhance the efficiency of photocatalytic CO2reduction.

关键词： Bi4NbO8Br/Bi2WO6 CO2 reduction Heterostructures Photocatalysts

LOW CyCLE FATIGUE BEHAVIOR OF Az91HP ALLOy IN AS HIGHP RESSURE DIE CASTING

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Acta Metallurgica Sinica(English Letters) 2000年第4期13卷 961-966页

作者： Liu, z. xu, y.y. Wang, z.G. Wang, y. Liu, z.y. Inst of Metal Research Chinese Acad of Sciences Shenyang China

Fully reversed total strain-controlled low-cycle fatigue tests were conducted at room temperature in air to study the fatigue behavior of Az91HP magnesium alloy in as high pressure die casting and subsequently heat treatment. All the specimens in different heat histories exhibit cyclic strain hardening in different degrees. It is difficult to distinguish the fatigue behavior of the die casting specimens from that of the solution aging specimens. The solution treated specimens show longer fatigue life at high strain amplitude and shorter fatigue life at low strain amplitude than the die casting and solution aging specimens though they have the lowest yield strength with higher strain hardening. Fatigue fracture surfaces for strain amplitude larger than 0.005 show very similar to those found by monotonic tensile tests. The SEM examination reveals that the regions of fatigue crack growth and final fracture can be characterized by quasi-cleavage mechanisms, but some shallow dimples, slip bands and secondary cracks are found on the fracture surface in the fracture crack growth areas.

关键词： Cracks Die casting Fatigue of materials Heat treatment

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A NOVEL METHOD FOR EVALUATING PLANE STRESS DyNAMIC FRACTURE TOUGHNESS OF 0Cr18Ni10Ti STAINLESS STEEL WELDED JOINTS

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Acta Metallurgica Sinica(English Letters) 2008年第4期21卷 303-312页

作者： z.J. xu y.L. Li School of Aeronautics Northwestern Polytechnical University Xi＇an 710072 China

A novel method was proposed for the evaluation of Mode I dynamic fracture toughness （DFT） under plane stress and small scale yielding conditions for welded joints of stainless steel （SS）, 0Cr18Ni10Ti. In a hybrid experimental-numerical approach, the experiments were carried out on the Hopkinson pressure bar apparatus, and three dimensional （3D） transient numerical simulations were performed by a finite element （FE） computer program. Macroscopical plastic deformation was observed at the loading and supporting points, on the specimens, after the test, which could cause a large error if omitted in the numerical simulation. Therefore, elustic-viscoplustic analysis was performed on the specimen by adopting the Johnson-Cook （J-C） model to describe the rate-dependent plastic flow behavior of the material. The material heterogeneity in the mismatched welded joints, induced by the difference in the base metal （BM） and the weld metal （WM） in yield stress, has also been taken into consideration by using the J-C models separately. Good accordance was obtained between the experimental and the computational results by the present approach. The relationship between plane stress DFT and loading rate was also obtained on the order of 108 MPa.m^1/2.s^-1.

关键词： 0Cr18Ni10Ti Welded joint High strain rate Dynamic fracture Plane stress

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