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Integrating machine learning and human use experience to identify personalized pharmacotherapy in Traditional Chinese Medicine:a case study on resistant hypertension

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Journal of Traditional Chinese Medicine 2025年第1期45卷 192-200页

作者： CHE qianzi liu Dasheng XIANG Xinghua TIAN Yaxin XIE Feibiao XU Wenyuan liu Jian WANG Xuejie WANG Liying BAI Weiguo HAN Xuejie YANG Wei Department of Medical Statistics Institute of Basic Research in Clinical MedicineChina Academy of Chinese Medical Sciences Department of Science and Education Medical Statistics Teaching and Research OfficeInstitute of Basic Research in Clinical MedicineChina Academy of Chinese Medical Sciences Computer Department Xiyuan Hospital of the China Academy of Chinese Medical Sciences Traditional Chinese Medicine Standards Research Center Medical Statistics Teaching and Research OfficeInstitute of Basic Research in Clinical MedicineChina Academy of Chinese Medical Sciences

OBJECTIVE: To enhance the understanding of identifying personalized pharmacotherapy options in Traditional Chinese Medicine(TCM), and further support the registration of new TCM drugs. METHODS: Generalized Boosted Models and XGBoost were employed to construct a classification model to identify the bad prognosis factors in resistant hypertension(RH) patients. Furthermore, we used association analysis to explore the rules of "symptomsyndrome" and "symptom-herb" for the major influencing factors, in order to summarize prescription pattern and applicable patients of TCM. RESULTS: Patients with major adverse cardiac events mostly have complex symptoms of phlegm, stasis, deficiency and fire intermingled with each other, and finally summarized the human experience of using Chinese herbal medicine to precisely intervene in some symptoms of RH patients on the basis of conventional Western medical treatment. CONCLUSIONS: Machine learning algorithms can make full use of human use experience and evidence to save clinical trial resources and accelerate the development of TCM varieties.

关键词： human clinical experience machine learning new drugs registration personalized pharmacotherapy

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Unraveling the complex interactions between plasmonic Ag nanoparticles and biomolecules for enhancing molecular chirality

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Science China Chemistry 2025年第2期68卷 543-551页

作者： Chen Wang Yunlong Tao qingqing Cheng Dandan Lu Chuang liu Guizeng Yang Xuehao Sun Lichao Sun qingfeng zhang College of Chemistry and Molecular Sciences Hubei Key Laboratory of Electrochemical Power SourcesWuhan UniversityWuhan 430072China Suzhou Institute of Wuhan University Suzhou 215123China

Plasmonic nanostructures have been widely employed to enhance the chiral light-matter interactions for chirality sensing owing to their intriguing optical ***,a quantitative understanding of the correlation between enhanced molecular chirality and plasmonic properties in plasmonic nanoparticle-molecule complexes remains a challenge yet to be *** we demonstrate the complex interactions between Ag nanoparticles and biomolecules that generate distinct plasmonic circular dichroism signals ranging from UV to visible *** deliberately changing the surface coverage of chiral molecules,the geometry of Ag nanoparticles,and the aggregation states of the complexes,three distinct underlying mechanisms were found to be intertwined and hybridized for enhancing circular dichroism *** further employed the chiral plasmonic nanoparticle-molecule complexes to quantify the enantiomeric purity of cysteine and explore their possible applications in other chiral *** insights gained from this work shed light on the underlying mechanisms dictating the enhanced circular dichroism signals of chiral plasmonic nanoparticle-molecule complexes.

关键词： chiral plasmonics plasmonic circular dichroism nanoparticle-molecule complexes Ag nanoparticles chirality sensing

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Effective nucleus-nucleus potentials for heavy-ion fusion reactions

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Nuclear Science and Techniques 2025年第2期36卷 103-111页

作者： Ning Wang Jin-Ming Chen Min liu Present Address:Department of Physics Guangxi Normal UniversityGuilin 541004China Guangxi Key Laboratory of Nuclear Physics and Technology Guilin 541004China

Based on the Skyrme energy density functional and reaction q-value,this study proposed an effective nucleus-nucleus poten-tial for describing the capture barrier in heavy-ion fusion *** 443 extracted barrier heights were well reproduced with a root-mean-square(RMS)error of 1.53 MeV,and the RMS deviations with respect to 144 time-dependent Hartree-Fock capture barrier heights were only 1.05 *** with the Siwek-Wilczyński formula,wherein three parameters were determined by the proposed effective potentials,the measured capture cross sections at energies around the barriers were reasonably well reproduced for several fusion reactions induced by nearly spherical nuclei as well as by nuclei with large deformations,such as^(154)Sm and^(238)*** shallow capture pockets and small values of the average barrier radii resulted in the reduction of the capture cross sections for 52,54Cr-and 64 Ni-induced reactions,which were related to the synthesis of new super-heavy nuclei.

关键词： Nucleus-nucleus potential Fusion reactions Superheavy nuclei Capture cross sections

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Territorial Ecological Restoration with a High-carbon Storage Focus in the Beibu Gulf Urban Agglomeration of China:Insights from Carbon Metabolism Spatial Security Patterns

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Chinese Geographical Science 2025年第1期35卷 73-91页

作者： qIN Menglin liu Yuting TAN qianxi zHU ziming WU Xinyu JIANG Hongbo LI Hang SHI qianqian School of Civil Engineering and Architecture Guangxi UniversityNanning 530004China School of Forestry Guangxi UniversityNanning 530004China Ecosystem Science and Management Program University of Northern British ColumbiaPrince George V2N 4Z9Canada zhuhai Institute of Planning and Design Zhuhai 519000China

This study focuses on urgent research on restoring and enhancing carbon storage capacity in the Beibu Gulf Urban Agglomer-ation of China,a key area in the‘Belt and Road’Initiative,which aligns with carbon peaking and neutrality *** research ana-lyzes the spatial characteristics of carbon metabolism from 2000 to 2020 and uses models to identify stable carbon sink areas,positive carbon flow corridors,and carbon sequestration *** goal is to construct a carbon metabolism spatial security pattern(CMSSP)and propose territorial ecological restoration strategies under different development demand *** results show the following:1)in 2020,the study area’s carbon sink decreased by 8.29×10^(4) t C/yr compared with that in 2010 and by 10.83×10^(4) t C/yr compared with that in ***-carbon sinks were found mainly in mountainous areas,whereas low-carbon sinks are concentrated in urban con-struction land,rural residential areas,and land margins.2)From 2000 to 2020,the spatial security pattern of carbon metabolism tended to be‘high in the middle of the east and west and low in the gulf.’In 2000,2010,and 2020,16 stable carbon sinks were *** carbon energy flow density in Guangxi was greater than that in Guangdong and Hainan,with positive carbon flow corridors located primarily in Guangxi and *** number of carbon sequestration nodes remained stable at approximately 15,mainly in Guangxi and Hainan.3)Scenario simulations revealed that under the Nature-based mild restoration scenario,the carbon sink rate will reach 611.85×10^(4) t C/yr by 2030 and increase to 612.45×10^(4) t C/yr by 2060,with stable carbon sinks increasing to *** the restora-tion scenario based on Anti-globalization,the carbon sink will decrease from 610.24×10^(4) t C/yr in 2030 to 605.19×10^(4) t C/yr in 2060,with the disappearance of some positive carbon flow corridors and stable carbon *** the Human-based sustainable restoration scenario,the carbon sink area wil

关键词： carbon metabolism spatial security pattern(CMSSP) territorial ecological restoration carbon sink carbon storage capacity Beibu Gulf Urban Agglomeration,China

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Microstructural softening induced adiabatic shear banding in Ti-23Nb-0.7Ta-2zr-O gum metal

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Journal of Materials Science & Technology 2020年第19期54卷 31-39页

作者： Silu liu Y.z.Guo z.L.Pan X.z.Liao E.J.Lavernia Y.T.zhu q,M,Wei Yonghao zhao Nano and Heterogeneous Materials Center School of Materials Science and EngineeringNanjing University of Science and TechnologyNanjing 210094China School of Aeronautics Northwestern Polytechnical UniversityXi’an 710072China Department of Mechanical Engineering University of North Carolina at CharlotteNC 28223-0001USA School of Aerospace Mechanical and Mechatronic EngineeringThe University of SydneyNSW 2006Australia Department of Materials Science and Engineering University of Californi1IrvineCA 92697USA Department of Materials Science and Engineering North Carolina State UniversityNC 27695USA

Ti-23Nb-0.7Ta-2zr-O gum metal(GM)is an attractive candidate material for applications that require superior mechanical *** our earlier investigation of the GM[1],geometrical softening and the generation of adiabatic shear bands(ASBs)were proposed as primary reasons for the documented anisotropic impact *** the present study,electron backscattered diffraction(EBSD)analysis reveals two different deformed microstructures,i.e.,deformed ultrafine grains(UFGs)and dynamically recrystallized UFGs,formed in the ASBs of GM samples processed by extrusion equal channel angular pressing(ECAP),*** calculation of temperature rise during dynamic compression suggests that the above microstructure differences in the ASBs was originated from their different maximum ASB temperatures(608 K for extruded GM and 1159 K for ECAP-processed GM).Moreover,our calculation on the temperature at the onset of ASBs indicates that microstructural softening is the primary cause for the development of ASBs in both extruded GM(321 K)and ECAP-processed GM(331 K).

关键词： Gum metal Split hopkinson bar Adiabatic shear band Microstructures

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Microstructure evolution and shape memory behaviors of Ni_(47)Ti_(44)Nb_(9)alloy subjected to multistep thermomechanical loading with different prestrain levels

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Journal of Materials Science & Technology 2024年第4期171卷 80-93页

作者： Y.H.zhang H.Li z.W.Yang X.liu q.F.Gu State Key Laboratory of Solidification Processing School of Materials Science and EngineeringNorthwestern Polytechnical UniversityXi’an 710072China Shaanxi Key Laboratory of High-Performance Precision Forming Technology and Equipment Northwestern Polytechnical UniversityXi’an 710072China

Ni_(47)Ti_(44)Nb_(9)shape memory alloy(SMA)is a promising material in the aerospace field due to its wide transformation *** application of shape memory effect depends on multistep thermomechan-ical loading,viz.,low-temperature deformation and subsequent heating to ***-temperature deformation prestrain plays a pivotal role in shape memory properties tailoring of SMA ***,microstructure evolution and deformation mechanisms of Ni_(47)Ti_(44)Nb_(9)SMA subjected to vari-ous prestrain levels are still *** this end,microstructure evolution and shape memory behaviors of Ni_(47)Ti_(44)Nb_(9)alloy subjected to multistep thermomechanical loading with prestrain levels of 8%-16%at-28℃(M_(s)+30℃)were *** results demonstrate that the stress-strain curve of the specimen exhibits four distinct stages at a maximal prestrain of 16%.Whereas stageⅡand stageⅢend at prestrains of∼8%and∼12%,*** stageⅡ,the stress-induced martensitic transformation is accompanied by the dislocation slip of the NiTi matrix andβ-Nb *** stageⅢ,in addition to the higher density of dislocations and further growth of stress-induced martensite variants(SIMVs),(001)compound twins are introduced as a result of the(001)deformation twinning in stress-induced ***{20-1}martensite twins are gradually introduced in stageⅣ.Correspondingly,after subsequent unloading and heating,a higher density of{114}austenite twins form in the specimen with a larger prestrain of 16%.With increasing prestrain from 8%to 16%,the recoverable strainε_(re)^(T)upon heating increases first and then ***ε_(re)^(T)obtains a maximum of 7.03%at 10%prestrain and de-creases to 6.17%at 16%*** increase ofε_(re)^(T)can be attributed to the formation of new SIMVs,the further growth of existing SIMVs,and the recoverable(001)compound *** the decrease ofε_(re)^(T)is mainly associated with the irrecoverable strain by{20−1}martensite *** effe

关键词： Ni_(47)Ti_(44)Nb_(9)shape memory alloy Wide transformation hysteresis Thermomechanical loading Microstructure evolution Shape memory behaviors Stress-induced martensitic transformation Deformation twinning

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EFFECT OF Cu-Ni CONTENT ON THE CORROSION RESISTANCE OF(Cu-Ni)/(10NiO-90NiFe_2O_4)CERMET INERT ANODE FOR ALUMINUM ELECTROLYSIS

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Acta Metallurgica Sinica(English Letters) 2008年第1期21卷 72-78页

作者： z.L. Tian Y.q. Lai J. Li Y.X. liu School of Metallurgical Science and Engineering Central South University Changsha 410083 China

（Cu-Ni）/（10NiO-90NiFe204） cermet inert anodes containing metal Cu-Ni0, 5, 10, 15 and 20 wt pct were prepared and their corrosion resistance to Na3AlF6-Al2O3 melts was investigated. The results indicate that the content of metal Cu-Ni has little effect on the steady-state concentration of Ni in the electrolyte and the values could not be used to effectively differentiate their corrosion resistance. The steady-state concentration of Fe decreases from 304×10^-6 to 168×10^-6 and that of Cu increases from 21×10^-6 to 71×10^-6 with the content of metal Cu-Ni increasing from 0 to 20 wt pct. Post-examination shows that metallic phase Cu-Ni is corroded preferentially during electrolysis and many pores are left at the anode surface. Considering the corrosion resistance and electrical conductivity, the cermet containing metal Cu-Ni 5 wt pct should be selected and studied further.

关键词： Aluminum electrolysis Inert anode NiFe2O4 based cermet Corrosion resistance

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MICROSTRUCTURE TRANSFORMATION IN THE WELDING HEAT AFFECTED zONE OF 800MPa GRADE ULTRA FINE STRUCTURED STEEL

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Acta Metallurgica Sinica(English Letters) 2004年第3期17卷 238-246页

作者： J.B. liu L.J. Hu Y.T.Wang z. q. liu K. Miao z.L. Tian Huazhong University of Science and Technology Wuhan 430074 China Technology Center of Wuhan Iron and Steel (Group) Corporation Wuhan 430080 China Central Iron and Steel Research Institute Beijing 100080 China

The transformation behavior and microstructure development in the heat affected zone(HAz)of 800MPa grade ultra fine structured steel was *** was found that the HAz has intermediate temperature transformation characteristics in a wide range of cooling rates,with the bainite sheaves consisting of bainite ferrite plates without carbide precipitation and retained austenite in the fast cooling *** relatively high cooling rates,which corresponded to low heat inputs,the hardness of the simulated HAz was above that of the base *** the cooling rate was below 9C/s,the welding HAz would have an obvious *** analysis of transformation rates in continuous cooling processes was completed by numerical differential *** result indicated that the microstructure transformation rate of the HAz in 800MPa grade ultra fine structured steel changed sharply to slow speeds when the cooling time t8/5 is longer than 7s.

关键词： ultra fine structured steel weld heat affected zone transformation rate microstructure

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Basic features of the multiscale interaction between tearing modes and slab ion-temperature-gradient modes

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Chinese Physics B 2019年第12期28卷 237-247页

作者： L Wei z X Wang J q Li z q Hu Y Kishimoto Key Laboratory of Materials Modification by Laser Ionand Electron Beams(Ministry of Education)School of PhysicsDalian University of TechnologyDalian 116024China Southwestern Institute of Physics Chengdu 610041China Graduate School of Energy Science Kyoto UniversityGokashoUjiKyoto 1-0011Japan

Nonlinear interaction between tearing modes(TM) and slab ion-temperature-gradient(ITG) modes is numerically investigated by using a Landau fluid model. It is observed that the energy spectra with respect to wavenumbers become broader during the transition phase from the ITG-dominated stage to TM-dominated stage. Accompanied with the fast growth of the magnetic island, the frequency of TM/ITG with long/short wavelength fluctuations in the electron/ion diamagnetic direction decreases/increases respectively. The decrease of TM frequency is identified to result from the effect of the profile flattening in the vicinity of the magnetic island, while the increase of the frequencies of ITG fluctuations is due to the eigenmode transition of ITG induced by the large scale zonal flow and zonal current related to TM. Roles of zonal current induced by the ITG fluctuations in the instability of TM are also analyzed. Finally, the electromagnetic transport features in the vicinity of the magnetic island are discussed.

关键词： magnetic reconnection tearing modes magnetohydrodynamics drift waves nonlinear phenomena

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PROCOAGULANT EFFECTS OF THROMBOLYTICTHERAPY IN ACUTE MYOCARDIAL INFARCTION

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Chinese Medical Sciences Journal 2002年第1期17卷 36-39页

作者： Wang Y liu q zhu J Yuan z Ma X Department of Cardiology the First Hospital Xi''an Jiaotong University Xi''an 710061

To examine the procoagulant effects of thrombolytic agent on h emostasis and study the role of hemostatic markers as predictors of clinical outcomes. Methods. In the present study, eighteen patients with acute myocardial in farction(AMI) received 1.5 or 2.0 million U nonspecific urokinase(UK), or 70～80 mg fibrin specific recombinant tissue plasminogen activator(rt PA)and did not use heparin until 8 hours after intravenous injection of the above agents. Eig ht patients with AMI and without thrombolytic therapy were enrolled as controls. Coagulant and thrombolytic activity markers included thrombin antithrombin Ⅲ complex (TAT), D dimer, fibrinogen (Fg), FMPV/Amax. All markers were determined before,immediately,1,2,4 and 8 hours after the administration of thrombolytic a gents respectively. Results. Molecular marker of thrombin generation——TAT showed an activated coa gulant state immediately after thrombolytic therapy. Level of TAT showed no sign ificant changes between every two observed phases in controls. However, level of TAT increased significantly from 4.95±1.75μg/L ( 4.63±1.37μg/L) to 14.71±3 .31μg/L ( 14.25±2.53μg/L) before and immediately after administration of thro mbolytic agents UK(or rt PA). There was significant difference between level of serum TAT of patients with and without thrombolytic therapy (P< 0.05). Patients achieving clinical reperfusion had lower TAT level than those failing in thromb olytic therapy, and higher FMPV/Amax level than controls. D dimer, a surrogate of thrombolytic activity increased markedly and Fg significantly declined afte r thrombolytic therapy(P< 0.05).Conclusions. Thrombin generation occurred in plasma in response to excess fibri nolysis induced by thrombolytic therapy. Both urokinase and rt PA had procoagul ant action. This transient activation of the coagulant system might contribute t o early reocclusion. These data provided the theoretical support for simultaneou s administration of antico

关键词： acute myocardial infarction thrombolysis urokinase rt PA

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