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Chinese Physics C 2024年第4期48卷 6-13页

作者： Y.mahmoud H.Abdallah m.T.Hussein S.Elgammal Centre for theoretical physics The British University in EgyptEgypt Physics Department Faculty of ScienceCairo UniversityEgypt

In this study,we conducted a search for dark matter using a part of the data recorded by the CmS experiment during run-I of the LHC in 2012 with a center of mass energy of 8 TeV and an integrated luminosity of 11.6 fb−*** data were gathered from the CmS open *** matter,in the framework of the simplified model(mono-z′),can be produced from proton-proton collisions in association with a new hypothetical gauge boson,z′.Thus,the search was conducted in the dimuon plus large missing transverse momentum *** benchmark scenario of mono-z′,which is known as light vector,was used for interpreting the CmS open *** evidence of dark matter was observed,and exclusion limits were set on the masses of dark matter and z′at 95%confidence level.

关键词： dark matter large hadron collider CmS open data search for new physics dark fermion

抗PD-1免疫疗法与雄激素剥夺疗法联合可显著增强诱导转移性去势敏感前列腺癌的免疫浸润

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中国临床药理学杂志 2024年第1期40卷 51-51页

作者： HAWLEY J E OBRADOVIC A z daLLOS m C 孟海峰

引自:HAWLEY J E,OBRADOVIC A z,daLLOS m C,et ***-PD-1 immunotherapy with androgen depriva⁃tion therapy induces robust immune infiltration in metastatic castration-sensitive prostate cancer[J].Cancer Cell,2023,41(11):1972-1988.研究表明,与其他恶性肿瘤比较,原发性和去势抗性前列腺癌症(CRPC)的肿瘤微环境(TmE)缺乏免疫浸润。尽管雄激素剥夺疗法(ADT)可以在局部性前列腺癌中诱导复杂的免疫浸润,但在转移性去势敏感性前列腺癌(mCSPC)中TmE的组成、ADT或其它治疗方法在这方面的作用尚不明确。研究者对参与Ⅱ期临床试验(NCT03951831)患者的转移灶进行了全面的单细胞RNA测序(scRNA-seq)分析,该试验评估了标准化疗激素疗法联合抗PD-1免疫疗法的疗效。研究者基于蛋白质活性对TmE亚群进行了纵向分析,揭示了在多个转移灶中的免疫亚群。研究者还观察到这些免疫亚群对治疗反应的动态变化以及与临床结果具有相关性。本研究揭示了一种具有治疗耐药性、转录不同的肿瘤亚群,该亚群在治疗难治性患者中细胞数量增加。

关键词： Ⅱ期临床试验肿瘤微环境免疫疗法标准化疗前列腺癌临床结果激素疗法去势

由超拍电子伏特加速器产生的超高能伽马射线气泡

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Science Bulletin 2024年第4期69卷 449-457页

作者： LHAASO Collaboration zhen Cao Chuandong Gao Cong Li Ruo-Yu Liu Ruizhi Yang 不详 Key Laboratory of Particle Astrophyics&Experimental Physics Division&Computing Center Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China TIANFU Cosmic Ray Research Center ChengduChina Institute of Frontier and Interdisciplinary Science Shandong UniversityQingdao 266237China School of Astronomy and Space Science Nanjing UniversityNanjing 210023China University of Science and Technology of China Hefei 230026China

We report the detection of aγ-ray bubble spanning at least 100deg2 in ultra-high energy(UHE)up to a few PeV in the direction of the star-forming region Cygnus X,implying the presence super PeVatron(s)accelerating protons to at least 10 PeV.A log-parabola form with the photon indexΓ(E)=(2.71±0.02)+(0.11±0.02)×log10(E/10 TeV)is found fitting the gamma-ray energy spectrum of the bubble *** sources,“hot spots”correlated with very massive molecular clouds,and a quasi-spherical amorphousγ-ray emitter with a sharp central brightening are observed in the *** the core of~0.5°,spatially associating with a region containing massive OB association(Cygnus OB2)and a microquasar(Cygnus X-3),as well as previously reported multi-TeV sources,an enhanced concentration of UHEγ-rays is observed with 2 photons at energies above 1 *** general feature of the bubble,the morphology,and the energy spectrum,are reasonably reproduced by the assumption of a particle accelerator in the core,continuously injecting protons into the ambient medium.

关键词： Cosmic rays γ-rays Interstellar medium Star cluster

Universal basis underlying temperature, pressure and size induced dynamical evolution in metallic glass-forming liquids

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Chinese Physics B 2024年第1期33卷 134-142页

作者：张华平范蓓蓓吴佳琦李茂枝 Department of Physics Beijing Key Laboratory of Opto-electronic Functional Materials&Micro-nano DevicesRenmin University of ChinaBeijing 100872China Songshan Lake materials Laboratory Dongguan 523808China Key Laboratory of Quantum State Construction and manipulation Renmin University of ChinaBeijing 100872China

The dramatic temperature-dependence of liquids dynamics has attracted considerable scientific interests and efforts in the past decades, but the physics of which remains elusive. In addition to temperature, some other parameters, such as pressure, loading and size, can also tune the liquid dynamics and induce glass transition, which makes the situation more complicated. Here, we performed molecular dynamics simulations for Ni_(50)zr_(50) bulk liquid and nanodroplet to study the dynamics evolution in the complex multivariate phase space, especially along the isotherm with the change of pressure or droplet size. It is found that the short-time Debye–Waller factor universally determines the long-time relaxation dynamics no matter how the temperature, pressure or size changes. The basic correlation even holds at the local atomic scale. This finding provides general understanding of the microscopic mechanism of dynamic arrest and dynamic heterogeneity.

关键词： metallic glass-forming liquids structure relaxation dynamical heterogeneity Debye–Waller factor

青藏高原及其周边二叠纪综合地层、生物群以及古地理和古气候演化

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中国科学：地球科学 2024年第4期54卷 1125-1170页

作者：沈树忠张以春袁东勋徐海鹏琚琦张华郑全锋罗茂侯章帅南京大学地球科学与工程学院内生金属矿床成矿机制研究国家重点实验室关键地球物质循环前沿科学中心南京210023 中国科学院南京地质古生物研究所现代古生物学和地层学国家重点实验室南京210008 中国科学院大学南京学院南京210049 中国矿业大学资源与地球科学学院徐州221116

二叠纪是青藏高原各块体演化的关键时段,发生了一系列重大地质和生物事件,当时横跨南北半球统一的泛大陆演化到了鼎盛阶段,阻断了全球东西向的赤道暖流的同时,在泛大陆的东侧形成了一个半封闭的、具有重要历史意义的特提斯洋暖池,是古-... 详细信息

二叠纪是青藏高原各块体演化的关键时段,发生了一系列重大地质和生物事件,当时横跨南北半球统一的泛大陆演化到了鼎盛阶段,阻断了全球东西向的赤道暖流的同时,在泛大陆的东侧形成了一个半封闭的、具有重要历史意义的特提斯洋暖池,是古-中生代之交生物与环境演变的引擎.青藏高原二叠纪地层分布广泛、化石丰富,从南到北由于跨越不同的纬度带体现出不同的特点.雅鲁藏布江以南的喜马拉雅特提斯带当时位于冈瓦纳大陆印度板块北缘,整个二叠纪沉积含有典型的冈瓦纳冷水型生物群;雅鲁藏布江缝合带内的灰岩外来体时代集中在瓜德鲁普世(Guadalupian,中二叠世)中、晚期至早三叠世,古生物地理与喜马拉雅特提斯带有显著差异,最有可能为新特提斯洋中的海山型沉积.基墨里(Cimmerian)微地块群在乌拉尔世(Cisuralian,早二叠世)早期阿瑟尔期-萨克马尔期(Asselian-Sakmarian)全部位于冈瓦纳大陆北缘,均发育冰海相沉积及冈瓦纳型冷水生物群.乌拉尔世中期(约290~280ma)基墨里微地块群由于印度板块北缘Panjal Traps等大火成岩省岩浆活动与冈瓦纳大陆裂解,并以不同的速度向北漂移.可以分为两个条带,由南羌塘、保山和Sibuma地块组成的北基墨里微地块群漂移速度较快,在亚丁斯克期(Artinskian)就已经出现大量碳酸盐岩沉积和暖水生物群,因此,它们最先从冈瓦纳大陆裂解并进入低纬度暖水区域;而由拉萨、腾冲和Irrawaddy地块组成的南基墨里微地块群,漂移速度相对较慢,在空谷(Kungurian)晚期才开始出现大规模碳酸盐岩沉积,并延续至乐平世(Lopingian,晚二叠世),瓜德鲁普世和乐平世地层中含暖水生物为主的动物群,因此,这些地块至少在空谷晚期已经从冈瓦纳大陆北缘分离,裂解时间稍晚于北基墨里微地块群;这种沉积和古生物地理的时空演变差异性表明乌拉尔世的裂解事件造成了中特提斯洋和新特提斯洋的开启和形成.更北的北羌塘地块由于整个二叠纪地层中均含有典型的暖水生物群,与华南地区、思茅地块和印支地块等可以比较,属于古特提斯洋北部的块体.因此,二叠纪中、晚期特提斯域形成了古、中、新特提斯多岛洋共存的局面,是当时构造活动最活跃的地区和全球生物多样性的中心.此外,青藏高原多个块体在二叠纪位于南半球中高纬度地区,完整记录了晚古生代大冰期、亚丁斯克期全球变暖和二叠纪末快速变暖等重大古气候事件,对于阐明板块运动和全球气候演变对生物群时空分布的影响具有举足轻重的作用.

关键词：二叠纪特提斯洋青藏高原生物群古地理

Numerical performance assessment of double-shell targets for z-pinch dynamic hohlraum

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matter and Radiation at Extremes 2022年第3期7卷 10-19页

作者： Y.Y.Chu z.Wang J.m.Qi z.P.Xu z.H.Li Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China

A z-pinch dynamic hohlraum can create the high-temperature radiation field required by indirect-drive inertial confinement fusion.A dynamic hohlraum with peak radiation temperature over 300 eV can be obtained with a>50 mA z-pinch driver according to the scaling law of dynamic hohlraum radiation temperature vs drive *** on a uniform 300 eV radiation temperature profile with a width of 10 ns,three double-shell capsules with radii of 2,2.5,and 3 mm are proposed,and the corresponding fusion yields from a one-dimensional calculation are 28.8,56.1,and 101.6 *** implosion dynamics of the 2.5 mm-radius capsule is investigated in *** ignition,the areal density of the fuel is about 0.53 g/cm^(2),the fuel pressure is about 80 Gbar,and the central ion temperature is about 4.5 keV,according to the one-dimensional simulation.A two-dimensional simulation indicates that the double-shell capsule can implode nearly spherically when driven by the radiation field of a z-pinch dynamic *** sensitivities of the fusion performance to the radiation temperature profiles and to deviations in the capsule parameter are investigated through one-dimensional simulation,and it is found that the capsule fusion yields are rather stable in a quite large parameter space.A one-dimensional simulation of a capsule embedded in 50 mg/cm^(3)CH foam indicates that the capsule performance does not change greatly in the mimicked environment of a z-pinch dynamic *** double-shell capsules designed here are also applicable to laser indirect-drive inertial fusion,if a laser facility can produce a uniform 300 eV radiation field and sustain it for about 10 ns.

关键词： dynamic double performance

前言:青藏高原及其周边综合地层、生物群与古地理演化

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中国科学：地球科学 2024年第4期54卷 911-914页

作者：沈树忠丁林朱茂炎王向东邓涛南京大学地球科学与工程学院关键地球物质循环前沿科学中心内生金属成矿机制研究国家重点实验室南京210023 中国科学院青藏高原研究所青藏高原地球系统全国重点实验室北京100101 中国科学院南京地质古生物研究所现代古生物学和地层学国家重点实验室南京210008 中国科学院大学地球与行星科学学院北京100049 中国科学院古脊椎动物与古人类研究所中国科学院脊椎动物演化与人类起源重点实验室北京100044

青藏高原研究对揭示地史时期全球构造、古地理、生物与环境等的演化都具有举足轻重的作用.文章介绍了“青藏高原及其周边综合地层、生物群与古地理演化”专辑的组织背景、主要内容和期望目标,同时总结了本专辑成果相比第一次青藏高原科... 详细信息

青藏高原研究对揭示地史时期全球构造、古地理、生物与环境等的演化都具有举足轻重的作用.文章介绍了“青藏高原及其周边综合地层、生物群与古地理演化”专辑的组织背景、主要内容和期望目标,同时总结了本专辑成果相比第一次青藏高原科考报告的显著进展.

关键词：期望目标生物群全球构造生物与环境青藏高原周边

具有高阻氧、阻湿性聚乳酸基共混膜的制备及其对酸奶的保鲜效果

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包装工程 2024年第15期45卷 123-133页

作者：安达孙嘉茂葛晨云雪艳内蒙古农业大学食品科学与工程学院呼和浩特010018

目的提高聚(L-乳酸)(PLLA)薄膜的氧气(O_(2))、水蒸气(H_(2)O)阻隔性,解决延展性差等问题。方法采用熔融共混法分别将聚(对苯二甲酸己二酸丁二醇酯)(PBAT)、聚(L-乳酸-衣康酸丁二醇酯)(P(LA-BI))与PLLA共混制备薄膜。在此基础上,加入具... 详细信息

目的提高聚(L-乳酸)(PLLA)薄膜的氧气(O_(2))、水蒸气(H_(2)O)阻隔性,解决延展性差等问题。方法采用熔融共混法分别将聚(对苯二甲酸己二酸丁二醇酯)(PBAT)、聚(L-乳酸-衣康酸丁二醇酯)(P(LA-BI))与PLLA共混制备薄膜。在此基础上,加入具有阻O_(2)、阻H_(2)O双功能的抗水解剂(z)进行进一步改性。结果z的添加(质量分数为6%)在保持PLLA/PBAT和PLLA/P(LA-BI)薄膜力学强度的基础上,将2种薄膜的断裂伸长率大幅提高至387%和316%,薄膜展现出优异的柔韧性;PLLA/P(LA-BI)/z6膜的氧气透过率(OTR)和水蒸气透过率(WVTR)分别为6.4 cm^(3)/(m^(2)·d)和43.1 g/(m^(2)·d),较添加z6前分别降低了54.6%和61.9%,薄膜获得了优异的O_(2)、H_(2)O阻隔性能。在酸奶的贮藏过程中,PLLA/PBAT/z6组和PLLA/P(LA-BI)/z6组酸奶的可滴定酸度在第21天时仍保持在合理范围内,达到了延缓酸奶贮藏过程中后酸化的效果。在后续的感官评定中相较于PLLA/PBAT组和PLLA/P(LA-BI)组,添加z6组包装的酸奶获得了更高的评分。结论将具有阻O_(2)、阻H_(2)O双功能的z6抗水解剂添加到PLLA基薄膜中改善了薄膜的延展性,提高了O_(2)、H_(2)O阻隔性能,同时在酸奶贮藏过程中起到良好的保质保鲜效果。因此,PLLA/PBAT/z6和PLLA/P(LA-BI)/z6薄膜可以代替市面上不可降解的酸奶包装材料进行推广使用。

关键词：生物可降解材料聚乳酸阻隔性柔韧性酸奶包装

基于状态空间模型的激光再制造熔池温度控制系统

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表面工程与再制造 2024年第2期24卷 50-50页

作者： Yang G.-z. Liu T.-m. Song B.-X. Jiang X.-Y. Wang z.-S. Chen K.-Q. Liu W.-J. School of mechanical Engineering Shenyang University of Technology Shenyang China

激光再制造是用于再制造的一项重要技术,在航空航天、冶金、能源等领域应用广泛。然而,形状控制问题一直是制约其规模化和工业化应用的瓶颈。在激光再制造过程中,熔池温度是决定再制造件形状和性能稳定性的关键。基于此,本文提出了一种... 详细信息

激光再制造是用于再制造的一项重要技术,在航空航天、冶金、能源等领域应用广泛。然而,形状控制问题一直是制约其规模化和工业化应用的瓶颈。在激光再制造过程中,熔池温度是决定再制造件形状和性能稳定性的关键。基于此,本文提出了一种基于状态空间模型的激光再制造熔池温度实时在线控制方法,解决了控制机理模型难以建立和多变量约束的问题。

关键词：状态空间模型激光再制造熔池温度航空航天形状控制控制系统变量约束性能稳定性

Is Li-ESWT effective in diabetic patients with severe erectile dysfunction?

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Asian Journal of Andrology 2022年第5期24卷 521-524页

作者： müslüm Ergün Osman Akyüz Department of Urology School of MedicineAtlas UniversityIstanbul 34200Turkey

Noninvasive low-intensity extracorporeal shockwave treatment(Li-ESWT)has been widely used to treat erection *** is no clear information regarding either the selection of patients for the treatment or the treatment *** this study,we aimed to investigate the efficacy of extracorporeal shockwave therapy in diabetic patients with severe erectile dysfunction(International Index of Erectile Function-5[IIEF-5]scores of 5 to 7).Sixty-three diabetes mellitus patients with erectile dysfunction having IIEF-5 scores of 5 to 7 and not showing a recovery of potency despite phosphodiesterase type 5 inhibitor therapy for the past 6 months were included in the *** patients were evaluated based on their IIEF-5 scores and Erection Hardness Scale *** IIEF-5 score(mean±standard deviation[s.d.])increased from 5.29±1.67 to 5.56±1.85,with a difference of 0.27±0.18(P>0.05).The Erection Hardness Scale scores(mean±s.d.),on the other hand,increased from 1.46±0.50 to 1.48±0.50,with a difference of 0.02±0(P>0.05).In conclusion,the response to phosphodiesterase type 5 inhibitors did not change after extracorporeal shockwave treatment in diabetes mellitus patients with severe erectile dysfunction(IIEF-5 scores of 5 to 7).

关键词： diabetes mellitus International Index of Erectile Function-5 score low-intensity extracorporeal shockwave treatment severe erectile dysfunction