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Endoplasmic reticulum stress and autophagy in cerebral ischemia/reperfusion injury:PErK as a potential target for intervention

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Neural regeneration research 2025年第5期20卷 1455-1466页

作者： Ju zheng Yixin Li Ting zhang Yanlin Fu Peiyan Long xiao Gao zhengwei Wang zhizhong Guan xiaolan Qi Wei Hong Yan xiao Key Laboratory of Endemic and Ethnic Diseases Ministry of Education&Key Laboratory of Medical Molecular Biology of Guizhou ProvinceGuizhou Medical UniversityGuiyangGuizhou ProvinceChina Guizhou Center for Disease Control and Prevention GuiyangGuizhou ProvinceChina Department of Histology and Embryology Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Collaborative Innovation Center for Prevention and Control of Endemic and Ethnic regional Diseases Co-constructed by the Province and Ministry GuiyangGuizhou ProvinceChina

Several studies have shown that activation of unfolded protein response and endoplasmic reticulum(Er)stress plays a crucial role in severe cerebral ischemia/reperfusion *** occurs within hours after cerebral ischemia,but the relationship between Er stress and autophagy remains *** this study,we established experimental models using oxygen-glucose deprivation/reoxygenation in PC12 cells and primary neurons to simulate cerebral ischemia/reperfusion *** found that prolongation of oxygen-glucose deprivation activated the Er stress pathway protein kinase-like endoplasmic reticulum kinase(PErK)/eukaryotic translation initiation factor 2 subunit alpha(e IF2α)-activating transcription factor 4(ATF4)-C/EBP homologous protein(CHOP),increased neuronal apoptosis,and induced ***,inhibition of Er stress using inhibitors or by si rNA knockdown of the PErK gene significantly attenuated excessive autophagy and neuronal apoptosis,indicating an interaction between autophagy and Er stress and suggesting PErK as an essential target for regulating *** autophagy with chloroquine exacerbated Er stress-induced apoptosis,indicating that normal levels of autophagy play a protective role in neuronal injury following cerebral ischemia/reperfusion *** from this study indicate that cerebral ischemia/reperfusion injury can trigger neuronal Er stress and promote autophagy,and suggest that PErK is a possible target for inhibiting excessive autophagy in cerebral ischemia/reperfusion injury.

关键词： apoptosis ATF4 autophagy C/EBP homologous protein cerebral ischemia/reperfusion injury eIF2α endoplasmic reticulum stress PErK

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An Effective Power Optimization Approach Based on Whale Optimization Algorithm with Two-Populations and Mutation Strategies

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Chinese Journal of Electronics 2024年第2期33卷 423-435页

作者： Juncai HE zhenxue HE Jia LIU Yan zHANG Fan zHANG Fangfang LIANG Tao WANG Limin xiao Xiang WANG Hebei Agricultural University Beijing Information Science and Technology University School of Computer Science and Engineering Beihang University School of Electronic and Information Engineering Beihang University

Power is an issue that must be considered in the design of logic circuits. Power optimization is a combinatorial optimization problem, since it is necessary to search for a logical expression that consumes the least amount of power from a large number of reed-Muller(rM) logical expressions. The existing approach for optimizing the power of multi-output mixed polarity rM(MPrM) logic circuits suffer from poor optimization results. To solve this problem, a whale optimization algorithm with two-populations strategy and mutation strategy(TMWOA) is proposed in this paper. The two-populations strategy speeds up the convergence of the algorithm by exchanging information about the two-populations. The mutation strategy enhances the ability of the algorithm to jump out of the local optimal solutions by using the information of the current optimal solution. Based on the TMWOA, we propose a multi-output MPrM logic circuits power optimization approach(TMMPOA). Experiments based on the benchmark circuits of the Microelectronics Center of North Carolina(MCNC) validate the effectiveness and superiority of the proposed TMMPOA.

关键词： Logic circuits Benchmark testing Search problems Whale optimization algorithms Microelectronics Optimization Convergence

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Cancer stem cells: advances in knowledge and implications for cancer therapy

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Signal Transduction and Targeted Therapy 2024年第8期9卷 3242-3304页

作者： Xianjing Chu Wentao Tian Jiaoyang Ning Gang xiao Yunqi zhou ziqi Wang zhuofan zhai Guilong Tanzhu Jie Yang rongrong zhou Department of Oncology Xiangya HospitalCentral South UniversityChangsha 410008China Department of Dermatology Xiangya HospitalCentral South UniversityChangsha 410008China xiangya Lung Cancer Center Xiangya HospitalCentral South UniversityChangsha 410008China National Clinical research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangshaHunan Province 410008China

Cancer stem cells(CSCs),a small subset of cells in tumors that are characterized by self-renewal and continuous proliferation,lead to tumorigenesis,metastasis,and maintain tumor *** continues to be a significant global disease *** the past,surgery,radiotherapy,and chemotherapy were the main cancer *** technology of cancer treatments continues to develop and advance,and the emergence of targeted therapy,and immunotherapy provides more options for patients to a certain ***,the limitations of efficacy and treatment resistance are still *** review begins with a brief introduction of the historical discoveries,original hypotheses,and pathways that regulate CSCs,such as WNT/β-Catenin,hedgehog,Notch,NFkB,JAK/STAT,TGF-β,PI3K/AKT,PPAr pathway,and their *** focus on the role of CSCs in various therapeutic outcomes and resistance,including how the treatments affect the content of CSCs and the alteration of related molecules,CSCs-mediated therapeutic resistance,and the clinical value of targeting CSCs in patients with refractory,progressed or advanced *** summary,CSCs affect therapeutic efficacy,and the treatment method of targeting CSCs is stll difficult to *** regulatory mechanisms and targeting biomarkers of CSCs is currently the mainstream idea.

关键词： Cancer maintain knowledge

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CMOS Temperature Sensors: From Module Design to System Design

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Chinese Journal of Electronics 2024年

作者： zhong TANG xiao-Peng YU zheng SHI Nianxiong Nick Tan Vango Technologies zhejiang Univerisity

In a smart CMOS temperature sensor, the temperature information is converted to an electrical signal, such as voltage, current, or time delay, and then it is digitized by an analog-to-digital converter(ADC). Instead of categorizing sensors according to their sensing elements, this work introduces different CMOS temperature sensors based on their signal processing domains of the readout circuits. To design a suitable sensor for a specific application,two general design methodologies are also introduced with state-of-the-art examples. Depending on the applications,the corresponding types of the sensor and design methodology can be chosen to optimize the performance.

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Theoretical calculations of proton emission half-lives based on a deformed Gamow-like model

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Chinese Physics C 2024年第4期48卷 107-114页

作者：张冬萌胡笑源亓林静刘宏铭李明李小华 School of Nuclear Science and Technology University of South ChinaHengyang 421001China Institute of Modern Physics Fudan UniversityShanghai 200433China National Exemplary Base for International Sci&Tech.Collaboration of Nuclear Energy and Nuclear Safety University of South ChinaHengyang 421001China Cooperative Innovation Center for Nuclear Fuel Cycle Technology&Equipment University of South ChinaHengyang 421001China Key Laboratory of Low Dimensional Quantum Structures and Quantum Control Hunan Normal UniversityChangsha 410081China

In this study,proton emission half-lives were investigated for deformed proton emitters with 53≤z≤83based on the presented deformed Gamow-like model,where the deformation effect was included in the Coulomb *** experimental half-lives of proton emitters can be reproduced within a factor of *** comparison,the results from the universal decay law and the new Geiger-Nuttall law are also ***,the relevance of the half-lives to the angular momentum l for ^(117)La,^(121)Pr,^(135)Tb,and ^(141)Ho were analyzed,and the corresponding possible values of l were proposed:l=3,3,4,4.

关键词： proton emission half-lives deformed nuclei Gamow-like model

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Fluid-Structure Interaction Analysis of Flexible Plate with Partitioned Coupling Method

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China Ocean Engineering 2019年第6期33卷 713-722页

作者： W.z.,Lim r.Y.,xiao Faculty of Computing Engineering and the Built EnvironmentBirmingham City UniversityBirminghamB47XGUnited Kingdom Department of Urban Engineering School of The Built Environment and ArchitectureLondon South Bank UniversityBorough RoadLondonSE10AAUnited Kingdom

The development and rapid usage of numerical codes for fluid-structure interaction(FSI) problems are of great relevance to researchers in many engineering fields such as civil engineering and ocean engineering. This multidisciplinary field known as FSI has been expanded to engineering fields such as offshore structures, tall slender structures and other flexible structures applications. The motivation of this paper is to investigate the numerical model of two-way coupling FSI partitioned flexible plate structure under fluid flow. The adopted partitioned method and approach utilized the advantage of the existing numerical algorithms in solving the two-way coupling fluid and structural interactions. The flexible plate was subjected to a fluid flow which causes large deformation on the fluid domain from the oscillation of the flexible plate. Both fluid and flexible plate are subjected to the interaction of load transfer within two physics by using the strong and weak coupling methods of MFS and Load Transfer Physics Environment, respectively. The oscillation and deformation results have been validated which demonstrate the reliability of both strong and weak method in resolving the two-way coupling problem in contribution of knowledge to the feasibility field study of ocean engineering and civil engineering.

关键词： fluid-structure interaction flexible plate structure two-way coupling partitioned method numerical simulation

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Insertion sequence transposition activates antimycobacteriophage immunity through an Isr2-silenced lipid metabolism gene island

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mLife 2024年第1期3卷 87-100页

作者： Yakun Li Yuyun Wei xiao Guo xiaohui Li Lining Lu Lihua Hu zheng-Guo He State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources Guangxi Research Center for Microbial and Enzyme Engineering TechnologyCollege of Life Scienceand TechnologyGuangxi UniversityNanningChina

Insertion sequences(ISs)exist widely in bacterial genomes,but their roles in the evolution of bacterial antiphage defense remain to be ***,we report that,under the pressure of phage infection,the IS1o96 transposition of Mycobacterium smegmatis into the Isr2 gene can occur at high frequencies,which endows the mutant mycobacterium with a broad-spectrum antiphage ***2 functions as a negative regulator and directly silences expression of a gene island composed of 11 lipid metabolism-related *** complete or partial loss of the gene island leads to a significant decrease of bacteriophage adsorption to the mycobacterium,thus defending against phage ***,a phage that has evolved mutations in two tail-filament genes can re-escape from the Isr2 inactivation-triggered host *** study uncovered a new signaling pathway for activating antimycobacteriophage immunity by Is transposition and provided insight into the natural evolution of bacterial antiphage defense.

关键词： antiphage defense bacteriophage gene island insertion sequence mycobacteria

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STCF conceptual design report (Volume 1): Physics & detector

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Frontiers of physics 2024年第1期19卷 1-154页

作者： M.Achasov X.C.Ai L.P.An r.Aliberti Q.An X.z.Bai Y.Bai O.Bakina A.Barnyakov V.Blinov V.Bobrovnikov D.Bodrov A.Bogomyagkov A.Bondar I.Boyko z.H.Bu F.M.Cai H.Cai J.J.Cao Q.H.Cao X.Cao z.Cao Q.Chang K.T.Chao D.Y.Chen H.Chen H.X.Chen J.F.Chen K.Chen L.L.Chen P.Chen S.L.Chen S.M.Chen S.Chen S.P.Chen W.Chen X.Chen X.F.Chen X.r.Chen Y.Chen Y.Q.Chen H.Y.Cheng J.Cheng S.Cheng T.G.Cheng J.P.Dai L.Y.Dai X.C.Dai D.Dedovich A.Denig I.Denisenko J.M.Dias D.z.Ding L.Y.Dong W.H.Dong V.Druzhinin D.S.Du Y.J.Du z.G.Du L.M.Duan D.Epifanov Y.L.Fan S.S.Fang z.J.Fang G.Fedotovich C.Q.Feng X.Feng Y.T.Feng J.L.Fu J.Gao Y.N.Gao P.S.Ge C.Q.Geng L.S.Geng A.Gilman L.Gong T.Gong B.Gou W.Gradl J.L.Gu A.Guevara L.C.Gui A.Q.Guo F.K.Guo J.C.Guo J.Guo Y.P.Guo z.H.Guo A.Guskov K.L.Han L.Han M.Han X.Q.Hao J.B.He S.Q.He X.G.He Y.L.He z.B.He z.X.Heng B.L.Hou T.J.Hou Y.r.Hou C.Y.Hu H.M.Hu K.Hu r.J.Hu W.H.Hu X.H.Hu Y.C.Hu J.Hua G.S.Huang J.S.Huang M.Huang Q.Y.Huang W.Q.Huang X.T.Huang X.J.Huang Y.B.Huang Y.S.Huang N.Hüsken V.Ivanov Q.P.Ji J.J.Jia S.Jia z.K.Jia H.B.Jiang J.Jiang S.z.Jiang J.B.Jiao z.Jiao H.J.Jing X.L.Kang X.S.Kang B.C.Ke M.Kenzie A.Khoukaz I.Koop E.Kravchenko A.Kuzmin Y.Lei E.Levichev C.H.Li C.Li D.Y.Li F.Li G.Li G.Li H.B.Li H.Li H.N.Li H.J.Li H.L.Li J.M.Li J.Li L.Li L.Li L.Y.Li N.Li P.r.Li r.H.Li S.Li T.Li W.J.Li X.Li X.H.Li X.Q.Li X.H.Li Y.Li Y.Y.Li z.J.Li H.Liang J.H.Liang Y.T.Liang G.r.Liao L.z.Liao Y.Liao C.X.Lin D.X.Lin X.S.Lin B.J.Liu C.W.Liu D.Liu F.Liu G.M.Liu H.B.Liu J.Liu J.J.Liu J.B.Liu K.Liu K.Y.Liu K.Liu L.Liu Q.Liu S.B.Liu T.Liu X.Liu Y.W.Liu Y.Liu Y.L.Liu z.Q.Liu z.Y.Liu z.W.Liu I.Logashenko Y.Long C.G.Lu J.X.Lu N.Lu Q.F.Lü Y.Lu Y.Lu z.Lu P.Lukin F.J.Luo T.Luo X.F.Luo Y.H.Luo H.J.Lyu X.r.Lyu J.P.Ma P.Ma Y.Ma Y.M.Ma F.Maas S.Malde D.Matvienko z.X.Meng r.Mitchell A.Nefediev Y.Nefedov S.L.Olsen Q.Ouyang P.Pakhlov G.Pakhlova X.Pan Y.Pan E.Passemar Y.P.Pei H.P.Peng L.Peng X.Y.Peng X.J.Peng K.Peters S.Pivovarov E.Pyata B.B.Qi Y.Q.Qi W.B.Qian Y.Qian C.F.Qiao J.J.Qin J.J.Qin L.Q.Qin X.S.Qin T.L.Qiu J.rademacker C.F.redmer H.Y.Sang Anhui University Hefei 230039China Beihang University Beijing 100191China Budker Institute of Nuclear Physics Novosibirsk 630090Russia CAS Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China Cavendish Laboratory University of CambridgeJJ Thomson AveCambridge CB30HEUnited Kingdom Central China Normal University Wuhan 430079China Central South University Changsha 410083China China University of Geosciences Wuhan 430074China China University of Mining and Technology Xuzhou 221116China École Polytechnique Fédérale de Lausanne(EPFL) LausanneSwitzerland Fudan University Shanghai 200433China Goethe University Frankfurt D-60325 Frankfurt am MainGermany Guangxi Normal University Guilin 541004China Guangxi Uninversity Nanning 530004China Hangzhou Institute for Advanced Study UCASHangzhou 310024China Hebei Normal University Shijiazhuang 050024China Hebei University Baoding 071002China Hefei University of Technology Hefei 230601China Helmholtz Institute Mainz Staudinger Weg 18D-55099 MainzGermany Henan Normal University Xinxiang 453007China Henan University Kaifeng 475004China High Energy Physics Center Chung-Ang UniversitySeoul 06974Korea Higher School of Economy 11 Pokrovsky Bulvar Moscow 109028Russia Huangshan University Huangshan 245000China Hubei University of Automotive Technology Shiyan 442002China Hunan Normal University Changsha 410081China Hunan University of Science and Technology Xiangtan 411201China Hunan University Changsha 410082China Indiana University BloomingtonIndiana 47405USA Inner Mongolia University Hohhot 010021China Institute of Advanced Science Facilities Shenzhen 518107China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China Institute of Physics Academia SinicaTaipeiTaiwan 11529China Institute of Theoretical Physics Chinese Academy of SciencesBeijing 100190China Jilin University Changch

The superτ-charm facility(STCF)is an electron–positron collider proposed by the Chinese particle physics *** is designed to operate in a center-of-mass energy range from 2 to 7 GeV with a peak luminosity of 0.5×10^(35) cm^(–2)·s^(–1) or *** STCF will produce a data sample about a factor of 100 larger than that of the presentτ-charm factory—the BEPCII,providing a unique platform for exploring the asymmetry of matter-antimatter(charge-parity violation),in-depth studies of the internal structure of hadrons and the nature of non-perturbative strong interactions,as well as searching for exotic hadrons and physics beyond the Standard *** STCF project in China is under development with an extensive r&D *** document presents the physics opportunities at the STCF,describes conceptual designs of the STCF detector system,and discusses future plans for detector r&D and physics case studies.

关键词： electron–positron collider tau-charm region high luminosity STCF detector conceptual design

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The role of renewable Protocatechol Acid in Epoxy Coating Modification: Significantly Improved Antibacterial and Adhesive Properties

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Chinese Journal of Polymer Science 2024年第1期42卷 63-72,I0008页

作者： Ming-Xuan Chen Jin-Yue Dai Li-Yue zhang Shuai-Peng Wang Jing-Kai Liu Yong-Gang Wu Xin-Wu Ba xiao-Qing Liu School of Chemistry and Materials Science Hebei UniversityBaoding 071000China Ningbo Institute of Materials Technology and Engineering Chinese Academy of SciencesNingbo 315201China Key Laboratory of Marine Materials and related Technologies Chinese Academy of SciencesNingbo 315201China

It is of great significance to design epoxy coatings with superior antibacterial properties and high adhesive properties, as well as excellent processing, superior durability, and high transparency. However, it is still a challenge because of the common complex design and synthesis. Herein, the bio-based monomer protocatechuic acid(PCA) was used as raw material, the catechol structure with high bonding and antibacterial properties was introduced into the flexible alkane segment of ethylene glycol diglycidyl ether(EGDE) through an efficient, and green method, and it was cured with isophorone diamine(IPDA) to prepare corresponding thermosets. The cured resins exhibited excellent allaround qualities, particularly in bonding and antibacterial. When 30% PCA was added to pure epoxy resin, the adhesion between substrate and coating increased from 4.40 MPa to 13.60 MPa and the antibacterial rate of coating against E. coli and S. aureus could approach 100%. All of this is due to the fact that the catechol structure present in PCA has the ability to interact with various substrates and alter the permeability of bacterial cell membranes. The architecture of this method offers a fresh approach to dealing with the issues of challenging raw material selection and complex synthesis techniques.

关键词： Epoxy coatings Thermosets Catechol structure Antibacterial High adhesion

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Break of thermal equilibrium between optical and acoustic phonon branches of CsPbI_(3)under continuous-wave light excitation and cryogenic temperature

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Chinese Chemical Letters 2024年第7期35卷 534-537页

作者： rongliang Deng Yihang Chen xiaotong Fan Guolong Chen Shuli Wang Changzhi Yu xiao Yang Tingzhu Wu zhong Chen Yue Lin Department of Electronic Science Fujian Engineering Research Center for Solid-State LightingXiamen UniversityXiamen 361005China Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province(IKKEM) Xiamen 361102China Institute of Electromagnetics and Acoustics School of Electronic Science and EngineeringXiamen UniversityXiamen 361005China

The kinetic of low-temperature carrier and lattice of lead-halide perovskite is yet to be fully *** this work,we investigate the steady-state photoluminescences(PLs)of CsPbI_(3)at the environmental temperature(Te)ranging from 20 K to 300 K,and observed anomalous behaviors at cryogenic temperatures:The carrier temperature(Tc)of pure CsPbI_(3)exhibits a negative correlation with Te,accompanied by an expansion in Urbach tails of absorption spectra(Abs.)and excessive red-shifts at peak energy of *** phenomena are also observed in those samples containing a certain amount of Cs_(4)PbI_(6),but to a lesser extent and occurs at lower *** is attributed to the intensified hot phonon bottleneck effect(HPB)in CsPbI_(3)at cryogenic Te,which hinders the energy transfer from hot carriers,via longitudinal optics(LO)phonons to longitudinal acoustic(LA)phonons,to the *** samples under continuous-wave laser excitation,in specific,the barrier induced by the enhanced HPB at low Teprevents the effective thermalization among carriers,LO and LA phonons,which,therefore,form thermally isolated ensembles with different *** cryogenic Terange,the elevated temperatures of carrier and LO phonon expand the high-energy side of PLs and the low-energy tail of Abs.,*** those samples in which the CsPbI_(3)is mixed with Cs_(4)PbI_(6),the interfacial LO-LO interaction across them provides a bypass for heat dissipation,mitigating the heat accumulation in LO-phonons of CsPbI_(3).The results suggest that a strong HPB effect may break the thermal equilibrium among different branches of phonons in the lattice under certain extreme conditions.

关键词： CsPbI_(3) Cs_(4)PbI_(6) Low-temperature carrier Lattice kinetic Hot phonon bottleneck effect Interfacial LO-LO interaction

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