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Androgen signaling inhibits de novo lipogenesis to alleviate lipid deposition in zebrafish

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zoological research 2024年第2期45卷 355-366页

作者： Jing-Yi Jia Guang-Hui Chen Ting-Ting Shu Qi-Yong Lou Xia Jin Jiang-Yan He Wu-Han xiao Gang zhai zhan Yin College of Fisheries Huazhong Agriculture UniversityWuhanHubei 430070China State Key Laboratory of Freshwater Ecology and Biotechnology Institute of HydrobiologyChinese Academy of SciencesWuhanHubei 430072China College of Advanced Agricultural Sciences University of Chinese Academy of SciencesBeijing 100049China Hubei Key Laboratory of Three Gorges Project for Conservation of Fishes Chinese Sturgeon Research InstituteChina Three Gorges CorporationYichangHubei 443100China Hubei Hongshan Laboratory Huazhong Agriculture UniversityWuhanHubei 430070China Innovative Academy of Seed Design Chinese Academy of SciencesBeijing 100049China

Testosterone is closely associated with lipid metabolism and known to affect body fat composition and muscle mass in ***,the mechanisms by which testosterone acts on lipid metabolism are not yet fully understood,especially in *** this study,cyp17a1-/-zebrafish(Danio rerio)exhibited excessive visceral adipose tissue(VAT),lipid content,and up-regulated expression and activity of hepatic de novo lipogenesis(DNL)*** assay for transposase accessible chromatinwithsequencing(ATAC-seq)results demonstrated that chromatin accessibility of DNL genes was increased in cyp17a1-/-fish compared to cyp17a1+/+male fish,including stearoyl-CoA desaturase(scd)and fatty acid synthase(fasn).Androgen response element(ArE)motifs in the androgen signaling pathway were significantly enriched in cyp17a1+/+male fish but not in cyp17a1-/-*** androgen receptor(ar)-/-and wildtype(WT)zebrafish administered with Ar antagonist flutamide displayed excessive visceral adipose tissue,lipid content,and up-regulated expression and activity of hepatic de novo lipogenesis *** Ar agonist BMS-564929 reduced the content of VAT and lipid content,and down-regulated acetyl-CoA carboxylase a(acaca),fasn,and scd ***,the rescue effect of testosterone on cyp17a1-/-fish in terms of phenotypes was abolished when ar was additionally ***,these findings reveal that testosterone inhibits lipid deposition by down-regulating DNL genes via Ar in zebrafish,thus expanding our understanding of the relationship between testosterone and lipid metabolism in teleosts.

关键词： Cyp17a1 Testosterone Androgen receptor De novo lipogenesis Fatty acid synthesis

Ultrahigh strength and improved electrical conductivity in an aging strengthened copper alloy processed by combination of equal channel angular pressing and thermomechanical treatment

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Journal of Central South University 2024年第6期31卷 1823-1837页

作者： WANG Xu LI zhou MENG Xiang-peng xiao zhu School of Materials Science and Engineering Central South UniversityChangsha 410083China Ningbo Boway Alloy Material Co. Ltd.Ningbo 315135China Key Laboratory of Non-ferrous Metal Materials Science and Engineering(Ministry of Education) Changsha 410083China

In this paper,equal channel angular pressing and thermomechanical treatment was employed to improve the strength and electrical conductivity of an aging strengthened Cu-Ti-Cr-Mg alloy,and the microstructure and properties of the alloy were investigated in *** results showed that the samples deformed by the combination of cryogenic equal channel angular pressing(ECAP)and rolling had good comprehensive properties after aging at 400℃.The tensile strength of the peak-aged and over-aged samples was 1120 MPa and 940 MPa,with their corresponding electrical conductivity of 14.7%IACS and 22.1%IACS,*** and cryogenic rolling introduced high density dislocations,leading to the inhibition of the softening effects and refinement of the *** a long time aging at 400℃,the alloy exhibited ultra-high strength with obvious increasing electrical *** high strength was attributed to the synergistic effect of work hardening,grain refinement strengthening and precipitation *** precipitation of a large amount of Ti atoms from the matrix led to the high electrical conductivity of the over-aged sample.

关键词： Cu-Ti alloy equal channel angular pressing rolling aging treatment high strength

Enhancing the Interaction of Carbon Nanotubes by Metal-Organic Decomposition with Improved Mechanical Strength and Ultra-Broadband EMI Shielding Performance

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Nano-Micro Letters 2024年第7期16卷 281-294页

作者： Yu-Ying Shi Si-Yuan Liao Qiao-Feng Wang Xin-Yun Xu xiao-Yun Wang Xin-Yin Gu You-Gen Hu Peng-Li zhu rong Sun Yan-Jun Wan Shenzhen Institute of Advanced Electronic Materials Shenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen 518055People’s Republic of China Southern University of Science and Technology Shenzhen 518055People’s Republic of China National Key Laboratory of Materials for Integrated Circuits Shanghai Institute of Microsystem and Information TechnologyChinese Academy of SciencesShanghai 200050People’s Republic of China

The remarkable properties of carbon nanotubes(CNTs)have led to promising applications in the field of electromagnetic inter-ference(EMI)***,for macroscopic CNT assemblies,such as CNT film,achieving high electrical and mechanical properties remains challenging,which heavily depends on the tube-tube interac-tions of ***,we develop a novel strategy based on metal-organic decomposition(MOD)to fabricate a flexible silver-carbon nanotube(Ag-CNT)*** Ag particles are introduced in situ into the CNT film through annealing of MOD,leading to enhanced tube-tube *** a result,the electrical conductivity of Ag-CNT film is up to 6.82×10^(5) S m^(-1),and the EMI shielding effectiveness of Ag-CNT film with a thickness of~7.8μm exceeds 66 dB in the ultra-broad frequency range(3-40 GHz).The tensile strength and Young’s modulus of Ag-CNT film increase from 30.09±3.14 to 76.06±6.20 MPa(~253%)and from 1.12±0.33 to 8.90±0.97 GPa(~795%),***,the Ag-CNT film exhibits excellent near-field shield-ing performance,which can effectively block wireless *** innovative approach provides an effective route to further apply macroscopic CNT assemblies to future portable and wearable electronic devices.

关键词： EMI shielding Mechanical strength Carbon nanotubes Metal-organic decomposition Flexibility

Cationic ordering transition in oxygen-redox layered oxide cathodes

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Carbon Energy 2024年第1期6卷 197-206页

作者： Xinyan Li Ang Gao Qinghua zhang Hao Yu Pengxiang Ji Dongdong xiao Xuefeng Wang Dong Su xiaohui rong Xiqian Yu Hong Li Yong-Sheng Hu Lin Gu Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijingChina College of Materials Science and Opto-Electronic Technology University of Chinese Academy of SciencesBeijingChina Beijing National Center for Electron Microscopy and Laboratory of Advanced Materials School of Materials Science and EngineeringTsinghua UniversityBeijingChina Beijing Advanced Innovation Center for Materials Genome Engineering Huairou DivisionInstitute of PhysicsChinese Academy of SciencesBeijingChina

Understanding the structural origin of the competition between oxygen 2p and transition-metal 3d orbitals in oxygen-redox(Or)layered oxides is eminently desirable for exploring reversible and high-energy-density Li/Na-ion ***,we reveal the correlation between cationic ordering transition and Or degradation in ribbon-ordered P3-Na_(0.6)Li_(0.2)Mn_(0.8)O_(2) via in situ structural *** two different voltage windows,the Or capacity can be improved approximately twofold when suppressing the in-plane cationic ordering *** find that the intralayer cationic migration is promoted by electrochemical reduction from Mn^(4+)to Jahn–Teller Mn^(3+)and the concomitant NaO_(6) stacking transformation from triangular prisms to octahedra,resulting in the loss of ribbon ordering and electrochemical ***-principles calculations reveal that Mn^(4+)/Mn^(3+)charge ordering and alignment of the degenerate eg orbital induce lattice-level collective Jahn–Teller distortion,which favors intralayer Mn-ion migration and thereby accelerates Or *** findings unravel the relationship between in-plane cationic ordering and Or reversibility and highlight the importance of superstructure protection for the rational design of reversible Or-active layered oxide cathodes.

关键词： cationic ordering layered oxide cathodes oxygen redox sodium-ion batteries

research and design of an expert diagnosis system for rail vehicle driven by data mechanism models

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railway Sciences 2024年第4期3卷 480-502页

作者： Lin Li Jiushan Wang Shilu xiao zhuzhou Guochuang rail Technology Company Limited ZhuzhouChina zhuzhou Guochuang rail Technology Company Limited Industrial Intelligence Research InstituteZhuzhouChina

Purpose-The aim of this work is to research and design an expert diagnosis system for rail vehicle driven by data mechanism ***/methodology/approach-The expert diagnosis system utilizes statistical and deep learning methods to model the real-time status and historical data features of rail *** on data mechanism models,it predicts the lifespan of key components,evaluates the health status of the vehicle and achieves intelligent monitoring and diagnosis of rail ***-The actual operation effect of this system shows that it has improved the intelligent level of the rail vehicle monitoring system,which helps operators to monitor the operation of vehicle online,predict potential risks and faults of vehicle and ensure the smooth and safe operation of ***/value-This system improves the efficiency of rail vehicle operation,scheduling and maintenance through intelligent monitoring and diagnosis of rail vehicle.

关键词： rail transit rail vehicle Expert diagnosis Intelligent operation and maintenance Deep learning Lifespan prediction reliability analysis

Chiral Pair Density Waves with residual Fermi Arcs in rbV3Sb5

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Chinese Physics Letters 2024年第9期41卷 88-92页

作者： xiao-Yu Yan Hanbin Deng Tianyu Yang Guowei Liu Wei Song Hu Miao zhijun Tu Hechang Lei Shuo Wang Ben-Chuan Lin Hailang Qin Jia-Xin Yin Department of Physics Southern University of Science and TechnologyShenzhen 518055China Materials Science and Technology Division Oak Ridge National LaboratoryOak RidgeTennessee 37831USA Beijing Key Laboratory of Optoelectronic Functional Materials MicroNano Devices Department of PhysicsRenmin University of ChinaBeijing 100872China Key Laboratory of Quantum State Construction and Manipulation(Ministry of Education) Renmin University of ChinaBeijing 100872China Shenzhen Institute for Quantum Science and Engineering Southern University of Science and TechnologyShenzhen 518055China Guangdong Provincial Key Laboratory of Quantum Science and Engineering Southern University of Science and TechnologyShenzhen 518055China Quantum Science Center of Guangdong-Hong Kong-Macao Greater Bay Area Shenzhen 518055China

The chiral 2×2 charge order has been reported and confirmed in the kagome superconductor rbV3Sb5,while its interplay with superconductivity remains elusive owing to its lowest superconducting transition temperature Tc of about 0.85K in the AV3Sb5 family(A=K,rb,Cs)that severely challenges electronic spectroscopic ***,utilizing dilution-refrigerator-based scanning tunneling microscopy down to 30 mK,we observe chiral 2×2 pair density waves with residual Fermi arcs in *** find a superconducting gap of 150eV with substantial residual in-gap *** spatial distribution of this gap exhibits chiral 2×2 modulations,signaling a chiral pair density wave(PDW).Our quasi-particle interference imaging of the zero-energy residual states further reveals arc-like *** discuss the relation of the gap modulations with the residual Fermi arcs under the space-momentum correspondence between PDW and Bogoliubov Fermi states.

关键词： Fermi chiral utilizing

Survey of the mechanisms of power take-off(PTO)devices of wave energy converters

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Acta Mechanica Sinica 2020年第3期36卷 644-658页

作者： z.Liu r.zhang H.xiao X.Wang School of Engineering RMIT UniversityBundooraVIC 3083Australia

Ocean wave energy conversion as one of the renewable clean energy sources is attracting the research interests of many *** review introduces different types of power take-off(PTO)technology of wave energy *** novelty of this paper is to present advantages and disadvantages of the linear direct and indirect drive PTO devices for ocean wave energy *** designs and optimizations of PTO systems of ocean wave energy converters have been studied from reviewing the recently published *** novel mechanical designs of the PTO systems have been compared and investigated in order to increase the energy harvesting efficiency.

关键词： ocean wave energy

Influencing mechanism of pre-existing nanoscale Al5Fe2 phase on Mg-Fe interface in friction stir spot welded Al-free zK60-Q235 joint

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Journal of Materials Science & Technology 2020年第7期42卷 220-228页

作者： r.z.Xu Q.Yang D.r.Ni B.L.xiao C.z.Liu z.Y.Ma Institute of Metal research Chinese Academy of SciencesShenyang110016China College of Material Science and Engineering Shenyang Aerospace UniversityShenyang110136China Department of Materials Science and Engineering University of Illinois at Urbana-Champaign1304 W Green StUrbanaIL61801United States Fredrick Seitz Materials research Laboratory University of Illinois at Urbana-Champaign104 S Goodwin AveUrbanaIL61801United States

Al-free zK60 magnesium (Mg) alloy sheet was selected as substrate material of Mg-steel pinless friction stir spot welding (FSSW), avoiding the effect of the Al element in the substrate on the alloying reaction of Mg-iron (Fe) interface. The sound FSSW joint of zK60 Mg alloy and Q235 steel with a hot-dipped aluminum (Al)-containing zinc (zn) coating was successfully realized. The detailed microstructural examinations proved that Al5Fe2 phase at the Mg-Fe interface came from the pre-existing Al5Fe2 phase in the coating and acted as the transition layer for promoting the metallurgical bonding of Mg and Fe. The interfaces with well-matched lattice sites among Fe, Al5Fe2 and Mg were formed during FSSW. A low energy interface with good match of lattice sites ((002)Al5Fe2//(110)Fe, [110]Al5Fe2//[113]Fe) between Al5Fe2 and Fe was identified. For the interface between Al5Fe2 and Mg, an orientation relationship of (622)Al5Fe2//(3112)Mgand[158]Al5Fe2//[2423]Mg was observed. The tensile-shear load of the zK60-steel joint could reach 4.6 kN. Moreover, the joint fracture occurred at the interface between the Al5Fe2 layer and the Mg alloy substrate, suggesting the brittle fracture characteristic.

关键词： Dissimilar welding Friction stir spot welding Magnesium alloys Steels zinc coating

Chromosome-level genome and population genomics of the intermediate horseshoe bat(rhinolophus affinis)reveal the molecular basis of virus tolerance in rhinolophus and echolocation call frequency variation

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zoological research 2024年第5期45卷 1147-1160页

作者： Le zhao Jiaqing Yuan Guiqiang Wang Haohao Jing Chen Huang Lulu Xu xiao Xu Ting Sun Wu Chen Xiuguang Mao Gang Li College of Life Sciences Shaanxi Normal UniversityXi’anShaanxi 710119China QinLing-Bashan Mountains Bioresources Comprehensive Development C.I.C. School of Bioscience and EngineeringShaanxi University of TechnologyHanzhongShaanxi 723001China Guangzhou zoo GuangzhouGuangdong 510070China School of Ecological and Environmental Sciences East China Normal UniversityShanghai 200241China

Horseshoe bats(genus rhinolophus,family rhinolophidae)represent an important group within chiropteran phylogeny due to their distinctive traits,including constant high-frequency echolocation,rapid karyotype evolution,and unique immune *** in evolutionary biology,supported by high-quality reference genomes and comprehensive whole-genome data,have significantly enhanced our understanding of species origins,speciation mechanisms,adaptive evolutionary processes,and phenotypic ***,genomic research and understanding of the evolutionary patterns of rhinolophus are severely constrained by limited data,with only a single published genome of *** currently *** this study,we constructed a high-quality chromosome-level reference genome for the intermediate horseshoe bat(***).Comparative genomic analyses revealed potential genetic characteristics associated with virus tolerance in ***,we observed expansions in several immune-related gene families and identified various genes functionally associated with the SArS-CoV-2 signaling pathway,DNA repair,and apoptosis,which displayed signs of rapid *** addition,we observed an expansion of the major histocompatibility complex class II(MHC-II)region and a higher copy number of the HLA-DQB2 gene in horseshoe bats compared to other chiropteran *** on whole-genome resequencing and population genomic analyses,we identified multiple candidate loci(e.g.,GLI3)associated with variations in echolocation call frequency across *** *** research not only expands our understanding of the genetic characteristics of the rhinolophus genus but also establishes a valuable foundation for future research.

关键词： reference-quality genome Comparative genomics Population genomics Positive selection Bats